A Review for the Pharmacological Effect of Lycopene in Central Nervous System Disorders

Carotenoids and human health

RAO, A., & RAO, L. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.012 · Cited by 2,024 · see citing works

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Tönnies, E., & Trushina, E. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161088 · Cited by 1,750 · see citing works

Glutamate receptors, neurotoxicity and neurodegeneration

Lau, A., & Tymianski, M. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0809-1 · Cited by 1,188 · see citing works

p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington’s Disease

Bae, B.-I., Xu, H., Igarashi, S., Fujimuro, M., Agrawal, N., Taya, Y., Hayward, S. D., Moran, T. H., Montell, C., Ross, C. A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.005 · Cited by 480 · see citing works

Overview of Mechanisms of Action of Lycopene

Heber, D., & Lu, Q. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701013 · Cited by 478 · see citing works

Chemistry, Distribution, and Metabolism of Tomato Carotenoids and Their Impact on Human Health

Khachik, F., Carvalho, L. S., Bernstein, P. S., Muir, G. J., Zhao, D.-Y., & Katz, N. B. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222701002 · Cited by 473 · see citing works

Microglial Activation Mediates Chronic Mild Stress-Induced Depressive- and Anxiety-like Behavior in Adult Rats

Wang, Y.-L., Han, Q.-Q., Gong, W.-Q., Pan, D.-H., Wang, L.-Z., Hu, W., Yang, M., Li, B., Yu, J., & Liu, Q. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1054-3 · Cited by 438 · see citing works

Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease

Butterfield, D. A., & Boyd-Kimball, D. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170543 · Cited by 403 · see citing works

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

Farr, S. A., Yamada, K. A., Butterfield, D. A., Abdul, H. M., Xu, L., Miller, N. E., Banks, W. A., & Morley, J. E. (2008) · Endocrinology · doi:10.1210/en.2007-1722 · Cited by 382 · see citing works

Intractable epilepsy: management and therapeutic alternatives

Schuele, S., & Lüders, H. O. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70108-x · Cited by 346 · see citing works

Metabolic Dysfunction and Oxidative Stress in Epilepsy

Pearson-Smith, J. N., & Patel, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112365 · Cited by 277 · see citing works

Processing Effects on Lycopene Content and Antioxidant Activity of Tomatoes

Takeoka, G. R., Dao, L., Flessa, S., Gillespie, D. M., Jewell, W. T., Huebner, B., Bertow, D., & Ebeler, S. E. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0102721 · Cited by 272 · see citing works

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

Li, P., Stetler, R. A., Leak, R. K., Shi, Y., Li, Y., Yu, W., Bennett, M. V. L., & Chen, J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.011 · Cited by 260 · see citing works

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

Eikelenboom, P., van Exel, E. R., Hoozemans, J. J. M., Veerhuis, R., Rozemüller, A. J. M., & van Gool, W. A. (2010) · Neurodegenerative Diseases · doi:10.1159/000283480 · Cited by 259 · see citing works

Fluoxetine versus other types of pharmacotherapy for depression

Magni, L. R., Purgato, M., Gastaldon, C., Papola, D., Furukawa, T. A., Cipriani, A., & Barbui, C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004185.pub3 · Cited by 251 · see citing works

Tau Proteins and Tauopathies in Alzheimer’s Disease

Chong, F. P., Ng, K. Y., Koh, R. Y., & Chye, S. M. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0574-1 · Cited by 248 · see citing works

Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Erkinjuntti, T., Román, G., Gauthier, S., Feldman, H., & Rockwood, K. (2004) · Stroke · doi:10.1161/01.str.0000120731.88236.33 · Cited by 232 · see citing works

The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat

Kanoski, S. E., Meisel, R. L., Mullins, A. J., & Davidson, T. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.004 · Cited by 226 · see citing works

Enhanced bioavailability of lycopene when consumed as cis‐isomers from tangerine compared to red tomato juice, a randomized, cross‐over clinical trial

Cooperstone, J. L., Ralston, R. A., Riedl, K. M., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400658 · Cited by 208 · see citing works

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

Spinelli, M., Fusco, S., Mainardi, M., Scala, F., Natale, F., Lapenta, R., Mattera, A., Rinaudo, M., Puma, D. D. L., Ripoli, C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02221-9 · Cited by 208 · see citing works

