Cited by 119Schizophrenia research and treatmentNeural and Behavioral Psychology StudiesCognitive Abilities and Testing

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence

Open access

Driesen, Naomi R., Leung, Hoi-Chung, Calhoun, Vincent D., Constable, R. Todd, Gueorguieva, Ralitza, Hoffman, Ralph, Skudlarski, Pawel, Goldman-Rakic, Patricia S., Krystal, John H.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.07.029PMC PMC2650279

Open this paper in CoChat — free account

Abstract

Background Comparing prefrontal cortical activity during particular phases of working memory in healthy subjects and individuals diagnosed with schizophrenia might help to define the phase-specific deficits in cortical function that contribute to cognitive impairments associated with schizophrenia. This study featured a spatial working memory task, similar to that used in nonhuman primates, that was designed to facilitate separating brain activation into encoding, maintenance, and response phases.Methods Fourteen patients with schizophrenia (4 medication-free) and 12 healthy comparison participants completed functional magnetic resonance imaging while performing a spatial working memory task with two levels of memory load.Results Task accuracy was similar in patients and healthy participants. However, patients showed reductions in brain activation during maintenance and response phases but not during the encoding phase. The reduced prefrontal activity during the maintenance phase of working memory was attributed to a greater rate of decay of prefrontal activity over time in patients. Cortical deficits in patients did not appear to be related to antipsychotic treatment. In patients and in healthy subjects, the time-dependent reduction in prefrontal activity during working memory maintenance correlated with poorer performance on the memory task.Conclusions Overall, these data highlight that basic research insights into the distinct neurobiologies of the maintenance and response phases of working memory are of potential importance for understanding the neurobiology of cognitive impairment in schizophrenia and advancing its treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.07.029

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Using multivariate statistics
Tabachnick, B. G., & Fidell, L. S. (1983) · Cited by 79,882
Working Memory
Baddeley, A. (1992) · Science · doi:10.1126/science.1736359 · Cited by 5,258
Movement‐Related effects in fMRI time‐series
Friston, K. J., Williams, S., Howard, R., Frackowiak, R. S. J., & Turner, R. (1996) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910350312 · Cited by 3,774
An Improved Diagnostic Evaluation Instrument for Substance Abuse Patients
McLellan, A. T., Luborsky, L. B., WOODY, G. E., & Brien, C. P. O. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198001000-00006 · Cited by 3,163
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Neuron Activity Related to Short-Term Memory
Fuster, J. M., & Alexander, G. E. (1971) · Science · doi:10.1126/science.173.3997.652 · Cited by 2,085
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
Scale for the Assessment of Negative Symptoms
Andreasen, N. C. (1982) · PsycTESTS Dataset · doi:10.1037/t12696-000 · Cited by 1,888
Applied Mixed Models in Medicine
Brown, H., & Presco, R. (2000) · Technometrics · doi:10.1080/00401706.2000.10485742 · Cited by 1,699
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593

Show all 55 references

Sorted by citations

Modelling neural correlates of working memory: A coordinate-based meta-analysis
Rottschy, C., Langner, R., Dogan, I., Reetz, K., Laird, A. R., Schulz, J. B., Fox, P. T., & Eickhoff, S. B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.050 · Cited by 951
Cognition in schizophrenia: core psychological and neural mechanisms
Barch, D. M., & Ceaser, A. E. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.015 · Cited by 792
Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex
Qin, S., Hermans, E. J., van Marle, H. J. F., Luo, J., & Fernández, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.006 · Cited by 675
Nonsocial and social cognition in schizophrenia: current evidence and future directions
Green, M. F., Horan, W. P., & Lee, J. (2019) · World Psychiatry · doi:10.1002/wps.20624 · Cited by 612
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489
NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
Anticevic, A., Gancsos, M., Murray, J. D., Repovs, G., Driesen, N. R., Ennis, D. J., Niciu, M. J., Morgan, P. T., Surti, T. S., Bloch, M. H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208494109 · Cited by 243
Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255
Dissociation, trauma, and the role of lived experience: Toward a new conceptualization of voice hearing.
