Centella asiatica ameliorates diabetes-induced stress in rat tissues via influences on antioxidants and inflammatory cytokines
Abstract
Centella asiatica (L.) Urban (Family: Apiaceae) is a perennial herb that has been used to elevate mood, improve memory, treat wounds and manage kidney-related ailments in African traditional medicine practice. This study evaluated the potential benefits of C. asiatica (CA) on diabetes-induced stress in kidney and brain of rats. Following the induction of diabetes mellitus (DM), rats were orally treated with vehicle, CA or Metformin daily for 14 days. After treatment, renal and brain levels of inflammatory cytokines, TNF-α, IFN-γ, IL-4, and IL-10 were assessed. Oxidant and antioxidant biomarkers were also evaluated. Phyto-compounds in the crude methanol extract of CA were analyzed by Gas Chromatography-Mass Spectroscopy. Diabetes increased malondialdehyde (MDA) concentration by 39%; elevated levels of TNF-α (44%) and IFN-γ (20%); and reduced the antioxidant status in the kidney in comparison to normal control rats. In the brain, diabetic control rats had significantly greater levels of MDA, TNF-α, and IFN-γ (182%, 40%, and 20%, respectively) in addition to the lowered antioxidant status when compared to normal control rats. However, treatment with CA significantly reduced the renal levels of MDA (33%), TNF-α (78%), and IFN-γ (42%) while that of IL-10 increased by 18% when compared to diabetic control rats. In the brain, CA treatment elicited significant reductions in MDA (37%), TNF-α (30%), and IFN-γ (37%) levels while those of IL-4 and IL-10 increased by 94% and 20% respectiv…
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C. asiatica extract with asiaticoside as major component protects diabetic tissues from stress via antioxidant mechanisms to protect against diabetic kidney disease.
“and protecting diabetic tissues from stress via antioxidant mechanisms to protect against diabetic kidney disease.”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [122]
C. asiatica extract with asiaticoside as major component restores activities of kidney enzymes involved in glucose and amino acid oxidation in diabetic rats.
“it demonstrated several pharmacological effects in diabetic rats such as restoring the activities of kidney enzymes involved in glucose and amino acid oxidation in diabetes”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [122]
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- Authors
- Masola, B., Oguntibeju, O. O., & Oyenihi, A. B.
- Affiliations
- University of KwaZulu-Natal (ZA)
- Cape Peninsula University of Technology (ZA)
- Corresponding author
- Oyenihi, Ayodeji B.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 101
- Pages
- 447-457
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2791723815
- Cited by
- 83
- References
- 2
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 11 · 2022: 7 · 2021: 11 · 2020: 13 · 2019: 4 · 2018: 2
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of KwaZulu-Natal
- National Research Foundation
- Cape Peninsula University of Technology (CPUTRO22, CPUT: CPUTRJ23)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, diabetes mellitus, diabetic nephropathy, diabetic brain, oxidative stress, antioxidant status, inflammatory cytokines, TNF-α, interferon-gamma, IL-10, IL-4, malondialdehyde, metformin, phytochemicals, asiatic acid, oleanolic acid, stigmasterol, stevioside, α-humulene, anti-inflammatory activity, diabetes complications
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Diabetes Mellitus, Experimental, Inflammation, Kidney, Male, Malondialdehyde, Plant Extracts, Triterpenes, Cytokines, Oxidants, Rats, Sprague-Dawley, Oxidative Stress, Asteraceae, Protective Agents, Centella, Rats
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