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

Wang, W., Wang, C., Ding, X., Pan, Y., Gu, T., Wang, M., Liu, Y., Wang, F., Wang, S., & Kong, L. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12226 · Cited by 196 · see citing works

Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease

Reddy, P. H., & Shirendeb, U. P. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.016 · Cited by 188 · see citing works

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

Sachdeva, A. K., & Chopra, K. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.01.012 · Cited by 180 · see citing works

The role of depressive subtypes within the neuroinflammation hypothesis of major depressive disorder

Woelfer, M., Kasties, V., Kahlfuss, S., & Walter, M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.034 · Cited by 171 · see citing works

Lycopene attenuates diabetes-associated cognitive decline in rats

Kuhad, A., Sethi, R., & Chopra, K. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.05.013 · Cited by 168 · see citing works

Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

Zhao, B., Ren, B., Guo, R., Zhang, W., Ma, S., Yao, Y., Yuan, T., Liu, Z., & Liu, X. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.050 · Cited by 164 · see citing works

Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

d’Avila, J. C., Siqueira, L. D., Mazeraud, A., Azevedo, E. P., Foguel, D., Castro-Faria-Neto, H. C., Sharshar, T., Chrétien, F. C., & Bozza, F. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1059-y · Cited by 164 · see citing works

Reconsidering the effects of monosodium glutamate: A literature review

Freeman, M. (2006) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2006.00160.x · Cited by 150 · see citing works

Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

Sandhir, R., Mehrotra, A., & Kamboj, S. S. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.07.005 · Cited by 149 · see citing works

Lycopene Deficiency in Ageing and Cardiovascular Disease

Petyaev, I. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3218605 · Cited by 147 · see citing works

Exposure to gestational diabetes mellitus induces neuroinflammation, derangement of hippocampal neurons, and cognitive changes in rat offspring

Vuong, B., Odero, G., Rozbacher, S., Stevenson, M., Kereliuk, S. M., Pereira, T. J., Dolinsky, V. W., & Kauppinen, T. M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0859-9 · Cited by 147 · see citing works

Tetrabenazine for the treatment of chorea and other hyperkinetic movement disorders

Jankovic, J. J., & Clarence‐Smith, K. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.149 · Cited by 146 · see citing works

Supplementation of lycopene attenuates lipopolysaccharide-induced amyloidogenesis and cognitive impairments via mediating neuroinflammation and oxidative stress

Wang, J., Li, L., Wang, Z., Cui, Y., Tan, X., Yuan, T., Liu, Q., Liu, Z., & Liu, X. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.009 · Cited by 145 · see citing works

Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus

Sharma, D. R., Wani, W. Y., Sunkaria, A., Kandimalla, R. J., Sharma, R. K., Verma, D., Bal, A., & Gill, K. D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.055 · Cited by 144 · see citing works

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Hajjar, I. M., Hayek, S. S., Goldstein, F. C., Martin, G. S., Jones, D. P., & Quyyumi, A. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1026-z · Cited by 143 · see citing works

Nano-liposomes of lycopene reduces ischemic brain damage in rodents by regulating iron metabolism

Zhao, Y., Xin, Z., Li, N., Chang, S., Chen, Y., Geng, L., Chang, H., Shi, H., & Chang, Y. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.082 · Cited by 139 · see citing works

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model

Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.12.023 · Cited by 138 · see citing works

Acute alterations in microvascular basal lamina after subarachnoid hemorrhage

Sehba, F. A., Mostafa, G., Knopman, J., Friedrich, V. L., & Bederson, J. B. (2004) · Journal of neurosurgery · doi:10.3171/jns.2004.101.4.0633 · Cited by 133 · see citing works

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson’s disease in mice

Prema, A., Janakiraman, U., Manivasagam, T., et al. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.024 · Cited by 127 · see citing works

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia

Wu, R. P., Hayashi, T., Cottam, H. B., Jin, G., Yao, S., Wu, C. C. N., Rosenbach, M., Corr, M., Schwab, R. B., & Carson, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002890107 · Cited by 126 · see citing works

Seed‐induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease

Ziegler‐Waldkirch, S., d’Errico, P., Sauer, J., Erny, D., Savanthrapadian, S., Loreth, D., Katzmarski, N., Blank, T., Bartos, M., Prinz, M., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201797021 · Cited by 121 · see citing works

