The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
A Tractography Analysis of Two Deep Brain Stimulation White Matter Targets for Depression
Open accessAbstract
Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCwm) or anterior limb of the internal capsule (ALIC) may be effective in treating depression. Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets.Methods Diffusion tensor imaging (DTI) and probabilistic tractography were performed in 13 nondepressed subjects to determine connectivity patterns of SCCwm and ALIC. Tract maps were generated for each target in each subject, and tract voxels were coded as being unique to either target or shared. Group level tract maps were generated by including only those voxels common to at least 10 of 13 (>75%) subjects.Results The two targets have distinct patterns of connectivity with regions of overlap. The SCCwm showed consistent ipsilateral connections to the medial frontal cortex, the full extent of the anterior and posterior cingulate, medial temporal lobe, dorsal medial thalamus, hypothalamus, nucleus accumbens, and the dorsal brainstem. The ALIC seed, in contrast, demonstrated widespread projections to frontal pole, medial temporal lobe, cerebellum, nucleus accumbens, thalamus, hypothalamus, and brainstem. Common to both targets, albeit through distinct white matter bundles, were connections to frontal pole, medial temporal lobe, nucleus accumbens, dorsal thalamus, and hypothalamus.Conclusions Connectivity patterns of these two DBS white matter targets suggest distinct neural networks with areas of overlap in regions implicated in depression and antidepressant response.
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“DBS targets in the VC/VS region structurally and functionally connect to the MFB and partially to the SCC [91], but the SCC has selective fibers that are not directly connected to VC/VS or NAc [92,93].”
From Deep brain stimulation for depression. (2022) · cites this paper as [92]
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“In addition, this structure and neighbouring medial frontal regions and linked basal ganglia have been also been strikingly linked with mood regulation, including depression and anxiety (Drevets et al., 2008; Gutman et al., 2009; Johansen-Berg et al., 2008; Mayberg et al., 2005).”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Gutman et al., 2009
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Metadata
- Authors
- Gutman, D. A., Holtzheimer, P. E., Behrens, T. E. J., Johansen-Berg, H., & Mayberg, H. S.
- Affiliations
- Emory University (US)
- University of Oxford (GB)
- Corresponding author
- Gutman, David A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 65
- Issue
- 4
- Pages
- 276-282
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4423548
- OpenAlex
- W2111456519
- Cited by
- 220
- References
- 65
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 15 · 2014: 26 · 2013: 22 · 2012: 24
- FWCI
- 11.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Stanley Medical Research Institute
- National Alliance for Research on Schizophrenia and Depression (K23 MH077869)
- Wellcome Trust
- Medical Research Council
- Dana Foundation
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- deep brain stimulation, depression, anterior limb of the internal capsule, white matter connectivity, probabilistic tractography, artificial neural networks, nucleus accumbens, medial temporal lobe, thalamus, hypothalamus, frontal pole, antidepressant response
- MeSH terms
- Adult, Brain Mapping, Depressive Disorder, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways, Models, Statistical, Internal Capsule, Diffusion Magnetic Resonance Imaging, Deep Brain Stimulation, Young Adult
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