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Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene
Open accessAbstract
Background Childhood maltreatment and early trauma leave lasting imprints on neural mechanisms of cognition and emotion. Using a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic marks at the Brain-derived Neurotrophic Factor (BDNF) gene in the CNS. Methods During the first postnatal week, we exposed infant rats to stressed caretakers that predominately displayed abusive behaviors. We then assessed DNA methylation patterns and gene expression throughout the life span, as well as DNA methylation patterns in the next generation of infants. Results Early maltreatment produced persisting changes in methylation of BDNF DNA that caused altered BDNF gene expression in the adult prefrontal cortex. Furthermore, we observed altered BDNF DNA methylation in offspring of females that had previously experienced the maltreatment regimen. Conclusions These results highlight an epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect.
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“Furthermore, the findings suggested germ-line inheritance because cross-fostering could not completely erase these DNA methylation changes.”
From Biological Embedding of Early-Life Adversity and a Scoping Review of the Evidence for Intergenerational Epigenetic Transmission of Stress and Trauma in Humans (2023) · cites this paper as [73]
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“ELS results in hippocampal hypermethylation at the promoter regions of genes related to the stress axis and brain development, including glucocorticoid receptor (NR3c1) region 17 29–31 and brain derived neurotrophic factor (BDNF) region IV32–34.”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [32]
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“Other animal findings also suggested ELS/CT-related epigenetic changes in the CNS growth and differentiation-related BDNF gene expression (407), while in a genome-wide blood DNA methylation analysis study by Houtepen et al. (408), a locus in the Kit ligand gene (KITLG;”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [407]
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“Early-life maltreatment of infant rats produced persistent changes in Bdnf DNA methylation that were passed to the next generation by maltreated mothers [73].”
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“Infant maltreatment increases DNA methylation and reduces BDNF gene expression in the PFC (191).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [191]
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“Differential levels of DNA methylation of genes related to stress reactivity have already been associated with PTSD and early life stress [93-95].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [94]
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“In a related study, adult rats exposed to mistreatment at an early age exhibited higher levels of DNA methylation at CpG sites within the Bdnf promoter as well as decreased levels of Bdnf mRNA.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [124]
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“as compared to average reported increases for the same regions resulting from early-life stress of 95%32–34 and 135%29, 30, 47, respectively”
From Maternal and Early-Life Circadian Disruption Have Long-Lasting Negative Consequences on Offspring Development and Adult Behavior in Mice (2017) · cites this paper as [32]
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Citations
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
DNA methylation landscapes: Provocative insights from epigenomics
Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039
Environmental epigenomics and disease susceptibility
Jirtle, R. L., & Skinner, M. K. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2045 · Cited by 2,492
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
The neurobiological consequences of early stress and childhood maltreatment
Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., Navalta, C. P., & Kim, D. M. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00007-1 · Cited by 1,465
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Olasunkanmi, O. I., Aremu, J., Wong, M., Licinio, J., & Zheng, P. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.10.028 · Cited by 5
Parks, K. C., Buthmann, J. L., Teh, A. L., Chen, L., Chen, H. Y., & Gotlib, I. H. (2025) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2025.107650 · Cited by 4
“It is noteworthy that CpG sites of genes that loaded highly on the DNAm component, such as CRHBP , HSD11B1 , HTR2A , and NCOR2 , were located within the gene body, where methylation is typically associated with increased gene expression (Roth et al., 2009).”
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Mariotti, V., Palumbo, S., & Pellegrini, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-25816-0_6 · Cited by 5
Meng, X., Bao, B., & Yue, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18469 · Cited by 4
Lauby, S. C., Agarwal, I., Lapp, H. E., Salazar, M., Semyrenko, S., Chauhan, D., Margolis, A. E., & Champagne, F. A. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105745 · Cited by 4
“Early-life maternal maltreatment or social enrichment has been associated with DNA methylation levels of several BDNF transcript variants and/or mRNA expression in multiple brain regions, including the hippocampus and amygdala (Branchi et al., 2013; Roceri et al., 2002; Roth et al., 2009, 2014).”
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Labonté, B., & Turecki, G. (2011) · Springer eBooks · doi:10.1007/978-3-642-17426-1_4 · Cited by 4
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Labonté, B., & Turecki, G. (2013) · Santé mentale au Québec · doi:10.7202/1014943ar · Cited by 4
Pittenger, C. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.041 · Cited by 4
On the origin of information in epigenetic structures in metazoans
Cabej, N. R. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.06.016 · Cited by 4
“their puppies as well and show the same hypermethylation of the bdnf gene [35].”
BackgroundUribe, E., & Wix, R. (2011) · eNeurobiología · Cited by 4
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Ratner, K. G., & Kubota, J. T. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00223 · Cited by 4
“For instance, rat pups raised by stressed mothers demonstrate increased methylation of the gene for BDNF and this methylation is passed on to offspring (Roth et al., 2009).”
BackgroundPost, R. M. (2014) · Journal of Child and Adolescent Behaviour · doi:10.4172/2375-4494.1000167 · Cited by 3
“It is likely that both mechanisms will carry vulnerablitity to psychiatric illness into the next generation, not only via conventional genetic transmission, but possibly via transgenerational epigenetic transmission which is now increasingly recognized for parental exposure to stressors and substance abuse [19-22].”
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Lee, R. S. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-24493-8_4 · Cited by 4
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Mundorf, A., & Freund, N. (2019) · RNA technologies · doi:10.1007/978-3-030-14792-1_9 · Cited by 5
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Pels, K. K. (2020) · Kosmos · doi:10.36921/kos.2020_2619 · Cited by 5
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Wu, R., & Rebok, G. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108552684.042 · Cited by 4
Gromov, V. S. (2020) · Biology Bulletin Reviews · doi:10.1134/s2079086420040027 · Cited by 4
Gkesoglou, T., Pervanidou, P., Bozikas, V. P., & Agorastos, A. (2022) · Psychiatriki · doi:10.22365/jpsych.2022.059 · Cited by 5
Park, H. Y., Bang, M., Seo, E., Koo, S. J., Lee, E. M., Lee, S., & An, S. K. (2022) · Schizophrenia · doi:10.1038/s41537-022-00258-4 · Cited by 5
Recław, R., Lachowicz, M., Chmielowiec, K., Chmielowiec, J., Strońska-Pluta, A., Kowalski, M. T., Kudliński, B., & Grzywacz, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010532 · Cited by 5
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BackgroundSchoenrock, S. A., & Tarantino, L. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00009-7 · Cited by 4
Cory‐Slechta, D. A. (2018) · Advances in neurotoxicology · doi:10.1016/bs.ant.2018.03.007 · Cited by 4
Curley, J. P., Rahia Mashoodh, A., & Champagne, F. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805388-1.00024-9 · Cited by 4
Factors inducing depression as effective tool in therapy
Khushboo, K., & Sharma, B. (2019) · Medical and Clinical Archives · doi:10.15761/mca.1000163 · Cited by 4
“The level of stressors in the life of humans is ever on increase in modern era since very transition from childhood, puberty and adulthood making them susceptible to development of psychological disorders finally leading to depression [1].”
BackgroundDifferent Types of Childhood Adverse Experiences and Mood Disorders
Alciati, A. (2012) · InTech eBooks · doi:10.5772/33568 · Cited by 4
Haselbeck, C., Kulle, A. E., Niederberger, U., Bergmann, T. O., Steinmann, E., Holterhus, P., Petermann, F., & Gerber, W. (2013) · Kindheit und Entwicklung · doi:10.1026/0942-5403/a000121 · Cited by 7
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Paslakis, G., Bleich, S., Frieling, H., & Deuschle, M. (2011) · Der Nervenarzt · doi:10.1007/s00115-010-3200-8 · Cited by 5
Schmidt, B. L., Santos, M. J., Cariaga-Martínez, A. E., Hill, L., Barloese, M. C. J., & Hall, Z. J. (2017) · Cited by 4
Lin, C. C., Hung, Y. Y., & Huang, T. L. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000343 · Cited by 4
“Epigenetic mechanisms have been applied to animal models of depression at the BDNF promoter [24-26], particularly in exon I, exon IV, and exon IX.”
