Cited by 45Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11

Open access
Eriksson, T M, Alvarsson, A, Stan, T L, Zhang, X, Hascup, K N, Hascup, E R, Kehr, J, Gerhardt, G A +6 more·2013·Molecular Psychiatry

Abstract

Cognitive impairments are common in depression and involve dysfunctional serotonin neurotransmission. The 5-HT1B receptor (5-HT(1B)R) regulates serotonin transmission, via presynaptic receptors, but can also affect transmitter release at heterosynaptic sites. This study aimed at investigating the roles of the 5-HT(1B)R, and its adapter protein p11, in emotional memory and object recognition memory processes by the use of p11 knockout (p11KO) mice, a genetic model for aspects of depression-related states. 5-HT(1B)R agonist treatment induced an impairing effect on emotional memory in wild type (WT) mice. In comparison, p11KO mice displayed reduced long-term emotional memory performance. Unexpectedly, 5-HT(1B)R agonist stimulation enhanced memory in p11KO mice, and this atypical switch was reversed after hippocampal adeno-associated virus mediated gene transfer of p11. Notably, 5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice, as measured by both pre- and postsynaptic criteria. Magnetic resonance spectroscopy demonstrated global hippocampal reductions of inhibitory GABA, which may contribute to the memory enhancement and potentiation of pre- and post-synaptic measures of glutamate transmission by a 5-HT(1B)R agonist in p11KO mice. It is concluded that the level of hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing and modulates hippocampal functionality. These results emphasize the importance of using relevant disease models when evaluating the role of serotonin neurotransmission in cognitive deficits related to psychiatric disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/mp.2012.130

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Eriksson, T. M., Alvarsson, A., Stan, T. L., Zhang, X., Hascup, K. N., Hascup, E. R., Kehr, J., Gerhardt, G. A., Warner-Schmidt, J., Arango-Lievano, M., Kaplitt, M. G., Ögren, S. O., Greengard, P., & Svenningsson, P.
Affiliations
  • Karolinska Institutet (SE)
  • University of Kentucky (US)
  • Weill Cornell Medicine (US)
  • Rockefeller University (US)
Corresponding author
Svenningsson, P
Venue
Molecular Psychiatry
Published
2012-10-02
Volume
18
Issue
10
Pages
1096-1105
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2092360524
Cited by
45
References
54
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 5
FWCI
2.45
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • European Commission (238055)
  • Karolinska Institutet
  • Vetenskapsrådet
  • National Institutes of Health (W81XWH, MH090963)
  • U.S. Public Health Service (DA017186)
  • National Institute of Mental Health (P50MH090963, MH090963)
  • National Institute on Drug Abuse (DA 017186, R01DA017186)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
5-HT1B receptor, p11, emotional memory, object recognition memory, depression, serotonergic neurotransmission, hippocampus, glutamatergic neurotransmission, GABA, presynaptic receptors, AAV gene delivery, cognitive impairment
MeSH terms
S100 Calcium Binding Protein A10, Animals, Avoidance Learning, Depression, Disease Models, Animal, Emotions, Exploratory Behavior, Female, Hippocampus, Male, Memory, Mice, Inbred C57BL, S100 Proteins, Synaptic Transmission, Phosphorylation, Protein Processing, Post-Translational, Pyridines, Reaction Time, Recombinant Fusion Proteins, Transduction, Genetic, Annexin A2, Presynaptic Terminals, Genes, Reporter, Receptors, AMPA, Mice, Knockout, Glutamic Acid, Nuclear Magnetic Resonance, Biomolecular, Receptor, Serotonin, 5-HT1B, Mice, Serotonin 5-HT1 Receptor Agonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review