Interrelationship between secondary metabolites and antioxidant capacities of Centella asiatica using bivariate and multivariate correlation analyses
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Centella asiatica L. Urban (CA) is a valuable medicinal herb that contains various bioactive secondary metabolites. In the present study, the harvested CA was divided into whole plant and leaf parts, and were heated-air-dried or freeze-dried. The dried CA was extracted under various extraction conditions to obtain 16 extracts, and their antioxidant activities were examined. Twelve types of secondary metabolites (five polyphenolic acids, four triterpenoids, and three flavonoids) were quantified in each extract. Finally, the intercorrelations between secondary metabolites and antioxidant activities were analyzed through statistical analyses, such as Pearson correlation coefficient, scatter plotting, and principal component analysis. The antioxidant capacities of CA might be primarily influenced by major triterpenoids such as madecassoside and asiaticoside, which showed high content in the ethanol extracts of freeze-dried leaf parts. The present study provides a valuable groundwork for the development of optimal extraction processes for C. asiatica L. as an antioxidant material.
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The pharmacological activity of Centella asiatica is attributed primarily to its secondary metabolites.
“The pharmacological activity of C. asiatica is attributed primarily to its secondary metabolites.”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Shin et al. 2021
Asiaticoside and madecassoside have been linked to VEGF-mediated angiogenesis.
“In particular, asiaticoside and madecassoside have been linked to transforming growth factor beta (TGF-β)/Smad activation, vascular endothelial growth factor (VEGF)-mediated angiogenesis, and improvements in structural skin integrity (Shin et al. 2021).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Shin et al. 2021
Asiaticoside and madecassoside have been linked to improvements in structural skin integrity.
“In particular, asiaticoside and madecassoside have been linked to transforming growth factor beta (TGF-β)/Smad activation, vascular endothelial growth factor (VEGF)-mediated angiogenesis, and improvements in structural skin integrity (Shin et al. 2021).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Shin et al. 2021
Asiaticoside and madecassoside have been linked to TGF-β/Smad activation.
“In particular, asiaticoside and madecassoside have been linked to transforming growth factor beta (TGF-β)/Smad activation, vascular endothelial growth factor (VEGF)-mediated angiogenesis, and improvements in structural skin integrity (Shin et al. 2021).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Shin et al. 2021
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- Authors
- Shin, H. Y., Kim, H., Jung, S., Jeong, E.-J., Lee, K.-H., Bae, Y.-J., Suh, H. J., Jang, K.-I., & Yu, K.-W.
- Affiliations
- Korea University (KR)
- Chung-Ang University (KR)
- Korea National University of Transportation (KR)
- Chungbuk National University (KR)
- Corresponding author
- Yu, Kwang-Won
- ORCID
- Venue
- Applied Biological Chemistry
- Published
- 2021-12
- Volume
- 64
- Issue
- 1
- ISSN
- 0368-2897 (ISSN-L)
- 2468-0834
- 2468-0842
- OpenAlex
- W4200404183
- Cited by
- 28
- References
- 38
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 12 · 2023: 3 · 2022: 1
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Applied Biological Chemistry (publishedVersion, cc-by)
- Funders
- Rural Development Administration (PJ0152852021)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- Centella asiatica, secondary metabolites, antioxidant activity, triterpenoids, madecassoside, asiaticoside, polyphenolic acids, flavonoids, plant extracts, extraction conditions, freeze-drying, leaf extract, medicinal plants
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