Reduction of orbital frontal cortex volume in geriatric depression
Abstract
Background Postmortem studies have documented abnormalities in the medial orbital frontal cortex in depressed patients. In this study we evaluated whether atrophy of this region can be identified in older depressed patients using magnetic resonance imaging. Methods Twenty elderly patients meeting DSM-IV criteria for major depression and 20 matched control subjects were studied. The orbital frontal cortex was measured in both hemispheres using magnetic resonance imaging. Results Depressive patients had reduced volume in the total orbital frontal cortex, right orbital frontal cortex, and left orbital frontal cortex. Conclusions Our finding of a reduction in orbital frontal cortex volume in both sides of the brain suggests that this region of the brain may have a critical role in the development of depression and raises questions about the etiology of the changes.
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Abnormal pathological dysfunctions, defects and alterations in these brain regions are significantly related to multiple psychiatric and mental health disorders, including depression and aggression.
“abnormal pathological dysfunctions/defects and alterations in these brain regions are significantly related to multiple psychiatric and mental health disorders (Lai, Payne, Byrum, Steffens, & Krishnan, 2000; Tamminga & Buchsbaum, 2004; van Heukelum et al., 2021), including depression (Lai et al., 2000), and aggression (van Heukelum et al., 2021)”
From Early-Initiated Childhood Reading for Pleasure: Associations with Better Cognitive Performance, Mental Well-being and Brain Structure in Young Adolescence (2024) · cites this paper as Lai, Payne, Byrum, Steffens, & Krishnan, 2000
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“…health disorders (Lai, Payne, Byrum, Steffens, & Krishnan, 2000; Tamminga & Buchsbaum, 2004; van Heukelum et al., 2021), including depression (Lai et al., 2000), and aggression (van Heukelum et al., 2021), etc. Impairments in these regions are also closely related to attention disorder…”
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- Authors
- Lai, T.-J., Payne, M. E., Byrum, C. E., Steffens, D. C., & Krishnan, K. R. R.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Krishnan, K.Ranga R
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2000-11
- Volume
- 48
- Issue
- 10
- Pages
- 971-975
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1982277568
- Cited by
- 223
- References
- 5
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 8 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 4 · 2018: 10 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 12 · 2012: 12
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (P30MH040159)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- geriatric depression, major depressive disorder, orbitofrontal cortex, brain atrophy, older adults
- MeSH terms
- Aged, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Psychiatric Status Rating Scales, Prefrontal Cortex
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