Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice
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Background Obsessive-compulsive disorder (OCD) is characterized by intrusive thoughts, images, or impulses and/or repetitive stereotypical behavior. Obsessive-compulsive disorder patients exhibit reduced prepulse inhibition (PPI) and symptom exacerbation after challenge with 5-HT1B receptor agonists. Recently, gain-of-function alleles of the serotonin transporter (5-HTT) have been associated with OCD. We tested the hypothesis that reducing 5-HTT function chronically, either genetically or via serotonin reuptake inhibitor (SRI) treatment, attenuates PPI deficits and perseverative hyperlocomotion induced by 5-HT1B agonists in mice.Methods Mice received subchronic or chronic pretreatment with the SRI fluoxetine and acute treatment with RU24969 (5-HT1A/1B agonist) or 8-OH-DPAT (5-HT1A agonist) and were assessed for PPI, locomotor activity, and spatial patterns of locomotion. The same measures were evaluated in 5-HTT wild-type (WT), heterozygous (HT), and knockout (KO) mice after RU24969 treatment. The effects of WAY100635 (5-HTA antagonist) or GR127935 (5-HT1B/D antagonist) pretreatment on RU24969-induced effects were evaluated. Finally, 5-HT1B binding and functional coupling were assessed in 5-HTT-WT, -HT, and -KO mice, and normal fluoxetine-treated mice.Results Chronic, but not subchronic, fluoxetine treatment prevented RU24969-induced PPI deficits and perseverative hyperlocomotion. These RU24969-induced effects were mediated via 5-HT1B and not 5-HT1A receptors. 5-HTT-KO mice showed no effects of RU24969, and 5-HTT-HT mice exhibited intermediate phenotypes. 5-HT1B binding and functional coupling were reduced in the globus pallidus and substantia nigra of 5-HTT-KO mice.Conclusions Our results demonstrate that chronic, but not subchronic, fluoxetine treatment and 5-HTT knockout robustly attenuate 5-HT1B agonist-induced PPI deficits and perseverative hyperlocomotion. These results may have implications for the etiology and treatment of OCD.
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In mice, administration of a 5-HT1B agonist leads to OCD-relevant perseverative locomotion and prepulse inhibition deficits, both reversed with chronic but not acute fluoxetine treatment.
“studies in mice demonstrate that administration of a 5-HT1B agonist leads to OCD-relevant perseverative locomotion and prepulse inhibition deficits, both of which are reversed with chronic, but not acute, fluoxetine treatment 38.”
From DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS: Review: Dissecting OCD Circuits: Animals to Treatments (2015) · cites this paper as [38]
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BRAFF, D. L., Geyer, M. A., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100810 · Cited by 1,701 · see citing works
Self-citationGeyer, M. A., Krebs-Thomson, K., Braff, D. L., & Swerdlow, N. R. (2001) · Psychopharmacology · doi:10.1007/s002130100811 · Cited by 1,484 · see citing works
Self-citationHu, X., Lipsky, R. H., Zhu, G., Akhtar, L. A., Taubman, J., Greenberg, B. D., Xu, K., Arnold, P. D., Richter, M. A., Kennedy, J. L., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/503850 · Cited by 1,124 · see citing works
The more or less startling effects of weak prestimulation
Graham, F. K. (1975) · Psychophysiology · doi:10.1111/j.1469-8986.1975.tb01284.x · Cited by 1,119 · see citing works
Neuropsychopharmacology: The Fifth Generation of Progress
Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023 · see citing works
Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B Receptor
Saudou, F., Amara, D. A., Dierich, A., LeMeur, M., Ramboz, S., Ségu, L., Buhot, M.-C., & Hen, R. (1994) · Science · doi:10.1126/science.8091214 · Cited by 839 · see citing works
Self-citationNeuropsychopharmacology : The Fifth Generation of Progress
Davis, K. L., Charney, D. S., Coyle, J. T., & Nemeroff, C. B. (2002) · Lippincott Williams & Wilkins eBooks · Cited by 747 · see citing works
Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression
Dulawa, S. C., Holick, K. A., Gundersen, B., & Hen, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300433 · Cited by 671 · see citing works
Self-citationBrain anatomy and sensorimotor gating in Asperger's syndrome
McAlonan, G. M. (2002) · Brain · doi:10.1093/brain/awf150 · Cited by 447 · see citing works
Gordon, C. T. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820180039004 · Cited by 390 · see citing works
