Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
Open accessAbstract
Cognitive impairments are common in depression and involve dysfunctional serotonin neurotransmission. The 5-HT1B receptor (5-HT(1B)R) regulates serotonin transmission, via presynaptic receptors, but can also affect transmitter release at heterosynaptic sites. This study aimed at investigating the roles of the 5-HT(1B)R, and its adapter protein p11, in emotional memory and object recognition memory processes by the use of p11 knockout (p11KO) mice, a genetic model for aspects of depression-related states. 5-HT(1B)R agonist treatment induced an impairing effect on emotional memory in wild type (WT) mice. In comparison, p11KO mice displayed reduced long-term emotional memory performance. Unexpectedly, 5-HT(1B)R agonist stimulation enhanced memory in p11KO mice, and this atypical switch was reversed after hippocampal adeno-associated virus mediated gene transfer of p11. Notably, 5-HT(1B)R stimulation increased glutamatergic neurotransmission in the hippocampus in p11KO mice, but not in WT mice, as measured by both pre- and postsynaptic criteria. Magnetic resonance spectroscopy demonstrated global hippocampal reductions of inhibitory GABA, which may contribute to the memory enhancement and potentiation of pre- and post-synaptic measures of glutamate transmission by a 5-HT(1B)R agonist in p11KO mice. It is concluded that the level of hippocampal p11 determines the directionality of 5-HT(1B)R action on emotional memory processing and modulates hippocampal functionality. These results emphasize the importance of using relevant disease models when evaluating the role of serotonin neurotransmission in cognitive deficits related to psychiatric disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The NOP-facilitating effect of the 5-HT1B-R agonist CP94253 in 5-HT1B-R adapter protein p11 knockout mice was prevented by overexpression of p11 selectively in the hippocampus.
“The NOP-facilitating effect of the 5-HT1B-R agonist CP94253 in 5-HT1B-R adapter protein p11 knockout mice was prevented by overexpression of p11 selectively in the hippocampus”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Eriksson et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
mouse brain in stereotaxic coordinates
Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258 · see citing works
THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCES
McGaugh, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144157 · Cited by 2,296 · see citing works
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Mechanisms of emotional arousal and lasting declarative memory.
Cahill, L., & McGaugh, J. L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01214-9 · Cited by 1,575 · see citing works
The neuroanatomical and neurochemical basis of conditioned fear
Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092 · see citing works
Course of illness, hippocampal function, and hippocampal volume in major depression
MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works
Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
5-HT1A receptor function in major depressive disorder
Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works
Alterations in 5-HT <sub>1B</sub> Receptor Function by p11 in Depression-Like States
Svenningsson, P., Chergui, K., Rachleff, I., Flajolet, M., Zhang, X., Yacoubi, M. E., Vaugeois, J.-M., Nomikos, G. G., & Greengard, P. (2006) · Science · doi:10.1126/science.1117571 · Cited by 572 · see citing works
Emotion Enhances Learning via Norepinephrine Regulation of AMPA-Receptor Trafficking
Hu, H., Real, E., Takamiya, K., Kang, M.-G., Ledoux, J., Huganir, R. L., & Malinow, R. (2007) · Cell · doi:10.1016/j.cell.2007.09.017 · Cited by 496 · see citing works
Neurocognitive Mechanisms in Depression: Implications for Treatment
Clark, L., Chamberlain, S. R., & Sahakian, B. J. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125618 · Cited by 446 · see citing works
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works
Hippocampus and context in classical conditioning
Holland, P. C., & Bouton, M. E. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80027-0 · Cited by 377 · see citing works
The role of 5-HT1A receptors in learning and memory
Ögren, S. O., Eriksson, T. M., Elvander-Tottie, E., D’Addario, C., Ekstrom, J. C., Svenningsson, P., Meister, B., Kehr, J., & Stiedl, O. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.023 · Cited by 341 · see citing works
Ross, J. M., Öberg, J., Brené, S., Coppotelli, G., Terzioglu, M., Pernold, K., Goiny, M., Sitnikov, R., Kehr, J., Trifunovic, A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008189107 · Cited by 299 · see citing works
Reduced hippocampal volume correlates with executive dysfunctioning in major depression
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jäger, M., Kümmler, P., Ronald Bottlender, A., Zetzsche, T., Born, C., Leinsinger, G. L., et al. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0636 · Cited by 280 · see citing works
Corticohippocampal Contributions to Spatial and Contextual Learning
Burwell, R. D., Saddoris, M. P., Bucci, D. J., & Wiig, K. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0410-04.2004 · Cited by 229 · see citing works
Serotonin and emotional processing: does it help explain antidepressant drug action?
