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Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome
Open accessAbstract
Background Structural and functional neuroimaging studies suggest abnormal activity in the striatum of patients with the fragile X syndrome (FXS), the most common form of inherited mental retardation.Methods Neurophysiological and immunofluorescence experiments in striatal brain slices. We studied the synaptic transmission in a mouse model for FXS, as well as the subcellular localization of fragile X mental retardation protein (FMRP) and brain cytoplasmic (BC1) RNA in striatal axons.Results Our results show that absence of FMRP is associated with apparently normal striatal glutamate-mediated transmission, but abnormal gamma-aminobutyric acid (GABA) transmission. This effect is likely secondary to increased transmitter release from GABAergic nerve terminals. We detected the presence of FMRP in axons of striatal neurons and observed a selective increase in the frequency of spontaneous and miniature inhibitory postsynaptic currents (sIPSCs, mIPSCs) in fmr1-knockout mice. We also observed reduced paired-pulse ratio of evoked IPSCs, a finding that is consistent with the idea that transmitter release probability from striatal GABAergic nerve terminals is higher than normal in these mutants. Finally, we have identified the small noncoding BC1 RNA as a critical coplayer of FMRP in the regulation of striatal synaptic transmission.Conclusions Understanding the physiologic action of FMRP and the synaptic defects associated with GABA transmission might be useful to design appropriate pharmacologic interventions for FXS.
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“The GABA receptor system has also been reported as downregulated in FXS, partially due to destabilization of the mRNAs encoding the GABA receptor subunits (76,80,113).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [76]
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“FMRP activity is regulated in response to metabotropic glutamate receptors (mGluRs) (78), 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl) propanoic acid (AMPA) receptors (79), γ-aminobutyric acid (GABA) receptors (76,80,81), N-methyl-d-aspartate (NMDA) receptors (82)(83)(84), and the tyrosine kinase or BDNF/NT-3 growth factor (TrkB) receptors (85).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [76]
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“Furthermore, extensive electrophysiological studies in the Fmr1 KO mouse model indicated an excitation/inhibition (glutamate/GABA; see below) imbalance (75)(76)(77).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [76]
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Citations
Cites
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science · doi:10.1126/science.252.5009.1097 · Cited by 1,499
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,108
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952
Inhibitory control of neostriatal projection neurons by GABAergic interneurons
Koós, T. Z., & Tepper, J. M. (1999) · Nature Neuroscience · doi:10.1038/8138 · Cited by 863
Zalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676
Self-citationNeuronal RNA Granules: Movers and Makers
Kiebler, M. A., & Bassell, G. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.021 · Cited by 595
Krichevsky, A. M., & Kosik, K. S. (2001) · Neuron · doi:10.1016/s0896-6273(01)00508-6 · Cited by 536
Wilson, C. J., & Groves, P. M. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901940308 · Cited by 527
The Fragile-X Premutation: A Maturing Perspective
Hagerman, P. J., & Hagerman, R. J. (2004) · The American Journal of Human Genetics · doi:10.1086/386296 · Cited by 524
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
Miyashiro, K. Y., Beckel-Mitchener, A., Purk, T. P., Becker, K. G., Barret, T., Liu, L., Carbonetto, S., Weiler, I. J., Greenough, W. T., & Eberwine, J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00034-5 · Cited by 495
From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Bagni, C., & Greenough, W. T. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1667 · Cited by 475
Self-citationHou, L., Antion, M. D., Hu, D., Spencer, C. M., Paylor, R., & Klann, E. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.005 · Cited by 469
Koekkoek, S. K. E., Yamaguchi, K., Milojkovic, B. A., Dortland, B. R., Ruigrok, T. J. H., Maex, R., Graaf, W. D., Smit, A. E., VanderWerf, F., Bakker, C. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.005 · Cited by 412
A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability
Zalfa, F., Eleuteri, B., Dickson, K. S., Mercaldo, V., Rubeis, S. D., di Penta, A., Tabolacci, E., Chiurazzi, P., Neri, G., Grant, S. G. N., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1893 · Cited by 370
Self-citationRNA and microRNAs in fragile X mental retardation
Jin, P., Alisch, R. S., & Warren, S. T. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1048 · Cited by 344
Decreased expression of the GABAA receptor in fragile X syndrome
D'Hulst, C., De Geest, N., Reeve, S. P., Van Dam, D., De Deyn, P. P., Hassan, B. A., & Kooy, R. F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.115 · Cited by 318
