From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome
Open accessAbstract
The mental retardation protein FMRP is involved in the transport of mRNAs and their translation at synapses. Patients with fragile X syndrome, in whom FMRP is absent or mutated, show deficits in learning and memory that might reflect impairments in the translational regulation of a subset of neuronal mRNAs. The study of FMRP provides important insights into the regulation and functions of local protein synthesis in the neuronal periphery, and increases our understanding of how these functions can produce specific effects at individual synapses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Fragile X syndrome is usually due to a trinucleotide expansion in FMR1 that results in transcriptional silencing of FMRP expression.
“Fragile X syndrome (FXS), the most common inherited cause of mental retardation (Bagni and Greenough, 2005; Bassell and Warren, 2008), is usually due to a trinucleotide expansion in the FMR1 gene that results in transcriptional silencing of FMRP (Fragile X mental retardation protein) expression.”
From Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132 (2010) · cites this paper as Bagni and Greenough, 2005
Fragile X syndrome results from transcriptional silencing of FMR1, which causes upregulated global dendritic translation rates that may contribute to elevated spine density.
“Fragile X syndrome results from transcriptional silencing of the FMR1 gene, which in turn causes an upregulation in global dendritic translation rates that may contribute to the elevated spine density observed in the brains of affected individuals42.”
From Dendritic spine pathology in neuropsychiatric disorders (2011) · cites this paper as [42]
FMRP forms large cytoplasmic ribonucleoparticles containing other proteins and RNAs.
“FMRP forms large cytoplasmic ribonucleoparticles containing several other proteins (61) and RNAs (62,63).”
From Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics (2012) · cites this paper as [61]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 5,910 · see citing works
Hollmann, M., & Heinemann, S. F. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.000335 · Cited by 4,011 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works
Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome
Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science · doi:10.1126/science.252.5009.1097 · Cited by 1,499 · see citing works
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208 · see citing works
Kanai, Y., Dohmae, N., & Hirokawa, N. (2004) · Neuron · doi:10.1016/j.neuron.2004.07.022 · Cited by 1,109 · see citing works
Brown, V., Jin, P., Ceman, S., Darnell, J. C., O'Donnell, W. T., Tenenbaum, S. A., Jin, X., Feng, Y., Wilkinson, K. D., Keene, J. D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00568-2 · Cited by 1,109 · see citing works
Fmr1 knockout mice: A model to study fragile X mental retardation
THEDUTCHBELGIANFRAGILEXCONSOR (1994) · Cell · doi:10.1016/0092-8674(94)90569-x · Cited by 1,075 · see citing works
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works
Self-citationMolecular mechanisms of translational control
Gebauer, F., & Hentze, M. W. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1488 · Cited by 991 · see citing works
Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Darnell, J. C., Jensen, K. B., Jin, P., Brown, V., Warren, S. T., & Darnell, R. B. (2001) · Cell · doi:10.1016/s0092-8674(01)00566-9 · Cited by 952 · see citing works
RNAi-mediated pathways in the nucleus
Matzke, M. A., & Birchler, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1500 · Cited by 840 · see citing works
Campbell, D. S., & Holt, C. E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00551-7 · Cited by 797 · see citing works
Stress granules: sites of mRNA triage that regulate mRNA stability and translatability
Kedersha, N., & Anderson, P. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300963 · Cited by 735 · see citing works
Zalfa, F., Giorgi, M., Primerano, B., Moro, A., Di Penta, A., Reis, S., Oostra, B., & Bagni, C. (2003) · Cell · doi:10.1016/s0092-8674(03)00079-5 · Cited by 676 · see citing works
Self-citationWeiler, I. J., Irwin, S. A., Klintsova, A. Y., Spencer, C. M., Brazelton, A. D., Miyashiro, K., Comery, T. A., Patel, B., Eberwine, J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5395 · Cited by 644 · cited 1× · see citing works
“FMR1 is one such cargo mRNA, and is translated at synapses in response to the activation of group I metabotropic glutamate receptors (mGluR1s”
BackgroundZhang, Y., Bailey, A. M., Matthies, H. J. G., Renden, R., Smith, M. A., Speese, S. D., Rubin, G. M., & Broadie, K. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00589-x · Cited by 641 · see citing works
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
Siomi, H., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1993) · Cell · doi:10.1016/0092-8674(93)90420-u · Cited by 641 · see citing works
A point mutation in the FMR-1 gene associated with fragile X mental retardation
Boulle, K. D., Verkerk, A. J. M. H., Reyniers, E., Vits, L., Hendrickx, J., Roy, B. V., Bos, F. V. D., de Graaff, E., Oostra, B. A., & Willems, P. J. (1993) · Nature Genetics · doi:10.1038/ng0193-31 · Cited by 624 · see citing works
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
Kiledjian, M., & Dreyfuss, G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05331.x · Cited by 619 · see citing works
Jin, P., Zarnescu, D. C., Ceman, S., Nakamoto, M., Mowrey, J., Jongens, T. A., Nelson, D. L., Moses, K., & Warren, S. T. (2004) · Nature Neuroscience · doi:10.1038/nn1174 · Cited by 604 · see citing works
Nonsense-mediated decay approaches the clinic
Holbrook, J. A., Neu‐Yilik, G., Hentze, M. W., & Kulozik, A. E. (2004) · Nature Genetics · doi:10.1038/ng1403 · Cited by 597 · see citing works
Evidence that fragile X mental retardation protein is a negative regulator of translation
Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571 · see citing works
Characterization of a β-Actin mRNA Zipcode-Binding Protein
Ross, A. F., Oleynikov, Y., Kislauskis, E., Taneja, K. L., & Singer, R. H. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2158 · Cited by 563 · see citing works
Abnormal Development of Dendritic Spines in<i>FMR1</i>Knock-Out Mice
Nimchinsky, E. A., Oberlander, A. M., & Svoboda, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05139.2001 · Cited by 560 · see citing works
Internalization of ionotropic glutamate receptors in response to mGluR activation
Snyder, E. M., Philpot, B. D., Huber, K. M., Dong, X., Fallon, J. R., & Bear, M. F. (2001) · Nature Neuroscience · doi:10.1038/nn746 · Cited by 539 · see citing works
Krichevsky, A. M., & Kosik, K. S. (2001) · Neuron · doi:10.1016/s0896-6273(01)00508-6 · Cited by 536 · see citing works
Feng, Y., Gutekunst, C.-A., Eberhart, D. E., Yi, H., Warren, S. T., & Hersch, S. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01539.1997 · Cited by 532 · see citing works
Analysis of neocortex in three males with the Fragile X syndrome
Hinton, V. J., Brown, W. T., Wisniewski, K., & Rudelli, R. D. (1991) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320410306 · Cited by 527 · see citing works
Chang, F., & Greenough, W. T. (1984) · Brain Research · doi:10.1016/0006-8993(84)91008-4 · Cited by 523 · see citing works
Self-citationDendritic Spine "Dysgenesis" and Mental Retardation
Purpura, D. P. (1974) · Science · doi:10.1126/science.186.4169.1126 · Cited by 522 · see citing works
Rearing complexity affects branching of dendrites in the visual cortex of the rat
Volkmar, F. R., & Greenough, W. T. (1972) · Science · doi:10.1126/science.176.4042.1445 · Cited by 513 · see citing works
Self-citationKislauskis, E., Zhu, X., & Singer, R. H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.2.441 · Cited by 511 · see citing works
Feng, Y., Absher, D., Eberhart, D. E., Brown, V., Malter, H. E., & Warren, S. T. (1997) · Molecular Cell · doi:10.1016/s1097-2765(00)80012-x · Cited by 511 · see citing works
Fragile X-related protein and VIG associate with the RNA interference machinery
Caudy, A. A., Myers, M., Hannon, G. J., & Hammond, S. M. (2002) · Genes & Development · doi:10.1101/gad.1025202 · Cited by 499 · see citing works
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
Miyashiro, K. Y., Beckel-Mitchener, A., Purk, T. P., Becker, K. G., Barret, T., Liu, L., Carbonetto, S., Weiler, I. J., Greenough, W. T., & Eberwine, J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00034-5 · Cited by 495 · see citing works
Self-citationA <i>Drosophila</i> fragile X protein interacts with components of RNAi and ribosomal proteins
Ishizuka, A., Siomi, M. C., & Siomi, H. (2002) · Genes & Development · doi:10.1101/gad.1022002 · Cited by 486 · see citing works
The Tudor domain ‘Royal Family’: Tudor, plant Agenet, Chromo, PWWP and MBT domains
Maurer‐Stroh, S., Dickens, N. J., Hughes‐Davies, L., Kouzarides, T., Eisenhaber, F., & Ponting, C. P. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00004-5 · Cited by 482 · see citing works
The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Schaeffer, C., Bardoni, B., Mandel, J., Ehresmann, B., Ehresmann, C., & Moine, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4803 · Cited by 471 · see citing works
Ostroff, L. E., Fiala, J. C., Allwardt, B., & Harris, K. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00785-7 · Cited by 461 · see citing works
Turner, A. M., & Greenough, W. T. (1985) · Brain Research · doi:10.1016/0006-8993(85)90525-6 · Cited by 459 · see citing works
Self-citationThe fragile X mental retardation protein inhibits translation via interacting with mRNA
Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448 · see citing works
Siomi, H., Choi, M., Siomi, M. C., Nussbaum, R. L., & Dreyfuss, G. (1994) · Cell · doi:10.1016/0092-8674(94)90232-1 · Cited by 446 · see citing works
Benaroya‐Milshtein, N., Hollander, N., Apter, A., Kukulansky, T., Raz, N., Wilf, A., Yaniv, I., & Pick, C. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03587.x · Cited by 439 · see citing works
Bao, N., Lye, K.-W., & Barton, M. K. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.10.003 · Cited by 401 · see citing works
Eberhart, D. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.8.1083 · Cited by 390 · see citing works
Compartmentalized Synthesis and Degradation of Proteins in Neurons
Steward, O., & Schuman, E. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00635-4 · Cited by 377 · see citing works
Differential rearing effects on rat visual cortex synapses.
Sirevaag, A. M., & Greenough, W. T. (1987) · Brain Research · doi:10.1016/0006-8993(87)91477-6 · Cited by 370 · see citing works
Self-citationAn eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay
Palacios, I. M., Gatfield, D., Johnston, D. S., & Izaurralde, E. (2004) · Nature · doi:10.1038/nature02351 · Cited by 362 · see citing works
Adult fragile X syndrome: Clinico-neuropathologic findings
Rudelli, R. D., Brown, W. T., Wisniewski, K., Jenkins, E. C., Laure-Kamionowska, M., Connell, F., & Wisniewski, H. M. (1985) · Acta Neuropathologica · doi:10.1007/bf00687814 · Cited by 362 · see citing works
Antar, L. N., Afroz, R., Dictenberg, J. B., Carroll, R. C., & Bassell, G. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-04.2004 · Cited by 360 · see citing works
Heterogeneous Nuclear Ribonucleoprotein K Is a Transcription Factor
Michelotti, E. F., Michelotti, G. A., Aronsohn, A. I., et al. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2350 · Cited by 357 · see citing works
Schenck, A., Bardoni, B., Moro, A., Bagni, C., & Mandel, J.-L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151231598 · Cited by 356 · see citing works
Self-citationCharacterization and localization of the FMR-1 gene product associated with fragile X syndrome
Verheij, C., Bakker, C. E., de Graaff, E., Keulemans, J., Willemsen, R., Verkerk, A. J. M. H., Galjaard, H., Reuser, A. J. J., Hoogeveen, A. T., & Oostra, B. A. (1993) · Nature · doi:10.1038/363722a0 · Cited by 343 · see citing works
The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Zhang, Y., O'Connor, J. P., Siomi, M. C., Srinivasan, S., Dutra, A., Nussbaum, R. L., & Dreyfuss, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00220.x · Cited by 327 · see citing works
Phosphorylation influences the translation state of FMRP-associated polyribosomes
Ceman, S., O'Donnell, W. T., Reed, M., Patton, S., Pohl, J., & Warren, S. T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg350 · Cited by 327 · see citing works
DUNCAN, R. C., Bazar, L. S., Michelotti, G. A., Tomonaga, T., Krutzsch, H. C., Avigan, M., & Levens, D. (1994) · Genes & Development · doi:10.1101/gad.8.4.465 · Cited by 326 · see citing works
Transport and Localization Elements in Myelin Basic Protein mRNA
Ainger, K. J., Avossa, D., Diana, A. S., Barry, C. T., Barbarese, E., & Carson, J. H. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.1077 · Cited by 323 · see citing works
Sequence-Specific RNA Binding by a Nova KH Domain
Lewis, H. A., Musunuru, K., Jensen, K. B., Edo, C., Chen, H., Darnell, R. B., & Burley, S. K. (2000) · Cell · doi:10.1016/s0092-8674(00)80668-6 · Cited by 319 · see citing works
Synaptic regulation of protein synthesis and the fragile X protein
Greenough, W. T., Klintsova, A. Y., Irwin, S. A., Galvez, R., Bates, K. E., & Weiler, I. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141145998 · Cited by 317 · see citing works
Self-citationSchenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316 · see citing works
Tiruchinapalli, D. M., Oleynikov, Y., Kelič, S., Shenoy, S. M., Hartley, A., Stanton, P. K., Singer, R. H., & Bassell, G. J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03251.2003 · Cited by 310 · see citing works
Köhrmann, M., Luo, M., Kaether, C., DesGroseillers, L., Dotti, C. G., & Kiebler, M. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.9.2945 · Cited by 306 · see citing works
Schrijver, N. C. A., Bahr, N. I., Weiss, I. C., & Würbel, H. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00790-6 · Cited by 294 · see citing works
Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study
Marin-Padilla, M. (1972) · Brain Research · doi:10.1016/0006-8993(72)90324-1 · Cited by 290 · see citing works
Localization of Xenopus Vg1 mRNA by Vera Protein and the Endoplasmic Reticulum
Deshler, J. O., Highett, M. I., & Schnapp, B. J. (1997) · Science · doi:10.1126/science.276.5315.1128 · Cited by 288 · see citing works
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
Stefani, G., Fraser, C. E., Darnell, J. C., & Darnell, R. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2306-04.2004 · Cited by 274 · see citing works
Siomi, M. C., Zhang, Y., Siomi, H., & Dreyfuss, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3825 · Cited by 271 · see citing works
Ashley, C. T., Sutcliffe, J. S., Kunst, C. B., Leiner, H. A., Eichler, E. E., Nelson, D. L., & Warren, S. T. (1993) · Nature Genetics · doi:10.1038/ng0793-244 · Cited by 269 · see citing works
Li, J., Pelletier, M. R., Perez-Velazquez, J. L., & Carlen, P. L. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1085 · Cited by 268 · see citing works
Sandri-Goldin, R. M. (1998) · Genes & Development · doi:10.1101/gad.12.6.868 · Cited by 265 · see citing works
The fragile X mental retardation protein is associated with ribosomes
Khandjian, E. W., Corbin, F., Woerly, S., & Rousseau, F. (1996) · Nature Genetics · doi:10.1038/ng0196-91 · Cited by 251 · see citing works
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
Kobayashi, K., Kuroda, S., Fukata, M., Nakamura, T., Nagase, T., Nomura, N., Matsuura, Y., Yoshida-Kubomura, N., Iwamatsu, A., & Kaibuchi, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.291 · Cited by 244 · see citing works
FXR1, an autosomal homolog of the fragile X mental retardation gene.
Siomi, M. C., Siomi, H., Sauer, W. H., Srinivasan, S., Nussbaum, R. L., & Dreyfuss, G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07237.x · Cited by 237 · see citing works
Galvez, R., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30709 · Cited by 231 · see citing works
Self-citationFragile X‐associated Tremor/Ataxia Syndrome (FXTAS)
Hagerman, P. J., & Hagerman, R. J. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20005 · Cited by 219 · see citing works
Ohashi, S., Koike, K., Omori, A., Ichinose, S., Ohara, S., Kobayashi, S., Sato, T., & Anzai, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203608200 · Cited by 214 · see citing works
Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407533101 · Cited by 210 · see citing works
Self-citationGibson, T. J., Thompson, J., & Heringa, J. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80152-k · Cited by 201 · see citing works
Sittler, A., Devys, D., Weber, C., & Mandel, J.-L. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.1.95 · Cited by 198 · see citing works
Stickeler, E., Fraser, S. D., Honig, A., Chen, A. L., Berget, S. M., & Cooper, T. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3821 · Cited by 196 · see citing works
Greenough, W. T., Hwang, H.-M., & Gorman, C. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4549 · Cited by 195 · see citing works
Self-citationVanderklish, P. W., & Edelman, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032681099 · Cited by 194 · see citing works
Brown, V., Small, K. M., Lakkis, L., Feng, Y., Gunter, C., Wilkinson, K. D., & Warren, S. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.25.15521 · Cited by 192 · see citing works
Nakamura, M., Masuda, H., Horii, J., Kuma, K., Yokoyama, N., Ohba, T., Nishitani, H., Miyata, T., Tanaka, M., & Nishimoto, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1041 · Cited by 191 · see citing works
Visualization of RNA–protein interactions in living cells: FMRP and IMP1 interact on mRNAs
Rackham, O., & Brown, C. M. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600341 · Cited by 189 · see citing works
Dendritic spine abnormalities in the occipital cortex of C57BL/6Fmr1 knockout mice
McKinney, B. C., Grossman, A. W., Elisseou, N. M., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30183 · Cited by 184 · see citing works
Self-citationCeman, S., Brown, V., & Warren, S. T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.7925 · Cited by 181 · see citing works
The RGG Domain in hnRNP A2 Affects Subcellular Localization
Nichols, R. C., Wang, X. W., Tang, J., et al. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4827 · Cited by 176 · see citing works
Lee, W. C., Xue, Z. X., & Mélèse, T. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.113.1.1 · Cited by 176 · see citing works
Translational attenuation mediated by an mRNA intron
Chapman, R. E., & Walter, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00373-3 · Cited by 175 · see citing works
Crystalline Fraction I Protein: Preparation in Large Yield
Chan, P. H., Sakano, K., Singh, S., & Wildman, S. G. (1972) · Science · doi:10.1126/science.176.4039.1145 · Cited by 169 · see citing works
Ling, S., Fahrner, P. S., Greenough, W. T., & Gelfand, V. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408114101 · Cited by 169 · see citing works
Self-citationThe neuroanatomy and neuroendocrinology of fragile X syndrome
Hessl, D., Rivera, S. M., & Reiss, A. L. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20004 · Cited by 165 · see citing works
Gu, W., Pan, F., Zhang, H., Bassell, G. J., & Singer, R. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200105133 · Cited by 163 · see citing works
Isolation and characterization of Staufen-containing ribonucleoprotein particles from rat brain
Mallardo, M., Deitinghoff, A., Müller, J. S., Goetze, B., Macchi, P., Peters, C., & Kiebler, M. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0334355100 · Cited by 163 · see citing works
Chen, L., Yun, S.-W., Seto, J., Liu, W., & Toth, M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00406-8 · Cited by 160 · see citing works
Villacé, P. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh552 · Cited by 150 · see citing works
FMRP Involvement in Formation of Synapses among Cultured Hippocampal Neurons
Braun, K. A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.1045 · Cited by 149 · see citing works
Aschrafi, A., Cunningham, B. A., Edelman, G. M., & Vanderklish, P. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409803102 · Cited by 148 · see citing works
Nekrasov, M., Ivshina, M. P., Chernov, K. G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209145200 · Cited by 143 · see citing works
Bardoni, B., Schenck, A., & Louis Mandel, J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.13.2557 · Cited by 136 · see citing works
Antic, D., & Keene, J. D. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.2.183 · Cited by 134 · see citing works
The function of dendritic spines: A review of theoretical issues
Coss, R. G., & Perkel, D. H. (1985) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(85)90170-0 · Cited by 134 · see citing works
Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo
Mientjes, E. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh150 · Cited by 132 · see citing works
A Molecular Mechanism for mRNA Trafficking in Neuronal Dendrites
Shan, J., Munro, T. P., Barbarese, E., Carson, J. H., & Smith, R. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08859.2003 · Cited by 130 · see citing works
Bardoni, B., & Mandel, J. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00300-3 · Cited by 129 · see citing works
Duchaîne, T. F., Hemraj, I., Furic, L., Deitinghoff, A., Kiebler, M. A., & DesGroseillers, L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.16.3285 · Cited by 128 · see citing works
Lapeyre, B., Mariottini, P., Mathieu, C., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.430 · Cited by 126 · see citing works
Ghisolfi, L., Kharrat, A., Joseph, G., et al. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17318.x · Cited by 125 · see citing works
G-quartet-dependent recognition between the FMRP RGG box and RNA
Ramos, A., Hollingworth, D., & Pastore, A. (2003) · RNA · doi:10.1261/rna.5960503 · Cited by 125 · see citing works
Two Genes Are Responsible for Griscelli Syndrome at the Same 15q21 Locus
Pastural, É., Ersoy, F., Yalman, N., Wulffraat, N. M., Grillo, E., Özkınay, F., Tezcan, İ., Gedikoğlu, G., Philippe, N., Fischer, A., et al. (2000) · Genomics · doi:10.1006/geno.1999.6081 · Cited by 120 · see citing works
Domain Structure of Human Nuclear DNA Helicase II (RNA Helicase A)
Zhang, S., & Große, F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11487 · Cited by 119 · see citing works
Galvez, R., Gopal, A. R., & Greenough, W. T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02363-1 · Cited by 118 · see citing works
Self-citationNovel isoforms of the fragile X related protein FXR1P are expressed during myogenesis
Khandjian, E. W. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.13.2121 · Cited by 114 · see citing works
Menon, R. P., Gibson, T. J., & Pastore, A. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.08.024 · Cited by 112 · see citing works
Tamanini, F., Bontekoe, C. J. M., Bakker, C. E., van Unen, L., Anar, B., Willemsen, R., Yoshida, M., GALJAARD, H., Oostra, B. A., & Hoogeveen, A. T. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.863 · Cited by 112 · see citing works
Greenough, W. T., & Chang, F. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90160-5 · Cited by 103 · see citing works
Self-citationAdinolfi, S., Bagni, C., Musco, G., Gibson, T. J., Mazzarella, L., & Pastore, A. (1999) · RNA · doi:10.1017/s1355838299990647 · Cited by 96 · see citing works
Self-citationAdinolfi, S., Ramos, A., Martin, S. R., Piaz, F. D., Pucci, P., Bardoni, B., Mandel, J., & Pastore, A. (2003) · Biochemistry · doi:10.1021/bi034909g · Cited by 92 · see citing works
Lee, E. H. Y., Hsu, W., Ma, Y., Lee, P. J., & Chao, C.-C. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03032.x · Cited by 90 · see citing works
The nuclear connection in RNA transport and localization
Farina, K. L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02357-7 · Cited by 90 · see citing works
Greene, J. R. T., & Totterdell, S. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970414)380:3 · Cited by 88 · see citing works
Irwin, S. A., Swain, R. A., Christmon, C. A., Chakravarti, A. B., Weiler, I. J., & Greenough, W. T. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3914 · Cited by 84 · see citing works
Self-citationNew insights into the formation of active nonsense-mediated decay complexes
Singh, G., & Lykke‐Andersen, J. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00176-2 · Cited by 82 · see citing works
Identification of Mouse YB1/p50 as a Component of the FMRP-Associated mRNP Particle
Ceman, S., Nelson, R., & Warren, S. T. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4035 · Cited by 81 · see citing works
Bardoni, B. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg181 · Cited by 79 · see citing works
Rozhdestvensky, T. S., Kopylov, A. M., Brosius, J., & Hüttenhofer, A. (2001) · RNA · doi:10.1017/s1355838201002485 · Cited by 79 · see citing works
Fragile X syndrome: Associated neurological abnormalities and developmental disabilities
Wisniewski, K. E., French, J. H., Fernando, S., Brown, W. T., Jenkins, E. C., Friedman, E., Hill, A. L., & Miezejeski, C. M. (1985) · Annals of Neurology · doi:10.1002/ana.410180607 · Cited by 74 · see citing works