Fibroblast growth factor 21 protects mouse brain against d-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation

Yu, Y., Bai, F., Wang, W., Liu, Y., Yuan, Q., Qu, S., Zhang, T., Tian, G., Li, S., Li, D., et al. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.020 · Cited by 119 · see citing works

Calycosin ameliorates diabetes-induced cognitive impairments in rats by reducing oxidative stress via the PI3K/Akt/GSK-3β signaling pathway

Wang, X., & Zhao, L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.024 · Cited by 118 · see citing works

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

Jiang, W., Guo, M., & Hai, X. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10180 · Cited by 118 · see citing works

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

Prakash, A. K., & Kumar, A. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.036 · Cited by 116 · see citing works

Does minocycline have antidepressant effect?

Pae, C., Marks, D. M., Han, C., & Patkar, A. A. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.12.005 · Cited by 108 · see citing works

Role of Mitochondria in Methamphetamine-Induced Dopaminergic Neurotoxicity: Involvement in Oxidative Stress, Neuroinflammation, and Pro-apoptosis—A Review

Shin, E., Tran, H., Nguyen, P. T., Jeong, J. H., Nah, S.-Y., Jang, C., Nabeshima, T., & Kim, H. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2318-5 · Cited by 108 · see citing works

Role of MCP-1 and CCR2 in ethanol-induced neuroinflammation and neurodegeneration in the developing brain

Zhang, K., Wang, H., Xu, M., Frank, J. A., & Luo, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1241-2 · Cited by 108 · see citing works

Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways

Jang, M., & Cho, I. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9230-2 · Cited by 107 · see citing works

Complex interactions between dietary and genetic factors impact lycopene metabolism and distribution

Moran, N. E., Erdman, J. W., & Clinton, S. K. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.06.017 · Cited by 104 · see citing works

A potent antioxidant, lycopene, affords neuroprotection against microglia activation and focal cerebral ischemia in rats.

Hsiao, G., Fong, T.-H., Tzu, N.-H., Lin, K., Chou, D., & Sheu, J. R. (2004) · PubMed · Cited by 103 · see citing works

Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: Opportunities, challenges and future directions for cerebral stroke management

Rana, A. K., & Singh, D. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.07.006 · Cited by 99 · see citing works

Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-α1/heme oxygenase-1 pathways

Lin, H.-Y., Huang, B.-R., Yeh, W., Lee, C., Huang, S.-S., Lai, C., Lin, H., & Lu, D. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.020 · Cited by 97 · see citing works

Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer’s disease models

Lipton, S. A., Rezaie, T., Nutter, A., Lopez, K. M., Parker, J., Kosaka, K., Satoh, T., McKercher, S. R., Masliah, E., & Nakanishi, N. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.389 · Cited by 97 · see citing works

Betulinic acid protects mice from cadmium chloride-induced toxicity by inhibiting cadmium-induced apoptosis in kidney and liver

Fan, R., Hu, P., Wang, Y., Lin, H.-Y., Su, K., Feng, X., Wei, L., & Yang, F. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.09.003 · Cited by 94 · see citing works

Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review.

Lee, S., Yang, M., Kim, J., Kang, S., Kim, J., Kim, J.-C., Jung, C., Shin, T., Kim, S.-H., & Moon, C. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.07.010 · Cited by 92 · see citing works

Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells

Hwang, S., Lim, J. W., & Kim, H. (2017) · Nutrients · doi:10.3390/nu9080883 · Cited by 92 · see citing works

Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats

Yin, Q., Ma, Y., Yan, H., Hou, X., Chen, J., Shen, C., Sun, M., Shang, Y., Dong, S., Zeng, Z., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.020 · Cited by 90 · see citing works

Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium.

Mundy, W. R., & Freudenrich, T. M. (2000) · PubMed · Cited by 90 · see citing works

Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity

Henriques, J. F., Portugal, C. C., Canedo, T., Relvas, J. B., Summavielle, T., & Socodato, R. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2017.11.002 · Cited by 89 · see citing works

Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons

Qu, M., Li, L., Chen, C., et al. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.048 · Cited by 88 · see citing works

Transplanted Neuroblasts Differentiate Appropriately into Projection Neurons with Correct Neurotransmitter and Receptor Phenotype in Neocortex Undergoing Targeted Projection Neuron Degeneration