Nosyreva, E. D., & Huber, K. M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01316.2005 · Cited by 301
Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome
Zhao, M.-G., Toyoda, H., Ko, S. W., Ding, H.-K., Wu, L.-J., & Zhuo, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1520-05.2005 · Cited by 296
Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1
Jacquemont, S., Hagerman, R. J., Hagerman, P. J., & Leehey, M. A. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70676-7 · Cited by 281
Plenz, D., & Kitai, S. T. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00266.1998 · Cited by 278
Synaptic input and output of parvalbumin-immunoreactive neurons in the neostriatum of the rat
Bennett, B. D., & Bolam, J. P. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90471-5 · Cited by 262
Autistic behavior in young boys with fragile X syndrome
Bailey, D. B., Mesibov, G. B., Hatton, D. D., Clark, R. D., Roberts, J. E., & Mayhew, L. (1998) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1026048027397 · Cited by 260
Antar, L. N., Li, C., Zhang, H., Carroll, R. C., & Bassell, G. J. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.02.001 · Cited by 259
Selby, L., Zhang, C., & Sun, Q.-Q. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.062 · Cited by 245
Centonze, D., Grande, C., Usiello, A., Gubellini, P., Erbs, E., Martín, A. B., Pisani, A., Tognazzi, N., Bernardi, G., Moratalla, R., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06245.2003 · Cited by 244
Self-citationDendritic BC1 RNA: Functional Role in Regulation of Translation Initiation
Wang, H., Iacoangeli, A., Popp, S., Muslimov, I., Imataka, H., Sonenberg, N., Lomakin, I., & Tiedge, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10232.2002 · Cited by 232
Kates, W. R., Abrams, M. T., Kaufmann, W. E., Breiter, S. N., & Reiss, A. L. (1997) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(97)00019-x · Cited by 223
Decreased GABAA receptor expression in the seizure-prone fragile X mouse
Idrissi, A. E., Ding, X., Scalia, J., Trenkner, E., Brown, W. T., & Dobkin, C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.087 · Cited by 210
Lessons from Fragile X Regarding Neurobiology, Autism, and Neurodegeneration
Hagerman, R. J. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200602000-00012 · Cited by 200
Neuroanatomy of fragile X syndrome
Reiss, A. L., Lee, J., & Freund, L. S. (1994) · Neurology · doi:10.1212/wnl.44.7.1317 · Cited by 191
Chuang, S.-C., Zhao, W., Bauchwitz, R., Yan, Q., Bianchi, R., & Wong, R. K. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1777-05.2005 · Cited by 190
Decreased cerebellar posterior vermis size in fragile X syndrome
Mostofsky, S. H., Mazzocco, M. M. M., Aakalu, G., Warsofsky, I. S., DENCKLA, M. B., & Reiss, A. L. (1998) · Neurology · doi:10.1212/wnl.50.1.121 · Cited by 188
Cognitive profiles associated with the fra(X) syndrome in males and females
Freund, L. S., & Reiss, A. L. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320380409 · Cited by 188
RNA binding proteins and the regulation of neuronal synaptic plasticity
Ule, J., & Darnell, R. B. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.01.003 · Cited by 181
Brain anatomy, gender and IQ in children and adolescents with fragile X syndrome
D, S. E. M. (2001) · Brain · doi:10.1093/brain/124.8.1610 · Cited by 169
Gantois, I., Vandesompele, J., Speleman, F., Reyniers, E., D’Hooge, R., Severijnen, L.-A. W. F. M., Willemsen, R., Tassone, F., & Kooy, R. F. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.017 · Cited by 166
The GABAA receptor: a novel target for treatment of fragile X?
D’Hulst, C., & Kooy, R. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.003 · Cited by 166
Chen, L., Yun, S.-W., Seto, J., Liu, W., & Toth, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00406-8 · Cited by 160
Zalfa, F., Adinolfi, S., Napoli, I., Kühn‐Hölsken, E., Urlaub, H., Achsel, T., Pastore, A., & Bagni, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504286200 · Cited by 141
Self-citationmRNPs, polysomes or granules: FMRP in neuronal protein synthesis
Zalfa, F., Achsel, T., & Bagni, C. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.010 · Cited by 138
Self-citationLarson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135
Contribution of the FMR1 gene mutation to human intellectual dysfunction
Reiss, A. L., Freund, L. S., Baumgardner, T. L., Abrams, M. T., & DENCKLA, M. B. (1995) · Nature Genetics · doi:10.1038/ng1195-331 · Cited by 133
Frontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expression
Menon, V., Leroux, J., White, C. D., & Reiss, A. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304544101 · Cited by 129
Yung, K. K. L., Smith, A. D., Levey, A. I., & Bolam, J. P. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01573.x · Cited by 128
Ferrari, F., Mercaldo, V., Piccoli, G., Sala, C., Cannata, S. M., Achsel, T., & Bagni, C. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.11.015 · Cited by 125
Self-citationRole of Purα in targeting mRNA to sites of translation in hippocampal neuronal dendrites
Johnson, E. M., Kinoshita, Y., Weinreb, D. B., Wortman, M. J., Simon, R., Khalili, K., Winckler, B., & Gordon, J. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20806 · Cited by 124
Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice
Wilson, B. M., & Cox, C. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610875104 · Cited by 121
Expression and Function of SNAP-25 as a Universal SNARE Component in GABAergic Neurons
Tafoya, L. C. R., Mameli, M., Miyashita, T., Guzowski, J. F., Valenzuela, C. F., & Wilson, M. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1866-06.2006 · Cited by 118
Kondrashov, A. V., Kiefmann, M., Ebnet, K., Khanam, T., Muddashetty, R. S., & Brosius, J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.07.049 · Cited by 118
Molecular‐neurobehavioral associations in females with the fragile X full mutation
Abrams, M. T., Reiss, A. L., Freund, L. S., Baumgardner, T. L., Chase, G. A., & DENCKLA, M. B. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320510407 · Cited by 112
Dendritic Transport and Localization of Protein Kinase Mζ mRNA
Muslimov, I. A., Nimmrich, V., Hernandez, A. I., Tcherepanov, A., Sacktor, T. C., & Tiedge, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409240200 · Cited by 106
Gustafson, N., Gireesh, E. D., Czubayko, U., Blackwell, K. T., & Plenz, D. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00802.2005 · Cited by 89
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro
Hack, S. P., Vaughan, C. W., & Christie, M. J. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00205-3 · Cited by 87
Centonze, D., Rossi, S., Prosperetti, C., Tscherter, A., Bernardi, G., Maccarrone, M., & Calabresi, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.008 · Cited by 77
Self-citationPrice, T. J., Flores, C. M., Cerveró, F., & Hargreaves, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.047 · Cited by 76
The fragile X mental retardation protein has nucleic acid chaperone properties
Gabus, C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh535 · Cited by 74
Neuronal Untranslated BC1 RNA: Targeted Gene Elimination in Mice
Skryabin, B. V., Sukonina, V., Jordan, U., Lewejohann, L., Sachser, N., Muslimov, I. A., Tiedge, H., & Brosius, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.18.6435-6441.2003 · Cited by 68
Involvement of cholinergic and gabaergic systems in the fragile X knockout mice
D’Antuono, M., Merlo, D., & Avoli, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00103-9 · Cited by 65
Transport of Neuronal BC1 RNA in Mauthner Axons
Muslimov, I. A., Titmus, M., KOENIG, E. C., & Tiedge, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04293.2002 · Cited by 59
The Brain Cytoplasmic RNA BC1 Regulates Dopamine D2Receptor-Mediated Transmission in the Striatum
Centonze, D., Rossi, S., Napoli, I., Mercaldo, V., Lacoux, C., Ferrari, F., Ciotti, M. T., De Chiara, V., Prosperetti, C., Maccarrone, M., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0548-07.2007 · Cited by 59
Self-citationMurphy, G. J., & Isaacson, J. S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00057-6 · Cited by 45
Gruss, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.12.001 · Cited by 40
Neuronal BC1 RNA: Intracellular Transport and Activity-Dependent Modulation
Brosius, J., & Tiedge, H. (2001) · Results and problems in cell differentiation · doi:10.1007/978-3-540-40025-7_8 · Cited by 31
Harvey, V. L., & Stephens, G. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03505.x · Cited by 31
Neuroimaging in developmental disorders
Greicius, M. D. (2003) · Current Opinion in Neurology · doi:10.1097/01.wco.0000063763.15877.d2 · Cited by 23
Neuronal BC1 RNA: Microtubule-dependent Dendritic Delivery
Cristofanilli, M., Iacoangeli, A., Muslimov, I. A., & Tiedge, H. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.090 · Cited by 19
Neuroimaging in developmental disorders
Greicius, M. D. (2003) · Current Opinion in Neurology · doi:10.1097/00019052-200304000-00004
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Metadata
- Authors
- Centonze, D., Rossi, S., Mercaldo, V., Napoli, I., Ciotti, M. T., De Chiara, V., Musella, A., Prosperetti, C., Calabresi, P., Bernardi, G., & Bagni, C.
- Affiliations
- University of Rome Tor Vergata (IT)
- University of Perugia (IT)
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 63
- Issue
- 10
- Pages
- 963-973
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2012460847
- Cited by
- 171
- References
- 68
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 9 · 2015: 7 · 2014: 15 · 2013: 11 · 2012: 15
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- fragile X syndrome, FMRP, BC1 RNA, striatum, GABAergic neurotransmission, inhibitory postsynaptic currents, miniature IPSCs, paired-pulse ratio, Fmr1 knockout mice, intellectual disability, synaptic plasticity
- MeSH terms
- Animals, Cerebral Cortex, Corpus Striatum, Disease Models, Animal, Electric Stimulation, Fragile X Syndrome, gamma-Aminobutyric Acid, Gene Expression Regulation, Mice, Inbred C57BL, Neural Inhibition, Synaptic Transmission, Phalloidine, Mice, Knockout, Patch-Clamp Techniques, Ribonucleoproteins, Small Cytoplasmic, RNA, Untranslated, Vesicular Inhibitory Amino Acid Transport Proteins, Mice, Fragile X Messenger Ribonucleoprotein 1, RNA, Long Noncoding, In Vitro Techniques
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