Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930 · see citing works

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397 · see citing works

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works

Oxidative mechanisms in the toxicity of metal ions

Stohs, S. J., & Bagchi, D. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00159-h · Cited by 4,219 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814 · see citing works

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630 · see citing works

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works

Neuropathological alterations in Alzheimer disease

Serrano-Pozo, A., Frosch, M. P., Masliah, E., & Hyman, B. T. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006189 · Cited by 3,345 · see citing works

Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality

Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease

Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376 · see citing works

The organization of recent and remote memories

Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138 · see citing works

Copper, iron and zinc in Alzheimer's disease senile plaques

Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(98)00092-6 · Cited by 2,120 · see citing works

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works

Intracellular amyloid-β in Alzheimer's disease

LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works

Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment

Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844 · see citing works

Redefining Oxidative Stress

Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726 · see citing works

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

Cleary, J. P., Walsh, D. M., Hofmeister, J. J., Shankar, G. M., Kuskowski, M. A., Selkoe, D. J., & Ashe, K. H. (2004) · Nature Neuroscience · doi:10.1038/nn1372 · Cited by 1,677 · see citing works

Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population‐based perspective

Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., & Johns, H. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.016 · Cited by 1,660 · see citing works

Role of ROS and RNS Sources in Physiological and Pathological Conditions

Meo, S. D., Reed, T. T., Venditti, P., & Víctor, V. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1245049 · Cited by 1,638 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 1× · see citing works

Rapid induction of Alzheimer A beta amyloid formation by zinc

Bush, A., Pettingell, W., Multhaup, G., d Paradis, M., Vonsattel, J., Gusella, J., Beyreuther, K., Masters, C., & Tanzi, R. (1994) · Science · doi:10.1126/science.8073293 · Cited by 1,522 · see citing works

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Cherny, R. A., Atwood, C. S., Xilinas, M. E., Gray, D. N., Jones, W. D., McLean, C. A., Barnham, K. J., Volitakis, I., Fraser, F. W., Kim, Y.-S., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00317-8 · Cited by 1,447 · see citing works

Alzheimer’s Disease: The Challenge of the Second Century

Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424 · see citing works

Hormesis defined

Mattson, M. P. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.08.007 · Cited by 1,253 · see citing works

Synaptic plasticity, memory and the hippocampus: a neural network approach to causality

Neves, G., Cooke, S. F., & Bliss, T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2303 · Cited by 1,207 · see citing works

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Spires-Jones, T. L., & Hyman, B. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.004 · Cited by 1,201 · see citing works

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

Ossenkoppele, R., Schonhaut, D. R., Schöll, M., Lockhart, S. N., Ayakta, N., Baker, S. L., O’Neil, J. P., Janabi, M., Lazaris, A., Cantwell, A., et al. (2016) · Brain · doi:10.1093/brain/aww027 · Cited by 1,185 · see citing works

Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

Cutler, R. G., Kelly, J., Storie, K., Pedersen, W. A., Tammara, A., Hatanpaa, K. J., Troncoso, J. C., & Mattson, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305799101 · Cited by 1,135 · see citing works

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., & Fahrenholz, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3922 · Cited by 1,132 · see citing works

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

Huang, X., Atwood, C., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J. T., Moir, R. D., et al. (1999) · Biochemistry · doi:10.1021/bi990438f · Cited by 1,107 · see citing works

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works

Ageing and neuronal vulnerability

Mattson, M. P., & Magnus, T. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1886 · Cited by 1,075 · see citing works

The cholinergic system in aging and neuronal degeneration

Schliebs, R., & Arendt, T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.058 · Cited by 1,047 · see citing works

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

Meng, T.-C., Fukada, T., & Tonks, N. K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00445-8 · Cited by 1,040 · see citing works

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

Selkoe, D. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.016 · Cited by 1,038 · see citing works

Biomarker Modeling of Alzheimer’s Disease

Jack, C. R., & Holtzman, D. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.12.003 · Cited by 1,002 · see citing works

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977 · see citing works

Amyloid beta, mitochondrial dysfunction and synaptic damage: Implications for cognitive decline in aging and Alzheimer’s disease

Reddy, P. H., & Beal, M. F. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.12.002 · Cited by 975 · see citing works

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

Bhat, A. H., Dar, K. B., Anees, S., Zargar, M. A., Masood, A., Sofi, M. A., & Ganie, S. A. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.07.025 · Cited by 938 · see citing works

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works

Peroxiredoxins are conserved markers of circadian rhythms

Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915 · see citing works

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909 · see citing works

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

Clark, C. M., Pontecorvo, M. J., Beach, T. G., Bedell, B. J., Coleman, R. E., Doraiswamy, P. M., Fleisher, A. S., Reiman, E. M., Sabbagh, M. N., Sadowsky, C. H., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70142-4 · Cited by 855 · see citing works

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Mańczak, M., Calkins, M. J., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr139 · Cited by 830 · see citing works

A Direct Role for Dual Oxidase in Drosophila Gut Immunity

Ha, E.-M., Oh, C.-T., Bae, Y. S., & Lee, W. (2005) · Science · doi:10.1126/science.1117311 · Cited by 824 · see citing works

Mitochondrial Dysfunction in Neurodegenerative Diseases

Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works

The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives

Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · cited 1× · see citing works

The case for rejecting the amyloid cascade hypothesis

Herrup, K. (2015) · Nature Neuroscience · doi:10.1038/nn.4017 · Cited by 768 · see citing works

Expression of Nrf2 in Neurodegenerative Diseases

Ramsey, C. P., Glass, C. A., Montgomery, M. B., Lindl, K. A., Ritson, G. P., Chia, L. A., Hamilton, R. L., Chu, C. T., & Jordan-Sciutto, K. L. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31802d6da9 · Cited by 760 · see citing works

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

Du, H., Guo, L., Yan, S., Sosunov, A. A., McKhann, G. M., & ShiDu Yan, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006586107 · Cited by 704 · see citing works

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

Adlard, P. A., Cherny, R. A., Finkelstein, D. I., Gautier, E., Robb, E., Cortes, M., Volitakis, I., Liu, X., Smith, J. P., Perez, K., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.018 · Cited by 672 · see citing works

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

Calkins, M. J., Manczak, M., Mao, P., Shirendeb, U., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr381 · Cited by 646 · see citing works

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

Kwon, J., Lee, S.-R., Yang, K.-S., Ahn, Y., Kim, Y. J., Stadtman, E. R., & Rhee, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407396101 · Cited by 631 · see citing works

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease: The TEAM-AD VA Cooperative Randomized Trial

Dysken, M. W., Sano, M., Asthana, S., Vertrees, J. E., Pallaki, M., Llorente, M., Love, S., Schellenberg, G. D., McCarten, J. R., Malphurs, J., et al. (2014) · JAMA · doi:10.1001/jama.2013.282834 · Cited by 628 · see citing works