Shin, J. J., Fricker‐Gates, R. A., Perez, F. A., Leavitt, B. R., Zurakowski, D., & Macklis, J. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07404.2000 · Cited by 88 · see citing works

Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response

Xu, W., Charles, I. G., & Moncada, S. (2005) · Cell Research · doi:10.1038/sj.cr.7290267 · Cited by 85 · see citing works

Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice

Zhao, B., Liu, H., Wang, J., Liu, P., Tan, X., Ren, B., Liu, Z., & Liu, X. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05770 · Cited by 84 · see citing works

Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway

Qu, M., Zhou, Z., Chen, C., Li, M., Pei, L., Chu, F., Yang, J., Wang, Y., Li, L., Liu, C., et al. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.005 · Cited by 83 · see citing works

Colchicine induces apoptosis in organotypic hippocampal slice cultures

Kristensen, B. W., Noer, H., Gramsbergen, J. B., Zimmer, J., & Noraberg, J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04080-5 · Cited by 80 · see citing works

Dietary Lycopene Supplementation Improves Cognitive Performances in Tau Transgenic Mice Expressing P301L Mutation via Inhibiting Oxidative Stress and Tau Hyperphosphorylation

Yu, L., Wang, W., Pang, W., Xiao, Z.-H., Jiang, Y., & Hong, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161216 · Cited by 77 · see citing works

Lycopene mitigates β-amyloid induced inflammatory response and inhibits NF-κB signaling at the choroid plexus in early stages of Alzheimer’s disease rats

Liu, C., Wang, R., Yi, Y., Gao, Z., & Chen, Y. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.014 · Cited by 77 · see citing works

Toxicokinetics of Colchicine in Humans: Analysis of Tissue, Plasma and Urine Data in Ten Cases

Rochdi, M., Sabouraud, A. E., Baud, F. J., et al. (1992) · Human & Experimental Toxicology · doi:10.1177/096032719201100612 · Cited by 76 · see citing works

Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression

Graff, R. E., Pettersson, A., Lis, R. T., Ahearn, T. U., Markt, S. C., Wilson, K. M., Rider, J. R., Fiorentino, M., Finn, S. P., Kenfield, S. A., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.118703 · Cited by 76 · see citing works

Lycopene Prevents Amyloid [Beta]-Induced Mitochondrial Oxidative Stress and Dysfunctions in Cultured Rat Cortical Neurons

Qu, M., Jiang, Z., Liao, Y., Song, Z., & Nan, X. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1837-9 · Cited by 76 · see citing works

Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus

Kanter, M., Ünsal, C., Aktaş, C., et al. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713504810 · Cited by 75 · see citing works

Serum lycopene decreases the risk of stroke in men

Karppi, J., Laukkanen, J. A., Sivenius, J., Ronkainen, K., & Kurl, S. (2012) · Neurology · doi:10.1212/wnl.0b013e31826e26a6 · Cited by 73 · see citing works

Loss of Brain Norepinephrine Elicits Neuroinflammation-Mediated Oxidative Injury and Selective Caudo-Rostral Neurodegeneration

Song, S., Jiang, L., Oyarzabal, E. A., Wilson, B. C., Li, Z., Shih, Y. I., Wang, Q., & Hong, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1235-1 · Cited by 73 · see citing works

Anticancer Effect of Lycopene in Gastric Carcinogenesis

Kim, M. J., & Kim, H. (2015) · Journal of Cancer Prevention · doi:10.15430/jcp.2015.20.2.92 · Cited by 70 · see citing works

Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo

Deng, Y., Wang, W., Yu, P., Xi, Z., Xu, L., Li, X., & He, N. (2013) · Nanoscale Research Letters · doi:10.1186/1556-276x-8-190 · Cited by 69 · see citing works

Glycemic extremes are related to cognitive dysfunction in children with type 1 diabetes: A meta‐analysis

He, J., Ryder, A. G., Li, S., Liu, W., & Zhu, X. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12840 · Cited by 69 · see citing works

Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway

LEI, X., Lei, L., ZHANG, Z., & Cheng, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4534 · Cited by 68 · see citing works

Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet

Zeng, Z., Wang, H., Jia, Z., & Hao, S. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-101919 · Cited by 67 · see citing works

Effect of meditation on neurophysiological changes in stress mediated depression

Kasala, E. R., Bodduluru, L. N., Maneti, Y., & Thipparaboina, R. (2013) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2013.10.001 · Cited by 66 · see citing works

Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity

Kumar, P., Kalonia, H., & Kumar, A. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.001 · Cited by 66 · see citing works

Mitochondrial Dysfunction in Epilepsy

Khurana, D. S., Valencia, I., Goldenthal, M. J., et al. (2013) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2013.10.001 · Cited by 64 · see citing works

Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model

Sadek, K. M., Abouzed, T. K., & Nasr, S. M. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0388 · Cited by 61 · see citing works

Baincalein alleviates early brain injury after experimental subarachnoid hemorrhage in rats: Possible involvement of TLR4/NF-κB-mediated inflammatory pathway

Wang, C., Xie, G.-B., Zhou, C., Zhang, X., Li, T., Xu, J., Li, N., Ding, K., Hang, C., Shi, J., et al. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.014 · Cited by 59 · see citing works

Diabetes in the Elderly

Kalra, S., & Sharma, S. K. (2018) · Diabetes Therapy · doi:10.1007/s13300-018-0380-x · Cited by 58 · see citing works

Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons

Qu, M., Nan, X., Gao, Z., Guo, B., Liu, B., & Chen, Z. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.005 · Cited by 57 · see citing works

Ursolic acid alleviates early brain injury after experimental subarachnoid hemorrhage by suppressing TLR4-mediated inflammatory pathway

Zhang, T., Su, J., Guo, B., et al. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.10.009 · Cited by 57 · see citing works

Plasma Lycopene, Other Carotenoids, and the Risk of Type 2 Diabetes in Women

Wang, L., Liu, S., Pradhan, A. D., Manson, J. E., Buring, J. E., Gaziano, J. M., & Sesso, H. D. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj240 · Cited by 57 · see citing works

Hypercholesterolemia induced cerebral small vessel disease

Kraft, P., Schuhmann, M. K., Garz, C., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182822 · Cited by 55 · see citing works

Effect of Tomato Intake on Striatal Monoamine Level in a Mouse Model of Experimental Parkinson's Disease.

Suganuma, H., Hirano, T., ARIMOTO, Y., et al. (2002) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.48.251 · Cited by 53 · see citing works

SIRT1 deacetylase in aging‐induced neuromuscular degeneration and amyotrophic lateral sclerosis

Herskovits, A. Z., Hunter, T. A., Maxwell, N. D., Pereira, K., Whittaker, C. A., Valdez, G., & Guarente, L. (2018) · Aging Cell · doi:10.1111/acel.12839 · Cited by 53 · see citing works

NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson’s disease

Cheng, L. T., Chen, L., Wei, X., Wang, Y., Ren, Z.-P., Zeng, S., Zhang, X., Wen, H., Gao, C., & Liu, H. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1289-z · Cited by 52 · see citing works

The Effects of Lycopene and Insulin on Histological Changes and the Expression Level of Bcl-2 Family Genes in the Hippocampus of Streptozotocin-Induced Diabetic Rats

Soleymaninejad, M., Jorsaraei, S. G. A., Feizi, F., & Anarkooli, I. J. (2017) · Journal of Diabetes Research · doi:10.1155/2017/4650939 · Cited by 51 · see citing works

Beneficial effects of lycopene against haloperidol induced orofacial dyskinesia in rats: Possible neurotransmitters and neuroinflammation modulation

Datta, S., Jamwal, S., Deshmukh, R. R., et al. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.032 · Cited by 50 · see citing works

Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism

Shin, E., Nam, Y., Tu, T.-H. T., Lim, Y., Wie, M., Kim, D., Jeong, J., & Kim, H.-C. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1516-7 · Cited by 49 · see citing works

Stroke Mechanisms

Wong, K. S., Caplan, L. R., & Kim, J. S. (2016) · Monographs in clinical neuroscience/Frontiers of neurology and neuroscience/Monographs in neural sciences · doi:10.1159/000448302 · Cited by 49 · see citing works

Lycopene protects against memory impairment and mito-oxidative damage induced by colchicine in rats: An evidence of nitric oxide signaling

Prakash, A. K., & Kumar, A. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.08.016 · Cited by 48 · see citing works

Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation

Zhang, F., Fu, Y., Zhou, X., Pan, W. X., Shi, Y., Wang, M., Zhang, X., Qi, D., Li, L., Ma, K., et al. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.06.001 · Cited by 48 · see citing works

