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Cited by 91Treatment of Major DepressionNeural and Behavioral Psychology StudiesFunctional Brain Connectivity Studies

Mapping brain size and cortical gray matter changes in elderly depression

Ballmaier, Martina, Sowell, Elizabeth R, Thompson, Paul M, Kumar, Anand, Narr, Katherine L, Lavretsky, Helen, Welcome, Suzanne E, DeLuca, Heather +1 more·2004·Biological Psychiatry
DOI 10.1016/j.biopsych.2003.09.004
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Abstract

Background In elderly depression, volumetric brain imaging findings suggest abnormalities of the frontal lobe, particularly the orbitofrontal cortex, and the hippocampus. No studies to date have mapped cortical abnormalities over the entire brain surface in major depression. Here, we conducted detailed spatial analyses of brain size and gray matter within the cortical mantle in elderly patients with major depression.Methods High-resolution, three-dimensional, structural magnetic resonance imaging data and cortical pattern matching methods were used in 24 depressed elderly patients and 19 group-matched controls to measure local brain size and proportions of gray matter at thousands of homologous cortical surface locations.Results Prominent brain size reductions were observed in the depressed subjects in the orbitofrontal cortex bilaterally. Cortical gray matter measurements revealed significant gray matter increases in the orbitofrontal cortex, adjacent to focal trend level significant decreases of gray matter in the same region. Depressed patients also exhibited significant gray matter increases in parietal cortices, as well as the left temporal cortex.Conclusions Complex cortical changes may contribute to the brain size reduction of the orbitofrontal cortex and to the gray matter abnormalities detected in orbitofrontal cortex and temporoparietal cortices, thereby providing a potentially new window into the pathophysiology of elderly depression.

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  • Existing studies in MDD have shown loss of gray matter volume across cortical regions including medial prefrontal anterior cingulate and orbitofrontal cortex, lateral prefrontal cortex, temporal cortex, and pre- and post-central gyri.

    “Existing studies in patients with MDD have shown loss of GM volume across a range of cortical brain regions, including the medial prefrontal regions of the anterior cingulate cortex and orbitofrontal cortex (OFC), the lateral prefrontal cortex, the temporal cortex (Ballmaier et al., 2004), and the pre- and post-central gyri (Taki et al., 2005).”

    From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Ballmaier et al., 2004

  • The findings of discrete GM volume and thickness loss in the gyrus rectus replicate previous data.

    “Our findings of discrete GM volume and thickness loss in the gyrus rectus replicate previous data (Ballmaier et al., 2004).”

    From Widespread reductions in gray matter volume in depression (2013) · cites this paper as Ballmaier et al., 2004

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Authors
Ballmaier, M., Sowell, E. R., Thompson, P. M., Kumar, A., Narr, K. L., Lavretsky, H., Welcome, S. E., DeLuca, H., & Toga, A. W.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Toga, Arthur W
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2004-02
Volume
55
Issue
4
Pages
382-389
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2003.09.004
OpenAlex
W2096831423
Cited by
91
References
52
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 12 · 2012: 4
FWCI
6.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (K01 MH 02043, R01MH061567, K01 MH 01733, 1P20 MH 65166, MH-55115, P20MH065166, K01MH001733, R01MH055115, MH61567)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB001561, EB01561)
  • National Center for Research Resources (2P41RR13642, P41RR013642, 2M01 RR 00865, M01RR000865)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
geriatric depression, major depressive disorder, brain size, cortical gray matter, orbitofrontal cortex, parietal cortex, temporal cortex, brain atrophy, depression pathophysiology
MeSH terms
Aged, Brain, Brain Mapping, Depression, Female, Health Services for the Aged, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Psychiatric Status Rating Scales, Case-Control Studies, Imaging, Three-Dimensional

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