Cited by 129Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesPersonality Traits and Psychology

The DOI matches its Crossref record; 63 of the 64 references it cites were found in a registry or an index.

Personality Traits Are Differentially Associated with Patterns of Reward and Novelty Processing in the Human Substantia Nigra/Ventral Tegmental Area

Krebs, Ruth M., Schott, Björn H., Düzel, Emrah·2009·Biological Psychiatry

DOI 10.1016/j.biopsych.2008.08.019

Open this paper in CoChat — free account

Abstract

Background The long-standing observation that the novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelty-seeking personality trait.Methods Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the nucleus accumbens (NAcc), and the hippocampus of 29 subjects were correlated with novelty-seeking scores. These correlations were compared with those obtained for scores of reward-dependence. The fMRI data were taken from two experiments in which the interaction of novelty and reward was manipulated as a within-subject variable, and long-term memory for the critical stimuli was assessed after 24 hours.Results Novelty-seeking was positively correlated with SN/VTA activation elicited by novel cues that did not predict reward, whereas reward-dependence was related to activations elicited by novel cues that predicted reward. The positive correlation between SN/VTA responses to novelty and novelty-seeking scores was accompanied by a negative correlation with reward-related SN/VTA activation and memory enhancement.Conclusions SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2008.08.019

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
From sensation to cognition
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
The temperament and character inventory (TCI) : a guide to its development and use
Cloninger, C. R. (1994) · Medical Entomology and Zoology · Cited by 2,319
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983
Nonlinear spatial normalization using basis functions
Ashburner, J., & Friston, K. J. (1999) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1999)7:4 · Cited by 1,888
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355
Personality and Risk‐Taking: Common Bisocial Factors
Zuckerman, M., & Kuhlman, D. M. (2000) · Journal of Personality · doi:10.1111/1467-6494.00124 · Cited by 1,329

