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Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression
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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Serotonin transporter genetic variation and the response of the human amygdala.
Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., Egan, M. F., & Weinberger, D. R. (2002) · Science · doi:10.1126/science.1071829 · Cited by 2,340
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551
Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001336 · Cited by 421
Anguelova, M., Benkelfat, C., & Turecki, G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001328 · Cited by 276
Meaney, M. J., Diorio, J., Francis, D., Weaver, S., Yau, J., Chapman, K., & Seckl, J. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03926.2000 · Cited by 266
Research works printed but not linked: 51
- Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP, et al (in press): Early experience and rh5-HTTLPR genotype interact to influence social behavior and aggression in nonhuman primates. Genes Brain Behav
- Bengel, 1998, Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice, Mol Pharmacol, 53, 649, 10.1124/mol.53.4.649 · DOI · Paper page
- Bennett, 2002, Early experience and serotonin transporter gene variation interact to influence primate CNS function, Mol Psychiatry, 7, 118, 10.1038/sj.mp.4000949 · DOI · Paper page
- Blakely, 1991, Cloning and expression of a functional serotonin transporter from rat brain, Nature, 354, 66, 10.1038/354066a0 · DOI · Paper page
- Bucan, 2002, The mouse, Nat Rev Genet, 3, 114, 10.1038/nrg728 · DOI · Paper page
- Caspi, 2002, Role of genotype in the cycle of violence in maltreated children, Science, 297, 851, 10.1126/science.1072290 · DOI · Paper page
- Champoux, 2002, Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates, Mol Psychiatry, 7, 1058, 10.1038/sj.mp.4001157 · DOI · Paper page
- Chen, 2001, Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter, J Neurosci, 21, 6348, 10.1523/JNEUROSCI.21-16-06348.2001 · DOI · Paper page
- Drevets, 2000, Serotonin type-1A receptor imaging in depression, Nucl Med Biol, 27, 499, 10.1016/S0969-8051(00)00119-0 · DOI · Paper page
- Fabre, 2000, Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter, Eur J Neurosci, 12, 2299, 10.1046/j.1460-9568.2000.00126.x · DOI · Paper page
- Gobbi, 2001, Modifications of the serotonergic system in mice lacking serotonin transporters, J Pharmacol Exp Ther, 296, 987
- Greenberg, 2000, Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample, Am J Med Genet, 96, 202, 10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J · DOI · Paper page
- Gross, 2002, Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult, Nature, 416, 396, 10.1038/416396a · DOI · Paper page
- Hariri AR, Weinberger DR (in press): Functional neuroimaging of genetic variation I serotonergic neurotransmission. Genes Brain Behav · DOI
- Herman, 2003, Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population, Alcohol Alcohol, 38, 446, 10.1093/alcalc/agg110 · DOI
- Holmes, 2001, Transgenic and gene knockout approaches to the study of anxiety-like behavior in mice, Neurosci Biobehav Rev, 25, 261, 10.1016/S0149-7634(01)00012-4 · DOI · Paper page
- Holmes A, Hariri AR (in press): The serotonin transporter gene-linked polymorphism and negative emotionality; placing single gene effects in the context of genetic background and environment. Genes Brain Behav · DOI
- Holmes A, Li Q, Murphy DL, Gold E, Crawley JN (in press): Abnormal anxiety-related behavior in serotonin transporter null mutant mice: The influence of genetic background. Genes Brain Behav · DOI · Paper page
- Holmes, 2002, Reduced aggression in mice lacking the 5-HT transporter, Psychopharmacology, 161, 160, 10.1007/s00213-002-1024-3 · DOI
- Holmes, 2002, Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter, Neuropsychopharmacology, 27, 914, 10.1016/S0893-133X(02)00374-3 · DOI · Paper page
- Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL (2003): Mice lacking the serotonin transporter exhibit 5-HT1A receptor-mediated abnormalities in anxiety-like and exploratory behavior. Neuropsychopharmacology Sept 10 [Epub ahead of print] · DOI · Paper page
- Kendler, 2001, Twin studies of psychiatric illness, Arch Gen Psychiatry, 58, 1005, 10.1001/archpsyc.58.11.1005 · DOI · Paper page
- Lauder, 1990, Ontogeny of the serotonergic system in the rat, Ann N Y Acad Sci, 600, 297, 10.1111/j.1749-6632.1990.tb16891.x · DOI · Paper page
- Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 · DOI · Paper page
- Lesch, 1990, Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression, Life Sci, 46, 1271, 10.1016/0024-3205(90)90359-Y · DOI
