Prepulse Inhibition and P50 Suppression Are Both Deficient but not Correlated in Schizophrenia Patients
Abstract
Background Inhibitory measures such as prepulse inhibition of the acoustic startle reflex (PPI) and event related potential P50 suppression have been widely reported to show deficits in schizophrenia patients. The relationship between PPI and P50 suppression in schizophrenia patients has remained unclear.Methods One hundred fifty-six schizophrenia patients and 104 normal comparison subjects (NCS) were tested on PPI and P50 suppression.Results Eighty-one patients and 70 NCS had valid and scorable data on both PPI and P50 suppression paradigms. As in the larger groups, these cohorts had deficits on both PPI (p < .05) and P50 suppression (p < .05). Analyses revealed a weak, but significant correlation between PPI and P50 suppression in the NCS group (r = .33, p < .05) but not in the patient group (r = .03, ns).Conclusions Although PPI and P50 suppression were both reduced in the patients, they were not correlated. This divergence suggests that these gating functions are complementary or redundant levels of "protection" against processes that may lead to cognitive fragmentation.
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In many patients the PPI and P50 gating deficits do not occur together, and thus they represent distinct aspects of pathophysiology.
“In many patients the two deficits do not occur together, and thus they represent distinct aspects of pathophysiology (11).”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [11]
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- Authors
- Braff, D. L., Light, G. A., & Swerdlow, N. R.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Braff, David L.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 61
- Issue
- 10
- Pages
- 1204-1207
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2062467533
- Cited by
- 90
- References
- 31
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH01436)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, prepulse inhibition, P50 suppression, acoustic startle response, event-related potentials, cognitive fragmentation, neuropsychological deficits
- MeSH terms
- Adult, Cerebral Cortex, Electroencephalography, Evoked Potentials, Female, Habituation, Psychophysiologic, Humans, Male, Middle Aged, Neural Inhibition, Psychiatric Status Rating Scales, Schizophrenia, Reflex, Startle, Statistics as Topic
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