Structure and novel exons of the human .tau. gene

Andreadis, A., Brown, W. M., & Kosik, K. S. (1992) · Biochemistry · doi:10.1021/bi00158a027 · Cited by 625 · see citing works

Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

Bubber, P., Haroutunian, V., Fisch, G., Blass, J. P., & Gibson, G. E. (2005) · Annals of Neurology · doi:10.1002/ana.20474 · Cited by 622 · see citing works

Is Alzheimer’s disease a type 3 diabetes? A critical appraisal

Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases

Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606 · see citing works

Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer’s Disease

Mosconi, L., Pupi, A., & de Leon, M. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 605 · see citing works

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

Quinlan, C. L., Perevoshchikova, I. V., Hey‐Mogensen, M., Orr, A. L., & Brand, M. D. (2013) · Redox Biology · doi:10.1016/j.redox.2013.04.005 · Cited by 595 · see citing works

Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer’s disease

Miller, L. M., Wang, Q., Telivala, T. P., Smith, R., Lanzirotti, A., & Judith Miklossy, A. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.09.004 · Cited by 588 · see citing works

Clinico‐pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease

Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

Parsons, M. P., & Raymond, L. A. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.030 · Cited by 555 · see citing works

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

Ringman, J. M., Frautschy, S. A., Teng, E., Begum, A. N., Bardens, J., Beigi, M., Gylys, K. H., Badmaev, V., Heath, D. D., Apostolova, L. G., et al. (2012) · Alzheimer s Research & Therapy · doi:10.1186/alzrt146 · Cited by 546 · see citing works

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid ß-protein

Selkoe, D. J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3111 · Cited by 538 · see citing works

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

Sayre, L. M., Perry, G. L., Harris, P. L. R., Liu, Y. A., Schubert, K. A., & Smith, M. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740270.x · Cited by 538 · see citing works

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

Lovell, M. A., & Markesbery, W. R. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm821 · Cited by 515 · see citing works

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

Kamat, P. K., Kalani, A., Rai, S., Swarnkar, S., Tota, S., Nath, C., & Tyagi, N. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9053-6 · Cited by 504 · see citing works

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Barnham, K. J., & Bush, A. I. (2014) · Chem. Soc. Rev. · doi:10.1039/c4cs00138a · Cited by 497 · see citing works

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

Mantyh, P. W., Ghilardi, J. R., Rogers, S. D., DeMaster, E., Allen, C. J., Stimson, E. R., & Maggio, J. E. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03639.x · Cited by 464 · see citing works

Drug development in Alzheimer’s disease: the path to 2025

Cummings, J., Aisen, P. S., DuBois, B., Frölich, L., Jack, C. R., Jones, R. W., Morris, J. C., Raskin, J., Dowsett, S. A., & Scheltens, P. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0207-9 · Cited by 459 · see citing works

Regulation of cholesterol and sphingomyelin metabolism by amyloid-β and presenilin

Grimm, M. O. W., Grimm, H. S., Pätzold, A. J., Zinser, E. G., Halonen, R., Duering, M., Tschäpe, J., Strooper, B. D., Müller, U., Shen, J., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1313 · Cited by 446 · see citing works

Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases

Trushina, E. V., & McMurray, C. T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.056 · Cited by 440 · see citing works

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

Greenough, M. A., Camakaris, J., & Bush, A. I. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.08.014 · Cited by 439 · see citing works

Identification of Altered Metabolic Pathways in Plasma and CSF in Mild Cognitive Impairment and Alzheimer’s Disease Using Metabolomics

Trushina, E., Dutta, T., Persson, X.-M. T., Mielke, M. M., & Petersen, R. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063644 · Cited by 438 · see citing works

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

Lee, J., Cole, T. B., Palmiter, R. D., Suh, S. W., & Koh, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092034699 · Cited by 432 · see citing works

Synaptic loss in Alzheimer's disease and other dementias

Hamos, J. E., DeGennaro, L. J., & Drachman, D. A. (1989) · Neurology · doi:10.1212/wnl.39.3.355 · Cited by 432 · see citing works

Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

Han, X., Rozen, S., Boyle, S. H., Hellegers, C., Cheng, H., Burke, J. R., Welsh-Bohmer, K. A., Doraiswamy, P. M., & Kaddurah-Daouk, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021643 · Cited by 429 · see citing works

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425 · see citing works

Unraveling the Truth About Antioxidants: Mitohormesis explains ROS-induced health benefits

Ristow, M. (2014) · Nature Medicine · doi:10.1038/nm.3624 · Cited by 417 · see citing works

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

Copeland, J. M., Cho, J., Lo, T., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., & Walker, D. W. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.016 · Cited by 409 · see citing works

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

Vlassenko, A. G., Vaishnavi, S. N., Couture, L., Sacco, D., Shannon, B. J., Mach, R. H., Morris, J. C., Raichle, M. E., & Mintun, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010461107 · Cited by 404 · see citing works

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402 · see citing works

The BCM theory of synapse modification at 30: interaction of theory with experiment

Cooper, L. N., & Bear, M. F. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3353 · Cited by 395 · see citing works

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer’s disease: Implications to mitochondria-targeted antioxidant therapeutics

Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394 · see citing works

Antioxidants for Alzheimer Disease: A Randomized Clinical Trial With Cerebrospinal Fluid Biomarker Measures

Galasko, D. R., Peskind, E., Clark, C. M., Quinn, J. F., Ringman, J. M., Jicha, G. A., Cotman, C., Cottrell, B., Montine, T. J., Thomas, R. G., et al. (2012) · Archives of Neurology · doi:10.1001/archneurol.2012.85 · Cited by 377 · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Microglia: activation and their significance in the central nervous system

Nakajima, K., & Kohsaka, S. (2001) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002969 · Cited by 371 · see citing works

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

Leuner, K., Schütt, T., Kurz, C., Eckert, S. H., Schiller, C., Occhipinti, A., Mai, S., Jendrach, M., Eckert, G. P., Kruse, S. E., et al. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4173 · Cited by 354 · see citing works

Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

Suh, S. W., Jensen, K. B., Jensen, M. S., Silva, D. S., Kesslak, P. J., Danscher, G., & Frederickson, C. J. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02096-x · Cited by 353 · see citing works

Evolutionary conservation of the <i>clk-1</i> -dependent mechanism of longevity: loss of <i>mclk1</i> increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes &amp; Development · doi:10.1101/gad.1352905 · Cited by 345 · see citing works

Targeting Oxidative Stress in Central Nervous System Disorders

Patel, M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.06.007 · Cited by 312 · see citing works