Show all 64 references

Sorted by citations

States of Curiosity Modulate Hippocampus-Dependent Learning via the Dopaminergic Circuit
Gruber, M. J., Gelman, B. D., & Ranganath, C. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.060 · Cited by 812
A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP
Lisman, J., Grace, A. A., & Duzel, E. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.07.006 · Cited by 465
Induction of Empathy by the Smell of Anxiety
Prehn‐Kristensen, A., Wiesner, C. D., Bergmann, T. O., Wolff, S., Jansen, O., Mehdorn, H. M., Ferstl, R., & Pause, B. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005987 · Cited by 264
NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging
Düzel, E., Bunzeck, N., Guitart-Masip, M., & Düzel, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.006 · Cited by 249
Neural correlates of personality: An integrative review
Kennis, M., Rademaker, A. R., & Geuze, E. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.012 · Cited by 264
Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain.
Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.023 · Cited by 218
Functional imaging of the human dopaminergic midbrain
Düzel, E., Bunzeck, N., Guitart-Masip, M., Wittmann, B., Schott, B. H., & Tobler, P. N. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.005 · Cited by 216
Gaining while giving: An fMRI study of the rewards of family assistance among White and Latino youth
Telzer, E. H., Masten, C. L., Berkman, E. T., Lieberman, M. D., & Fuligni, A. J. (2010) · Social Neuroscience · doi:10.1080/17470911003687913 · Cited by 189
Dopamine Modulates Episodic Memory Persistence in Old Age
Chowdhury, R., Guitart‐Masip, M., Bunzeck, N., Dolan, R. J., & Düzel, E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1278-12.2012 · Cited by 179
Influence of reward motivation on human declarative memory
Lombard, E., Bavelier, D., & Schwartz, S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.015 · Cited by 191
Reward Modulation of Hippocampal Subfield Activation during Successful Associative Encoding and Retrieval
Wolosin, S. M., Zeithamová, D., & Preston, A. R. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00237 · Cited by 162
Revisiting the Role of Rewards in Motivation and Learning: Implications of Neuroscientific Research
Hidi, S. E. (2015) · Educational Psychology Review · doi:10.1007/s10648-015-9307-5 · Cited by 167
Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: Evidence from high-resolution fMRI
Krebs, R. M., Heipertz, D., Schuetze, H., & Duzel, E. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.038 · Cited by 135
The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings
Cloninger, C. R., Cloninger, K. M., Zwir, I. J. S., & Keltikangas‐Järvinen, L. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0621-4 · Cited by 149
Curiosity in old age: A possible key to achieving adaptive aging
Sakaki, M., Yagi, A., & Murayama, K. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.007 · Cited by 147
The novelty exploration bonus and its attentional modulation☆
Krebs, R. M., Schott, B. H., Schütze, H., & Düzel, E. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.01.015 · Cited by 127
Uncovering the complex genetics of human temperament
Zwir, I. J. S., Arnedo, J., del Val, C., Pulkki-Råbäck, L., Konte, B., Yang, S. S., Romero‐Zaliz, R., Hintsanen, M., Cloninger, K. M., Garcia, D., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0264-5 · Cited by 125
The canary in the coalmine: The sensitivity of mesolimbic dopamine to environmental adversity during development
Gatzke‐Kopp, L. M. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.013 · Cited by 119
Reward Processing in Healthy Offspring of Parents With Bipolar Disorder
Singh, M. K., Kelley, R. G., Howe, M. E., Reiss, A. L., Gotlib, I. H., & Chang, K. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1031 · Cited by 109
The Big Five default brain: functional evidence
Sampaio, A., Soares, J. M., Coutinho, J. F. P., Sousa, N., & Gonçalves, Ó. F. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0610-y · Cited by 108
A common mechanism for adaptive scaling of reward and novelty
Bunzeck, N., Dayan, P., Dolan, R. J., & Düzel, E. (2010) · Human Brain Mapping · doi:10.1002/hbm.20939 · Cited by 108
Generation and the subjective feeling of “aha!” are independently related to learning from insight
Kizilirmak, J. M., da Silva, J. G. G., Imamoglu, F., & Richardson‐Klavehn, A. (2015) · Psychological Research · doi:10.1007/s00426-015-0697-2 · Cited by 96
Functional neuroanatomical review of the ventral tegmental area
Trutti, A. C., Mulder, M., Hommel, B., & Forstmann, B. U. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.01.062 · Cited by 97
Neural Correlates of Learning from Induced Insight: A Case for Reward-Based Episodic Encoding
Kizilirmak, J. M., Thuerich, H., Folta-Schoofs, K., Schott, B. H., & Richardson‐Klavehn, A. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.01693 · Cited by 80
Connectome-based individualized prediction of temperament trait scores
Jiang, R., Calhoun, V. D., Zuo, N., Lin, D., Li, J., Fan, L., Qi, S., Sun, H., Fu, Z., Song, M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.038 · Cited by 82
Behavioral endophenotypes of drug addiction: Etiological insights from neuroimaging studies
Jupp, B., & Dalley, J. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.041 · Cited by 78
The Subcortical Cocktail Problem; Mixed Signals from the Subthalamic Nucleus and Substantia Nigra
de Hollander, G., Keuken, M. C., & Forstmann, B. U. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120572 · Cited by 67
Brain activity in near-death experiencers during a meditative state