BackgroundCurley, J. P., Rahia Mashoodh, A., & Champagne, F. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00023-2 · Cited by 4
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Perez-Polo, J. R. (2017) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.08.002 · Cited by 4
Kumar, A., Kumar, P., Faiq, M. A., Pareek, V., Raza, K., Mochan, S., Prasoon, P., & Sharma, V. (2017) · Preprints.org · doi:10.20944/preprints201710.0047.v2 · Cited by 3
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BackgroundEpigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · Research Publications (Maastricht University) · doi:10.26481/dis.20131129fb · Cited by 4
Vaishnav, V. A. D., Patel, R., Maturkar, V., Patel, C., & Jain, N. S. (2025) · Synapse · doi:10.1002/syn.70028 · Cited by 3
Wang, L., Lv, B., & Ma, Z. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1734160 · Cited by 5
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Pace, R., & Blundell, R. (2018) · Open Journal of Genetics · doi:10.4236/ojgen.2018.83007 · Cited by 3
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BackgroundEpigenetic processes associated with neonatal spinal transection
Collins, N. J., Campbell, T. S., Bozeman, A. L., Martes, A. C., Ross, S. E., Doherty, T. S., Brumley, M. R., & Roth, T. L. (2024) · Developmental Psychobiology · doi:10.1002/dev.22466 · Cited by 3
Self-citationWang, J., Schupp, W., & Sakata, K. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01196-4 · Cited by 4
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Matt, S. M., Roth, E. D., & Roth, T. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00005-x · Cited by 3
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Schafe, G. E. (2014) · Epigenomics · doi:10.2217/epi.14.6 · Cited by 3
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Weaver, I. C. G. (2014) · Cell & Developmental Biology · doi:10.4172/2168-9296.1000132 · Cited by 3
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BackgroundThe Biosocial Bases of Aggressivity and Aggressive Behavior
Львович, М. А. (2018) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-018-0558-8 · Cited by 3
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Oh, Y.-E., Nguyen, T. B., Rami, F. Z., Karamikheirabad, M., & Chung, Y. (2022) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2022.20.1.51 · Cited by 3
“We measured DNA methylation levels of the Drd2, Nr3c1, and Stmn1 genes in the PFC, AMY, and HIP using pyrosequencing.”
BackgroundMethodInfluentialBereft and Left: The interplay between insecure attachment, isolation, and neurobiology
Bell, K., McMillin, K., & Ethridge, L. E. (2022) · Developmental Review · doi:10.1016/j.dr.2022.101020 · Cited by 3
Campbell, T. S., & Roth, T. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821785-6.00013-x · Cited by 3
Self-citationSiller, S., Westneat, D. F., Heidinger, B. J., Solomon, J. W., & Rubenstein, D. R. (2023) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2023.114336 · Cited by 4
Lonstein, J. S., Vitale, E. M., Olekanma, D. I., McLocklin, A., Pence, N., Bredewold, R., Veenema, A. H., Johnson, A. W., & Burt, S. A. (2023) · Developmental Psychobiology · doi:10.1002/dev.22421 · Cited by 4
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Bocchio‐Chiavetto, L., & Maffioletti, E. (2015) · MALTRATTAMENTO E ABUSO ALL INFANZIA · doi:10.3280/mal2015-003003 · Cited by 3
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Roth, T. L. (2017) · Policy Insights from the Behavioral and Brain Sciences · doi:10.1177/2372732217719091 · Cited by 3
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BackgroundSelf-citationGene-Environment Interactions and Epigenetic Mechanisms in Depression
Jawahar, M. C., Toben, C. G., & Baune, B. T. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00003-2 · Cited by 3
An, I., Bang, M., & Lee, S.-H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.03.008 · Cited by 3
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Lozupone, M., Mollica, A., Berardino, G., Sardone, R., & