The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
The Munich Vulnerability Study on Affective Disorders: Premorbid Polysomnographic Profile of Affected High-Risk Probands
Abstract
Background The most characteristic alterations in the sleep electroencephalogram (EEG) during major depression are a shortened latency to rapid eye movement (REM) sleep and an elevated REM density. Because these changes persist in remission, they might represent vulnerability markers. To identify vulnerability markers, we investigated premorbid sleep EEG parameters in healthy high-risk probands (HRPs) with a positive family history of affective disorders.Methods We identified 136 depressed inpatients from referrals to our hospital who had first-degree relatives with an affective disorder as well as first-degree relatives with no current or lifetime history of psychiatric disorders. The latter (the HRP group) were investigated by polysomnography. During the follow-up period, 20 HRPs developed an affective disorder. Their premorbid sleep data were analyzed.Results Premorbid sleep EEG of affected HRPs showed an increased REM density (total night and first REM period) compared with the control group without personal or family history of a psychiatric disorder.Conclusions Increased REM density can be observed not only in patients with depression, but also in their healthy relatives. Moreover, it is predictive for the onset of a psychiatric disorder. Therefore, it can be recommended as a possible endophenotype of these diseases.
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From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Modell et al., 2005
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Self-citation
Metadata
- Authors
- Modell, S., Ising, M., Holsboer, F., & Lauer, C. J.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Max Planck Society (DE)
- Corresponding author
- Ising, Marcus
- ORCID
- Ising, Marcus
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 58
- Issue
- 9
- Pages
- 694-699
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2031579467
- Cited by
- 103
- References
- 41
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 10 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- mood disorders, major depressive disorder, REM density, REM latency, sleep EEG, family history (medicine), vulnerability indicators, endophenotypes, first-degree relatives
- MeSH terms
- Adolescent, Adult, Electroencephalography, Female, Germany, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Wake Disorders, Sleep, REM, Polysomnography, Age of Onset, Risk Assessment, Mood Disorders
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