Cited by 28Medicinal Plants and NeuroprotectionPhytochemicals and Antioxidant ActivitiesPhytochemistry and Biological Activities

Interrelationship between secondary metabolites and antioxidant capacities of Centella asiatica using bivariate and multivariate correlation analyses

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Shin, Hyun Young, Kim, Hoon, Jung, Soontag, Jeong, Eun-Jin, Lee, Kyung-Haeng, Bae, Yun-Jung, Suh, Hyung Joo, Jang, Keum-Il +1 more·2021·Applied Biological Chemistry

Abstract

Centella asiatica L. Urban (CA) is a valuable medicinal herb that contains various bioactive secondary metabolites. In the present study, the harvested CA was divided into whole plant and leaf parts, and were heated-air-dried or freeze-dried. The dried CA was extracted under various extraction conditions to obtain 16 extracts, and their antioxidant activities were examined. Twelve types of secondary metabolites (five polyphenolic acids, four triterpenoids, and three flavonoids) were quantified in each extract. Finally, the intercorrelations between secondary metabolites and antioxidant activities were analyzed through statistical analyses, such as Pearson correlation coefficient, scatter plotting, and principal component analysis. The antioxidant capacities of CA might be primarily influenced by major triterpenoids such as madecassoside and asiaticoside, which showed high content in the ethanol extracts of freeze-dried leaf parts. The present study provides a valuable groundwork for the development of optimal extraction processes for C. asiatica L. as an antioxidant material.

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Crossref · 10.1186/s13765-021-00656-9

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Authors
Shin, H. Y., Kim, H., Jung, S., Jeong, E.-J., Lee, K.-H., Bae, Y.-J., Suh, H. J., Jang, K.-I., & Yu, K.-W.
Affiliations
  • Korea University (KR)
  • Chung-Ang University (KR)
  • Korea National University of Transportation (KR)
  • Chungbuk National University (KR)
Corresponding author
Yu, Kwang-Won
Venue
Applied Biological Chemistry
Published
2021-12
Volume
64
Issue
1
ISSN
  • 0368-2897 (ISSN-L)
  • 2468-0834
  • 2468-0842
OpenAlex
W4200404183
Cited by
28
References
38
Citations by year
2026: 4 · 2025: 8 · 2024: 12 · 2023: 3 · 2022: 1
FWCI
4.51
Type
journal article
Language
en
Open access
Locations
Applied Biological Chemistry (publishedVersion, cc-by)
Funders
Rural Development Administration (PJ0152852021)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
Centella asiatica, secondary metabolites, antioxidant activity, triterpenoids, madecassoside, asiaticoside, polyphenolic acids, flavonoids, plant extracts, extraction conditions, freeze-drying, leaf extract, medicinal plants

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