Harmer, C. J. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.036 · Cited by 219 · see citing works
Coolen, L. M., & Wood, R. I. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980921)399:2 · Cited by 207 · see citing works
Role of p11 in Cellular and Behavioral Effects of 5-HT4 Receptor Stimulation
Warner‐Schmidt, J. L., Flajolet, M., Maller, A., Chen, E. Y.-S., Qi, H., Svenningsson, P., & Greengard, P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5343-08.2009 · Cited by 167 · see citing works
Murrough, J. W., Henry, S. E., Hu, J., Gallezot, J., Planeta‐Wilson, B., Neumaier, J. F., & Neumeister, A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1881-0 · Cited by 155 · see citing works
Anisman, H., Du, L., Palkovits, M., Faludi, G., Kovács, G. G., Szontagh-Kisházi, P., Merali, Z., & Poulter, M. O. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0815 · Cited by 143 · see citing works
Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens
Alexander, B., Warner-Schmidt, J., Eriksson, T. M., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001079 · Cited by 140 · see citing works
A cognitive neuropsychological model of antidepressant drug action
Pringle, A., Browning, M., Cowen, P. J., & Harmer, C. J. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.022 · Cited by 130 · see citing works
Emotional memory and psychopathology
The American Association for Research into Nervous and Mental Diseases, LeDoux, J. E., & Muller, J. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0154 · Cited by 124 · see citing works
p11 (S100A10) — an inducible adaptor protein that modulates neuronal functions
Svenningsson, P., & Greengard, P. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.10.001 · Cited by 123 · see citing works
The Effects of Tryptophan Depletion on Neural Responses to Emotional Words in Remitted Depression
Roiser, J. P., Levy, J., Fromm, S. J., Nugent, A. C., Talagala, S. L., Hasler, G., Henn, F. A., Sahakian, B. J., & Drevets, W. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.002 · Cited by 123 · see citing works
Efficacy markers in depression
Harmer, C. J., Cowen, P. J., & Goodwin, G. M. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110367722 · Cited by 122 · see citing works
Zhang, X., Andrén, P. E., Greengard, P., & Svenningsson, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711839105 · Cited by 117 · see citing works
Second-by-Second Measures of l-Glutamate in the Prefrontal Cortex and Striatum of Freely Moving Mice
Hascup, K. N., Hascup, E. R., Pomerleau, F., Huettl, P. F., & Gerhardt, G. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.131698 · Cited by 110 · see citing works
Shanahan, N. A., Holick Pierz, K. A., Masten, V. L., Waeber, C., Ansorge, M., Gingrich, J. A., Geyer, M. A., Hen, R., & Dulawa, S. C. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.026 · Cited by 102 · see citing works
Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains
Noga, J. T., Hyde, T. M., Herman, M. M., Spurney, C. F., Bigelow, L. B., Weinberger, D. R., & Kleinman, J. E. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199711)27:3 · Cited by 97 · see citing works
Neurogenic Effects of Fluoxetine Are Attenuated in p11 (S100A10) Knockout Mice
Egeland, M., Warner-Schmidt, J., Greengard, P., & Svenningsson, P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.024 · Cited by 94 · see citing works
Lieben, C. K. J., van Oorsouw, K. I. M., Deutz, N. E. P., & Blokland, A. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.08.002 · Cited by 93 · see citing works
Differential involvement of the dorsal hippocampus in passive avoidance in C57bl/6J and DBA/2J mice
Baarendse, P. J. J., van Grootheest, G., Jansen, R. F., Pieneman, A. W., Ögren, S. O., Verhage, M., & Stiedl, O. (2007) · Hippocampus · doi:10.1002/hipo.20356 · Cited by 88 · see citing works
Sambeth, A., Blokland, A., Harmer, C. J., Kilkens, T. O. C., Nathan, P. J., Porter, R., Schmitt, J. A. J., Scholtissen, B., Sobczak, S., Young, A. H., et al. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.009 · Cited by 83 · see citing works
Bao, X., Pal, R., Hascup, K. N., Wang, Y., Wang, W., Xu, W., Hui, D., Aǵbaş, A., Wang, X., Michaelis, M. L., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4413-09.2009 · Cited by 82 · see citing works
Eriksson, T. M., Delagrange, P., Spedding, M., Popoli, M., Mathé, A. A., Ögren, S. O., & Svenningsson, P. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.131 · Cited by 73 · see citing works