The Role of Oxidative Stress in Alzheimer Disease

Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 307 · see citing works

Oxidative stress, protein modification and Alzheimer disease

Tramutola, A., Lanzillotta, C., Perluigi, M., & Butterfield, D. A. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.005 · Cited by 303 · see citing works

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A

Chalfant, C. E., Kishikawa, K., Mumby, M. C., Kamibayashi, C., Bielawska, A. E., & Hannun, Y. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20313 · Cited by 300 · see citing works

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

Reddy, P. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.052 · Cited by 300 · see citing works

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

Wang, L. Y., Benzinger, T. L. S., Su, Y., Christensen, J. J., Friedrichsen, K. A., Aldea, P., McConathy, J., Cairns, N. J., Fagan, A. M., Morris, J. C., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2078 · Cited by 295 · see citing works

Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer's Disease

Baker, L. D., Frank, L. L., Foster‐Schubert, K. E., Green, P. S., Wilkinson, C. W., McTiernan, A., Cholerton, B., Plymate, S. R., Fishel, M. A., Watson, G. S., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100768 · Cited by 292 · see citing works

Decreased plasma antioxidants in patients with Alzheimer's disease

Kim, T., Pae, C., Yoon, S.-J., Jang, W., Lee, N. J., Kim, J.-J., Lee, S., Lee, C., Paik, I.-H., & Lee, C. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1469 · Cited by 291 · see citing works

New perspectives on S100 proteins: a multi-functional Ca 2+ -, Zn 2+ - and Cu 2+ -binding protein family

Heizmann, C. W., & Cox, J. A. (1998) · BioMetals · doi:10.1023/a:1009212521172 · Cited by 285 · see citing works

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

Kinoshita, A., Fukumoto, H., Shah, T., Whelan, C. M., Irizarry, M. C., & Hyman, B. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00643 · Cited by 284 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer’s disease

Atamna, H., & Frey, W. H. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.06.001 · Cited by 278 · see citing works

Implications of GABAergic Neurotransmission in Alzheimer’s Disease

Li, Y., Sun, H., Chen, Z., Xu, H., Bu, G., & Zheng, H. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00031 · Cited by 274 · see citing works

Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

Haughey, N. J., Bandaru, V. V. R., Bae, M. H., & Mattson, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.003 · Cited by 271 · see citing works

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

Mecocci, P., & Polidori, M. C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.006 · Cited by 270 · see citing works

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Trushina, E. V., Nemutlu, E., Zhang, S., Christensen, T. A., Camp, J. J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032737 · Cited by 268 · see citing works

Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients

Migliore, L., Fontana, I., Trippi, F., Colognato, R., Coppedè, F., Tognoni, G., Nucciarone, B., & Siciliano, G. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.016 · Cited by 263 · see citing works

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aβ toxicity

Cardoso, S. M., Santana, I. J., Swerdlow, R. H., & Oliveira, C. R. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02438.x · Cited by 262 · see citing works

Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice

Knobloch, M., Konietzko, U., Krebs, D. C., & Nitsch, R. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.019 · Cited by 259 · see citing works

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen, K. M., Malm, T., Jyrkkänen, H.-K., Goldsteins, G., Keksa-Goldsteine, V., Tanila, H., Yamamoto, M. P., Ylä‐Herttuala, S., Levonen, A., & Koıstınaho, J. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.010 · Cited by 256 · see citing works

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E., & Troncoso, J. C. (2001) · Archives of Pathology &amp; Laboratory Medicine · doi:10.5858/2001-125-0489-iaapdo · Cited by 248 · see citing works

The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative Diseases

Gururaj Joshi, A., & Johnson, J. A. (2012) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488912803252023 · Cited by 246 · see citing works

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance

Vernochet, C., Mourier, A., Bezy, O., Macotela, Y., Boucher, J., Rardin, M. J., An, D., Lee, K. Y., Ilkayeva, O. R., Zingaretti, C. M., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.016 · Cited by 245 · see citing works

Therapies for Prevention and Treatment of Alzheimer’s Disease

Mendiola-Precoma, J., Berumen, L. C., Padilla, K., & García‐Alcocer, G. (2016) · BioMed Research International · doi:10.1155/2016/2589276 · Cited by 245 · see citing works

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

Zhu, X., Perry, G., Smith, M. A., & Wang, X. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-129005 · Cited by 242 · see citing works

Carbonyl‐Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease

Smith, M. A., Rudnicka-Nawrot, M., Richey, P., Praprotnik, D., Mulvihill, P., Miller, C., Sayre, L., & Perry, G. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64062660.x · Cited by 240 · see citing works

A Randomized Trial of Vitamin E Supplementation and Cognitive Function in Women

Kang, J. H. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.22.2462 · Cited by 226 · see citing works

The Metabolism of Tyramine by Monoamine Oxidase A/B Causes Oxidative Damage to Mitochondrial DNA

Hauptmann, N., Grimsby, J. S., Shih, J. C., & Cadenas, E. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0510 · Cited by 221 · see citing works

NMDA receptor function, memory, and brain aging

Newcomer, J. W., Farber, N. B., & Olney, J. W. (2000) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2000.2.3/jnewcomer · Cited by 220 · see citing works

Binding of zinc(II) and copper(II) to the full‐length Alzheimer’s amyloid‐β peptide

Tõugu, V., Tiiman, A., & Palumaa, P. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05061.x · Cited by 216 · see citing works

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

Mecocci, P., Beal, M. F., Cecchetti, R., Polidori, M. C., Cherubini, A., Chionne, F., Avellini, L., Romano, G., & Senin, U. (1997) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815160 · Cited by 215 · see citing works

Mitochondrial alterations Alzheimer's disease

Baloyannis, S. J., Costa, V., & Michmizos, D. (2004) · American Journal of Alzheimer's Disease &amp; Other Dementias® · doi:10.1177/153331750401900205 · Cited by 206 · see citing works

Increased lipoprotein oxidation in alzheimer’s disease

Schippling, S., Kontush, A., Arlt, S., Buhmann, C., Stürenburg, H.-J., Mann, U. M., Müller‐Thomsen, T., & Beisiegel†, U. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00247-6 · Cited by 201 · see citing works

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

Schipper, H. M., BENNETT, D., Liberman, A., Bienias, J. L., Schneider, J. A., Kelly, J. W., & Arvanitakis, Z. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.016 · Cited by 199 · see citing works

Altered brain energetics induces mitochondrial fission arrest in Alzheimer’s Disease

Zhang, L., Trushin, S., Christensen, T. A., Bachmeier, B. V., Gateno, B., Schroeder, A., Yao, J., Itoh, K., Sesaki, H., Poon, W. W., et al. (2016) · Scientific Reports · doi:10.1038/srep18725 · Cited by 198 · see citing works

Recent advances in the application of metabolomics to Alzheimer's Disease

Trushina, E. V., & Mielke, M. M. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.014 · Cited by 197 · see citing works

The influence of common free radicals and antioxidants on development of Alzheimer’s Disease

Wojtunik‐Kulesza, K. A., Oniszczuk, A., Oniszczuk, T., & Waksmundzka‐Hajnos, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.12.024 · Cited by 195 · see citing works

Carbonyl Toxicology and Alzheimer's Disease

Picklo, M. J. (2002) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2002.9506 · Cited by 194 · see citing works

Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways.

