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Cited by 1,024Deep Brain Stimulation and Movement DisordersObsessive-Compulsive Spectrum DisordersTreatment of Major Depression

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

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Lozano, Andres M., Mayberg, Helen S., Giacobbe, Peter, Hamani, Clement, Craddock, R. Cameron, Kennedy, Sydney H.·2008·Biological Psychiatry
DOI 10.1016/j.biopsych.2008.05.034
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Abstract

Background A preliminary report in six patients suggested that deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) may provide benefit in treatment-resistant depression (TRD). We now report the results of these and an additional 14 patients with extended follow-up.Methods Twenty patients with TRD underwent serial assessments before and after SCG DBS. We determined the percentage of patients who achieved a response (50% or greater reduction in the 17-item Hamilton Rating Scale for Depression [HRSD-17]) or remission (scores of 7 or less) after surgery. We also examined changes in brain metabolism associated with DBS, using positron emission tomography.Results There were both early and progressive benefits to DBS. One month after surgery, 35% of patients met criteria for response with 10% of patients in remission. Six months after surgery, 60% of patients were responders and 35% met criteria for remission, benefits that were largely maintained at 12 months. Deep brain stimulation therapy was associated with specific changes in the metabolic activity localized to cortical and limbic circuits implicated in the pathogenesis of depression. The number of serious adverse effects was small with no patient experiencing permanent deficits.Conclusions This study suggests that DBS is relatively safe and provides significant improvement in patients with TRD. Subcallosal cingulate gyrus DBS likely acts by modulating brain networks whose dysfunction leads to depression. The procedure is well tolerated and benefits are sustained for at least 1 year. A careful double-blind appraisal is required before the procedure can be recommended for use on a wider scale.

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  1. Rush, 2005, Vagus nerve stimulation for treatment-resistant depression: A randomized, controlled acute phase trial, Biol Psychiatry, 58, 347, 10.1016/j.biopsych.2005.05.025 · DOI · Paper page

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Metadata

Authors
Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C., Craddock, R. C., & Kennedy, S. H.
Affiliations
  • Emory University (US)
  • University of Toronto (CA)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2008-09
Volume
64
Issue
6
Pages
461-467
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2008.05.034
OpenAlex
W2132969335
Cited by
1,024
References
25
Citations by year
2026: 34 · 2025: 34 · 2024: 37 · 2023: 37 · 2022: 38 · 2021: 57 · 2020: 46 · 2019: 52 · 2018: 56 · 2017: 46 · 2016: 54 · 2015: 73 · 2014: 75 · 2013: 77 · 2012: 88
FWCI
45.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Alliance for Research on Schizophrenia and Depression
Topics
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords
deep brain stimulation, treatment-resistant depression, depression remission, brain metabolism, limbic circuits, adverse effects, long-term outcomes
MeSH terms
Cerebral Cortex, Corpus Callosum, Major Depressive Disorder, Drug Resistance, Female, Glucose, Gyrus Cinguli, Humans, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, Stereotaxic Techniques, Neurosurgical Procedures, Deep Brain Stimulation, Positron-Emission Tomography

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