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A Mouse Model System for Genetic Analysis of Sociability: C57BL/6J Versus BALB/cJ Inbred Mouse Strains
Abstract
Background Impairments in social behaviors are highly disabling symptoms of autism, schizophrenia, and other psychiatric disorders. Mouse model systems are useful for identifying the many genes and environmental factors likely to affect complex behaviors, such as sociability (the tendency to seek social interaction). To progress toward developing such a model system, we tested the hypothesis that C57BL/6J inbred mice show higher levels of sociability than BALB/cJ inbred mice.Methods Mice tested for sociability were 4- and 9-week-old, male and female C57BL/6J and BALB/cJ mice. On 2 consecutive days, the sociability of each test mouse toward an unfamiliar 4-week-old DBA/2J stimulus mouse was assessed with a social choice paradigm conducted in a three-chambered apparatus. Measures of sociability included the time that the test mouse spent near versus far from the stimulus mouse, the time spent directly sniffing the stimulus mouse, and the time spent in contact between test and stimulus mice in a free interaction.Results C57BL/6J mice showed higher levels of sociability than BALB/cJ mice overall in each of these measures.Conclusions We propose that C57BL/6J and BALB/cJ mice will be a useful mouse model system for future genetic and neurobiological studies of sociability.
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“Several naturally occurring inbred strains of mice display behavioral features that recapitulate diagnostic symptoms of neurodevelopmental disorders (59–70).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [59]
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Metadata
- Authors
- Sankoorikal, G. M. V., Kaercher, K. A., Boon, C. J., Lee, J. K., & Brodkin, E. S.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Brodkin, Edward S.
- ORCID
- Brodkin, Edward S.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 59
- Issue
- 5
- Pages
- 415-423
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2053588982
- Cited by
- 231
- References
- 43
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 6 · 2023: 4 · 2022: 10 · 2021: 10 · 2020: 19 · 2019: 12 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 21 · 2012: 12
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K08MH068586, KO8MH068586)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- sociability, inbred mouse strains, C57BL/6J mice, BALB/cJ mice, social behavior, autism spectrum disorder, schizophrenia
- MeSH terms
- Aggression, Animals, Choice Behavior, Female, Genotype, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Models, Genetic, Social Behavior, Social Environment, Mice
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