Swerdlow, N. R., Caine, S. B., BRAFF, D. L., & Geyer, M. A. (1992) · Journal of Psychopharmacology · doi:10.1177/026988119200600210 · Cited by 388 · see citing works
Self-citationLira, A., Zhou, M., Castanon, N., Ansorge, M. S., Gordon, J. A., Francis, J. H., Bradley-Moore, M., Lira, J., Underwood, M. D., Arango, V., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00696-6 · Cited by 385 · see citing works
Self-citationA preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder
Swerdlow, N. R., Benbow, C. H., Zisook, S., Geyer, M. A., & BRAFF, D. L. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90300-3 · Cited by 351 · see citing works
Self-citationPeroutka, S. J. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb04532.x · Cited by 347 · see citing works
Oksenberg, D., Marsters, S. A., O’Dowd, B. F., Jin, H., Havlik, S., Peroutka, S. J., & Ashkenazi, A. (1992) · Nature · doi:10.1038/360161a0 · Cited by 276 · see citing works
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
Ozaki, N., Goldman, D. A., Kaye, W. H., Plotnicov, K. H., Greenberg, B. D., Lappalainen, J., Rudnick, G., & Murphy, D. L. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001365 · Cited by 275 · see citing works
Fabre, V., Beaufour, C., Evrard, A., Bilan, A. R., Hanoun, N., Lesch, K., Murphy, D. L., Lanfumey, L., Hamon, M., & Martres, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00126.x · Cited by 274 · see citing works
5-hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons
Johnson, S., Mercuri, N. B., & North, R. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-05-02000.1992 · Cited by 249 · see citing works
Delfs, J. M., & Kelley, A. E. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90221-o · Cited by 200 · see citing works
Serotonin microinfusion into the ventral tegmental area increases accumbens dopamine release
Guan, X.-M., & McBride, W. J. (1989) · Brain Research Bulletin · doi:10.1016/0361-9230(89)90198-6 · Cited by 187 · see citing works
Impaired Prepulse Inhibition of Acoustic Startle in Obsessive-Compulsive Disorder
Hoenig, K., Hochrein, A., Quednow, B. B., Maier, W., & Wagner, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.040 · Cited by 185 · see citing works
Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats
Sipes, T. E., & Geyer, M. A. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90074-4 · Cited by 184 · see citing works
Self-citationBakshi, V. P., & Geyer, M. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08394.1998 · Cited by 167 · see citing works
Self-citationSprouse, J. S., Reynolds, L. S., Li, X., Braselton, J. P., & Schmidt, A. W. (2003) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.007 · Cited by 137 · see citing works
A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
Wendland, J. R., Moya, P. R., Kruse, M. R., Ren‐Patterson, R. F., Jensen, C. L., Timpano, K. R., & Murphy, D. L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm343 · Cited by 136 · see citing works
Dulawa, S. C., Hen, R., Scearce-Levie, K. A., & Geyer, M. A. (1997) · Psychopharmacology · doi:10.1007/s002130050328 · Cited by 122 · see citing works
Self-citationPaulus, M. P., Dulawa, S. C., Ralph, R. J., & Geyer, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01137-3 · Cited by 117 · see citing works
Self-citationIs the 5-HT1Dβ Receptor Gene Implicated in the Pathogenesis of Obsessive-Compulsive Disorder?
Mundo, E., Richter, M. A., Sam, F., Macciardi, F. M., & Kennedy, J. L. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1160 · Cited by 103 · see citing works
Effects of strain and serotonergic agents on prepulse inhibition and habituation in mice
Dulawa, S. C., & Geyer, M. A. (2000) · Neuropharmacology · doi:10.1016/s0028-3908(00)00030-7 · Cited by 99 · see citing works
Self-citationBakshi, V. P., & Geyer, M. A. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37049-1 · Cited by 99 · see citing works
Self-citationFletcher, P. J., Sinyard, J., & Higgins, G. A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0453-9 · Cited by 93 · see citing works
Serotonin1B Receptor Activation Mimics Behavioral Effects of Presynaptic Serotonin Release
Rempel, N. L., Callaway, C. W., & Geyer, M. A. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.22 · Cited by 91 · see citing works
Self-citationParker, E. M., Grisel, D. A., Iben, L. G., & Shapiro, R. A. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb05865.x · Cited by 91 · see citing works
Gross‐Isseroff, R., Cohen, R., Sasson, Y., Voet, H., & Zohar, J. (2004) · Neuropsychobiology · doi:10.1159/000079970 · Cited by 86 · see citing works
American Academy of Pediatrics. Presidential address--1974.
