The Brain Cytoplasmic RNA BC1 Regulates Dopamine D2Receptor-Mediated Transmission in the Striatum
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Dopamine D 2 receptor (D 2 DR)-mediated transmission in the striatum is remarkably flexible, and changes in its efficacy have been heavily implicated in a variety of physiological and pathological conditions. Although receptor-associated proteins are clearly involved in specific forms of synaptic plasticity, the molecular mechanisms regulating the sensitivity of D 2 receptors in this brain area are essentially obscure. We have studied the physiological responses of the D 2 DR stimulations in mice lacking the brain cytoplasmic RNA BC1, a small noncoding dendritically localized RNA that is supposed to play a role in mRNA translation. We show that the efficiency of D 2-mediated transmission regulating striatal GABA synapses is under the control of BC1 RNA, through a negative influence on D 2 receptor protein level affecting the functional pool of receptors. Ablation of the BC1 gene did not result in widespread dysregulation of synaptic transmission, because the sensitivity of cannabinoid CB 1 receptors was intact in the striatum of BC1 knock-out (KO) mice despite D 2 and CB 1 receptors mediated similar electrophysiological actions. Interestingly, the fragile X mental retardation protein FMRP, one of the multiple BC1 partners, is not involved in the BC1 effects on the D 2-mediated transmission. Because D 2 DR mRNA is apparently equally translated in the BC1-KO and wild-type mice, whereas the protein level is higher in BC1-KO mice, we suggest that BC1 RNA controls D 2 DR indirectly, probably regulating translation of molecules involved in D 2 DR turnover and/or stability.
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Brain cytoplasmic lncRNA BC1 regulates metabotropic receptor signaling.
“brain cytoplasmic lncRNA (BC1), one of the earliest lncRNAs studied in the brain, regulates metabotropic receptor signaling.304”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [304]
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Braný, D., Dvorská, D., Lockwood, L. E., Strnádel, J., & Youssef, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00011-3
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607502
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607523
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607517
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607526
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607499
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607520
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607505
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607508
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607514
Li, Y., Wei, L., Wang, C., Zhao, J., Han, S., Zhang, Y., & Du, W. (2022) · Figshare · doi:10.6084/m9.figshare.19607511
- Authors
- Centonze, D., Rossi, S., Napoli, I., Mercaldo, V., Lacoux, C., Ferrari, F., Ciotti, M. T., De Chiara, V., Prosperetti, C., Maccarrone, M., Fezza, F., Calabresi, P., Bernardi, G., & Bagni, C.
- Affiliations
- University of Rome Tor Vergata (IT)
- Istituto Neurologico Mediterraneo (IT)
- Fondazione Santa Lucia (IT)
- National Research Council (IT)
- University of Teramo (IT)
- University of Perugia (IT)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-08-15
- Volume
- 27
- Issue
- 33
- Pages
- 8885-8892
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672174
- OpenAlex
- W2011574075
- Cited by
- 59
- References
- 44
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 13 · 2021: 3 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (acceptedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- Ministero della Salute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- BC1 RNA, dopamine D2 receptor, striatum, GABAergic synapses, synaptic transmission, mRNA translation, CB1 receptor, FMRP
- MeSH terms
- Animals, Animals, Newborn, Biphenyl Compounds, Cells, Cultured, Corpus Striatum, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Isoenzymes, Male, Mice, Inbred C57BL, Microtubule-Associated Proteins, Synaptic Transmission, Neurons, Oligonucleotides, Piperazines, RNA, Messenger, Guanosine 5'-O-(3-Thiotriphosphate), Receptors, Dopamine D2, Mice, Knockout, Patch-Clamp Techniques, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleoproteins, Small Cytoplasmic, RNA, Untranslated, Mice, Inhibitory Postsynaptic Potentials, RNA, Long Noncoding, Dopamine D2 Receptor Antagonists, In Vitro Techniques
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