- Lesch, 1998, Genetically driven variation in serotonin uptake, Biol Psychiatry, 44, 179, 10.1016/S0006-3223(98)00121-8 · DOI · Paper page
- Li, 2000, Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice, J Neurosci, 20, 7888, 10.1523/JNEUROSCI.20-21-07888.2000 · DOI · Paper page
- Li, 2003, Brain-region specific alterations of 5-HT2A and 5-HT2C receptors in 5-HT transporter knockout mice, J Neurochem, 84, 1256, 10.1046/j.1471-4159.2003.01607.x · DOI
- Linnoila, 1992, Aggression, suicidality, and serotonin, J Clin Psychiatry, 53, S6
- Lira A, Zhou M, Castanon N, Ansorge MS, Gordon JA, Francis JH, et al (2003): Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice. Biol Psychiatry 54:960–971 · DOI · Paper page
- Liu, 2002, Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter, Am J Physiol Gastrointest Liver Physiol, 283, 1398, 10.1152/ajpgi.00203.2002 · DOI
- Mannoury la Cour, 2001, Functional consequences of 5-HT transporter gene disruption on 5-HT(1a) receptor-mediated regulation of dorsal raphe and hippocampal cell activity, J Neurosci, 21, 2178, 10.1523/JNEUROSCI.21-06-02178.2001 · DOI
- Mazzanti, 1998, Role of the serotonin transporter promoter polymorphism in anxiety-related traits, Arch Gen Psychiatry, 55, 936, 10.1001/archpsyc.55.10.936 · DOI · Paper page
- McGuffin, 2001, Genomics and behavior. Toward behavioral genomics, Science, 291, 1232, 10.1126/science.1057264 · DOI · Paper page
- Montanez, 2003, Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice, J Neurochem, 86, 210, 10.1046/j.1471-4159.2003.01836.x · DOI
- Morgan, 2001, Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress, Psychosom Med, 63, 412, 10.1097/00006842-200105000-00010 · DOI · Paper page
- Murphy DL, Holmes A, Ren-Patterson R, Sora I, Detera-Wadleigh S, Hall FS, et al (in press): Experimental gene interaction studies with SERT mutant mice as models for human polygenic traits and disorders. Genes Brain Behav · DOI
- Murphy, 2001, Genetic perspectives on the serotonin transporter, Brain Res Bull, 56, 487, 10.1016/S0361-9230(01)00622-0 · DOI
- Nadeau, 2001, Modifier genes in mice and humans, Nat Rev Genet, 2, 165, 10.1038/35056009 · DOI · Paper page
- Owens, 1998, The serotonin transporter and depression, Depress Anxiety, 8, 5, 10.1002/(SICI)1520-6394(1998)8:1+<5::AID-DA2>3.0.CO;2-I · DOI
- Pattij, 2002, GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv background, Eur J Pharmacol, 447, 67, 10.1016/S0014-2999(02)01893-9 · DOI
- Persico, 2001, Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release, J Neurosci, 21, 6862, 10.1523/JNEUROSCI.21-17-06862.2001 · DOI · Paper page
- Riedel, 2002, Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge, Neuropsychopharmacology, 26, 358, 10.1016/S0893-133X(01)00361-X · DOI
- Rutter, 2002, The interplay of nature, nurture, and developmental influences, Arch Gen Psychiatry, 59, 996, 10.1001/archpsyc.59.11.996 · DOI
- Salichon, 2001, Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice, J Neurosci, 21, 884, 10.1523/JNEUROSCI.21-03-00884.2001 · DOI · Paper page
- Seifritz, 2001, Contribution of sleep physiology to depressive pathophysiology, Neuropsychopharmacology, 25, S85, 10.1016/S0893-133X(01)00319-0 · DOI
- Tjurmina, 2002, Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene, Endocrinology, 143, 4520, 10.1210/en.2002-220416 · DOI
- Uhl, 2002, Cocaine, reward, movement and monoamine transporters, Mol Psychiatry, 7, 21, 10.1038/sj.mp.4000964 · DOI · Paper page
- Wisor, 2003, Altered rapid eye movement sleep timing in serotonin transporter knockout mice, Neuroreport, 14, 233, 10.1097/00001756-200302100-00015 · DOI
- Wolfer, 2002, Knockout mice, Trends Neurosci, 25, 336, 10.1016/S0166-2236(02)02192-6 · DOI · Paper page
- Zhang, 2003, Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development, J Neurosci, 23, 3373, 10.1523/JNEUROSCI.23-08-03373.2003 · DOI
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Alvaro, P. K., Roberts, R. M., & Harris, J. K. (2013) · Sleep · doi:10.5665/sleep.2810 · Cited by 1,573
Gene–environment interactions in psychiatry: joining forces with neuroscience
Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300
The ascent of mouse: advances in modelling human depression and anxiety
Cryan, J. F., & Holmes, A. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1825 · Cited by 1,198
Self-citationKorte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097
The GABAergic deficit hypothesis of major depressive disorder
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Metadata
- Authors
- Holmes, A., Murphy, D. L., & Crawley, J. N.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 54
- Issue
- 10
- Pages
- 953-959
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1999238614
- Cited by
- 341
- References
- 6
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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