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Cited by 111Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

Sustained Low-Grade Pro-inflammatory State in Unmedicated, Remitted Women with Major Depressive Disorder as Evidenced by Elevated Serum Levels of the Acute Phase Proteins C-reactive Protein and Serum Amyloid A

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Kling, Mitchel A., Alesci, Salvatore, Csako, Gyorgy, Costello, Rene, Luckenbaugh, David A., Bonne, Omer, Duncko, Roman, Drevets, Wayne C. +4 more·2007·Biological Psychiatry
DOI 10.1016/j.biopsych.2006.09.033PMC PMC2546515
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Abstract

Background Major depressive disorder (MDD) shows increased coronary artery disease (CAD) risk of unknown mechanism(s). MDD is more common in women than men; CAD diagnosis can be difficult in women. Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients. Methods We measured fasting am serum CRP (high sensitivity, CRP(hs)) and SAA in 18 unmedicated, remitted women with MDD (mean age 41 +/- (SD)12, body mass index (BMI) 25.2 +/- 4.1 kg/m(2)) and 18 BMI-matched healthy control subjects (age 36 +/- 10, BMI 25.3 +/- 3.8 kg/m(2)) on 2 separate occasions, > or = 6 days apart. Results Repeat SAA and CRP(hs) measurements strongly correlated across study days (SAA: r = .83, p < .001; CRP(hs): r = .94, p < .001). Both SAA (5.30 +/- 3.39 vs. 2.84 +/- 1.87 mg/L, p < .005) and CRP(hs) (3.23 +/- 3.17 vs. 1.12 +/- 1.45 mg/L; p < .01) were significantly elevated in MDD women versus controls. Conclusions Elevated SAA and CRP(hs) in remitted, unmedicated women with MDD indicate a pro-inflammatory state unrelated to current depressive symptoms or pharmacotherapy. These findings suggest that inflammatory mechanisms may in part underlie findings of increased CAD risk in MDD.

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Authors
Kling, M. A., Alesci, S., Csako, G., Costello, R., Luckenbaugh, D. A., Bonne, O., Duncko, R., Drevets, W. C., Manji, H. K., Charney, D. S., Gold, P. W., & Neumeister, A.
Affiliations
  • National Institute of Mental Health (US)
  • National Institutes of Health (US)
  • Hadassah Medical Center (IL)
  • Icahn School of Medicine at Mount Sinai (US)
  • Yale University (US)
Corresponding author
Kling, Mitchel A.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2007-08
Volume
62
Issue
4
Pages
309-313
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2006.09.033
PMC
PMC2546515
OpenAlex
W2079816943
Cited by
111
References
3
Citations by year
2026: 3 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 10
FWCI
2.42
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (Z01MH002817, Z01MH002659)
  • NIH Clinical Center (Z01CL010306)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, women, remitted depression, unmedicated patients, low-grade inflammation, C-reactive protein, serum amyloid A, acute phase proteins, coronary artery disease risk
MeSH terms
Age Factors, Serum Amyloid A Protein, C-Reactive Protein, Cardiovascular Diseases, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Middle Aged, Reference Values, Risk Factors, Biomarkers, Body Mass Index, Case-Control Studies, Matched-Pair Analysis, Statistics, Nonparametric, Inflammation Mediators

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