Free [NADH]/[NAD+] regulates sirtuin expression

Gambini, J., Gómez‐Cabrera, M. C., Borrás, C., Vallés, S. L., López-Grueso, R., Martinez-Bello, V. E., Herranz, D., Pallardó, F. V., Tresguerres, J. A. F., Serrano, M., et al. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.04.020 · Cited by 47 · see citing works

Neuroprotective Effect of Lycopene Against PTZ-induced Kindling Seizures in Mice: Possible Behavioural, Biochemical and Mitochondrial Dysfunction

Bhardwaj, M., & Kumar, A. (2015) · Phytotherapy Research · doi:10.1002/ptr.5533 · Cited by 47 · see citing works

Lycopene Dietary Intervention

Biddle, M., Lennie, T. A., Bricker, G. V., Kopec, R. E., Schwartz, S. J., & Moser, D. K. (2014) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000108 · Cited by 47 · see citing works

Intracellular pH changes during oligodendrocyte differentiation in primary culture

Boussouf, A., & Gaillard, S. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000315)59:6 · Cited by 46 · see citing works

Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats

Wang, Z., Fan, J., Wang, J., Li, Y., Xiao, L., Duan, D., & Wang, Q. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.014 · Cited by 46 · see citing works

Are Non-steroidal Anti-Inflammatory Drugs Clinically Suitable for the Treatment of Symptoms in Depression-Associated Inflammation?

Baune, B. T. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_19 · Cited by 46 · see citing works

Side Effects to Antidepressant Treatment in Patients With Depression and Comorbid Panic Disorder

Shankman, S. A., Gorka, S. M., Katz, A. C., Klein, D. N., Markowitz, J. C., Arnow, B. A., Manber, R., Rothbaum, B. O., Thase, M. E., Schatzberg, A. F., et al. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10370 · Cited by 45 · see citing works

TRPM7 channels play a role in high glucose–induced endoplasmic reticulum stress and neuronal cell apoptosis

Huang, Y., Leng, T., Inoue, K., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001032 · Cited by 45 · see citing works

Protective effect of naringin on 3-nitropropionic acid-induced neurodegeneration through the modulation of matrix metalloproteinases and glial fibrillary acidic protein

Gopinath, K., & Sudhandiran, G. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2015-0035 · Cited by 43 · see citing works

Alzheimer';s Disease and Natural Products: Future Regimens Emerging from Nature

Islam, M. A., Khandker, S. S., Alam, F., Khalil, M. I., Kamal, M. A., & Gan, S. H. (2017) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026617666170103163054 · Cited by 43 · see citing works

The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert‐Butyl Hydroperoxide‐Induced Neuron Oxidative Damage

Huang, C., Gan, D., Fan, C., Wen, C., Li, A., Li, Q., Zhao, J., Wang, Z., Zhu, L., & Lu, D. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5490218 · Cited by 43 · see citing works

Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

Lee, M., Ban, J.-J., Chung, J. Y., Im, W., & Kim, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195968 · Cited by 42 · see citing works

Lycopene Inhibits the Isomerization of β-Carotene during Quenching of Singlet Oxygen and Free Radicals

Heymann, T., Heinz, P., & Glomb, M. A. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00377 · Cited by 41 · see citing works

Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro

Hossain, M. E., Matsuzaki, K., Katakura, M., Sugimoto, N., Mamun, A. A., Islam, R., Hashimoto, M., & Shido, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0190356 · Cited by 40 · see citing works

Tangerine tomatoes increase total and tetra- cis -lycopene isomer concentrations more than red tomatoes in healthy adult humans

Burri, B. J., Burri, B. J., Chapman, M. H., Neidlinger, T. R., Seo, J., Ishida, B. K., Burri, B. J., Chapman, M. H., Neidlinger, T. R., Seo, J., et al. (2008) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480701782084 · Cited by 39 · see citing works

Medical Management of Parkinsons Disease: Focus on Neuroprotection

Rı́os, C., Boll, M., & Alcaraz-Zubeldia, M. (2011) · Current Neuropharmacology · doi:10.2174/157015911795596577 · Cited by 39 · see citing works

Lycopene Inhibits Ischemia/Reperfusion-Induced Neuronal Apoptosis in Gerbil Hippocampal Tissue

