Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
Abstract
Arginine vasopressin influences male reproductive and social behaviours in several vertebrate taxa through its actions at the V1a receptor in the brain. The neuroanatomical distribution of vasopressin V1a receptors varies greatly between species with different forms of social organization. Here we show that centrally administered arginine vasopressin increases affiliative behaviour in the highly social, monogamous prairie vole, but not in the relatively asocial, promiscuous montane vole. Molecular analyses indicate that gene duplication and/or changes in promoter structure of the prairie vole receptor gene may contribute to the species differences in vasopressin-receptor expression. We further show that mice that are transgenic for the prairie vole receptor gene have a neuroanatomical pattern of receptor binding that is similar to that of the prairie vole, and exhibit increased affiliative behaviour after injection with arginine vasopressin. These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates.
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Viral-mediated Avpr1a receptor overexpression studies show that species differences in Avpr1a expression mediate species differences in social behavior, and variation in Avpr1a expression in the brain is related to microsatellite diversity in the gene's 5' flanking region.
“Viral-mediated Avpr1a receptor overexpression studies show that species differences in Avpr1a expression mediate species differences in social behavior, and variation in Avpr1a expression in the brain is related to microsatellite diversity in the gene's 5′ flanking region (151-154).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [154]
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Vasopressin innervation of the mouse ( <i>Mus musculus</i> ) brain and spinal cord
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Sexual and social stimuli elicit rapid and contrasting genomic responses
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Mammalian monogamy is not controlled by a single gene
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Association of vasopressin 1a receptor levels with a regulatory microsatellite and behavior
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Neuropeptides and the social brain: potential rodent models of autism
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Self-citationThe Neurobiology of Social Affiliation and Pair Bonding
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- Authors
- Young, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R.
- Affiliations
- Emory University (US)
- Corresponding author
- Nilsen, Roger
- Venue
- Nature
- Published
- 1999-08
- Volume
- 400
- Issue
- 6746
- Pages
- 766-768
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1556396873
- Cited by
- 488
- References
- 19
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 13 · 2023: 5 · 2022: 13 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 13 · 2017: 21 · 2016: 12 · 2015: 17 · 2014: 24 · 2013: 23 · 2012: 18
- FWCI
- 39.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, V1a receptor, Microtus ochrogaster, montane vole, affiliative behavior, social behavior, monogamy, gene duplication, promoter structure, transgenic mice, receptor gene expression, species differences, social organization
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Arvicolinae, Female, Male, Mice, Transgenic, Molecular Sequence Data, Pair Bond, Social Behavior, Species Specificity, Gene Expression, Receptors, Vasopressin, Mice
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