Khan, S. M., Cassarino, D. S., Abramova, N. N., Keeney, P. M., Borland, M. K., Pa, T., Krebs, C. T., Bennett, J. C., Parks, J. K., Swerdlow, R. H., et al. (2000) · PubMed · Cited by 176 · see citing works

Mitohormesis in exercise training

Merry, T. L., & Ristow, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.11.032 · Cited by 176 · see citing works

In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain

Sepulcre, J., Schultz, A. P., Sabuncu, M. R., Gómez‐Isla, T., Chhatwal, J. P., Becker, A., Sperling, R. A., & Johnson, K. A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0639-16.2016 · Cited by 175 · see citing works

Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains

Danscher, G., Jensen, K. B., Frederickson, C. J., Kemp, K., Andreasen, A., Juhl, S., Stoltenberg, M., & Ravid, R. (1997) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(97)00079-4 · Cited by 174 · see citing works

Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease

Dias, K. S. T., & Viegas, C. (2014) · Current Neuropharmacology · doi:10.2174/1570159x1203140511153200 · Cited by 174 · see citing works

Regulated Formation of Golgi Secretory Vesicles Containing Alzheimer β-Amyloid Precursor Protein

Xu, H., Greengard, P., & Gandy, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23243 · Cited by 168 · see citing works

Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging

Jagust, W. J., Landau, S. M., & Initiative, F. T. A. D. N. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3266-12.2012 · Cited by 162 · see citing works

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

Quinn, J. F., Bussiere, J. R., Hammond, R., Montine, T. J., Henson, E., Jones, R. E., & Stackman, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.12.014 · Cited by 160 · see citing works

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer’s disease in the oldest-old

Robinson, J. L., Molina-Porcel, L., Corrada, M. M., Raible, K., Lee, E. B., Lee, V. M.-Y., Kawas, C. H., & Trojanowski, J. Q. (2014) · Brain · doi:10.1093/brain/awu190 · Cited by 157 · see citing works

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

Mondragón‐Rodríguez, S., Perry, G. L., Zhu, X., Moreira, P. I., Acevedo, M., & Williams, S. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/940603 · Cited by 156 · see citing works

Multi-dimensional mass spectrometry-based shotgun lipidomics and the altered lipids at the mild cognitive impairment stage of Alzheimer's disease

Han, X. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.01.010 · Cited by 154 · see citing works

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

Kumar, A., & Singh, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00206 · Cited by 154 · see citing works

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

Eckert, A., Hauptmann, S., Scherping, I., Rhein, V. F., Müller-Spahn, F., Götz, J., & Müller, W. E. (2008) · Neurodegenerative Diseases · doi:10.1159/000113689 · Cited by 153 · see citing works

The oxidative stress hypothesis in Alzheimer's disease.

Pădurariu, M., Ciobica, A. S., Lefter, R. M., Șerban, I. L., Ștefănescu, C., & Chiriță, R. (2013) · PubMed · Cited by 151 · see citing works

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

Valla, J., Yaari, R., Wolf, A. B., Kusne, Y., Beach, T. G., Roher, A. E., Corneveaux, J. J., Huentelman, M. J., Caselli, R. J., & Reiman, E. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100129 · Cited by 150 · see citing works

The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome

Blass, J. P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05576.x · Cited by 147 · see citing works

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.01.014 · Cited by 147 · see citing works

Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

Cristóvão, J. S., Santos, R., & Gomes, C. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9812178 · Cited by 146 · see citing works

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Schmeisser, S., Priebe, S., Groth, M., Monajembashi, S., Hemmerich, P. H., Guthke, R., Platzer, M., & Ristow, M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.02.002 · Cited by 145 · see citing works

Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries

Ichimura, H., Parthasarathi, K., Quadri, S. K., Issekutz, A. C., & Bhattacharya, J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17271 · Cited by 144 · see citing works

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

Kandimalla, R. J. L., & Reddy, P. H. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.018 · Cited by 144 · see citing works

Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance

Wredenberg, A., Freyer, C., Sandström, M. E., Katz, A., Wibom, R., Westerblad, H., & Larsson, N.-G. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.029 · Cited by 141 · see citing works

Neuronal Zinc Exchange with the Blood Vessel Wall Promotes Cerebral Amyloid Angiopathy in an Animal Model of Alzheimer's Disease

Friedlich, A. L., Lee, J., van Groen, T., Cherny, R. A., Volitakis, I., Cole, T. B., Palmiter, R. D., Koh, J., & Bush, A. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0297-04.2004 · Cited by 138 · see citing works

Biochemistry and Molecular Biology of Amyloid β‐Protein and the Mechanism of Alzheimer's Disease

(2008) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)01223-7 · Cited by 137 · see citing works

Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation

Blass, J. P., Baker, A. C., Ko, L., & Black, R. S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530080046009 · Cited by 137 · see citing works

Current Alzheimer's disease clinical trials: Methods and placebo outcomes

Schneider, L. S. S., & Sano, M. C. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.07.038 · Cited by 137 · see citing works

Vitamin E, Vitamin C, Beta Carotene, and Cognitive Function Among Women With or at Risk of Cardiovascular Disease: The Women’s Antioxidant and Cardiovascular Study

Kang, J. H., Cook, N. R., Manson, J. E., Buring, J. E., Albert, C. M., & Grodstein, F. (2009) · Circulation · doi:10.1161/circulationaha.108.816900 · Cited by 136 · see citing works

Histochemically Reactive Zinc in Plaques of the Swedish Mutant β-Amyloid Precursor Protein Transgenic Mice

Lee, J., Mook‐Jung, I., & Koh, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-j0002.1999 · Cited by 136 · see citing works

Metal exposure and Alzheimer’s pathogenesis

Liu, G., Huang, W., Moir, R. D., Vanderburg, C. R., Lai, B. C. H., Peng, Z., Tanzi, R. E., Rogers, J. T., & Huang, X. (2006) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.12.011 · Cited by 135 · see citing works

Antioxidant and cytoprotective responses to redox stress

Mathers, J. E., Fraser, J. A., McMahon, M. J., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710157 · Cited by 134 · see citing works

