Functional boundaries in the human cerebellum revealed by a multi-domain task battery
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Abstract
There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cognitive tasks. A fundamental question centers on whether the cerebellum is organized into distinct functional subregions. To address this question, we employed a rich task battery designed to tap into a broad range of cognitive processes. During four functional MRI sessions, participants performed a battery of 26 diverse tasks comprising 47 unique conditions. Using the data from this multi-domain task battery, we derived a comprehensive functional parcellation of the cerebellar cortex and evaluated it by predicting functional boundaries in a novel set of tasks. The new parcellation successfully identified distinct functional subregions, providing significant improvements over existing parcellations derived from task-free data. Lobular boundaries, commonly used to summarize functional data, did not coincide with functional subdivisions. The new parcellation provides a functional atlas to guide future neuroimaging studies.
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OCD symptoms are positively correlated with parietal cortex-cerebellar connectivity.
“OCD symptoms are also positively correlated with parietal cortex-cerebellar connectivity(36,37).”
From Functional disruption of cerebello-thalamo-cortical networks in obsessive-compulsive disorder (2020) · cites this paper as [36]
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- Authors
- King, M., Hernandez-Castillo, C. R., Poldrack, R. A., Ivry, R. B., & Diedrichsen, J.
- Affiliations
- Western University (CA)
- Stanford University (US)
- University of California, Berkeley (US)
- Corresponding author
- Diedrichsen, Jörn
- Venue
- Nature Neuroscience
- Published
- 2019-07-08
- Volume
- 22
- Issue
- 8
- Pages
- 1371-1378
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC8312478
- OpenAlex
- W2955632554
- Cited by
- 673
- References
- 40
- Citations by year
- 2026: 98 · 2025: 115 · 2024: 114 · 2023: 86 · 2022: 108 · 2021: 75 · 2020: 60 · 2019: 17
- FWCI
- 37.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Neuroscience (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- National Institutes of Health (5u54mh091657-05)
- National Institute of Mental Health (U54-MH091657)
- National Institute of Neurological Disorders and Stroke (R01NS105839, R01NS092079)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- human cerebellum, functional parcellation, cerebellar cortex
- MeSH terms
- Atlases as Topic, Brain Mapping, Cerebellar Cortex, Cerebellum, Eye Movements, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Movement, Psychomotor Performance, Young Adult, Neuroimaging
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