Longden, E., Madill, A., & Waterman, M. G. (2012) · Psychological Bulletin · doi:10.1037/a0025995 · Cited by 248
Executive Function, Neural Circuitry, and Genetic Mechanisms in Schizophrenia
Eisenberg, D. P., & Berman, K. F. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.111 · Cited by 253
A comprehensive review of auditory verbal hallucinations: lifetime prevalence, correlates and mechanisms in healthy and clinical individuals
de Leede-Smith, S., & Barkus, E. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00367 · Cited by 222
Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
Krystal, J. H., Anticevic, A., Yang, G., Dragoi, G., Driesen, N. R., Wang, X., & Murray, J. D. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.004 · Cited by 201
Dysfunctional Prefrontal Gamma-Band Oscillations Reflect Working Memory and Other Cognitive Deficits in Schizophrenia
Senkowski, D., & Gallinat, J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.02.034 · Cited by 179
Cognitive impairments in psychotic disorders: common mechanisms and measurement
Barch, D. M., & Sheffield, J. M. (2014) · World Psychiatry · doi:10.1002/wps.20145 · Cited by 154
The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity
Driesen, N. R., McCarthy, G., Bhagwagar, Z., Bloch, M. H., Calhoun, V. D., D'Souza, D. C., Gueorguieva, R., He, G., Leung, H.-C., Ramani, R., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.170 · Cited by 148
Self-citation
New perspectives on catecholaminergic regulation of executive circuits: evidence for independent modulation of prefrontal functions by midbrain dopaminergic and noradrenergic neurons
Chandler, D. J., Waterhouse, B. D., & Gao, W. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00053 · Cited by 143
Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?
Keefe, R. S. E., Buchanan, R. W., Marder, S. R., Schooler, N. R., Dugar, A., Zivkov, M., & Stewart, M. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr153 · Cited by 138
Working memory impairment as an endophenotypic marker of a schizophrenia diathesis
Park, S., & Gooding, D. C. (2014) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2014.09.005 · Cited by 135
Working Memory Encoding and Maintenance Deficits in Schizophrenia: Neural Evidence for Activation and Deactivation Abnormalities
Anticevic, A., Repovš, G., & Barch, D. M. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr107 · Cited by 121
Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia
Karlsgodt, K. H., Sanz, J. H., van Erp, T. G. M., Bearden, C. E., Nuechterlein, K. H., & Cannon, T. D. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.12.025 · Cited by 103
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94
Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments
Sakurai, T., Gamo, N. J., Hikida, T., Kim, S.-H., Murai, T., Tomoda, T., & Sawa, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.010 · Cited by 102
Differential spatiotemporal characteristics of the prefrontal hemodynamic response and their association with functional impairment in schizophrenia and major depression
Kinou, M., Takizawa, R., Marumo, K., Kawasaki, S., Kawakubo, Y., Fukuda, M., & Kasai, K. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.08.026 · Cited by 85
Reduced serial dependence suggests deficits in synaptic potentiation in anti-NMDAR encephalitis and schizophrenia
Stein, H., Barbosa, J., Rosa-Justícia, M., Prades, L., Morató, A., Galan-Gadea, A., Ariño, H., Martínez‐Hernández, E., Castro‐Fornieles, J., Dalmau, J. O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18033-3 · Cited by 80
Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex
Nocjar, C., Alex, K. D., Sonneborn, A., Abbas, A. I., Roth, B. L., & Pehek, E. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.050 · Cited by 82
Molecular Influences on Working Memory Circuits in Dorsolateral Prefrontal Cortex
Arnsten, A. F. T., & Jin, L. E. (2014) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-420170-5.00008-8 · Cited by 77
Negative and Nonemotional Interference with Visual Working Memory in Schizophrenia
Anticevic, A., Repovs, G., Corlett, P. R., & Barch, D. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.010 · Cited by 75
Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
Pantelis, C., Wood, S. J., Proffitt, T., Testa, R., Mahony, K. E., Brewer, W. J., Buchanan, J., Velakoulis, D., & McGorry, P. D. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.039 · Cited by 75
Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis
Chao, H. H., Uchio, E., Zhang, S., Hu, S., Bednarski, S. R., Luo, X., Rose, M. G., Concato, J., & Li, C. R. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-371 · Cited by 80
Substance use in adolescence and psychosis: clarifying the relationship.
