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The Role of the Cerebellum in Schizophrenia
Open accessAbstract
For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.
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“Noninvasive stimulation of the cerebellum with transcranial magnetic stimulation (TMS), specifically posterior cerebellum-targeted intermittent theta burst stimulation (CBM-iTBS), has demonstrated benefits for psychiatric conditions, such as schizophrenia, which manifest potentially cerebellum-mediated symptoms including mood dysregulation and cognitive dysmetria (Andreasen, 1999; Andreasen et al.”
From A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects (2025) · cites this paper as Andreasen & Pierson, 2008
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Metadata
- Authors
- Andreasen, N. C., & Pierson, R.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Andreasen, Nancy C.
- ORCID
- Andreasen, Nancy C.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 64
- Issue
- 2
- Pages
- 81-88
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3175494
- OpenAlex
- W2079590167
- Cited by
- 669
- References
- 250
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 52 · 2023: 35 · 2022: 46 · 2021: 60 · 2020: 31 · 2019: 47 · 2018: 50 · 2017: 41 · 2016: 27 · 2015: 36 · 2014: 36 · 2013: 26 · 2012: 25
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH060990, R01MH040856, 5 R01 MH 04856-20)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- cerebellum, schizophrenia, cerebellar function, higher cortical functions, cerebellar abnormalities, motor coordination
- MeSH terms
- Brain Mapping, Cerebellum, Cerebral Cortex, Cognition Disorders, Higher Nervous Activity, Humans, Nerve Net, Neuropsychological Tests, Olivary Nucleus, Pons, Psychiatric Status Rating Scales, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Thalamus, Long-Term Potentiation, Positron-Emission Tomography
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