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Cited by 234Bipolar Disorder and TreatmentFatty Acid Research and HealthTreatment of Major Depression

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Double-Blind, Randomized, Placebo-Controlled Trials of Ethyl-Eicosapentanoate in the Treatment of Bipolar Depression and Rapid Cycling Bipolar Disorder

Keck, Paul E., Mintz, Jim, McElroy, Susan L., Freeman, Marlene P., Suppes, Trisha, Frye, Mark A., Altshuler, Lori L., Kupka, Ralph, Nolen, Willem A., Leverich, Gabriele S., Denicoff, Kirk D., Grunze, Heinz, Duan, Naihua, Post, Robert M.·2006·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.03.056
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Abstract

Background The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder.Methods We conducted a 4-month, randomized, placebo-controlled, adjunctive trial of ethyl-eicosapentanoate (EPA) 6 g/day in the treatment of bipolar depression and rapid cycling bipolar disorder. Subjects were receiving mood-stabilizing medications at therapeutic doses or plasma concentrations. The measures of efficacy were early study discontinuation, changes from baseline in depressive symptoms (Inventory for Depressive Symptomology total score) and in manic symptoms (Young Mania Rating Scale total score), and manic exacerbations ("switches"). We also measured side effects and bleeding time, a biomarker of drug action.Results Overall, there were no significant differences on any outcome measure between the EPA and placebo groups.Conclusions This study did not find overall evidence of efficacy for adjunctive treatment with EPA 6 g/day in outpatients with bipolar depression or rapid cycling bipolar disorder.

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Crossref · 10.1016/j.biopsych.2006.03.056

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  1. Frangou, 2002, Efficacy of ethyl-eicosapentaenoate in bipolardepression: a randomized, double-blind, placebo-controlled study, Bipolar Disorders, 4, 123

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Metadata

Authors
Keck, P. E., Mintz, J., McElroy, S. L., Freeman, M. P., Suppes, T., Frye, M. A., Altshuler, L. L., Kupka, R., Nolen, W. A., Leverich, G. S., Denicoff, K. D., Grunze, H., Duan, N., & Post, R. M.
Affiliations
  • Cincinnati VA Medical Center (US)
  • University of California, Los Angeles (US)
  • University of Cincinnati (US)
  • University of Arizona (US)
  • The University of Texas Southwestern Medical Center (US)
  • University Medical Center Utrecht (NL)
  • University Medical Center Groningen (NL)
  • National Institutes of Health (US)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Keck, Paul E.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-11
Volume
60
Issue
9
Pages
1020-1022
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.03.056
OpenAlex
W2054486548
Cited by
234
References
21
Citations by year
2026: 4 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 8 · 2017: 10 · 2016: 18 · 2015: 11 · 2014: 11 · 2013: 15 · 2012: 16
FWCI
15.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • Stanley Medical Research Institute
  • American Psychiatric Association
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
omega-3 fatty acids, bipolar depression, rapid cycling bipolar disorder, adjunctive therapy, mood stabilizers, manic symptoms, bleeding time, antidepressant efficacy
MeSH terms
Adult, Antidepressive Agents, Bipolar Disorder, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Eicosapentaenoic Acid, Treatment Outcome

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