Barkus, E., & Murray, R. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131220 · Cited by 70
Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
Starc, M., Murray, J. D., Santamauro, N. P., Savić, A., Diehl, C., Cho, Y., Srihari, V. H., MORGAN, P. T., Krystal, J. H., Wang, X., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.10.011 · Cited by 70
A neural measure of behavioral engagement: Task-residual low-frequency blood oxygenation level-dependent activity in the precuneus
Zhang, S., & Li, C. R. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.004 · Cited by 67
A broken filter: Prefrontal functional connectivity abnormalities in schizophrenia during working memory interference
Anticevic, A., Repovš, G., Krystal, J. H., & Barch, D. M. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.07.007 · Cited by 69
Influence of Emotional Processing on Working Memory in Schizophrenia
Becerril, K. E., & Barch, D. M. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq009 · Cited by 67
Modulation of Hippocampus-Prefrontal Cortex Synaptic Transmission and Disruption of Executive Cognitive Functions by MK-801
Blot, K., Kimura, S.-I., Bai, J., Kemp, A., Manahan-Vaughan, D., Giros, B., Tzavara, E., & Otani, S. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht329 · Cited by 58
Disrupted functional connectivity for controlled visual processing as a basis for impaired spatial working memory in schizophrenia
Kang, S. S., Sponheim, S. R., Chafee, M. V., & MacDonald, A. W. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.06.009 · Cited by 63
Transcranial magnetic stimulation on the modulation of gamma oscillations in schizophrenia
Farzan, F., Barr, M. S., Sun, Y., Fitzgerald, P. B., & Daskalakis, Z. J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06543.x · Cited by 59
The When and Where of Working Memory Dysfunction in Early-Onset Schizophrenia—A Functional Magnetic Resonance Imaging Study
Bittner, R. A., Linden, D. E. J., Roebroeck, A. F., Härtling, F., Rotarska-Jagiela, A., Maurer, K., Goebel, R., Singer, W., & Haenschel, C. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu050 · Cited by 61
Metacognition in Schizophrenia: Processes Underlying Patients' Reflections on Their Own Episodic Memory
Bacon, É., & Izaute, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.013 · Cited by 57
Amelioration of ketamine-induced working memory deficits by dopamine D1 receptor agonists
Roberts, B. M., Seymour, P. A., Schmidt, C. J., Williams, G. V., & Castner, S. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1840-9 · Cited by 56
Visuospatial imagery and working memory in schizophrenia
Matthews, N. L., Collins, K., Thakkar, K. N., & Park, S. (2013) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2013.779577 · Cited by 55
Neural Correlates of Impaired Cognitive Control over Working Memory in Schizophrenia
Eich, T. S., Nee, D. E., Insel, C., Malapani, C., & Smith, E. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.032 · Cited by 47
The dynamics of disordered dialogue: Prefrontal, hippocampal and thalamic miscommunication underlying working memory deficits in schizophrenia
Kupferschmidt, D. A., & Gordon, J. A. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818771821 · Cited by 46
Prevention of ketamine-induced working memory impairments by AMPA potentiators in a nonhuman primate model of cognitive dysfunction
Roberts, B. M., Holden, D., Shaffer, C. L., Seymour, P. A., Menniti, F. S., Schmidt, C. J., Williams, G. V., & Castner, S. A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.03.039 · Cited by 43
Contribution of NMDA receptors to dorsolateral prefrontal cortical networks in primates
Wang, M., & Arnsten, A. F. T. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-014-1504-6 · Cited by 41
