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Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression

Holmes, Andrew, Murphy, Dennis L, Crawley, Jacqueline N·2003·Biological Psychiatry

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Research works printed but not linked: 51

  1. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP, et al (in press): Early experience and rh5-HTTLPR genotype interact to influence social behavior and aggression in nonhuman primates. Genes Brain Behav
  2. Bengel, 1998, Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice, Mol Pharmacol, 53, 649, 10.1124/mol.53.4.649 · DOI · Paper page
  3. Bennett, 2002, Early experience and serotonin transporter gene variation interact to influence primate CNS function, Mol Psychiatry, 7, 118, 10.1038/sj.mp.4000949 · DOI · Paper page
  4. Blakely, 1991, Cloning and expression of a functional serotonin transporter from rat brain, Nature, 354, 66, 10.1038/354066a0 · DOI · Paper page
  5. Bucan, 2002, The mouse, Nat Rev Genet, 3, 114, 10.1038/nrg728 · DOI · Paper page
  6. Caspi, 2002, Role of genotype in the cycle of violence in maltreated children, Science, 297, 851, 10.1126/science.1072290 · DOI · Paper page
  7. Champoux, 2002, Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates, Mol Psychiatry, 7, 1058, 10.1038/sj.mp.4001157 · DOI · Paper page
  8. Chen, 2001, Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter, J Neurosci, 21, 6348, 10.1523/JNEUROSCI.21-16-06348.2001 · DOI · Paper page
  9. Drevets, 2000, Serotonin type-1A receptor imaging in depression, Nucl Med Biol, 27, 499, 10.1016/S0969-8051(00)00119-0 · DOI · Paper page
  10. Fabre, 2000, Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter, Eur J Neurosci, 12, 2299, 10.1046/j.1460-9568.2000.00126.x · DOI · Paper page
  11. Gobbi, 2001, Modifications of the serotonergic system in mice lacking serotonin transporters, J Pharmacol Exp Ther, 296, 987
  12. Greenberg, 2000, Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample, Am J Med Genet, 96, 202, 10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J · DOI · Paper page
  13. Gross, 2002, Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult, Nature, 416, 396, 10.1038/416396a · DOI · Paper page
  14. Hariri AR, Weinberger DR (in press): Functional neuroimaging of genetic variation I serotonergic neurotransmission. Genes Brain Behav · DOI
  15. Herman, 2003, Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population, Alcohol Alcohol, 38, 446, 10.1093/alcalc/agg110 · DOI
  16. Holmes, 2001, Transgenic and gene knockout approaches to the study of anxiety-like behavior in mice, Neurosci Biobehav Rev, 25, 261, 10.1016/S0149-7634(01)00012-4 · DOI · Paper page
  17. Holmes A, Hariri AR (in press): The serotonin transporter gene-linked polymorphism and negative emotionality; placing single gene effects in the context of genetic background and environment. Genes Brain Behav · DOI
  18. Holmes A, Li Q, Murphy DL, Gold E, Crawley JN (in press): Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background. Genes Brain Behav · DOI · Paper page
  19. Holmes, 2002, Reduced aggression in mice lacking the 5-HT transporter, Psychopharmacology, 161, 160, 10.1007/s00213-002-1024-3 · DOI
  20. Holmes, 2002, Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter, Neuropsychopharmacology, 27, 914, 10.1016/S0893-133X(02)00374-3 · DOI · Paper page
  21. Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL (2003): Mice lacking the serotonin transporter exhibit 5-HT1A receptor-mediated abnormalities in anxiety-like and exploratory behavior. Neuropsychopharmacology Sept 10 [Epub ahead of print] · DOI · Paper page
  22. Kendler, 2001, Twin studies of psychiatric illness, Arch Gen Psychiatry, 58, 1005, 10.1001/archpsyc.58.11.1005 · DOI · Paper page
  23. Lauder, 1990, Ontogeny of the serotonergic system in the rat, Ann N Y Acad Sci, 600, 297, 10.1111/j.1749-6632.1990.tb16891.x · DOI · Paper page
  24. Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 · DOI · Paper page
  25. Lesch, 1990, Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression, Life Sci, 46, 1271, 10.1016/0024-3205(90)90359-Y · DOI
  26. Lesch, 1998, Genetically driven variation in serotonin uptake, Biol Psychiatry, 44, 179, 10.1016/S0006-3223(98)00121-8 · DOI · Paper page