The fragile X mental retardation protein has nucleic acid chaperone properties
Gabus, C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh535 · Cited by 74 · see citing works
Characterization of Staufen 1 ribonucleoprotein complexes
Brendel, C., Rehbein, M., Kreienkamp, H., Buck, F., Richter, D., & Kindler, S. (2004) · Biochemical Journal · doi:10.1042/bj20040812 · Cited by 73 · see citing works
An RNA-Guided Pathway for the Epigenome
Jenuwein, T. (2002) · Science · doi:10.1126/science.1077903 · Cited by 71 · see citing works
Nucleolin Associates with a Subset of the Human Ro Ribonucleoprotein Complexes
Fouraux, M. A., Bouvet, P., Verkaart, S., et al. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00518-1 · Cited by 68 · see citing works
Bardoni, B. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00222-2 · Cited by 66 · see citing works
Novel RNA-binding motif: The KH module
Adinolfi, S., Bagni, C., Morelli, M. A. C., Fraternali, F., Musco, G., & Pastore, A. (1999) · Biopolymers · doi:10.1002/(sici)1097-0282(1999)51:2 · Cited by 65 · see citing works
Self-citationTodd, P. K., & Mack, K. J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00098-x · Cited by 63 · see citing works
Steward, O., Bakker, C. E., Willems, P. J., & Oostra, B. A. (1998) · Neuroreport · doi:10.1097/00001756-199802160-00022 · Cited by 59 · see citing works
Expression of FMR1, FXR1, and FXR2 Genes in Human Prenatal Tissues
Agulhon, C., Blanchet, P., Kobetz, A., Marchant, D., Biguet, N. F., Sarda, P., Moraine, C., Sittler, A., Biancalana, V., Malafosse, A., et al. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199908000-00009 · Cited by 58 · see citing works
Cardiac abnormalities in the fragile X syndrome.
Sreeram, N., Wren, C., BHATE, M. S., Robertson, P., & Hunter, S. (1989) · Heart · doi:10.1136/hrt.61.3.289 · Cited by 56 · see citing works
Ohashi, S., Kobayashi, S., Omori, A., Ohara, S., Omae, A., Muramatsu, T., Li, Y., & Anzai, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751781.x · Cited by 56 · see citing works
Bagni, C., & Lapeyre, B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10868 · Cited by 54 · see citing works
Self-citationmRNA localisation gets more complex
Bor, V. V. D., & Davis, I. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.03.008 · Cited by 50 · see citing works
Hoelz, A., & Blobel, G. (2004) · Nature · doi:10.1038/432815a · Cited by 48 · see citing works
Schrier, M., Severijnen, L., Reis, S. A., Rife, M. F., VANTPADJE, S., VANCAPPELLEN, G., Oostra, B. A., & Willemsen, R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.039 · Cited by 34 · see citing works
Greenbaum, L., Katcoff, D. J., Dou, H., Gozlan, Y., & Malik, Z. (2003) · Oncogene · doi:10.1038/sj.onc.1206723 · Cited by 30 · see citing works
Greenough, W. T., Yuwiler, A., & Dollinger, M. J. (1973) · Behavioral Biology · doi:10.1016/s0091-6773(73)80025-2 · Cited by 24 · see citing works
Self-citationPlasticity of the Aging Cerebral Cortex
Diamond, M. C., & Connor, J. R. (1982) · Experimental brain research. Supplementum · doi:10.1007/978-3-642-68507-1_6 · Cited by 19 · see citing works
Yanmei, L. I., Koike, K., Ohashi, S., Funakoshi, T., TADANO, M., Kobayashi, S., Anzai, K., Shibata, N., & Kobayashi, M. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.231 · Cited by 19 · see citing works
Long‐term potentiation in the hippocampus of fragile X knockout mice
Godfraind, J., Reyniers, E., Boulle, K. D., D’Hooge, R., Deyn, P. P. D., Bakker, C. E., Oostra, B. A., Kooy, R. F., & Willems, P. J. (1996) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19960809)64:2 · Cited by 16 · see citing works
Fragile X syndrome phenotype with normal FMR1 gene studies
Clarke, N. F., Mowat, D. R., Kooy, R. F., et al. (2004) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30194 · Cited by 2 · see citing works
Irwin (2001) · doi:10.1002/1096-8628(20010115)98:2
Huttenlocher (1997) · doi:10.1002/(sici)1096-9861(19971020)387:2
Flagged first, then by citations
Cited by
Sorted by citations
Dendritic spine pathology in neuropsychiatric disorders
Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J.-E., & Woolfrey, K. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2741 · Cited by 1,523 · see citing works
Normal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391 · see citing works
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works
Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838 · see citing works
Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C.-F., Seeburg, D. P., Batterton, M. N., Tada, T., Dolan, B. M., Sharp, P. A., & Sheng, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.005 · Cited by 735 · see citing works
Branching out: mechanisms of dendritic arborization
Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693 · see citing works
The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609 · see citing works
Self-citationThe Autistic Neuron: Troubled Translation?
Kelleher, R. J., & Bear, M. F. (2008) · Cell · doi:10.1016/j.cell.2008.10.017 · Cited by 598 · see citing works
Searching for ways out of the autism maze: genetic, epigenetic and environmental clues
Persico, A. M., & Bourgeron, T. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.010 · Cited by 575 · see citing works
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516 · see citing works
“Fragile X syndrome results from transcriptional silencing of the FMR1 gene, which encodes for the transcription regulator FMRP; loss of FMRP causes an upregulation in global dendritic translation rates that may contribute to the elevated spine density observed in the brains of affected individuals [217].”
BackgroundMuddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421 · see citing works
Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S. T., & Bassell, G. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.006 · Cited by 364 · see citing works
Tsai, N.-P., Wilkerson, J. R., Guo, W., Maksimova, M. A., DeMartino, G. N., Cowan, C. W., & Huber, K. M. (2012) · Cell · doi:10.1016/j.cell.2012.11.040 · Cited by 316 · see citing works
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
Bagni, C., Tassone, F., Neri, G., & Hagerman, R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63141 · Cited by 321 · see citing works
Self-citationDelayed Stabilization of Dendritic Spines in Fragile X Mice
Cruz-Martin, A., Crespo, M., & Portera-Cailliau, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0577-10.2010 · Cited by 321 · see citing works
FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Westmark, C. J., & Malter, J. S. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050052 · Cited by 292 · see citing works
“other proteins have all been proposed [9,12,37,38].”
BackgroundNishimura, Y., Martin, C. L., Vazquez-Lopez, A., Spence, S. J., Alvarez-Retuerto, A. I., Sigman, M., Steindler, C., Pellegrini, S., Schanen, N. C., Warren, S. T., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm116 · Cited by 276 · see citing works
Open-Label Treatment Trial of Lithium to Target the Underlying Defect in Fragile X Syndrome
Berry-Kravis, E., Sumis, A., Hervey, C., Nelson, M., Porges, S. W., Weng, N., Weiler, I. J., & Greenough, W. T. (2008) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e31817dc447 · Cited by 215 · see citing works
Self-citationPan, F., Aldridge, G. M., Greenough, W. T., & Gan, W.-B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012496107 · Cited by 208 · see citing works
Self-citationAltered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., & Tassone, F. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00768.x · Cited by 198 · see citing works
Deidda, G., Bozarth, I. F., & Cancedda, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00119 · Cited by 192 · see citing works
FMRP Acts as a Key Messenger for Dopamine Modulation in the Forebrain
Wang, H., Wu, L.-J., Kim, S. S., Lee, F. J. S., Gong, B., Toyoda, H., Ren, M., Shang, Y.-Z., Xu, H., Liu, F., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.027 · Cited by 186 · see citing works
Meredith, R. M., Holmgren, C. D., Weidum, M., Burnashev, N., & Mansvelder, H. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.028 · Cited by 190 · see citing works
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism
Huber, K. M., Klann, E., Costa-Mattioli, M., & Zukin, R. S. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2656-15.2015 · Cited by 167 · see citing works
Altered differentiation of neural stem cells in fragile X syndrome
Castrén, M., Tervonen, T., Kärkkäinen, V., Heinonen, S., Castrén, E., Larsson, K., Bakker, C. E., Oostra, B. A., & Åkerman, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508995102 · Cited by 176 · see citing works
Abnormal Striatal GABA Transmission in the Mouse Model for the Fragile X Syndrome
Centonze, D., Rossi, S., Mercaldo, V., Napoli, I., Ciotti, M. T., De Chiara, V., Musella, A., Prosperetti, C., Calabresi, P., Bernardi, G., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.09.008 · Cited by 171 · see citing works
Self-citationMcLennan, Y., Polussa, J., Tassone, F., & Hagerman, R. (2011) · Current Genomics · doi:10.2174/138920211795677886 · Cited by 160 · see citing works
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex
Kwan, K. Y., Lam, M. M. S., Johnson, M. B., Dube, U., Shim, S., Rašin, M.-R., Sousa, A. M. M., Fertuzinhos, S., Chen, J.-G., Arellano, J. I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.060 · Cited by 137 · see citing works
Pacey, L. K. K., Heximer, S. P., & Hampson, D. R. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.056127 · Cited by 133 · see citing works
Larson, J., Jessen, R. E., Kim, D., Fine, A.-K. S., & du Hoffmann, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2638-05.2005 · Cited by 135 · see citing works
De Rubeis, S., & Bagni, C. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.09.013 · Cited by 126 · see citing works
Self-citationReversal of Fragile X Phenotypes by Manipulation of AβPP/Aβ Levels in Fmr1KO Mice
Westmark, C. J., Westmark, P. R., O'Riordan, K. J., Ray, B. C., Hervey, C. M., Salamat, M. S., Abozeid, S. H., Stein, K. M., Stodola, L. A., Tranfaglia, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026549 · Cited by 110 · see citing works
El Bekay, R., Romero‐Zerbo, Y., Decara, J., Sanchez‐Salido, L., Del Arco‐Herrera, I., Rodríguez‐de Fonseca, F., & De Diego‐Otero, Y. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05939.x · Cited by 85 · see citing works
Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.
Tervonen, T. A., Louhivuori, V., Sun, X., Hokkanen, M.-E., Kratochwil, C. F., Zebryk, P., Castrén, E., & Castrén, M. L. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.010 · Cited by 82 · see citing works
Shang, Y., Wang, H., Mercaldo, V., Li, X., Chen, T., & Zhuo, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06314.x · Cited by 72 · see citing works
Musumeci, S. A., Calabrese, G., Bonaccorso, C. M., D'Antoni, S., Brouwer, J. R., Bakker, C. E., Elia, M., Ferri, R., Nelson, D. L., Oostra, B. A., et al. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.08.007 · Cited by 70 · see citing works
Garcia-Pino, E., Gessele, N., & Koch, U. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2310-16.2017 · Cited by 58 · see citing works
Wang, H., Kim, S. S., & Zhuo, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.116293 · Cited by 52 · see citing works
De Rubeis, S., Fernández, E., Buzzi, A., Di Marino, D., & Bagni, C. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_23 · Cited by 48 · see citing works
Self-citationHeads‐up: New roles for the fragile X mental retardation protein in neural stem and progenitor cells
Callan, M. A., & Zarnescu, D. C. (2011) · genesis · doi:10.1002/dvg.20745 · Cited by 39 · see citing works
Zang, T., Maksimova, M. A., Cowan, C. W., Bassel-Duby, R., Olson, E. N., & Huber, K. M. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.03.002 · Cited by 31 · see citing works
de Bartolomeis, A., Iasevoli, F., Tomasetti, C., & Buonaguro, E. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-014-8962-8 · Cited by 21 · see citing works
Reynolds, K. E., Huang, E., Sabbineni, M., Wiseman, E., Murtaza, N., Ahuja, D., Napier, M., Murphy, K. M., Singh, K. K., & Scott, A. L. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04181-w · Cited by 6 · see citing works
- Authors
- Bagni, C., & Greenough, W. T.
- Affiliations
- University of Rome Tor Vergata (IT)
- University of Illinois Urbana-Champaign (US)
- Corresponding author
- Bagni, Claudia
- ORCID
- Bagni, Claudia
- Venue
- Nature Reviews Neuroscience
- Published
- 2005-05
- Volume
- 6
- Issue
- 5
- Pages
- 376-387
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2000434144
- Cited by
- 475
- References
- 154
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 11 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 21 · 2019: 12 · 2018: 19 · 2017: 14 · 2016: 19 · 2015: 27 · 2014: 32 · 2013: 33 · 2012: 31
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Funders
- Ministero della Salute
- National Institute of Mental Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- fragile X syndrome, FMRP, mRNA transport, local protein synthesis, synapses, learning and memory impairment, translational regulation
- MeSH terms
- Animals, Fragile X Syndrome, Humans, Nerve Tissue Proteins, Ribonucleoproteins, Spinal Cord, RNA-Binding Proteins, Protein Transport, Fragile X Mental Retardation Protein, Fragile X Messenger Ribonucleoprotein 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review