The Contribution of AMPA and NMDA Receptors to Persistent Firing in the Dorsolateral Prefrontal Cortex in Working Memory
van Vugt, B., van Kerkoerle, T., Vartak, D., & Roelfsema, P. R. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2121-19.2020 · Cited by 44
On the relationship of first-episode psychosis to the amphetamine-sensitized state: a dopamine D2/3 receptor agonist radioligand study
Weidenauer, A., Bauer, M., Sauerzopf, U., Bartova, L., Nics, L., Pfaff, S., Philippe, C., Berroterán-Infante, N., Pichler, V., Meyer, B., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-019-0681-5 · Cited by 38
Involvement of 5‐HT2A receptor and α2‐adrenoceptor blockade in the asenapine‐induced elevation of prefrontal cortical monoamine outflow
Frånberg, O., Marcus, M. M., & Svensson, T. H. (2012) · Synapse · doi:10.1002/syn.21551 · Cited by 39
Multilevel models from biology to psychology: Mission impossible?
Bilder, R. M., Howe, A. G., & Sabb, F. W. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0032263 · Cited by 37
Convergent approaches for defining functional imaging endophenotypes in schizophrenia
Pearlson, G. D. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.037.2009 · Cited by 35
Common and Differential Pathophysiological Features Accompany Comparable Cognitive Impairments in Medication-Free Patients with Schizophrenia and in Healthy Aging Subjects
Dreher, J., Koch, P. F., Kohn, P. D., Apud, J. A., Weinberger, D. R., & Berman, K. F. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.002 · Cited by 38
Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D3 Receptor Blockade
Torrisi, S. A., Salomone, S., Geraci, F., Caraci, F., Bucolo, C., Drago, F., & Leggio, G. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00710 · Cited by 34
Abnormal cortical neural synchrony during working memory in schizophrenia
Kang, S. S., MacDonald, A. W., Chafee, M. V., Im, C., Bernat, E. M., Davenport, N. D., & Sponheim, S. R. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.10.024 · Cited by 35
Possible Role of Glia in Cognitive Impairment in Schizophrenia
Mitterauer, B. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00113.x · Cited by 33
Neurological Disorders in Schizophrenia
Danielyan, A., & Nasrallah, H. A. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.08.004 · Cited by 36
Working Memory in Schizophrenia: Behavioral and Neural Evidence for Reduced Susceptibility to Item-Specific Proactive Interference
Kaller, C. P., Loosli, S. V., Rahm, B., Gössel, A., Schieting, S., Hornig, T., Hennig, J., van Elst, L. T., Weiller, C., & Katzev, M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.012 · Cited by 26
Lower functional connectivity of white matter during rest and working memory tasks is associated with cognitive impairments in schizophrenia
Gao, Y., Li, M., Huang, A., Anderson, A. W., Ding, Z., Heckers, S., Woodward, N. D., & Gore, J. C. (2021) · Schizophrenia Research · doi:10.1016/j.schres.2021.06.013 · Cited by 27
Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder
Huang, A., Rogers, B. P., Anticevic, A., Blackford, J. U., Heckers, S., & Woodward, N. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0434-4 · Cited by 27
Neuroanatomical Mechanism on the Effect of Distraction in Working Memory Maintenance in Patients With Schizophrenia
Kim, G.-W., Chung, Y., Yang, J.-C., Chung, G. H., Park, T., & Jeong, G. (2014) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13080177 · Cited by 27
Towards biologically constrained attractor models of schizophrenia
Stein, H., Barbosa, J., & Compte, A. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.10.013 · Cited by 27
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes, F., Ji, J. L., Rahmati, M., Burt, J. B., Schleifer, C. H., Adkinson, B. D., Savić, A., Santamauro, N. P., Tamayo, Z., Diehl, C., et al. (2024) · eLife · doi:10.7554/elife.84173 · Cited by 31
