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Personality Traits Are Differentially Associated with Patterns of Reward and Novelty Processing in the Human Substantia Nigra/Ventral Tegmental Area
Abstract
Background The long-standing observation that the novelty-seeking personality trait is a predictor of drug use and other reinforcable risky behaviors raises the question as to how novelty and reward processing functionally interact in mesolimbic dopaminergic circuitry and how this interaction is modulated by the novelty-seeking personality trait.Methods Functional magnetic resonance imaging (fMRI) hemodynamic responses to novelty and reward (monetary incentive) from the substantia nigra/ventral tegmental area (SN/VTA), the nucleus accumbens (NAcc), and the hippocampus of 29 subjects were correlated with novelty-seeking scores. These correlations were compared with those obtained for scores of reward-dependence. The fMRI data were taken from two experiments in which the interaction of novelty and reward was manipulated as a within-subject variable, and long-term memory for the critical stimuli was assessed after 24 hours.Results Novelty-seeking was positively correlated with SN/VTA activation elicited by novel cues that did not predict reward, whereas reward-dependence was related to activations elicited by novel cues that predicted reward. The positive correlation between SN/VTA responses to novelty and novelty-seeking scores was accompanied by a negative correlation with reward-related SN/VTA activation and memory enhancement.Conclusions SN/VTA responses to novelty and reward are differentially affected by personality traits of novelty-seeking and reward-dependence. Importantly, novelty-seekers were more responsive to novel cues in the absence of reward and needed less reward to boost their memory for novel cues. These observations strongly suggest that for novelty-seekers, the motivational value of novelty is not necessarily based on actual reward-predicting stimulus properties.
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“It was found that the prospect of receiving reward (e.g., monetary gain) improved long-term episodic memory for novel stimuli in incidental [47, 55–57] and intentional [46] encoding paradigms.”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
In the citing paper
“Interestingly, the personality trait of novelty seeking is correlated with the magnitude of the SN/VTA novelty fMRI response even when novel stimuli predict the absence of reward [56]”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
In the citing paper
“Memory enhancement after long retention intervals (e.g. 24 hours) has been consistently found [56, 57].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [56]
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Metadata
- Authors
- Krebs, R. M., Schott, B. H., & Düzel, E.
- Affiliations
- Otto-von-Guericke-Universität Magdeburg (DE)
- Charité – Universitätsmedizin Berlin (DE)
- University College London (GB)
- Corresponding author
- Düzel, Emrah
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 65
- Issue
- 2
- Pages
- 103-110
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2034607657
- Cited by
- 129
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 11 · 2021: 4 · 2020: 7 · 2019: 10 · 2018: 18 · 2017: 5 · 2016: 3 · 2015: 14 · 2014: 4 · 2013: 8 · 2012: 10
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Keywords
- novelty seeking, reward dependence, personality traits, substantia nigra/ventral tegmental area, novelty processing, reward processing, nucleus accumbens, hippocampus, memory enhancement, financial incentives
- MeSH terms
- Arousal, Brain Mapping, Cerebrovascular Circulation, Dopamine, Exploratory Behavior, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Models, Neurological, Neural Pathways, Nucleus Accumbens, Personality, Probability Learning, Reaction Time, Mental Recall, Reference Values, Regression Analysis, Reward, Substantia Nigra, Ventral Tegmental Area, Young Adult
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