Insights into Mitochondrial Dysfunction: Aging, Amyloid-β, and Tau–A Deleterious Trio

Schmitt, K., Grimm, A., Wilkaniec, A., Strosznajder, J. B., Götz, J., & Eckert, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4400 · Cited by 132 · see citing works

Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer‐induced <scp>AMPA</scp> glutamate receptor signaling deficits

Miller, E. C., Teravskis, P. J., Dummer, B. W., Zhao, X., Huganir, R. L., & Liao, D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12507 · Cited by 131 · see citing works

Mechanisms of Amyloid‐Beta Peptide Uptake by Neurons: The Role of Lipid Rafts and Lipid Raft‐Associated Proteins

Lai, A. Y., & McLaurin, J. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2011/548380 · Cited by 130 · see citing works

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

Rai, S., Kamat, P. K., Nath, C., & Shukla, R. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2012.08.008 · Cited by 129 · see citing works

Metal ions influx is a double edged sword for the pathogenesis of Alzheimer’s disease

Wang, P., & Wang, Z. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.003 · Cited by 122 · see citing works

Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is ‘too big to fail’

Castellani, R. J., & Smith, M. A. (2011) · The Journal of Pathology · doi:10.1002/path.2885 · Cited by 121 · see citing works

Caloric restriction: Beneficial effects on brain aging and Alzheimer’s disease

Van Cauwenberghe, C., Vandendriessche, C., Libert, C., & Vandenbroucke, R. E. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9647-6 · Cited by 121 · see citing works

Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency

Stoltenberg, M., Bush, A. I., Bach, G., Smidt, K., Larsen, A., Rungby, J., Lund, S. A., Doering, P., & Danscher, G. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.025 · Cited by 114 · see citing works

Nucleic acid oxidation: an early feature of Alzheimer's disease

Bradley‐Whitman, M. A., Timmons, M. D., Beckett, T. L., Murphy, M. P., Lynn, B. C., & Lovell, M. A. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12444 · Cited by 112 · see citing works

Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimer's Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder

Sultana, R., Mecocci, P., Mangialasche, F., Cecchetti, R., Baglioni, M., & Butterfield, D. A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101425 · Cited by 111 · see citing works

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P. S., Pinto, M., Jin, L., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.03.009 · Cited by 110 · see citing works

Effect of One-Year Vitamin C- and E-Supplementation on Cerebrospinal Fluid Oxidation Parameters and Clinical Course in Alzheimer’s Disease

Arlt, S., Müller‐Thomsen, T., Beisiegel†, U., & Kontush, A. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0860-8 · Cited by 98 · see citing works

Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain

Ramassamy, C., Krzywkowski, P., Averill‐Bates, D. A., Lussier‐Cacan, S., Théroux, L., Christen, Y., Davignon, J., & Poirier, J. (2001) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00268-0 · Cited by 97 · see citing works

The co‐occurrence of mt DNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V. V., et al. (2013) · Aging Cell · doi:10.1111/acel.12186 · Cited by 97 · see citing works

Oxidatively modified RNA in mild cognitive impairment

Lovell, M. A., & Markesbery, W. R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.030 · Cited by 93 · see citing works

Oxidative damage as an early marker of Alzheimer's disease and mild cognitive impairment

Beal, M. F. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.022 · Cited by 93 · see citing works

Modulation of mitochondrial dysfunction in neurodegenerative diseases via activation of nuclear factor erythroid-2-related factor 2 by food-derived compounds

Denzer, I., Münch, G. W., & Friedland, K. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.019 · Cited by 90 · see citing works

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells

Gasparini, L., Racchi, M., Benussi, L., Curti, D., Binetti, G., Bianchetti, A., Trabucchi, M., & Govoni, S. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00536-3 · Cited by 89 · see citing works

Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity

Jang, S.-S., & Chung, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/7969272 · Cited by 89 · see citing works

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

Kamat, P., Rai, S., Swarnkar, S., Shukla, R., Ali, S., Najmi, A. K., & Nath, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.075 · Cited by 88 · see citing works

Neuroprotective effect of curcumin on okadaic acid induced memory impairment in mice

Rajasekar, N., Dwivedi, S., Tota, S., Kamat, P. K., Hanif, K., Nath, C., & Shukla, R. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.033 · Cited by 85 · see citing works

A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations

Szabados, T., Dul, C., Majtényi, K., Hargitai, J., Pénzes, Z., & Urbanics, R. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.016 · Cited by 84 · see citing works

Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities

Caldwell, C. C., Yao, J., & Brinton, R. D. (2014) · Neurotherapeutics · doi:10.1007/s13311-014-0324-8 · Cited by 83 · see citing works

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models

Boom, A., Pochet, R., Authelet, M., Pradier, L., Borghgraef, P., LEUVEN, F. V., Heizmann, C. W., & Brion, J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.011 · Cited by 83 · see citing works

Exercise for the diabetic brain: how physical training may help prevent dementia and Alzheimer’s disease in T2DM patients

Bertram, S., Brixius, K., & Brinkmann, C. K. (2016) · Endocrine · doi:10.1007/s12020-016-0976-8 · Cited by 83 · see citing works

The role of iron as a mediator of oxidative stress in Alzheimer disease

Castellani, R. J., Moreira, P. I., Perry, G. L., & Zhu, X. (2012) · BioFactors · doi:10.1002/biof.1010 · Cited by 82 · see citing works

Copper reduction by copper binding proteins and its relation to neurodegenerative diseases

Opazo, C., Barría, M. I., Ruiz, F. H., & Inestrosa, N. C. (2003) · BioMetals · doi:10.1023/a:1020795422185 · Cited by 81 · see citing works

Oxidative stress, aging, and diseases

Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979 · see citing works

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

Simpson, D. S. A., & Oliver, P. L. (2020) · Antioxidants · doi:10.3390/antiox9080743 · Cited by 1,044 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Role of oxidative stress in depression

Bhatt, S., Nagappa, A. N., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.05.001 · Cited by 839 · see citing works

The plastic brain: neurotoxicity of micro- and nanoplastics

Prüst, M., Meijer, J., & Westerink, R. H. S. (2020) · Particle and Fibre Toxicology · doi:10.1186/s12989-020-00358-y · Cited by 811 · see citing works

Emerging roles of oxidative stress in brain aging and Alzheimer's disease

Ionescu-Tucker, A., & Cotman, C. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.07.014 · Cited by 737 · see citing works

Oxidative stress and inflammation in the pathogenesis of neurological disorders: Mechanisms and implications

Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 726 · see citing works

Lipids and Alzheimer’s Disease

Kao, Y.-C., Ho, P.-C., Tu, Y.-K., Jou, I.-M., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041505 · Cited by 485 · see citing works

The initiation of oxidative stress and therapeutic strategies in wound healing.