Abnormal medial temporal activity for bound information during working memory maintenance in patients with schizophrenia
Luck, D., Danion, J., Marrer, C., Pham, B., Gounot, D., & Foucher, J. (2009) · Hippocampus · doi:10.1002/hipo.20689 · Cited by 26
Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder
Li, Y., Zhang, C., Han, J.-C., Shang, Y., Chen, Z., Cui, G., & Wang, W. (2024) · Therapeutic Advances in Psychopharmacology · doi:10.1177/20451253241243290 · Cited by 28
The association between cognitive deficits and prefrontal hemodynamic responses during performance of working memory task in patients with schizophrenia
Pu, S., Nakagome, K., Itakura, M., Iwata, M., Nagata, I., & Kaneko, K. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.045 · Cited by 22
Qualitatively Different Delay-Dependent Working Memory Distortions in People With Schizophrenia and Healthy Control Participants
Bansal, S., Bae, G., Robinson, B. M., Dutterer, J., Hahn, B., Luck, S. J., & Gold, J. M. (2023) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2023.07.004 · Cited by 22
Dysfunction in different phases of working memory in schizophrenia: Evidence from ERP recordings
Zhao, Y. L., Tan, S., Yang, F. D., Wang, L., Feng, W. F., Chan, R. C. K., Gao, X., Zhou, D. F., Li, B. B., Song, C. S., et al. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.017 · Cited by 21
Emotion–cognition interactions in schizophrenia
Habel, U., Pauly, K. D., Koch, K., Kellermann, T., Reske, M., Backes, V., Stöcker, T., Amunts, K., Shah, N. J., & Schneider, F. W. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.501820 · Cited by 21
Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk
Tang, Y., Zhou, Q., Chang, M., Chekroud, A. M., Gueorguieva, R. V., Jiang, X., Zhou, Y., He, G. S., Rowland, M. A., Wang, D., et al. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2018.12.041 · Cited by 20
Using model systems to understand errant plasticity mechanisms in psychiatric disorders
Averbeck, B. B., & Chafee, M. V. (2016) · Nature Neuroscience · doi:10.1038/nn.4413 · Cited by 18
Impaired spatial working memory maintenance in schizophrenia involves both spatial coordinates and spatial reference frames
Mazhari, S., Badcock, J. C., Waters, F., Dragović, M., Badcock, D. R., & Jablensky, A. V. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.09.002 · Cited by 21
Thermotherapy to the facial region in and around the eyelids altered prefrontal hemodynamic responses and autonomic nervous activity during mental arithmetic
Takamoto, K., Hori, E., Urakawa, S., Katayama, M., Nagashima, Y., Yada, Y., Ono, T., & Nishijo, H. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2012.01488.x · Cited by 19
Cognitive Control in Schizophrenia
Barch, D. M., & Sheffield, J. M. (2017) · Wiley eBooks · doi:10.1002/9781118920497.ch31 · Cited by 20
Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia
Krystal, J. H., & Moghaddam, B. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch21 · Cited by 17
Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia
Wu, S., Wang, H., Chen, C., Zou, J., Huang, H., Li, P., Zhao, Y., Xu, Q., Zhang, L., Wang, H., et al. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00056 · Cited by 16
Salience of working-memory maintenance and manipulation deficits in schizophrenia
Hill, S. K., Griffin, G. B., Miura, T. K., Herbener, E. S., & Sweeney, J. A. (2010) · Psychological Medicine · doi:10.1017/s003329171000019x · Cited by 16
Working memory alpha–beta band oscillatory signatures in adolescents and young adults
Zammit, N., Falzon, O., Camilleri, K. P., & Muscat, R. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13897 · Cited by 16
A Potential Mechanism Underlying the Therapeutic Effects of Progesterone and Allopregnanolone on Ketamine-Induced Cognitive Deficits
Cao, T., Tang, M., Jiang, P., Zhang, B., Wu, X., Chen, Q., Zeng, C., Li, N., Zhang, S., & Cai, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.612083 · Cited by 16
Differentiating between clinical and behavioral phenotypes in first-episode psychosis during maintenance of visuospatial working memory
Jalbrzikowski, M., Murty, V. P., Stan, P. L., Saifullan, J., Simmonds, D. J., Foran, W., & Luna, B. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.11.012 · Cited by 15
Use of Translational Pharmacodynamic Biomarkers in Early-Phase Clinical Studies for Schizophrenia
English, B. A., Thomas, K. L. H., Johnstone, J., Bazih, A., Gertsik, L., & Ereshefsky, L. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.135 · Cited by 16
Future‐directed thinking in first‐episode psychosis
Goodby, E., & MacLeod, A. K. (2015) · British Journal of Clinical Psychology · doi:10.1111/bjc.12096 · Cited by 16
Using MoCA-Thai to evaluate cognitive impairment in patients with schizophrenia.
Arunpongpaisal, S., & Sangsirilak, A. (2013) · PubMed · Cited by 13
Working memory dysfunction in delusional disorders: An fMRI investigation
Oflaz, S., Akyüz, F., Hamamcı, A., Fırat, Z., Keskinkılıç, C., Kılıçkesmez, Ö., & Cihangiroğlu, M. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.022 · Cited by 13
Cognitive Control Errors in Nonhuman Primates Resembling Those in Schizophrenia Reflect Opposing Effects of NMDA Receptor Blockade on Causal Interactions Between Cells and Circuits in Prefrontal and Parietal Cortices
Kummerfeld, E., Ma, S., Blackman, R. K., DeNicola, A. L., Redish, A. D., Vinogradov, S., Crowe, D. A., & Chafee, M. V. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.02.013 · Cited by 13
Evidence of some strategic preservation of episodic learning in patients with schizophrenia
Thuaire, F., Izaute, M., & Bacon, É. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.07.036 · Cited by 12
Looking into a Deluded Brain through a Neuroimaging Lens
Arjmand, S., Kohlmeier, K. A., Behzadi, M., Ilaghi, M., Mazhari, S., & Shabani, M. (2020) · The Neuroscientist · doi:10.1177/1073858420936172 · Cited by 12
Refining the Empirical Constraints on Computational Models of Spatial Working Memory in Schizophrenia
Gold, J. M., Bansal, S., Anticevic, A., Cho, Y., Repovš, G., Murray, J. D., Hahn, B., Robinson, B. M., & Luck, S. J. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.05.003 · Cited by 12
β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce, M. K. P., Yang, S., Morin, K., Duque, A., Arellano, J. I., Datta, D., Wang, M., & Arnsten, A. F. T. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100628 · Cited by 11
Impaired working memory for visual motion direction in schizophrenia: Absence of recency effects and association with psychopathology.
Stäblein, M., Sieprath, L., Knöchel, C., Landertinger, A., Schmied, C., Ghinea, D., Mayer, J. S., Bittner, R. A., Reif, A., & Oertel‐Knöchel, V. (2016) · Neuropsychology · doi:10.1037/neu0000267 · Cited by 10
Computational modeling of psychiatric illnesses via well-defined neurophysiological and neurocognitive biomarkers
Siekmeier, P. J. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.014 · Cited by 9
Functional Dissociation of Confident and Not-Confident Errors in the Spatial Delayed Response Task Demonstrates Impairments in Working Memory Encoding and Maintenance in Schizophrenia
Mayer, J. S., Stäblein, M., Oertel‐Knöchel, V., & Fiebach, C. J. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00202 · Cited by 10
Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia
Perellón‐Alfonso, R., Oblak, A., Kuclar, M., Škrlj, B., Pileckyte, I., Škodlar, B., Pregelj, P., Abellaneda‐Pérez, K., David Bartrés-faz, A., Repovš, G., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1205119 · Cited by 7
Metamemory in Schizophrenia: Monitoring or Control Deficit?
Izaute, M., & Bacon, É. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6546-2_7 · Cited by 7
Spatial–temporal topography in neurogenesis of the macaque thalamus
Spadory, T., Duque, A., & Selemon, L. D. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02463-4 · Cited by 8
Mechanisms Underlying Visuospatial Working Memory Impairments in Schizophrenia
Ichinose, M. C., & Park, S. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_99 · Cited by 7
Retrospective: Patricia S. Goldman-Rakic, pioneer in neuroscience and co-founder of the journal, Cerebral Cortex
Arnsten, A. F. T. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad159 · Cited by 6
Spatiotemporal Alterations in Working Memory-Related Beta Band Neuromagnetic Activity of Patients With Schizophrenia On and Off Antipsychotic Medication: Investigation With MEG
Rubinstein, D., Eisenberg, D. P., Carver, F. W., Holroyd, T., Apud, J. A., Coppola, R., & Berman, K. F. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbac178 · Cited by 5
Stochastic Mesocortical Dynamics and Robustness of Working Memory during Delay-Period
Reneaux, M., Gupta, R., & Karmeshu (2015) · PLoS ONE · doi:10.1371/journal.pone.0144378 · Cited by 3
Brainnetome of schizophrenia: focus on impaired cognitive function.
Jiang, T., & Zhou, Y. (2012) · PubMed Central · doi:10.3969/j.issn.1002-0829.2012.01.001 · Cited by 5
Memory-Related Metacognition in Patients with Schizophrenia
Bacon, É., & Izaute, M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405172-0.00005-3 · Cited by 3
Age of Onset, Brain Controllability, and Working Memory Performance in First-Episode Schizophrenia
Wang, F., Liu, Z., Yang, J., Cheng, P., Tan, W., Huang, D., Liu, X., Zhong, M., Yang, J., & Palaniyappan, L. K. (2025) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaf156 · Cited by 2
Alpha oscillations underlie working memory abnormalities in the psychosis high-risk state
Ramyead, A., Kometer, M., Studerus, E., Baumeler, D., von Rotz, R., & Riecher‐Rössler, A. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.04.002 · Cited by 2

Authors: Driesen, N. R., Leung, H.-C., Calhoun, V. D., Constable, R. T., Gueorguieva, R., Hoffman, R., Skudlarski, P., Goldman-Rakic, P. S., & Krystal, J. H.
Affiliations: Yale University (US)
Stony Brook University (US)
Corresponding author: Driesen, Naomi R.
ORCID: Leung, Hoi-Chung
Constable, R. Todd
Gueorguieva, Ralitza
Krystal, John H.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-12
Volume: 64
Issue: 12
Pages: 1026-1034
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.07.029
PMC: PMC2650279
OpenAlex: W2039965895
Cited by: 119
References: 55
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 17 · 2012: 9
FWCI: 7.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5k05aa014906-03)
National Institute on Alcohol Abuse and Alcoholism (R01AA011321, K05-AA014906)
National Institute of Mental Health (P50 MH44866, P50MH068789, P50MH044866)
National Center for Research Resources (M01RR000125, MO-1 RR00125)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords: schizophrenia, working memory, working memory maintenance, prefrontal cortex, memory encoding, secondary immune response, memory load, cognitive impairment, antipsychotic drugs, medication-free patients
MeSH terms: Adult, Brain, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory Disorders, Memory, Short-Term, Neuropsychological Tests, Oxygen, Reaction Time, Schizophrenia, Time Factors, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impairment of Working Memory Maintenance and Response in Schizophrenia: Functional Magnetic Resonance Imaging Evidence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks