Cited by 103Sleep and Wakefulness ResearchSleep and related disordersTreatment of Major Depression

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The Munich Vulnerability Study on Affective Disorders: Premorbid Polysomnographic Profile of Affected High-Risk Probands

Modell, Sieglinde, Ising, Marcus, Holsboer, Florian, Lauer, Christoph Johannes·2005·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.05.004

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Abstract

Background The most characteristic alterations in the sleep electroencephalogram (EEG) during major depression are a shortened latency to rapid eye movement (REM) sleep and an elevated REM density. Because these changes persist in remission, they might represent vulnerability markers. To identify vulnerability markers, we investigated premorbid sleep EEG parameters in healthy high-risk probands (HRPs) with a positive family history of affective disorders.Methods We identified 136 depressed inpatients from referrals to our hospital who had first-degree relatives with an affective disorder as well as first-degree relatives with no current or lifetime history of psychiatric disorders. The latter (the HRP group) were investigated by polysomnography. During the follow-up period, 20 HRPs developed an affective disorder. Their premorbid sleep data were analyzed.Results Premorbid sleep EEG of affected HRPs showed an increased REM density (total night and first REM period) compared with the control group without personal or family history of a psychiatric disorder.Conclusions Increased REM density can be observed not only in patients with depression, but also in their healthy relatives. Moreover, it is predictive for the onset of a psychiatric disorder. Therefore, it can be recommended as a possible endophenotype of these diseases.

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Regarding “The Munich Vulnerability Study on Affective Disorders: Premorbid Polysomnographic Profile of Affected High-Risk Probands”
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Table of Contents
(2007) · Biological Psychiatry · doi:10.1016/s0006-3223(07)00757-3
Author Index to Volume 58
(2005) · Biological Psychiatry · doi:10.1016/s0006-3223(05)01358-2
Reply
Modell, S., Ising, M., Holsboer, F., & Lauer, C. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.003
Invariant relationship unites REM and NonREM sleepPreprint
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(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0

Authors: Modell, S., Ising, M., Holsboer, F., & Lauer, C. J.
Affiliations: Max Planck Institute of Psychiatry (DE)
Max Planck Society (DE)
Corresponding author: Ising, Marcus
ORCID: Ising, Marcus
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2005-11
Volume: 58
Issue: 9
Pages: 694-699
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.05.004
OpenAlex: W2031579467
Cited by: 103
References: 41
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 10 · 2014: 2 · 2013: 10 · 2012: 6
FWCI: 3.31
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: mood disorders, major depressive disorder, REM density, REM latency, sleep EEG, family history (medicine), vulnerability indicators, endophenotypes, first-degree relatives
MeSH terms: Adolescent, Adult, Electroencephalography, Female, Germany, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, Sleep Wake Disorders, Sleep, REM, Polysomnography, Age of Onset, Risk Assessment, Mood Disorders

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