Gillespie, J. B. (1974) · PubMed · Cited by 75 · see citing works
Stein, D. J., van Heerden, B., Wessels, C., van Kradenburg, J., Warwick, J., & Wasserman, H. J. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00051-2 · Cited by 74 · see citing works
Pejchal, T., Foley, M., Kosofsky, B. E., & Waeber, C. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704555 · Cited by 72 · see citing works
Self-citationSumatriptan, 5-HT1D receptors and obsessive-compulsive disorder
Koran, L. M., Pallanti, S., & Quercioli, L. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00082-7 · Cited by 71 · see citing works
Callaway, C. W., & Geyer, M. A. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10342-x · Cited by 64 · see citing works
Self-citationHollander, E. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00121-9 · Cited by 64 · see citing works
Serotonin-1D hypothesis of obsessive-compulsive disorder: an update.
Zohar, J., Kennedy, J. L., Hollander, E., & Koran, L. M. (2004) · PubMed · Cited by 63 · see citing works
Cheetham, S. C., & Heal, D. J. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb14010.x · Cited by 61 · see citing works
Quednow, B. B., K�hn, K.-U., Stelzenmueller, R., Hoenig, K., Maier, W., & Wagner, M. (2003) · Psychopharmacology · doi:10.1007/s00213-004-1842-6 · Cited by 53 · see citing works
DNA variation and psychopharmacology of the human serotonin receptor 1B(HTR1B) gene
Sanders, A. R., Duan, J., & Gejman, P. V. (2002) · Pharmacogenomics · doi:10.1517/14622416.3.6.745 · Cited by 52 · see citing works
Oberlander, C., Blaquière, B., & Pujol, J. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90382-4 · Cited by 51 · see citing works
Delorme, R., Betancur, C., Wagner, M., Krebs, M., Gorwood, P. A. P. M., Pearl, P. L., Nygren, G., Durand, C. M., Buhtz, F., Pickering, P., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001728 · Cited by 51 · see citing works
Higgins, G. A., JORDAN, C. C., & Skingle, M. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12170.x · Cited by 47 · see citing works
Sumatriptan (5-HT 1D receptor agonist) does not exacerbate symptoms in obsessive compulsive disorder
Pian, K. L. H., Westenberg, H. G. M., van Megen, H. J. G. M., & den Boer, J. A. (1998) · Psychopharmacology · doi:10.1007/s002130050777 · Cited by 40 · see citing works
Sulpiride injection into the dorsal striatum increases methamphetamine-induced gnawing in rats
Koshikawa, N., Aoki, S., Tomiyama, K., Maruyama, Y., & Kobayashi, M. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90213-5 · Cited by 39 · see citing works
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
Ozaki, N., Goldman, D. A., Kaye, W. H., Plotnicov, K. H., Greenberg, B. D., Lappalainen, J., Rudnick, G., & Murphy, D. L. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001415 · Cited by 37 · see citing works
Chaouloff, F., Courvoisier, H., Moisan, M., & Mormède, P. (1999) · Psychopharmacology · doi:10.1007/s002130050841 · Cited by 36 · see citing works
Dulawa, S. C., Hen, R., Scearce-Levie, K. A., & Geyer, M. A. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10176.x · Cited by 33 · see citing works
Self-citationIncreased growth hormone response to sumatriptan challenge in adult autistic disorders
Novotny, S., Hollander, E., Allen, A., Mosovich, S., Aronowitz, B., Cartwright, C., DeCaria, C. M., & Dolgoff-Kaspar, R. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00134-7 · Cited by 29 · see citing works
Paulus, M. P., & Geyer, M. A. (1993) · Psychopharmacology · doi:10.1007/bf02245695 · Cited by 27 · see citing works
Self-citationWisniecki, A., Correa, M., Arizzi, M. N., Ishiwari, K., & Salamone, J. D. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1521-z · Cited by 27 · see citing works
Boshuisen, M. L., & den Boer, J. A. (2000) · Psychopharmacology · doi:10.1007/s002130000529 · Cited by 24 · see citing works
Effects of acute treatment with antidepressant drugs on sensorimotor gating deficits in rats
Pouzet, B., Andersen, M. P., & Hogg, S. L. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1976-6 · Cited by 22 · see citing works
5‐HT3 receptor antagonism by anpirtoline, a mixed 5‐HT1 receptor agonist/5‐HT3 receptor antagonist
Göthert, M., Hamon, M., Barann, M., Bönisch, H., GOZLAN, H., Laguzzi, R. F., Metzenauer, P., Nickel, B., & Szelenyi, I. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13222.x · Cited by 22 · see citing works
Boulenguez, P., Peters, S. L., Mitchell, S. N., Chauveau, J., Gray, J. A., & Joseph, M. H. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200305 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
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Pittenger, C., Bloch, M. H., & Williams, K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.006 · Cited by 426 · see citing works
Haenisch, B., & Bönisch, H. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.12.002 · Cited by 209 · see citing works
Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
Kalueff, A. V., Olivier, J. D. A., Nonkes, L. J. P., & Homberg, J. R. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.003 · Cited by 203 · see citing works
Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder
Ahmari, S. E., Risbrough, V. B., Geyer, M. A., & Simpson, H. B. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.308 · Cited by 189 · see citing works
Self-citationAnimal models of depression and anxiety: What do they tell us about human condition?
Neumann, I. D., Wegener, G., Homberg, J. R., Cohen, H., Slattery, D. A., Zohar, J., Olivier, J. D. A., & Mathé, A. A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.028 · Cited by 159 · see citing works
Ahmari, S. E., & Dougherty, D. D. (2015) · Depression and Anxiety · doi:10.1002/da.22367 · Cited by 128 · see citing works
Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders
Powell, S. B., Weber, M., & Geyer, M. A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_195 · Cited by 120 · see citing works
Self-citationMurphy, D. L., Moya, P. R., Fox, M. A., Rubenstein, L. M., Wendland, J. R., & Timpano, K. R. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0435 · Cited by 107 · see citing works
Placental serotonin: implications for the developmental effects of SSRIs and maternal depression
Velasquez, J. C., Goeden, N., & Bonnin, A. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00047 · Cited by 100 · see citing works
Zike, I. D., Xu, T., Hong, N., & Veenstra-VanderWeele, J. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.012 · Cited by 82 · see citing works
Animal models of obsessive–compulsive disorder: utility and limitations
Alonso, P., López‐Solà, C., Real, E., Segalàs, C., & Menchón, J. M. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s62785 · Cited by 84 · see citing works
Fluoxetine Exerts Age-Dependent Effects on Behavior and Amygdala Neuroplasticity in the Rat
Homberg, J. R., Olivier, J. D. A., Blom, T., Arentsen, T., van Brunschot, C., Schipper, P., Korte-Bouws, G. A. H., van Luijtelaar, G., & Reneman, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016646 · Cited by 84 · see citing works
Marble-burying behavior test as a murine model of compulsive-like behavior
Dixit, P. V., Sahu, R. A., & Mishra, D. K. (2020) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2020.106676 · Cited by 77 · see citing works
Shanahan, N. A., Velez, L. P., Masten, V. L., & Dulawa, S. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.032 · Cited by 72 · see citing works
Self-citationAnimal models of obsessive-compulsive spectrum disorders
d'Angelo, L.-S. C., Eagle, D. M., Grant, J. E., Fineberg, N. A., Robbins, T. W., & Chamberlain, S. R. (2013) · CNS Spectrums · doi:10.1017/s1092852913000564 · Cited by 71 · see citing works
Using mice to model Obsessive Compulsive Disorder: From genes to circuits
Ahmari, S. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.009 · Cited by 68 · see citing works
Pittenger, C., Adams, T. G., Gallezot, J., Crowley, M. J., Nabulsi, N., Ropchan, J., Gao, H., Kichuk, S. A., Simpson, R., Billingslea, E., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.021 · Cited by 54 · see citing works
Wolmarans, D. W., Stein, D. J., & Harvey, B. H. (2016) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-016-0413-8 · Cited by 55 · see citing works
5‐HT1B autoreceptor regulation of serotonin transporter activity in synaptosomes
Hagan, C. E., McDevitt, R. A., Liu, Y. K., Furay, A. R., & Neumaier, J. F. (2012) · Synapse · doi:10.1002/syn.21608 · Cited by 55 · see citing works
Coba, M. P., Ramaker, M. J., Ho, E. V., Thompson, S. L., Komiyama, N. H., Grant, S. G. N., Knowles, J. A., & Dulawa, S. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-20610-y · Cited by 48 · see citing works
Self-citationVelez, L., Sokoloff, G., Miczek, K. A., Palmer, A. A., & Dulawa, S. C. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9325-5 · Cited by 52 · see citing works
Self-citationAssessing the validity of current mouse genetic models of obsessive-compulsive disorder
Wang, L., Simpson, H. B., & Dulawa, S. C. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832a80ad · Cited by 50 · see citing works
Self-citationPharmacotherapeutic Strategies and New Targets in OCD
Pittenger, C. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_204 · Cited by 51 · see citing works
Steiner, J. A., Carneiro, A. M., Wright, J., Matthies, H. J. G., Prasad, H. C., Nicki, C. K., Dostmann, W. R., Buchanan, C. C., Corbin, J. D., Francis, S. H., et al. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-26 · Cited by 48 · see citing works
Arakawa, H. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113432 · Cited by 46 · see citing works
Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
Eriksson, T. M., Alvarsson, A., Stan, T. L., Zhang, X., Hascup, K. N., Hascup, E. R., Kehr, J., Gerhardt, G. A., Warner-Schmidt, J., Arango-Lievano, M., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.130 · Cited by 45 · see citing works
Rogers, J., Li, S., Lanfumey, L., Hannan, A. J., & Renoir, T. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.06.009 · Cited by 42 · see citing works
Jennings, K. A., Lesch, K., Sharp, T., & Cragg, S. J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07001.x · Cited by 41 · see citing works
Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior
Piantadosi, S. C., Manning, E. E., Chamberlain, B. L., Hyde, J., LaPalombara, Z., Bannon, N. M., Pierson, J. L., Namboodiri, V. M. K., & Ahmari, S. E. (2024) · Nature Communications · doi:10.1038/s41467-024-48331-z · Cited by 39 · see citing works
Manning, E. E., Wang, A. Y., Saikali, L. M., Winner, A. S., & Ahmari, S. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-88769-5 · Cited by 36 · see citing works
Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but Not Male Rats
Homberg, J. R., la Fleur, S. E., & Cuppen, E. P. J. G. (2009) · Obesity · doi:10.1038/oby.2009.139 · Cited by 35 · see citing works
Samocha, K. E., Lim, J. E., Cheng, R., Sokoloff, G., & Palmer, A. A. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00613.x · Cited by 35 · see citing works
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice
Thompson, S. L., Welch, A. C., Ho, E. V., Bessa, J. M., Portugal‐Nunes, C., Morais, M., Young, J. W., Knowles, J. A., & Dulawa, S. C. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0558-7 · Cited by 33 · see citing works
Self-citationHTR1B as a risk profile maker in psychiatric disorders: a review through motivation and memory
Drago, A., Alboni, S., Brunello, N., Ronchi, D. D., & Serretti, A. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0724-6 · Cited by 34 · see citing works
5-HT1B receptor modulation of the serotonin transporter in vivo: Studies using KO mice
Montañez, S., Munn, J. L., Owens, W. A., Horton, R. E., & Daws, L. C. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.11.004 · Cited by 34 · see citing works
Ho, E. V., Thompson, S. L., Katzka, W. R., Sharifi, M. F., Knowles, J. A., & Dulawa, S. C. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4086-8 · Cited by 31 · see citing works
Self-citationCosta, D. L. D. C., Shavitt, R. G., Cesar, R. C., Joaquim, M. A., Borcato, S., Valério, C., Miguel, E. C., & Diniz, J. B. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.006 · Cited by 33 · see citing works