Wang, G., Yang, F., Zhou, W., Xiao, N.-Y., Luo, M., & Tang, Z. (2022) · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · doi:10.1016/j.biopha.2022.114004 · Cited by 388 · see citing works

Mitochondrial dysfunction in neurodegenerative disorders

Klemmensen, M. M., Borrowman, S. H., Pearce, C., Pyles, B., & Chandra, B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2023.10.002 · Cited by 396 · see citing works

Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism

Cui, Z., Zhao, X., Amevor, F. K., Du, X., Wang, Y., Li, D., Shu, G., Tian, Y., & Zhao, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943321 · Cited by 400 · see citing works

Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance

Gadhave, D. G., Sugandhi, V. V., Jha, S. K., Nangare, S., Gupta, G., Singh, S. K., Dua, K., Cho, H., Hansbro, P. M., & Paudel, K. R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102357 · Cited by 391 · see citing works

Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review

Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568032 · Cited by 353 · see citing works

The Role of Oxidative Stress in Parkinson’s Disease

Chang, K., & Chen, C. (2020) · Antioxidants · doi:10.3390/antiox9070597 · Cited by 357 · see citing works

Exercise benefits on Alzheimer’s disease: State-of-the-science

Valenzuela, P. L., Castillo-García, A., Morales, J. S., de la Villa, P., Hampel, H., Emanuele, E., Lista, S., & Lucia, A. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101108 · Cited by 337 · see citing works

The Role of Oxidative Stress in Physiopathology and Pharmacological Treatment with Pro- and Antioxidant Properties in Chronic Diseases

García-Sánchez, A., Miranda‐Díaz, A. G., & Cardona-Muñóz, E. G. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2082145 · Cited by 333 · see citing works

Neuroinflammation in Alzheimer’s Disease

Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works

Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

Shandilya, S., Kumar, S., Jha, N. K., Kesari, K. K., & Ruokolainen, J. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.09.005 · Cited by 300 · see citing works

Oxidative stress in alzheimer’s disease: A review on emergent natural polyphenolic therapeutics

Cassidy, L., Fernandez, F., Johnson, J. B., Naiker, M., Owoola, A. G., & Broszczak, D. A. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102294 · Cited by 283 · see citing works

Application of Metabolomics in Alzheimer’s Disease

Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268 · see citing works

The Association of Tau With Mitochondrial Dysfunction in Alzheimer’s Disease

Cheng, Y., & Bai, F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00163 · Cited by 239 · see citing works

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

Jamwal, S., Blackburn, J. K., & Elsworth, J. D. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107705 · Cited by 236 · see citing works

Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress

Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works

Neuroprotective Natural Products for Alzheimer’s Disease

Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236 · see citing works

The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

Razani, E., Pourbagheri‐Sigaroodi, A., Safaroghli‐Azar, A., Zoghi, A., Bavarsad, M. S., & Bashash, D. (2021) · Cell Stress and Chaperones · doi:10.1007/s12192-021-01231-3 · Cited by 229 · see citing works

Alzheimer’s Disease: Key Insights from Two Decades of Clinical Trial Failures

Kim, C. K., Lee, Y. R., Ong, L., Gold, M., Kalali, A., & Sarkar, J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215699 · Cited by 241 · see citing works

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, A., Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., et al. (2017) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-017-0317-z · Cited by 225 · see citing works

A review on advances of treatment modalities for Alzheimer's disease

Thoe, E. S., Fauzi, A., Tang, Y.-Q., Chamyuang, S., & Chia, A. Y. Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119129 · Cited by 224 · see citing works

Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review

Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works

Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease

Nand, S., Singh, C., Singh, A., Singh, M. P., & Singh, S. P. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01945-y · Cited by 213 · see citing works

Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Dumitrescu, L., Mitrea, I., Cozma, L., Tulbă, D., Hinescu, M. E., Ceafalan, L. C., Gherghiceanu, M., & Popescu, B. O. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/2406594 · Cited by 212 · see citing works

Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System

Hannan, M. A., Dash, R., Sohag, A. A. M., Haque, M. N., & Moon, I. S. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00116 · Cited by 212 · see citing works

A Review for the Pharmacological Effect of Lycopene in Central Nervous System Disorders

Chen, D., Huang, C., & Chen, Z. (2019) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.12.151 · Cited by 206 · see citing works

The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy

Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208 · see citing works

Role of Nrf2 in aging, Alzheimer’s and other neurodegenerative diseases

George, M., Tharakan, M., Culberson, J. W., Reddy, A. P., & Reddy, P. H. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101756 · Cited by 212 · see citing works

Role of reactive oxygen species in the progression of Alzheimer’s disease

Bhatt, S., Puli, L., & Patil, C. R. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.12.004 · Cited by 207 · see citing works

Updates in Alzheimer's disease: from basic research to diagnosis and therapies

Liu, E., Zhang, Y., & Wang, J. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00432-x · Cited by 220 · see citing works

Mitochondrial dynamics and transport in Alzheimer's disease

Flannery, P. J., & Trushina, E. V. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.06.009 · Cited by 198 · see citing works

Novel target for treating Alzheimer’s Diseases: Crosstalk between the Nrf2 pathway and autophagy

Zhang, W., Feng, C., & Jiang, H. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101207 · Cited by 200 · see citing works

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

Konovalova, J., Gerasymchuk, D., Parkkinen, I., Chmielarz, P., & Domanskyi, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236055 · Cited by 199 · see citing works

The duality of amyloid-β: its role in normal and Alzheimer’s disease states

Azargoonjahromi, A. (2024) · Molecular Brain · doi:10.1186/s13041-024-01118-1 · Cited by 173 · see citing works

Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimer's Disease-Associated Genes

Moulton, M. J., Barish, S., Ralhan, I., Chang, J., Goodman, L. D., Harland, J. G., Marcogliese, P. C., Johansson, J. O., Ioannou, M. S., & Bellen, H. J. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112095118 · Cited by 180 · see citing works

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

HOOK, V. Y. H., Yoon, M. C., Mosier, C., Ito, G., Podvin, S., Head, B. P., Rissman, R. A., O’Donoghue, A. J., & Hook, G. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2020.140428 · Cited by 174 · see citing works

A review on fly ash from coal-fired power plants: chemical composition, regulations, and health evidence

Zierold, K. M., & Odoh, C. (2020) · Reviews on Environmental Health · doi:10.1515/reveh-2019-0039 · Cited by 169 · see citing works

An aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease

Lau, V. Z., Ramer, L. M., & Tremblay, M. (2023) · Nature Communications · doi:10.1038/s41467-023-37304-3 · Cited by 168 · see citing works

Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

Lee, H.-J., Lee, K.-E., Kim, J.-K., & Kim, D.-H. (2019) · Scientific Reports · doi:10.1038/s41598-019-48342-7 · Cited by 164 · see citing works