McDevitt, R. A., Hiroi, R., Mackenzie, S. M., Robin, N. C., Cohn, A., Kim, J. J., & Neumaier, J. F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.029 · Cited by 60 · see citing works
Thomas, T. C., Grandy, D. K., Gerhardt, G. A., & Glaser, P. E. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.74 · Cited by 53 · see citing works
Neurocognitive Impairment and Dementia in Mood Disorders
Pfennig, A., Littmann, E., & Bauer, M. (2007) · Journal of Neuropsychiatry · doi:10.1176/jnp.2007.19.4.373 · Cited by 40 · see citing works
Mlinar, B., Falsini, C., & Corradetti, R. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705026 · Cited by 38 · see citing works
Analysis of the Role of the 5-HT1B Receptor in Spatial and Aversive Learning in the Rat
Lüttgen, M., Madjid, N., Schött, P. A., Sandin, J., & Ögren, S. O. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300235 · Cited by 33 · see citing works
Cell-Type-Specific Modulation of Feedback Inhibition by Serotonin in the Hippocampus
Winterer, J., Stempel, A. V., Dugladze, T., Földy, C., Maziashvili, N., Zivkovic, A. R., Priller, J., Soltész, I., Gloveli, T., & Schmitz, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6382-10.2011 · Cited by 31 · see citing works
Eriksson, T. M., Madjid, N., Elvander-Tottie, E., Stiedl, O., Svenningsson, P., & Ögren, S. O. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.007 · Cited by 30 · see citing works
Uchida, S., Umeeda, H., Kitamoto, A., Masushige, S., & Kida, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.049 · Cited by 28 · see citing works
Peddie, C. J., Davies, H. A., Colyer, F. M., Stewart, M. G., & Rodríguez, J. J. (2008) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2008.05.001 · Cited by 28 · see citing works
Hu, X. J., Wang, F., Stenfors, C., Ögren, S. O., & Kehr, J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.12.002 · Cited by 20 · see citing works
Stark, K. L., & Hen, R. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114579900142x · Cited by 18 · see citing works
Symptom relief and facilitation of emotional processing
Goodwin, G. M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.016 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Running-induced systemic cathepsin B secretion is associated with memory function
Moon, H. Y., Becke, A., Berron, D., Becker, B., Sah, N., Benoni, G., Janke, E., Lubejko, S. T., Greig, N. H., Mattison, J. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.025 · Cited by 628 · see citing works
Barnes, N. M., Ahern, G. P., Bécamel, C., Bockaert, J., Camilleri, M., Chaumont‐Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C. F., Gershon, M. D., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.118.015552 · Cited by 264 · see citing works
Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders
Fakhoury, M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9152-z · Cited by 248 · see citing works
p11 and its role in depression and therapeutic responses to antidepressants
Svenningsson, P., Kim, Y. D., Warner‐Schmidt, J. L., Oh, Y., & Greengard, P. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3564 · Cited by 175 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
The role of serotonin in memory: interactions with neurotransmitters and downstream signaling
Seyedabadi, M., Fakhfouri, G., Ramezani, V., Mehr, S. E., & Rahimian, R. (2014) · Experimental Brain Research · doi:10.1007/s00221-013-3818-4 · Cited by 137 · see citing works
Mechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111 · see citing works
Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice
Cheon, S. Y., Koo, B., Kim, S. Y., Kam, E. H., Nam, J., & Kim, E. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87790-y · Cited by 97 · see citing works
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., Gómez‐Galán, M., Sopova, E., Joodmardi, E., Yoshitake, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4004 · Cited by 80 · see citing works
Cao, J. P., LaRocque, E., & Li, D. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32128 · Cited by 63 · see citing works
Alvarsson, A., Zhang, X., Stan, T. L., Schintu, N., Kadkhodaei, B., Millan, M. J., Perlmann, T., & Svenningsson, P. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1312-15.2015 · Cited by 62 · see citing works
Modulation of Ion Channels and Receptors by p11 (S100A10)
Seo, J.-S., & Svenningsson, P. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.04.004 · Cited by 51 · see citing works