Beauregard, M., Courtemanche, J., & Paquette, V. (2009) · Resuscitation · doi:10.1016/j.resuscitation.2009.05.006 · Cited by 65
Behavioral specifications of reward-associated long-term memory enhancement in humans
Wittmann, B. C., Dolan, R. J., & Düzel, E. (2011) · Learning & Memory · doi:10.1101/lm.1996811 · Cited by 62
Novelty Enhances Visual Salience Independently of Reward in the Parietal Lobe
Foley, N. C., Jangraw, D. C., Peck, C., & Gottlieb, J. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4171-13.2014 · Cited by 63
Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met Polymorphism Impacts Novelty Seeking and Harm Avoidance
Montag, C., Markett, S. A., Basten, U., Stelzel, C., Fiebach, C. J., Canli, T., & Reuter, M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.55 · Cited by 60
The Mesolimbic Dopamine Pathway and Romantic Love
Xu, X., Weng, X., & Aron, A. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00057-9 · Cited by 57
The Hippocampal-VTA Loop: The Role of Novelty and Motivation in Controlling the Entry of Information into Long-Term Memory
Otmakhova, N. A., Düzel, E., Deutch, A. Y., & Lisman, J. E. (2012) · Springer eBooks · doi:10.1007/978-3-642-32375-1_10 · Cited by 59
Seeking motivation and reward: Roles of dopamine, hippocampus, and supramammillo-septal pathway
Kesner, A. J., Calva, C. B., & Ikemoto, S. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102252 · Cited by 61
Functional Connectome of the Five-Factor Model of Personality
Toschi, N., Riccelli, R., Indovina, I., Terracciano, A., & Passamonti, L. (2018) · Personality Neuroscience · doi:10.1017/pen.2017.2 · Cited by 52
Distinct Medial Temporal Lobe Network States as Neural Contexts for Motivated Memory Formation
Murty, V. P., & Adcock, R. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-50406-3_15 · Cited by 55
Novelty Manipulations, Memory Performance, and Predictive Coding: the Role of Unexpectedness
Reichardt, R., Polner, B., & Simor, P. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00152 · Cited by 52
Reward network connectivity “at rest” is associated with reward sensitivity in healthy adults: A resting-state fMRI study
Adrián‐Ventura, J., Costumero, V., Parcet, M. A., & Ávila, C. (2019) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-019-00688-1 · Cited by 57
Differential effects of white noise in cognitive and perceptual tasks
Herweg, N. A., & Bunzeck, N. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01639 · Cited by 51
Learning of novel semantic relationships via sudden comprehension is associated with a hippocampus-independent network
Kizilirmak, J. M., Schott, B. H., Thuerich, H., Sweeney‐Reed, C. M., Richter, A., Folta-Schoofs, K., & Richardson‐Klavehn, A. (2019) · Consciousness and Cognition · doi:10.1016/j.concog.2019.01.005 · Cited by 43
Approach–withdrawal and the role of the striatum in the temperament of behavioral inhibition.
Helfinstein, S. M., Fox, N. A., & Pine, D. S. (2011) · Developmental Psychology · doi:10.1037/a0026402 · Cited by 45
Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making
Wang, Y., Liu, Y., Yang, L., Gu, F., Li, X., Zha, R., Wei, Z., Pei, Y., Zhang, P., Zhou, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep10534 · Cited by 42
Fiber connectivity between the striatum and cortical and subcortical regions is associated with temperaments in Chinese males
Lei, X., Chen, C., Xue, F., He, Q., Chen, C., Liu, Q., Moyzis, R. K., Xue, G., Cao, Z., Li, J., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.043 · Cited by 41
The effect of novelty on reinforcement learning
Houillon, A., Lorenz, R. C., Böhmer, W., Rapp, M. A., Heinz, A., Gallinat, J., & Obermayer, K. (2013) · Progress in brain research · doi:10.1016/b978-0-444-62604-2.00021-6 · Cited by 43
To Add or Not to Add Game Elements? Exploring the Effects of Different Cognitive Task Designs Using Eye Tracking
Ninaus, M., Kiili, K. J. M., Wood, G. M. D. O., Moeller, K., & Kober, S. E. (2020) · IEEE Transactions on Learning Technologies · doi:10.1109/tlt.2020.3031644 · Cited by 35
Increased Echogenicity of the Substantia Nigra in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder
Krauel, K., Feldhaus, H. C., Simon, A., Rehe, C., Glaser, M. B., Flechtner, H., Heinze, H., & Niehaus, L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.013 · Cited by 33
Attachment styles in dogs and their relationship with separation-related disorder – A questionnaire based clustering
Konok, V., Marx, A., & Faragó, T. (2019) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2019.02.014 · Cited by 33
Oxytocin and Facial Emotion Recognition
Ellenbogen, M. A. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_20 · Cited by 34
Assessing Relationships Among Impulsive Sensation Seeking, Reward Circuitry Activity, and Risk for Psychopathology: A Functional Magnetic Resonance Imaging Replication and Extension Study
Edmiston, E. K., Fournier, J. C. J., Chase, H. W., Bertocci, M. A., Greenberg, T., Aslam, H. A., Lockovich, J., Graur, S., Bebko, G. M., Forbes, E. E., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.10.012 · Cited by 32
Constraints on decision making: Implications from genetics, personality, and addiction
Baker, T. E., Stockwell, T. R., & Holroyd, C. B. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0164-8 · Cited by 33
Social rank-associated stress vulnerability predisposes individuals to cocaine attraction
Yanovich, C., Kirby, M. L., Michaelevski, I., Yadid, G., & Pinhasov, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-19816-x · Cited by 33
Exploration of a novel virtual environment improves memory consolidation in ADHD
Baumann, V., Birnbaum, T., Breitling-Ziegler, C., Tegelbeckers, J., Dambacher, J., Edelmann, E., Bergado-Acosta, J. R., Flechtner, H., & Krauel, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-78222-4 · Cited by 33
Disentangling the personality pathways to well-being
Moreira, P., Inman, R. A., & Cloninger, C. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-29642-5 · Cited by 35
Effects of active exploration on novelty-related declarative memory enhancement
Schomaker, J., & Wittmann, B. C. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107403 · Cited by 29
Blast–related disinhibition and risk seeking in mice and combat Veterans: Potential role for dysfunctional phasic dopamine release
Schindler, A. G., Meabon, J. S., Pagulayan, K. F., Hendrickson, R. C., Meeker, K. D., Cline, M. M., Li, G., Sikkema, C. L., Wilkinson, C. W., Perl, D. P., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.004 · Cited by 28
Neurochemical modulation of repetition suppression and novelty signals in the human brain
Bunzeck, N., & Thiel, C. M. (2015) · Cortex · doi:10.1016/j.cortex.2015.10.013 · Cited by 30
Motivational salience modulates hippocampal repetition suppression and functional connectivity in humans
Zweynert, S. (2011) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00144 · Cited by 28
Perceptual, Cognitive, and Personality Rigidity in Parkinson’s Disease
Díaz-Santos, M., Cao, B., Yazdanbakhsh, A., Norton, D. J., Neargarder, S., & Cronin-Golomb, A. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.01.044 · Cited by 27
Neural Correlates of Motor Vigour and Motor Urgency During Exercise
Rauch, L., Schönbächler, G., & Noakes, T. D. (2013) · Sports Medicine · doi:10.1007/s40279-013-0025-1 · Cited by 25
Novelty seeking and reward dependence‐related large‐scale brain networks functional connectivity variation during salience expectancy
Li, S., Demenescu, L. R., Sweeney‐Reed, C. M., Krause, A. L., Metzger, C. D., & Walter, M. (2017) · Human Brain Mapping · doi:10.1002/hbm.23648 · Cited by 26
Dopamine D4 receptor deficiency in mice alters behavioral responses to anxiogenic stimuli and the psychostimulant methylphenidate
Keck, T. M., Suchland, K. L., Jimenez, C. C., & Grandy, D. K. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.006 · Cited by 26
Increased Reward-Related Behaviors during Sleep and Wakefulness in Sleepwalking and Idiopathic Nightmares
Perogamvros, L., Aberg, K., Gex-Fabry, M., Perrig, S., Cloninger, C. R., & Schwartz, S. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134504 · Cited by 25
Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory
Barman, A., Assmann, A., Richter, S., Soch, J., Schuetze, H., Wüstenberg, T., Deibele, A., Klein, M., Richter, A., Behnisch, G., et al. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00260 · Cited by 25
Variables influencing the neural correlates of perceived risk of physical harm
Coaster, M., Rogers, B. P., Jones, O. D., Viscusi, W. K., Merkle, K. L., Zald, D. H., & Gore, J. C. (2011) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0047-9 · Cited by 24
“The midbrain has been previously reported for processing novel salient stimuli ( Krebs, Schott, & Duzel, 2009 ) and for voluntary risk-taking choice behavior in the balloon assessment risk task (Rao, Korczykowski, Pluta, Hoang, & Detre, 2008).”
Background
Too little, too late or too much, too early? Differential hemodynamics of response inhibition in high and low sensation seekers
Collins, H. R., Corbly, C. R., Liu, X., Kelly, T. H., Lynam, D. R., & Joseph, J. E. (2012) · Brain Research · doi:10.1016/j.brainres.2012.08.004 · Cited by 24
Reinforcement Sensitivity Theory, Research, Applications, and Future
Smillie, L. D., Loxton, N. J., & Avery, R. E. (2011) · Wiley eBooks · doi:10.1002/9781444343120.ch4 · Cited by 24
Functional lateralization of the medial temporal lobe in novel associative processing during creativity evaluation
Ren, J., Huang, F., Gao, C., Gott, J., Schoch, S. F., Qin, S., Dresler, M., & Luo, J. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac129 · Cited by 23
Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions
Schott, B. H., Voss, M., Wagner, B., Wüstenberg, T., Düzel, E., & Behr, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00144 · Cited by 23
Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults
Guran, C.-N. A., Lehmann-Grube, J., & Bunzeck, N. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02997 · Cited by 26
The Intricacies of Dopamine Neuron Modulation
Heinz, A., Grace, A. A., & Beck, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.003 · Cited by 20
The influence of genes on “positive valence systems” constructs: A systematic review
Hess, J., Kawaguchi, D. M., Wagner, K. E., Faraone, S. V., & Glatt, S. J. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32382 · Cited by 18
Levodopa effects on [11C]raclopride binding in the resting human brain
BLACK, K. J., Piccirillo, M. L., Koller, J. M., Hseih, T., Wang, L., & Mintun, M. A. (2015) · F1000Research · doi:10.12688/f1000research.5672.1 · Cited by 18
Effects of valence and arousal on implicit approach/ avoidance tendencies: A fMRI study
Ascheid, S., Wessa, M., & Linke, J. O. (2019) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2019.05.028 · Cited by 19
“Wanting” versus “needing” related value: An fMRI meta‐analysis
Bosulu, J., Allaire, M., Tremblay‐Grénier, L., Luo, Y., Eickhoff, S. B., & Hétu, S. (2022) · Brain and Behavior · doi:10.1002/brb3.2713 · Cited by 17
Midbrain fMRI: Applications, Limitations and Challenges
Düzel, E., Guitart-Masip, M., Maass, A., Hämmerer, D., Betts, M. J., Speck, O., Weiskopf, N., & Kanowski, M. (2015) · Biological Magnetic Resonance · doi:10.1007/978-1-4899-7591-1_20 · Cited by 16
Active Reward Processing during Human Sleep: Insights from Sleep-Related Eating Disorder
Perogamvros, L., Baud, P., Hasler, R., Cloninger, C. R., Schwartz, S., & Perrig, S. H. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00168 · Cited by 17
The striatum and beyond: contributions of the hippocampus to decision making
Wimmer, G. E., & Shohamy, D. (2011) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199600434.003.0013 · Cited by 14
Novelty seeking is associated with increased body weight and orbitofrontal grey matter volume reduction
Ludwig, M., Richter, M. F., Goltermann, J., Redlich, R., Repple, J., Flint, C., Grotegerd, D., Koch, K., Leehr, E. J., Meinert, S. L., et al. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105148 · Cited by 13
[Personality differences between alcohol abusers and matched controls: Relation to frontal symptoms and subtypes of addicts].
Pérez, E. J. P., de León, J. M. R. S., Arroyo, Á. O., Mota, G. R., Luque, M. L., & García, C. P. (2011) · PubMed · Cited by 11
Adaptive scaling of reward in episodic memory: a replication study
Mason, A., Ludwig, C. J. H., & Farrell, S. (2016) · Quarterly Journal of Experimental Psychology · doi:10.1080/17470218.2016.1233439 · Cited by 11
Increased behavioral inhibition trait and negative stress coping in non–rapid eye movement parasomnias
Ramm, M., Urbanek, A., Failing, A., Young, P., Scherfler, C., Högl, B., & Heidbreder, A. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8688 · Cited by 12
Motivation and Memory
Dickerson, K. C., & Adcock, R. A. (2018) · Wiley eBooks · doi:10.1002/9781119170174.epcn107 · Cited by 13
Transdiagnostic brain correlates of self-reported trait impulsivity: A dimensional structure-symptom investigation
Schaub, A.-C., Vogel, M., Lang, U. E., Kaiser, S., Walter, M., Herdener, M., Wrege, J. S., Kirschner, M., & Schmidt, A. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103423 · Cited by 9
Reward-related limbic memory and stimulation of the cannabinoid system: An upgrade in value attribution?
Brancato, A., Cavallaro, A., Lavanco, G., Plescia, F., & Cannizzaro, C. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725683 · Cited by 9
Do Event-Related Evoked Potentials Reflect Apathy Tendency and Motivation?
Takayoshi, H., Onoda, K., & Yamaguchi, S. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00011 · Cited by 9
Time-resolved connectome of the five-factor model of personality
Passamonti, L., Riccelli, R., Indovina, I., Duggento, A., Terracciano, A., & Toschi, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-51469-2 · Cited by 9
A bias toward the unknown: individual and environmental factors influencing exploratory behavior
Petzke, T. M., & Schomaker, J. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14757 · Cited by 8
The Mediating Role of Temperamental Traits on the Relationship between Age of Puberty and Eating Disorders: A Mediating Analysis through Structural Equation Modelling of Australian Eating Disorder Outpatients
Paganini, C., Peterson, G. M., & Andrews, K. (2021) · The Journal of Genetic Psychology · doi:10.1080/00221325.2021.1940822 · Cited by 9
Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients
Basile, G. A., Bramanti, A., Bertino, S., Cutroneo, G., Bruno, A., Tisano, A., Paladina, G., Milardi, D., & Anastasi, G. (2020) · Medicina · doi:10.3390/medicina56120686 · Cited by 8
The Fragmented Personality
Švrakić, D. M., & Jovanovic, M. D. (2018) · doi:10.1093/med/9780190884574.001.0001 · Cited by 7
The Ratio of Second and Fourth Digit Length: A Biomarker for Methamphetamine Dependence?
Kim, Y., Won, S.-D., Kwon, H., & Han, C. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.4.694 · Cited by 6
Genes and Human Decision-Making
Reuter, M., & Montag, C. (2016) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-642-35923-1_4 · Cited by 6
The Cortico-basal-cerebellar Neurocircuit is Linked to Personality Trait of Novelty Seeking
Wei, L., Weng, T., Dong, H., Baeken, C., Jiang, T., & Wu, G. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.02.027 · Cited by 5
Personality Traits Induce Different Brain Patterns When Processing Social and Valence Information
Hevia-Orozco, J. C., Reyes-Aguilar, A., Hernández-Pérez, R., González-Santos, L., Pasaye, E. H., & Barrios, F. A. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.782754 · Cited by 5
Exploring distinct and joint contributions of the locus coeruleus and the substantia nigra/ventral tegmental area complex to reward and valence processing using high-resolution fMRI
Hall, J. M., Shahnazian, D., & Krebs, R. M. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00336 · Cited by 7
Psychobiological personality traits of children and adolescents with disorders of arousal
Turner, K., Castelnovo, A., Perogamvros, L., Cloninger, R. C., Galbiati, A., Bertolotti, A., Proserpio, P., Terzaghi, M., Manni, R., Ferini Strambi, L., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.12.035 · Cited by 4
Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity
Galinowski, A., Miranda, R., Lemaître, H., Artiges, É., Martinot, M. P., Filippi, I., Penttilä, J., Grimmer, Y., van Noort, B. M., Stringaris, A. K., et al. (2019) · Addiction Biology · doi:10.1111/adb.12781 · Cited by 4
Three joint temperament-character configurations account for learning, personality and well-being: normative demographic findings in a representative national population
Moreira, P., Inman, R. A., & Cloninger, C. R. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1193441 · Cited by 3
Genetics, drugs, and cognitive control: uncovering individual differences in substance dependence
Baker, T. E. (2012) · UVic’s Research and Learning Repository (University of Victoria) · Cited by 3
The Impact of Exposure to a Novel Virtual Environment on Episodic Memory as a Function of the Level of Processing During Encoding
Aron, C., Schomaker, J., & Bastin, C. (2025) · Applied Cognitive Psychology · doi:10.1002/acp.70109 · Cited by 3

Authors: Krebs, R. M., Schott, B. H., & Düzel, E.
Affiliations: Otto-von-Guericke-Universität Magdeburg (DE)
Charité – Universitätsmedizin Berlin (DE)
University College London (GB)
Corresponding author: Düzel, Emrah
ORCID: Krebs, Ruth M.
Schott, Björn H.
Düzel, Emrah
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-01
Volume: 65
Issue: 2
Pages: 103-110
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2008.08.019
OpenAlex: W2034607657
Cited by: 129
References: 64
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 18 · 2017: 5 · 2016: 3 · 2015: 14 · 2014: 4 · 2013: 8 · 2012: 10
FWCI: 3.18
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
Keywords: novelty seeking, reward dependence, personality traits, substantia nigra/ventral tegmental area, novelty processing, reward processing, nucleus accumbens, hippocampus, memory enhancement, financial incentives
MeSH terms: Arousal, Brain Mapping, Cerebrovascular Circulation, Dopamine, Exploratory Behavior, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Nucleus Accumbens, Personality, Probability Learning, Reaction Time, Mental Recall, Reference Values, Regression Analysis, Reward, Substantia Nigra, Ventral Tegmental Area, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Personality Traits Are Differentially Associated with Patterns of Reward and Novelty Processing in the Human Substantia Nigra/Ventral Tegmental Area

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks