Cited by 326Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and ApplicationsSchizophrenia research and treatment

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A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder

Guastella, Adam J., Richardson, Rick, Lovibond, Peter F., Rapee, Ronald M., Gaston, Jonathan E., Mitchell, Philip, Dadds, Mark R.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2007.11.011

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Abstract

Background Pilot research has suggested that D-cycloserine (DCS) enhances treatment outcomes for anxiety disorders when employed as an adjunct to exposure therapy (ET). The aim of this study was to determine whether 50 mg of DCS enhances ET for social anxiety disorder (SAD) according to a comprehensive set of symptom and life impairment measures.Methods In a randomized double-blind placebo-controlled trial, we administered 50 mg of DCS or placebo in combination with ET to 56 participants who met primary diagnosis for SAD.Results Participants administered DCS reported greater improvement on measures of symptom severity, dysfunctional cognitions, and life-impairment from SAD in comparison with placebo-treated participants. Effect sizes were mostly in the medium range. Results also indicated that the amount of adaptive learning about one's ability to give speeches in front of an audience interacted with DCS to enhance treatment outcome.Conclusions This study shows that the administration of DCS before ET enhances treatment outcomes for SAD. Results also provide the first preliminary evidence to suggest that DCS moderates the relationship between a reduction in negative appraisals about one's speech performance and improvement in overall SAD symptoms.

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Authors: Guastella, A. J., Richardson, R., Lovibond, P. F., Rapee, R. M., Gaston, J. E., Mitchell, P., & Dadds, M. R.
Affiliations: UNSW Sydney (AU)
Macquarie University (AU)
Corresponding author: Guastella, Adam J.
ORCID: Guastella, Adam J.
Richardson, Rick
Lovibond, Peter F.
Rapee, Ronald M.
Gaston, Jonathan E.
Mitchell, Philip
Dadds, Mark R.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-03
Volume: 63
Issue: 6
Pages: 544-549
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2007.11.011
OpenAlex: W2028445187
Semantic Scholar: e41984c470918166ac39c6aec20bd21dfc842860
Cited by: 326
References: 30
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 9 · 2018: 13 · 2017: 23 · 2016: 12 · 2015: 15 · 2014: 41 · 2013: 32 · 2012: 31
FWCI: 53.98
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council (350963)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: D-cycloserine, social anxiety disorder, exposure therapy, adjunctive pharmacotherapy, treatment enhancement, speech performance, dysfunctional cognitions, negative appraisals
MeSH terms: Adolescent, Adult, Combined Modality Therapy, Cycloserine, Desensitization, Psychologic, Double-Blind Method, Fear, Female, Humans, Male, Middle Aged, New South Wales, Phobic Disorders, Premedication, Speech

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A Randomized Controlled Trial of D-Cycloserine Enhancement of Exposure Therapy for Social Anxiety Disorder

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