Fujita, K., Yoshimoto, N., Kato, T., Imada, H., Matsumoto, G., Inakuma, T., Nagata, Y., & Miyachi, E. (2013) · Neurochemical Research · doi:10.1007/s11064-012-0952-5 · Cited by 39 · see citing works

Interaction between Monoamine Oxidase B Inhibitors and Selective Serotonin Reuptake Inhibitors

Aboukarr, A., & Giudice, M. (2018) · The Canadian Journal of Hospital Pharmacy · doi:10.4212/cjhp.v71i3.2586 · Cited by 39 · see citing works

Acupuncture Improves Cerebral Microenvironment in Mice with Alzheimer’s Disease Treated with Hippocampal Neural Stem Cells

Zhao, L., Zhou, C., Li, L., Liu, J., Shi, H., Kan, B., Li, Z., Li, Y., Han, J., & Yu, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0054-5 · Cited by 38 · see citing works

Antagonistic effects of lycopene on cadmium-induced hippocampal dysfunctions in autophagy, calcium homeostatis and redox

Zhang, F., Xing, S.-P., & Li, Z. (2017) · Oncotarget · doi:10.18632/oncotarget.18249 · Cited by 38 · see citing works

Protection of the Blood–Brain Barrier as a Therapeutic Strategy for Brain Damage

Michinaga, S., & Kōyama, Y. (2017) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b16-00991 · Cited by 35 · see citing works

Passionflower Fruit—A "New" Source of Lycopene?

Mourvaki, E., Gizzi, S., Rossi, R., & Rufini, S. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.104 · Cited by 33 · see citing works

Insulin deficiency: A possible link between obesity and cognitive function

Nameni, G., Farhangi, M. A., Hajiluian, G., Shahabi, P., & Abbasi, M. M. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.02.008 · Cited by 32 · see citing works

Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia

Yang, W., Shen, Z., Wen, S., Wang, W., & Hu, M. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0660-5 · Cited by 32 · see citing works

Moderate exercise prevents neurodegeneration in D-galactose-induced aging mice

Wei, S., Li, L., Xu, M. J., Shen, B., Li, M., & Gao, Q. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.182709 · Cited by 31 · see citing works

Effects of dietary methylmercury on the dopaminergic system of adult fathead minnows and their offspring

Nielsen, K. M., Venables, B. J., & Roberts, A. P. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3630 · Cited by 31 · see citing works

Effects and Trimethyltin on Hippocampal Dopaminergic Markers and Cognitive Behaviour

Mignini, F., Nasuti, C., Artico, M., Giovannetti, F., Fabrizi, C., Fumagalli, L., Iannetti, G., & Pompili, E. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500428 · Cited by 30 · see citing works

Effects of Lycopene and Sodium Valproate on Pentylenetetrazol-Induced Kindling in Mice.

Kumar, V., Sharma, S., Nagarajan, K., et al. (2016) · PubMed · Cited by 29 · see citing works

Intake of Tomato-Enriched Diet Protects from 6-Hydroxydopamine-Induced Degeneration of Rat Nigral Dopaminergic Neurons

Matteo, V. D., Pierucci, M., Giovanni, G. D., et al. (2009) · Springer eBooks · doi:10.1007/978-3-211-92660-4_28 · Cited by 28 · see citing works

Lycopene attenuates early brain injury and inflammation following subarachnoid hemorrhage in rats.

Wu, A., Liu, R., Dai, W.-M., et al. (2015) · PubMed · Cited by 27 · see citing works

A polymeric colchicinoid prodrug with reduced toxicity and improved efficacy for vascular disruption in cancer therapy

Crielaard, B. J., van der Wal, Lammers, et al. (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s24450 · Cited by 27 · see citing works

Hydrogen sulfide may attenuate methylmercury-induced neurotoxicity via mitochondrial preservation

Han, J., Yang, X., Chen, X., Li, Z., Fang, M., Bai, B., & Tan, D. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.12.020 · Cited by 23 · see citing works

Hypercholesterolemia and neurodegeneration. Comparison of hippocampal phenotypes in LDLr knockout and APPswe/PS1dE9 mice

Ettcheto, M., Petrov, D., Pedrós, I., de Lemos, L., Pallàs, M., Alegret, M., Laguna, J. C., Folch, J., & Camins, A. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.010 · Cited by 22 · see citing works