Cell‐ and region‐specific expression of depression‐related protein p11 (S100a10) in the brain
Milosevic, A., Liebmann, T., Knudsen, M. G., Schintu, N., Svenningsson, P., & Greengard, P. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24113 · Cited by 50 · see citing works
Conversion of short-term to long-term memory in the novel object recognition paradigm
Moore, S. J., Deshpande, K. S., Stinnett, G. S., Seasholtz, A. F., & Murphy, G. G. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.06.014 · Cited by 49 · see citing works
Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor
Lian, L., Xu, Y., Zhang, J., Yu, Y., Zhu, N., Guan, X., Huang, H., Chen, R., Chen, J., Shi, G., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.003 · Cited by 48 · see citing works
Oh, S.-J., Cheng, J., Jang, J., Arace, J., Jeong, M., Shin, C.-H., Park, J., Jin, J., Greengard, P., & Oh, Y. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0384-6 · Cited by 47 · see citing works
5-HT6 receptor agonism facilitates emotional learning
Pereira, M., Martynhak, B. J., Andreatini, R., & Svenningsson, P. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00200 · Cited by 44 · see citing works
Axo‐axonic synapses: Diversity in neural circuit function
Cover, K. K., & Mathur, B. N. (2020) · The Journal of Comparative Neurology · doi:10.1002/cne.25087 · Cited by 44 · see citing works
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression
Medrihan, L., Umschweif, G., Sinha, A., Reed, S., Lee, J., Gindinova, K., Sinha, S. C., Greengard, P., & Sagi, Y. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.1179 · Cited by 37 · see citing works
Insights into Serotonin Receptor Trafficking
Darmon, M. C., Awabdh, S. A., Emerit, M. B., & Masson, J. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.02.009 · Cited by 34 · see citing works
Marin, P., Bécamel, C., Chaumont‐Dubel, S., Vandermoere, F., Bockaert, J., & Claeysen, S. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00005-0 · Cited by 32 · see citing works
Stan, T. L., Alvarsson, A., Branzell, N., Sousa, V. C., & Svenningsson, P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.39 · Cited by 28 · see citing works
P11 deficiency increases stress reactivity along with HPA axis and autonomic hyperresponsiveness
Sousa, V. C., Mantas, I., Stroth, N., Hager, T., Pereira, M., Jiang, H., Jabre, S., Pasławski, W., Stiedl, O., & Svenningsson, P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00887-0 · Cited by 25 · see citing works
Molecular and Cellular Aspects of Major Depressive Disorder
Chottekalapanda, R. U., Greengard, P., & Sagi, Y. (2019) · doi:10.1093/oso/9780190455132.003.0004 · Cited by 23 · see citing works
Probable involvement of p11 with interferon alpha induced depression
Guo, J., Zhang, W., Zhang, L., Ding, H., Zhang, J., Song, C., Zhang, Y., Xia, N., Li, M., Liang, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep17029 · Cited by 23 · see citing works
How do stupendous cannabinoids modulate memory processing via affecting neurotransmitter systems?
Vaseghi, S., Nasehi, M., & Zarrindast, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.018 · Cited by 21 · see citing works
Electrochemical techniques for subsecond neurotransmitter detection in live rodents.
Hascup, K. N., & Hascup, E. R. (2014) · PubMed Central · Cited by 20 · see citing works
Frameworking memory and serotonergic markers
Meneses, A. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0079 · Cited by 19 · see citing works
Stan, T. L., Sousa, V. C., Zhang, X., Ono, M., & Svenningsson, P. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.007 · Cited by 18 · see citing works
Zhou, M.-H., Sun, F., Xu, C. S., Chen, H., Qiao, H., Cai, X., Ma, X., & An, S.-C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.021 · Cited by 12 · see citing works
Ibrahim, E. C., Guillemot, V., Comte, M., Tenenhaus, A., Zendjidjian, X. Y., Cancel, A., Belzeaux-R, R., Sauvanaud, F., Blin, O., Frouin, V., et al. (2017) · Schizophrenia · doi:10.1038/s41537-017-0027-3 · Cited by 11 · see citing works
The Effect of Early Life Stress on Emotional Behaviors in GPR37KO Mice
Veenit, V., Zhang, X., Ambrosini, A., Sousa, V. C., & Svenningsson, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010410 · Cited by 11 · see citing works
Reduction of p11 in dorsal raphe nucleus serotonergic neurons mediates depression-like behaviors
Li, W., Shen, Z., Yin, X., Chang, W., Chen, X., Yu, J. M., & Xu, S. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02664-3 · Cited by 10 · see citing works
Weiss, R., Bitton, A., Nahary, L., Arango, M., Benhar, I., Blank, M., Shoenfeld, Y., & Chapman, J. (2016) · Immunologic Research · doi:10.1007/s12026-016-8840-8 · Cited by 9 · see citing works
Camargo, A., Nilsson, A., Shariatgorji, M., Appleton, E., Branzell, N., Doyon, D., Giovenzana, M., Zhang, X., Dautan, D., Andrén, P. E., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02853-6 · Cited by 7 · see citing works
Impaired Aversive Memory Formation in GPR37L1KO Mice
Veenit, V., Zhang, X., Pasławski, W., Mantas, I., & Svenningsson, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214290 · Cited by 4 · see citing works
Guo, J., Ding, H., Lv, Z., Jiao, J., Wang, H., & Ji, Y. (2019) · Journal of Biosciences · doi:10.1007/s12038-019-9906-2 · Cited by 3 · see citing works
Scopolamine-induced Delirium Promotes Neuroinflammation and Neuropsychiatric Disorder in MicePreprint
Cheon, S. Y., Koo, B., Kim, S. Y., Kam, E. H., Nam, J., & Kim, E. J. (2020) · Research Square · doi:10.21203/rs.3.rs-126768/v1 · Cited by 1 · see citing works
Serotonergic Modulation of Activity Pattern on Neuronal Network
Shimba, K., Arimatsu, K., Isomura, T., Takeuchi, A., Kotani, K., & Jimbo, Y. (2013) · IEEJ Transactions on Electronics Information and Systems · doi:10.1541/ieejeiss.133.1814
The new molecular targets for antidepressants
Kuznetsov, Y. V., Евдокимов, Д. В., & Абрамец, И. И. (2021) · Medical Herald of the South of Russia · doi:10.21886/2219-8075-2021-12-1-24-32
(2014) · Elsevier eBooks · doi:10.1016/b978-0-12-800836-2.00022-2
Altered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction
Dautan, D., Camargo, A., Branzell, N., Brioschi, V. I., Doyon, D., Covatta, E., Marongiu, R., Kaplitt, M. G., Chergui, K., Zhang, X., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03324-2
Zolmitriptan ameliorates memory impairment secondary to depression via 5-HT-1B/1D receptors
Afzal, A., Batool, Z., Rafiq, S., Agha, F., Nawaz, A., & Haider, S. (2026) · Next research. · doi:10.1016/j.nexres.2026.102204
Targeting the serotonin 1B receptor for the treatment of depression and anxiety
Fleury, S., & Nautiyal, K. M. (2026) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2026.2738183
Fleury, S., Shang, Y., & Nautiyal, K. M. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07184-8
- Authors
- Eriksson, T. M., Alvarsson, A., Stan, T. L., Zhang, X., Hascup, K. N., Hascup, E. R., Kehr, J., Gerhardt, G. A., Warner-Schmidt, J., Arango-Lievano, M., Kaplitt, M. G., Ögren, S. O., Greengard, P., & Svenningsson, P.
- Affiliations
- Karolinska Institutet (SE)
- University of Kentucky (US)
- Weill Cornell Medicine (US)
- Rockefeller University (US)
- Corresponding author
- Svenningsson, P
- ORCID
- Venue
- Molecular Psychiatry
- Published
- 2012-10-02
- Volume
- 18
- Issue
- 10
- Pages
- 1096-1105
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC3781317
- OpenAlex
- W2092360524
- Cited by
- 45
- References
- 54
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 9 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 4 · 2013: 5
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Molecular Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- European Commission (238055)
- Karolinska Institutet
- Vetenskapsrådet
- National Institutes of Health (W81XWH, MH090963)
- U.S. Public Health Service (DA017186)
- National Institute of Mental Health (P50MH090963, MH090963)
- National Institute on Drug Abuse (DA 017186, R01DA017186)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 5-HT1B receptor, p11, emotional memory, object recognition memory, depression, serotonergic neurotransmission, hippocampus, glutamatergic neurotransmission, GABA, presynaptic receptors, AAV gene delivery, cognitive impairment
- MeSH terms
- S100 Calcium Binding Protein A10, Animals, Avoidance Learning, Depression, Disease Models, Animal, Emotions, Exploratory Behavior, Female, Hippocampus, Male, Memory, Mice, Inbred C57BL, S100 Proteins, Synaptic Transmission, Phosphorylation, Protein Processing, Post-Translational, Pyridines, Reaction Time, Recombinant Fusion Proteins, Transduction, Genetic, Annexin A2, Presynaptic Terminals, Genes, Reporter, Receptors, AMPA, Mice, Knockout, Glutamic Acid, Nuclear Magnetic Resonance, Biomolecular, Receptor, Serotonin, 5-HT1B, Mice, Serotonin 5-HT1 Receptor Agonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review