  27. Li, 2000, Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice, J Neurosci, 20, 7888, 10.1523/JNEUROSCI.20-21-07888.2000 · DOI · Paper page
  28. Li, 2003, Brain-region specific alterations of 5-HT2A and 5-HT2C receptors in 5-HT transporter knockout mice, J Neurochem, 84, 1256, 10.1046/j.1471-4159.2003.01607.x · DOI
  29. Linnoila, 1992, Aggression, suicidality, and serotonin, J Clin Psychiatry, 53, S6
  30. Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, Francis JH, et al (2003): Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 54:960–971 · DOI · Paper page
  31. Liu, 2002, Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter, Am J Physiol Gastrointest Liver Physiol, 283, 1398, 10.1152/ajpgi.00203.2002 · DOI
  32. Mannoury la Cour, 2001, Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity, J Neurosci, 21, 2178, 10.1523/JNEUROSCI.21-06-02178.2001 · DOI
  33. Mazzanti, 1998, Role of the serotonin transporter promoter polymorphism in anxiety-related traits, Arch Gen Psychiatry, 55, 936, 10.1001/archpsyc.55.10.936 · DOI · Paper page
  34. McGuffin, 2001, Genomics and behavior. Toward behavioral genomics, Science, 291, 1232, 10.1126/science.1057264 · DOI · Paper page
  35. Montanez, 2003, Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice, J Neurochem, 86, 210, 10.1046/j.1471-4159.2003.01836.x · DOI
  36. Morgan, 2001, Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress, Psychosom Med, 63, 412, 10.1097/00006842-200105000-00010 · DOI · Paper page
  37. Murphy DL, Holmes A, Ren-Patterson R, Sora I, Detera-Wadleigh S, Hall FS, et al (in press): Experimental gene interaction studies with SERT mutant mice as models for human polygenic traits and disorders. Genes Brain Behav · DOI
  38. Murphy, 2001, Genetic perspectives on the serotonin transporter, Brain Res Bull, 56, 487, 10.1016/S0361-9230(01)00622-0 · DOI
  39. Nadeau, 2001, Modifier genes in mice and humans, Nat Rev Genet, 2, 165, 10.1038/35056009 · DOI · Paper page
  40. Owens, 1998, The serotonin transporter and depression, Depress Anxiety, 8, 5, 10.1002/(SICI)1520-6394(1998)8:1+<5::AID-DA2>3.0.CO;2-I · DOI
  41. Pattij, 2002, GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background, Eur J Pharmacol, 447, 67, 10.1016/S0014-2999(02)01893-9 · DOI
  42. Persico, 2001, Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release, J Neurosci, 21, 6862, 10.1523/JNEUROSCI.21-17-06862.2001 · DOI · Paper page
  43. Riedel, 2002, Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge, Neuropsychopharmacology, 26, 358, 10.1016/S0893-133X(01)00361-X · DOI
  44. Rutter, 2002, The interplay of nature, nurture, and developmental influences, Arch Gen Psychiatry, 59, 996, 10.1001/archpsyc.59.11.996 · DOI
  45. Salichon, 2001, Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice, J Neurosci, 21, 884, 10.1523/JNEUROSCI.21-03-00884.2001 · DOI · Paper page
  46. Seifritz, 2001, Contribution of sleep physiology to depressive pathophysiology, Neuropsychopharmacology, 25, S85, 10.1016/S0893-133X(01)00319-0 · DOI
  47. Tjurmina, 2002, Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene, Endocrinology, 143, 4520, 10.1210/en.2002-220416 · DOI
  48. Uhl, 2002, Cocaine, reward, movement and monoamine transporters, Mol Psychiatry, 7, 21, 10.1038/sj.mp.4000964 · DOI · Paper page
  49. Wisor, 2003, Altered rapid eye movement sleep timing in serotonin transporter knockout mice, Neuroreport, 14, 233, 10.1097/00001756-200302100-00015 · DOI
  50. Wolfer, 2002, Knockout mice, Trends Neurosci, 25, 336, 10.1016/S0166-2236(02)02192-6 · DOI · Paper page
  51. Zhang, 2003, Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development, J Neurosci, 23, 3373, 10.1523/JNEUROSCI.23-08-03373.2003 · DOI

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Metadata

Authors
Holmes, A., Murphy, D. L., & Crawley, J. N.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2003-11
Volume
54
Issue
10
Pages
953-959
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1999238614
Cited by
341
References
6
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. https://app.cochat.ai/papers/10.1016/j.biopsych.2003.09.003
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Holmes, A., Murphy, D. L., & Crawley, J. N. (2003). Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2003.09.003

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