Anxiolytic-like effects of sinapic acid in mice
Abstract
Sinapic acid is a phenylpropanoid compound and is found in various herbal materials and high-bran cereals. With the exception of its antioxidant activities, the pharmacological properties of sinapic acid have been rarely reported. The purpose of this study was to characterize the putative anxiolytic-like properties of sinapic acid using an elevated plus-maze (EPM) and hole-board test. Control mice were orally treated with an equal volume of vehicle (10% Tween 80 solution), and positive control mice were treated with diazepam (1 mg/kg, i.p.). Sinapic acid (4 mg/kg, p.o.) significantly increased the percentages of time spent in the open arms of the EPM test (P<0.05). In the hole-board test, sinapic acid also significantly increased the number of head-dips at 4 mg/kg (P<0.05). In addition, the anxiolytic-like properties of sinapic acid examined in the EPM test were blocked by flumazenil or bicuculline, which are GABA(A) antagonists. Moreover, sinapic acid markedly potentiated GABA current in single cortical neurons in a dose-dependant manner, and reactive I(GABA) increased to 1.8 times at 1 muM of sinapic acid. These results suggested that sinapic acid is a prominent anxiolytic agent, and that its anxiolytic-like effects are mediated via GABA(A) receptors and potentiating Cl(-) currents.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sinapinic acid in the composition of quinoa grains can potentiate GABA currents in individual cortical neurons and thus exert pronounced anxiolytic effects.
“Sinapinic acid in the composition of quinoa grains can potentiate GABA currents in individual cortical neurons and thus exert pronounced anxiolytic effects [8,15].”
From Anxiolytic and Antioxidant Effect of Phytoecdysteroids and Polyphenols from Chenopodium quinoa on an In Vivo Restraint Stress Model (2022) · cites this paper as [15]
Cites
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
Antioxidant Properties of Ferulic Acid and Its Related Compounds
Kikuzaki, H., Hisamoto, M., Hirose, K., Akiyama, K., & Taniguchi, H. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf011348w · Cited by 1,016 · see citing works
Handley, S. L., & Mithani, S. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00504983 · Cited by 974 · see citing works
Mattila, P. H., Pihlava, J., & Hellström, J. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051437z · Cited by 567 · see citing works
Hudson, E. A., Dinh, P. A., Kokubun, T., Simmonds, M. S. J., & Gescher, A. J. (2000) · PubMed · Cited by 443 · see citing works
Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects
Bonetti, E. P., Pieri, L., Cumin, R., Schaffner, R., Pieri, M., Gamzu, E. R., M�ller, R. K. M., & Haefely, W. E. (1982) · Psychopharmacology · doi:10.1007/bf00470579 · Cited by 337 · see citing works
Nystatin Perforated Patch Recording and Its Applications to Analyses of Intracellular Mechanisms.
Akaike, N., & Harata, N. C. (1994) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.44.433 · Cited by 306 · see citing works
Content of Phenolic Acids and Ferulic Acid Dehydrodimers in 17 Rye (Secale cereale L.) Varieties
Andreasen, M. F., Christensen, L. P., Meyer, A. S., & Hansen, Å. S. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991266w · Cited by 234 · see citing works
Absorption of Hydroxycinnamates in Humans after High-Bran Cereal Consumption
Kern, S. M., Bennett, R. N., Mellon, F. A., Kroon, P. A., & García‐Conesa, M. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0302299 · Cited by 214 · see citing works
Alasalvar, C., Karamać, M., Amarowicz, R., & Shahidi, F. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0601259 · Cited by 174 · see citing works
Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines
Akao, Y., Maruyama, H., Matsumoto, K., et al. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1057 · Cited by 173 · see citing works
Galato, D., Ckless, K., Susin, M. F., et al. (2001) · Redox Report · doi:10.1179/135100001101536391 · Cited by 146 · see citing works
Zou, Y., Kim, A. R., Kim, J. E., Choi, J. S., & Chung, H. Y. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020496z · Cited by 128 · see citing works
GABA-A receptors: a viable target for novel anxiolytics?
Whiting, P. J. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.08.005 · Cited by 126 · see citing works
Anxiolytic-Like Effects of Gastrodia elata and Its Phenolic Constituents in Mice
Jung, J. W., Yoon, B. H., Oh, H. R., et al. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.261 · Cited by 117 · see citing works
Self-citationLADER, M. H., & Morton, S. V. (1991) · British Journal of Addiction · doi:10.1111/j.1360-0443.1991.tb01831.x · Cited by 93 · see citing works
Giacomelli, C., Miranda, F. S., Gonçalves, N. S., et al. (2004) · Redox Report · doi:10.1179/135100004225006038 · Cited by 70 · see citing works
Niwa, T., Doi, U., Kato, Y., & Osawa, T. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01216-8 · Cited by 67 · see citing works
Cabib, S., Algeri, S., Perego, C., & Puglisi‐Allegra, S. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90089-m · Cited by 63 · see citing works
Kaempferol tetraglucosides from cabbage leaves
NIELSEN, J. K., Nørbæk, R., & Olsen, C. E. (1998) · Phytochemistry · doi:10.1016/s0031-9422(98)00422-1 · Cited by 61 · see citing works
Anxiolytic effects of the aqueous extract of Uncaria rhynchophylla
Jung, J. W., Ahn, N. Y., Oh, H. R., et al. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.05.019 · Cited by 56 · see citing works
Self-citationMin, B. I., Kim, C., Rhee, J. S., et al. (1996) · Brain Research · doi:10.1016/0006-8993(96)00614-2 · Cited by 44 · see citing works
Jeong, H., Han, S.-H., Min, B.-I., et al. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00062-4 · Cited by 43 · see citing works
Acylated flavonol sophorotriosides from pea shoots
Ferreres, F., Esteban, E., Carpena‐Ruiz, R. O., et al. (1995) · Phytochemistry · doi:10.1016/0031-9422(95)00137-v · Cited by 37 · see citing works
Lee, J., Hahm, E.-T., Min, B.-I., et al. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00039-x · Cited by 20 · see citing works
Self-citationAkhter, S., Green, J. R., Root, P. D., et al. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00031-4 · Cited by 17 · see citing works
Cho, Y., Han, S. H., Min, B.-I., Rhee, J., & Akaike, N. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02864-5 · Cited by 14 · see citing works
Self-citationAnxiolytic-like Effects of Phenylpropanoids Using the Elevated Plus-Maze in Mice
윤병훈, 최지웅, 정지욱, et al. (2005) · Yakhak Hoeji · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Quinoa Secondary Metabolites and Their Biological Activities or Functions
Lin, M., Han, P., Li, Y., Wang, W., Lai, D., & Zhou, L. (2019) · Molecules · doi:10.3390/molecules24132512 · Cited by 152 · see citing works
Fedotova, J., Kubatka, P., Büsselberg, D., Shleikin, A. G., Caprnda, M., Dragasek, J., Rodrigo, L., Pohanka, M., Gasparova, I., Nosal, V., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.107 · Cited by 59 · see citing works
Wang, J., Ma, H., Pan, Z., & Qu, W. (2017) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2017.05.034 · Cited by 40 · see citing works
Ouahabi, S., Daoudi, N. E., Loukili, E. H., Asmae, H., Merzouki, M., Bnouham, M., Challioui, A., Hammouti, B., Fauconnier, M.-L., Rhazi, L., et al. (2024) · Marine Drugs · doi:10.3390/md22060240 · Cited by 37 · see citing works
Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2022) · Molecules · doi:10.3390/molecules27249003 · Cited by 11 · see citing works
- Authors
- Yoon, B. H., Jung, J. W., Lee, J.-J., Cho, Y.-W., Jang, C.-G., Jin, C., Oh, T. H., & Ryu, J. H.
- Affiliations
- Kyung Hee University (KR)
- Daegu Haany University (KR)
- Sungkyunkwan University (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Ryu, Jong Hoon
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 81
- Issue
- 3
- Pages
- 234-240
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2047802797
- Cited by
- 129
- References
- 28
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 4
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sinapic acid, anxiolytic effects, GABAA receptor, chloride currents, phenylpropanoids, elevated plus maze, hole board test, flumazenil, bicuculline, diazepam, cortical neurons, anxiety
- MeSH terms
- Animals, Anxiety, Bicuculline, Cerebral Cortex, Coumaric Acids, Diazepam, Electrophysiology, Postural Balance, Flumazenil, gamma-Aminobutyric Acid, Male, Mice, Inbred ICR, Motor Activity, Muscle Relaxation, Muscle, Smooth, Neurons, Piperazines, Pyridines, Serotonin Antagonists, Anti-Anxiety Agents, Chloride Channels, Neurotransmitter Agents, GABA Antagonists, GABA Modulators, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