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

Sambra, V., Echeverría, F., Valenzuela, A., Chouinard‐Watkins, R., & Valenzuela, R. (2021) · Nutrients · doi:10.3390/nu13030986 · Cited by 160 · see citing works

An Overview of Cognitive Impairment

Morley, J. E. (2018) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2018.06.003 · Cited by 159 · see citing works

The role of mitophagy in the regulation of mitochondrial energetic status in neurons

Han, S., Zhang, M., Jeong, Y. Y., Margolis, D. J., & Cai, Q. (2021) · Autophagy · doi:10.1080/15548627.2021.1907167 · Cited by 151 · see citing works

Resveratrol Derivatives as Potential Treatments for Alzheimer’s and Parkinson’s Disease

Arbo, B. D., André‐Miral, C., Nasre‐Nasser, R. G., Schimith, L. E., dos Santos, M. G., da Costa-Silva, D. G., Muccillo-Baisch, A. L., & Hort, M. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00103 · Cited by 156 · see citing works

Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012067 · Cited by 153 · see citing works

Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease

Harris, S. A., & Harris, E. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00048 · Cited by 147 · see citing works

The redox language in neurodegenerative diseases: oxidative post-translational modifications by hydrogen peroxide

Lee, Y. M., He, W., & Liou, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03355-3 · Cited by 150 · see citing works

Incident dementia and long-term exposure to constituents of fine particle air pollution: a national cohort study in the United States

Shi, L., Zhu, Q., Wang, Y., Hao, H., Zhang, H., Schwartz, J., Amini, H., van Donkelaar, A., Martin, R. V., Steenland, K., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211282119 · Cited by 145 · see citing works

Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer’s Disease Model

Tramontin, N. D. S., da Silva, S., Arruda, R., Simon, K. U., Canteiro, P. B., Silveira, G. D. B., Mendes, C., Silveira, P. C. L., & Muller, A. P. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01780-w · Cited by 147 · see citing works

Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms

Chen, C., & Nakagawa, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101868 · Cited by 156 · see citing works

Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer’s disease mice

Liu, Y., Chu, J. M. T., Yan, T., Zhang, Y., Chen, Y., Chang, R. C., & Wong, G. T. C. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1653-7 · Cited by 146 · see citing works

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Fu, P., & Yung, K. K. L. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-200483 · Cited by 146 · see citing works

MIND diet and cognitive performance in older adults: a systematic review

Kheirouri, S., & Alizadeh, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1925220 · Cited by 145 · see citing works

Omics sciences for systems biology in Alzheimer’s disease: State-of-the-art of the evidence

Hampel, H. J., Nisticò, R., Seyfried, N. T., Levey, A. I., Modeste, E. S., Lemercier, P., Baldacci, F., Toschi, N., Garaci, F., Perry, G. L., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101346 · Cited by 142 · see citing works

Signal pathways in the treatment of Alzheimer’s disease with traditional Chinese medicine

Ding, M.-R., Qu, Y.-J., Hu, B., & An, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113208 · Cited by 144 · see citing works

Role of natural products for the treatment of Alzheimer’s disease

Noori, T., Dehpour, A. R., Sureda, A., Sobarzo-Sanchez, E., & Shirooie, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173974 · Cited by 141 · see citing works

Glutamatergic synaptic plasticity and dysfunction in Alzheimer disease

Benarroch, E. E. (2018) · Neurology · doi:10.1212/wnl.0000000000005807 · Cited by 134 · see citing works

Lower brain and blood nutrient status in Alzheimer's disease: Results from meta‐analyses

de Wilde, M. C., Vellas, B. J., Girault, E. M., Cetinyurek‐Yavuz, A., & Sijben, J. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.06.002 · Cited by 138 · see citing works

Antioxidant Therapies for Neuroprotection—A Review

Teleanu, R. I., Chircov, C., Grumezescu, A. M., Volceanov, A., & Teleanu, D. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101659 · Cited by 135 · see citing works

Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease

Villavicencio-Tejo, F., & Quintanilla, R. A. (2021) · Antioxidants · doi:10.3390/antiox10071069 · Cited by 135 · see citing works

Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases

Zhang, Y., Yang, H. N., Wei, D., Zhang, X., Wang, J., Wu, X., & Chang, J. K. (2021) · Exploration · doi:10.1002/exp.20210115 · Cited by 133 · see citing works

Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease

Cheignon, C., Jones, M., Atrián-Blasco, E., Kieffer, I., Faller, P., Collin, F., & Hureau, C. (2017) · Chemical Science · doi:10.1039/c7sc00809k · Cited by 132 · see citing works

Effects of Combined Physical and Cognitive Virtual Reality-Based Training on Cognitive Impairment and Oxidative Stress in MCI Patients: A Pilot Study

Mrakic‐Sposta, S., Santo, S. G. D., Franchini, F., Arlati, S., Zangiacomi, A., Greci, L., Moretti, S., Jesuthasan, N., Marzorati, M., Rizzo, G., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00282 · Cited by 134 · see citing works

From birth to death: A role for reactive oxygen species in neuronal development

Wilson, C., Muñoz-Palma, E., & González-Billault, C. E. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.09.012 · Cited by 129 · see citing works

Mitochondrial complex I as a therapeutic target for Alzheimer's disease

Trushina, E. V., Trushin, S., & Hasan, M. F. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.11.003 · Cited by 130 · see citing works

Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease

Wang, C., Cai, X., Hu, W., Li, Z., Kong, F., Chen, X., & Wang, D. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.4032 · Cited by 128 · see citing works

Nanozymes for Regenerative Medicine

Mou, X., Wu, Q., Zhang, Z., Liu, Y., Zhang, J., Zhang, C., Chen, X., Fan, K., & Liu, H. (2022) · Small Methods · doi:10.1002/smtd.202200997 · Cited by 128 · see citing works

Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress

Sang, Z., Wang, K., Dong, J., & Tang, L. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114464 · Cited by 127 · see citing works

The Role of Vitamins in Neurodegenerative Disease: An Update

Nand, S., Singh, P., Steinbusch, H. W. M., Vamanu, E., Ashraf, G. M., & Singh, M. P. (2021) · Biomedicines · doi:10.3390/biomedicines9101284 · Cited by 126 · see citing works

Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification

Cummings, J. L., Osse, A. M. L., & Kinney, J. W. (2023) · Drugs · doi:10.1007/s40265-023-01938-w · Cited by 123 · see citing works

Zinc promotes liquid–liquid phase separation of tau protein

Singh, V. P., Xu, L., Boyko, S., Surewicz, K. A., & Surewicz, W. K. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ac120.013166 · Cited by 122 · see citing works

Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products

Sun, C., Zhang, X., Morisseau, C. H. P., Hwang, S. H., Zhang, Z., Hammock, B. D., & Ma, X. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01507 · Cited by 122 · see citing works

Future Therapeutic Perspectives into the Alzheimer’s Disease Targeting the Oxidative Stress Hypothesis

Teixeira, J. P., de Castro, A. A., Soares, F. V., da Cunha, E. F. F., & Ramalho, T. C. (2019) · Molecules · doi:10.3390/molecules24234410 · Cited by 122 · see citing works

The role of the citric acid cycle in cells of the immune system and its importance in sepsis, trauma and burns.