Woehrle, N. S., Klenotich, S. J., Jamnia, N., Ho, E. V., & Dulawa, S. C. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2985-0 · Cited by 31 · see citing works
Self-citationSertraline exposure leads to small left heart syndrome in adult mice
Haskell, S. E., Hermann, G. M., Reinking, B. E., Volk, K. A., Peotta, V. A., Zhu, V. L., & Roghair, R. D. (2012) · Pediatric Research · doi:10.1038/pr.2012.183 · Cited by 31 · see citing works
Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
Zabegalov, K. N., Khatsko, S. L., Lakstygal, A. M., Demin, K. A., Cleal, M., Fontana, B. D., McBride, S. D., Harvey, B. H., de Abreu, M. S., Parker, M. O., et al. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.03.044 · Cited by 31 · see citing works
Animal Models for OCD Research
Chamberlain, B. L., & Ahmari, S. E. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_196 · Cited by 26 · see citing works
Duncan, M. J., Hester, J., Hopper, J. A., & Franklin, K. M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07186.x · Cited by 27 · see citing works
Dere, E., Winkler, D., Ritter, C., Ronnenberg, A., Poggi, G., Patzig, J., Gernert, M., Müller, C. P., Nave, K., Ehrenreich, H., et al. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.021 · Cited by 27 · see citing works
Popova, N. K., Naumenko, V. S., Tibeikina, M. A., & Kulikov, A. V. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22155 · Cited by 25 · see citing works
Ketamine induces immediate and delayed alterations of OCD-like behavior
Thompson, S. L., Welch, A. C., Iourinets, J., & Dulawa, S. C. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05397-8 · Cited by 23 · see citing works
Self-citationEmerging drugs to treat obsessive–compulsive disorder
Pallanti, S., Grassi, G., & Cantisani, A. (2013) · Expert Opinion on Emerging Drugs · doi:10.1517/14728214.2014.875157 · Cited by 23 · see citing works
Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice
Lawson, S. K., Gray, A. C., & Woehrle, N. S. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.07.027 · Cited by 25 · see citing works
Bond, C. M., Johnson, J. C., Chaudhary, V., McCarthy, E. M., McWhorter, M. L., & Woehrle, N. S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.06.001 · Cited by 25 · see citing works
Gene knockout animal models of depression, anxiety and obsessive compulsive disorders
Scherma, M., Giunti, E., Fratta, W., & Fadda, P. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000238 · Cited by 21 · see citing works
Chen, X., Yue, J.-H., Luo, Y., Huang, L.-Y., Li, B.-X., & Wen, S.-L. (2021) · Behavioral and Brain Functions · doi:10.1186/s12993-021-00177-x · Cited by 19 · see citing works
Wilson, C., Gattuso, J. J., Hannan, A. J., & Renoir, T. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106223 · Cited by 22 · see citing works
PREPULSE INHIBITION DEFICITS ONLY IN FEMALES WITH OBSESSIVE-COMPULSIVE DISORDER
Steinman, S. A., Ahmari, S. E., Choo, T. H., Kimeldorf, M. B., Feit, R., Loh, S. A., Risbrough, V. B., Geyer, M. A., STEINGLASS, J. E., Wall, M. M., et al. (2016) · Depression and Anxiety · doi:10.1002/da.22474 · Cited by 21 · see citing works
Self-citationCompton, D. M., Dietrich, K. L., Selinger, M. C., & Testa, E. K. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.01.021 · Cited by 21 · see citing works
Andrade, P., Fernández‐Guasti, A., Carrillo-Ruiz, J. D., Ulloa, R. E., Ramírez, Y., Reyes, R., & Jiménez, F. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.04.026 · Cited by 18 · see citing works
Thompson, S. L., & Dulawa, S. C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211239 · Cited by 17 · see citing works
Self-citationAronsen, D., Webster, J., & Schenk, S. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.008 · Cited by 17 · see citing works
Uchiumi, O., Kasahara, Y., Fukui, A., Hall, F. S., Uhl, G. R., & Sora, I. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.07.016 · Cited by 17 · see citing works
Vahabzadeh, A. B. N., & McDougle, C. J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386456-7.05213-8 · Cited by 18 · see citing works
Banerjee, E., Banerjee, D., Chatterjee, A., Sinha, S., & Nandagopal, K. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.04.003 · Cited by 16 · see citing works
Compton, D. M., Selinger, M. C., Westman, E., & Otero, P. (2011) · Psychology & Neuroscience · doi:10.3922/j.psns.2011.1.018 · Cited by 16 · see citing works
O’Reilly, K. C., Connor, M., Pierson, J. L., Shuffrey, L. C., Blakely, R., Ahmari, S. E., & Veenstra-VanderWeele, J. M. (2021) · Psychopharmacology · doi:10.1007/s00213-020-05758-8 · Cited by 14 · see citing works
Zou, J., Gopalakrishnan, S., Parker, C. C., Nicod, J., Mott, R., Cai, N., Lionikas, A., Davies, R. W., Palmer, A. A., & Jonathan Flint, C. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab394 · Cited by 12 · see citing works
Marques, A. M., Macena, M. V., Cardoso, A. R., Hammes, C. S. O., Pinheiro, F. M. L., Castro, N. G., & Neves, G. A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05485-0 · Cited by 10 · see citing works
Animal Models of Tourette Syndrome and Obsessive-Compulsive Disorder
Pittenger, C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00047-0 · Cited by 10 · see citing works
Ho, E. V., Welch, A. C., Thompson, S. L., Knowles, J. A., & Dulawa, S. C. (2023) · PLoS ONE · doi:10.1371/journal.pone.0277446 · Cited by 9 · see citing works
Self-citationMcDougall, S. A., Robinson, J. A. M., Ramirez, E. L., & Diaz, H. A. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172857 · Cited by 9 · see citing works
Borba, J. V., Canzian, J., Resmim, C. M., da Silva, R. M., Duarte, M. C. F., Mohammed, K. A., Schoenau, W., Adedara, I. A., & Rosemberg, D. B. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105715 · Cited by 8 · see citing works
Manning, E. E., & Ahmari, S. E. (2018) · Brain and Neuroscience Advances · doi:10.1177/2398212818783896 · Cited by 7 · see citing works
Kishi, T., Moriwaki, M., Kitajima, T., Kawashima, K., Okochi, T., Fukuo, Y., Furukawa, O., Naitoh, H., Fujita, K., & Iwata, N. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1787-x · Cited by 7 · see citing works
Manning, E. E., Wang, A. Y., Saikali, L. M., Winner, A. S., & Ahmari, S. E. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/694935 · Cited by 7 · see citing works
Payamani, M., Abdollahi-Keyvani, S.-T., Sajjadi, M., Akhondzadeh, S., Javid, R., Nakhaei-Zadeh, R., Jalalian-Javadpour, M., & Vaseghi, S. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174027 · Cited by 7 · see citing works
N-acetylcysteine blocks serotonin 1B agonist-induced OCD-related behavior in mice.
Allen, E. M., Hughes, E. F., Anderson, C. J., & Woehrle, N. S. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000251 · Cited by 6 · see citing works
Anticataleptic effects of 5-HT1B receptors in the globus pallidus
Wang, H., Chen, X., Chen, W., Xue, Y., Wei, L., & Chen, L. (2013) · Neuroscience Research · doi:10.1016/j.neures.2013.09.002 · Cited by 6 · see citing works
Vinkers, C. H., Groenink, L., Pattij, T., Olivier, B., & Bouwknecht, J. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.06.018 · Cited by 6 · see citing works
Circadian rhythmicity in serotonin transporter knockout mice
Pang, R. D., Holschneider, D. P., & Miller, J. D. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.07.018 · Cited by 5 · see citing works
Fitzgerald, P. J. (2013) · International Journal of Neuroscience · doi:10.3109/00207454.2013.856010 · Cited by 5 · see citing works
McDougall, S. A., Roe, M. J., Robinson, J. A. M., Cotter, L. L., Gonzalez, D. J., Gleason, D. C., & Crawford, C. A. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175019 · Cited by 4 · see citing works
Pathophysiological Modeling of Obsessive-Compulsive Disorder: Challenges, and Progress
Pittenger, C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.005 · Cited by 4 · see citing works
Bidirectional Behavioral Selection in Mice: A Novel Pre-clinical Approach to Examining Compulsivity
Mitra, S., & Bult‐Ito, A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.716619 · Cited by 4 · see citing works
Acute serotonin 1B/1A receptor activation impairs behavioral flexibility in C57BL/6J mice
Oliver, B. L., Burdette, M. H., Pahua, A. E., Cavazos, C., Morales, C. A., Alvarez, B. D., & Amodeo, D. A. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113865 · Cited by 3 · see citing works
Roles of serotonin in the fetal brain
Zhao, Q., & Bonnin, A. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00024-4 · Cited by 3 · see citing works
McDougall, S. A., Montejano, N. R., Park, G. I., & Robinson, J. A. M. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-02011-z · Cited by 3 · see citing works
Zou, J., Gopalakrishnan, S., Parker, C. C., Nicod, J., Mott, R., Cai, N., Lionikas, A., Davies, R. W., Palmer, A. A., & Jonathan Flint, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.05.429998 · Cited by 3 · see citing works
Bai, T., Wang, Y., Ruan, H., Zhang, G., Gao, J., Zheng, Z., Li, D., Zhao, Q., Han, H., Fan, Q., et al. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02375-5 · Cited by 2 · see citing works
Wilson, C., Hannan, A. J., & Renoir, T. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109801 · Cited by 3 · see citing works
Yi, M., Zhang, Y., Wang, Y., Su, N., & Liu, S. (2015) · Asia-Pacific Psychiatry · doi:10.1111/appy.12196 · Cited by 1 · see citing works
Uncovering novel therapeutics for schizophrenia: a multitarget approach using the CANDO platformPreprint
Hu, Y., Elefteriou, K., Falls, Z., & Samudrala, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.24.684257 · Cited by 1 · see citing works
SEROTONIN IN EMOTIONAL MEMORY PROCESSES: NEUROPHARMACOLOGICAL STUDIES WITH EMPHASIS ON DEPRESSION
Eriksson, T. (2012) · Figshare
McDougall, S. A., Taylor, J. A., Roe, M. J., & Greenwood, C. J. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06012-5
Ho, E. V., Welch, A. C., Knowles, J., & Dulawa, S. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.28.514214
Self-citationChen, X., Yue, J., Luo, Y., Huang, L., Li, B., & Wen, S. (2021) · Figshare · doi:10.6084/m9.figshare.14615399
Chen, X., Yue, J., Luo, Y., Huang, L., Li, B., & Wen, S. (2021) · Figshare · doi:10.6084/m9.figshare.14615396
Chen, X., Yue, J., Luo, Y., Huang, L., Li, B., & Wen, S. (2021) · Figshare · doi:10.6084/m9.figshare.14615390
Contribution des récepteurs 5-HT4 à la motivation et la prise de décision de manger
Jean, A. (2010) · theses.fr (ABES) · doi:10.70675/804a4a80z3585z415fzba64z9a7f076dd88d
- Authors
- Shanahan, N. A., Holick Pierz, K. A., Masten, V. L., Waeber, C., Ansorge, M., Gingrich, J. A., Geyer, M. A., Hen, R., & Dulawa, S. C.
- Affiliations
- University of California San Diego (US)
- Harvard University (US)
- Columbia University (US)
- University of Chicago (US)
- Corresponding author
- Dulawa, Stephanie C.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 65
- Issue
- 5
- Pages
- 401-408
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2674010
- OpenAlex
- W2058616430
- Cited by
- 102
- References
- 60
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 13 · 2020: 6 · 2019: 8 · 2018: 3 · 2017: 1 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 8
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01MH071555, R01MH079424)
- National Institute on Drug Abuse (DA 02925, T32DA07255-15, R01DA002925, T32DA007255)
- National Institute of Neurological Disorders and Stroke (R01NS049263, R21NS052195)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- serotonin transporter, 5-HT1B receptor, obsessive-compulsive disorder, prepulse inhibition, fluoxetine, serotonin reuptake inhibitors, 8-OH-DPAT, 5-HT1A receptor, globus pallidus, substantia nigra, gain-of-function alleles
- MeSH terms
- Animals, Female, Fluoxetine, Globus Pallidus, Indoles, Mice, Inbred BALB C, Motor Activity, Oxadiazoles, Piperazines, Pyridines, Reflex, Startle, Substantia Nigra, 8-Hydroxy-2-(di-n-propylamino)tetralin, Mice, Knockout, Receptor, Serotonin, 5-HT1B, Serotonin Plasma Membrane Transport Proteins, Mice, Serotonin 5-HT1 Receptor Agonists, Serotonin 5-HT1 Receptor Antagonists
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