Homocysteine has anti-inflammatory properties in a hypercholesterolemic rat model in vivo

Pirchl, M., Ullrich, C., Sperner‐Unterweger, B., & Humpel, C. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.03.001 · Cited by 22 · see citing works

Neurologic Complications of Diabetes

Charnogursky, G. A., Emanuele, N., & Emanuele, M. A. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0457-5 · Cited by 20 · see citing works

L-Theanine Decreases Orofacial Dyskinesia Induced by Reserpine in Rats

Soung, H.-S., Wang, M., Chang, K.-C., Chen, C.-N., Chang, Y. F., Yang, C.-C., & Tseng, H.-C. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9897-z · Cited by 18 · see citing works

Deuterium Tetrabenazine for Tardive Dyskinesia

Cummings, M. A., Proctor, G. J., & Stahl, S. M. (2018) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.cupr.010318 · Cited by 16 · see citing works

Anandamide attenuates haloperidol-induced vacuous chewing movements in rats

Röpke, J., Busanello, A., Leal, C. Q., Reis, E. D. M., de Freitas, C. M., Villarinho, J. G., Figueira, F. H., Mello, C. F., Ferreira, J., & Fachinetto, R. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.04.006 · Cited by 15 · see citing works

Plasma profiles of lycopene after single oral and intravenous administrations in dogs

Vertzoni, M., Valsami, G. N., & Reppas, C. I. (2006) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.58.9.0007 · Cited by 14 · see citing works

WHAT'S THAT STUFF?

DALTON, L. W. (2002) · Chemical & Engineering News · doi:10.1021/cen-v080n045.p040 · Cited by 14 · see citing works

Increased Risk of Anxiety or Depression After Traumatic Spinal Cord Injury in Patients with Preexisting Hyperlipidemia: A Population-Based Study

Lim, S.-W., Nyam, T.-T. E., Ho, C., Shiue, Y., Wang, J., Chio, C., & Kuo, J. (2017) · World Neurosurgery · doi:10.1016/j.wneu.2017.06.182 · Cited by 9 · see citing works

Lycopene depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebrocortical nerve terminals

Lü, C.-W., Hung, C., Jean, W.-H., et al. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0520 · Cited by 9 · see citing works

Lycopene Pretreatment Ameliorates Acute Ethanol Induced NAD+ Depletion in Human Astroglial Cells

Guest, J., Guillemin, G., Heng, B., & Grant, R. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/741612 · Cited by 6 · see citing works

NEPHROPROTECTIVE EFFECT OF LYCOPENE IN HYPERGLYCEMIA INDUCED OXIDATIVE STRESS IN MALE WISTAR RATS

Akilandeswari, V., Sekkizhar, M., Santhakumari, A., et al. (2015) · International Journal of Current Pharmaceutical Research · Cited by 5 · see citing works

Spontaneously hypertensive rats exhibit higher sensitivity to ethanol-induced hypotensive effects: Role of NMDA receptors and nitric oxide in rostral ventrolateral medulla

Lin, H., Cheng, T.-T., Lo, H., et al. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.04.001 · Cited by 5 · see citing works

Central action of CART induces neuronal activation in the paraventricular and dorsomedial hypothalamus of diet-induced obese and lean mice

Romeu, D. D. P., Ribeiro, L. M., & Antunes, V. R. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.015 · Cited by 1 · see citing works

Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders

Imran, M., Ghorat, F., Ul-Haq, I., Ur-Rehman, H., Aslam, F., Heydari, M., Shariati, M. A., Okuskhanova, E., Yessimbekov, Z., Thiruvengadam, M., et al. (2020) · Antioxidants · doi:10.3390/antiox9080706 · Cited by 426 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets

Cohn, W., Thürmann, P., Tenter, U., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0476-0 · Cited by 51 · see citing works

1,5-Dihydroxyiridanyl-lycopene in Tomato Puree

Yokota, T., Etoh, H., Ukai, N., et al. (1997) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.61.549 · Cited by 14 · see citing works

Review on the study of lycopene stability

Gao, Y. (2008) · China Food Additives

A Food-Based Formulation Provides Lycopene with the Same Bioavailability to Humans as That from Tomato Paste

Richelle, M., Bortlik, K., Hager, C., et al. (2002) · Journal of Nutrition · doi:10.1093/jn/132.3.404 · Cited by 122 · see citing works