Newsholme, E. A., Newsholme, P., & Curi, R. (1987) · PubMed · Cited by 121 · see citing works

Alzheimer’s Disease, Inflammation, and the Role of Antioxidants

Sinyor, B., Mineo, J., & Ochner, C. (2020) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200171 · Cited by 120 · see citing works

The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease

Jung, Y., & Damoiseaux, J. S. (2023) · Brain · doi:10.1093/brain/awad267 · Cited by 117 · see citing works

Advance of sporadic Alzheimer's disease animal models

Zhang, L., Chen, C., Mak, M. S., Lu, J., Wu, Z., Chen, Q., Han, Y., Li, Y., & Pi, R. (2020) · Medicinal Research Reviews · doi:10.1002/med.21624 · Cited by 116 · see citing works

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases

Nand, S., Mishra, D., Singh, P., Vamanu, E., & Singh, M. P. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111377 · Cited by 116 · see citing works

New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer’s disease

Wu, J., Yu, Y., Wan, Y., Xia, J., Xu, J., Zhang, L., Liu, D., Chen, L., Tang, F., Ao, H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113207 · Cited by 115 · see citing works

The neuroprotective potential of carotenoids in vitro and in vivo

Manochkumar, J., Doss, C. G. P., El-Seedi, H. R., Efferth, T., & Ramamoorthy, S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153676 · Cited by 115 · see citing works

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

Bjørklund, G., Gasmi, A., Lenchyk, L. V., Shanaida, M., Zafar, S., Mujawdiya, P. K., Lysiuk, R., Antonyak, H., Noor, S., Akram, M., et al. (2022) · Molecules · doi:10.3390/molecules27217167 · Cited by 119 · see citing works

Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB/BDNF expressions

Olugbemide, A. S., Ben‐Azu, B., Bakre, A. G., Ajayi, A. M., Femi-Akinlosotu, O. M., & Umukoro, S. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.12.003 · Cited by 110 · see citing works

The Role of Mitochondrial Calcium Homeostasis in Alzheimer’s and Related Diseases

Ryan, K. C., Ashkavand, Z., & Norman, K. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239153 · Cited by 107 · see citing works

Oxidative Stress, Endoplasmic Reticulum Stress and Apoptosis in the Pathology of Alzheimer’s Disease

Ekundayo, B. E., Obafemi, T. O., Adewale, O. B., Obafemi, B. A., Oyinloye, B. E., & Ekundayo, S. K. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01248-2 · Cited by 108 · see citing works

A dual-ligand fusion peptide improves the brain-neuron targeting of nanocarriers in Alzheimer's disease mice

Guo, Q., Xu, S., Yang, P., Wang, P., Lü, S., Sheng, D., Qian, K., Cao, J., Lü, W., & Zhang, Q. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.039 · Cited by 103 · see citing works

Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer’s disease

Venkataraman, A. V., Mansur, A., Rizzo, G., Bishop, C., Lewis, Y., Kocagoncu, E., Lingford-Hughes, A., Huiban, M., Passchier, J., Rowe, J. B., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abk1051 · Cited by 101 · see citing works

Antioxidant Compounds from Edible Mushrooms as Potential Candidates for Treating Age-Related Neurodegenerative Diseases

Liuzzi, G. M., Petraglia, T., Latronico, T., Crescenzi, A., & Rossano, R. (2023) · Nutrients · doi:10.3390/nu15081913 · Cited by 101 · see citing works

A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment

Vinceti, M., Chiari, A., Eichmüller, M., Rothman, K. J., Filippini, T., Malagoli, C., Weuve, J., Tondelli, M., Zamboni, G., Nichelli, P., et al. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0323-1 · Cited by 112 · see citing works

Dietary antioxidants remodel DNA methylation patterns in chronic disease

Beetch, M., Harandi‐Zadeh, S., Shen, K., Lubecka, K., Kitts, D. D., O’Hagan, H. M., & Stefañska, B. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14888 · Cited by 100 · see citing works

Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases

Bartman, S., Coppotelli, G., & Ross, J. M. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030130 · Cited by 101 · see citing works

Jaboticaba berry: A comprehensive review on its polyphenol composition, health effects, metabolism, and the development of food products

Inada, K. O. P., Leite, I. B., Martins, A. B. N., Fialho, E., Tomás-Barberán, F. A., Perrone, D., & Monteiro, M. C. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110518 · Cited by 99 · see citing works

Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

Esmieu, C., Guettas, D., Conte‐Daban, A., Sabater, L., Faller, P., & Hureau, C. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.9b00995 · Cited by 100 · see citing works

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

Han, S., Jeong, Y. Y., Sheshadri, P., Su, X. Y., & Cai, Q. (2020) · EMBO Reports · doi:10.15252/embr.201949801 · Cited by 92 · see citing works

Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and Treatment

Alkhalifa, A. E., Alkhalifa, O., Durdanovic, I., Ibrahim, D. R., & Maragkou, S. (2025) · Journal of Dementia and Alzheimer's Disease · doi:10.3390/jdad2020017 · Cited by 66 · see citing works

Roles of Oxidative Stress in Synaptic Dysfunction and Neuronal Cell Death in Alzheimer’s Disease

Plascencia‐Villa, G., & Perry, G. L. (2023) · Antioxidants · doi:10.3390/antiox12081628 · Cited by 167 · see citing works

Unravelling of molecular biomarkers in synaptic plasticity of Alzheimer’s disease: Critical role of the restoration of neuronal circuits

Pinky, P., Neha, N., Ali, M., Tiwari, P., Alam, M. M., Hattiwale, H. M., Jamal, A., & Parvez, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102069 · Cited by 17 · see citing works

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

Kamat, P. K., Kalani, A., Rai, S., Swarnkar, S., Tota, S., Nath, C., & Tyagi, N. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9053-6 · Cited by 504 · see citing works

Mitochondrial Defects and Oxidative Stress in Alzheimer Disease

Abraki, S. B., & Chavoshinezhad, S. (2014) · The Neuroscience Journal of Shefaye Khatam · doi:10.18869/acadpub.shefa.2.1.85 · Cited by 9 · see citing works