Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Erkinjuntti, Timo; Román, Gustavo; Gauthier, Serge; Feldman, Howard; Rockwood, Kenneth

doi:10.1161/01.str.0000120731.88236.33

Cited by 232Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

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Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

Erkinjuntti, Timo, Román, Gustavo, Gauthier, Serge, Feldman, Howard, Rockwood, Kenneth·2004·Stroke

DOI 10.1161/01.str.0000120731.88236.33

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Abstract

Background— Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD). Summary— Progress in understanding vascular cognitive impairment (VCI) and vascular dementia (VaD) has resulted in promising symptomatic and preventive treatments. Cholinergic deficits in VaD due to ischemia of basal forebrain nuclei and cholinergic pathways can be treated with cholinesterase inhibitors used in AD. Controlled clinical trials with donepezil and galantamine in patients with VaD, as well as in patients with AD plus CVD, have demonstrated improvement in cognition, behavior, and activities of daily living. The N -methyl- d -aspartate receptor antagonist memantine stabilized progression of VaD compared with placebo. Primary and secondary stroke prevention, in particular with control of hypertension and hyperlipidemia, can decrease VaD incidence. Conclusions— From a public health viewpoint, recognition of VCI before the development of dementia and correction of vascular burden on the brain may lead to a global decrease of incident dementia.

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Management of vascular risks and symptomatic pharmacotherapy targeting VaD has been the primary approach.
“Management of vascular risks and symptomatic pharmacotherapy targeting VaD has been the primary approach.390”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [390]

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Authors: Erkinjuntti, T., Román, G., Gauthier, S., Feldman, H., & Rockwood, K.
Affiliations: Dalhousie University (CA)
From Helsinki University Central Hospital, Helsinki, Finland (T.E.); University of Texas Health Science Center at San Antonio and A. Murphy Veterans Administration Hospital, San Antonio, Tex (G.R.); Alzheimer’s Disease Research Unit, McGill Centre for Studies on Aging, Montreal, Quebec, Canada (S.G.); Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada (H.F.); and Queen Elizabeth II Health Science Centre, Geriatric Medicine Research Unit, Dalhousie University,...
ORCID: Erkinjuntti, Timo
Gauthier, Serge
Feldman, Howard
Rockwood, Kenneth
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-04
Volume: 35
Issue: 4
Pages: 1010-1017
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000120731.88236.33
OpenAlex: W2167597327
Cited by: 232
References: 85
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 38 · 2019: 5 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 9
FWCI: 13.17
Type: journal article
Language: en
Open access: closed
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: vascular dementia, vascular cognitive impairment, cholinesterase inhibitors, donepezil, galantamine, memantine, NMDA receptor antagonists, Alzheimer's disease, cerebrovascular disease, stroke prevention, hypertension, hyperlipidemia, cholinergic deficit, dementia prevention
MeSH terms: Rivastigmine, Donepezil, Carbamates, Cardiovascular Diseases, Cerebrovascular Disorders, Cholinesterase Inhibitors, Cognition Disorders, Galantamine, Humans, Indans, Terminology as Topic, Piperidines, Risk Factors, Dementia, Vascular, Controlled Clinical Trials as Topic, Stroke, Phenylcarbamates

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Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

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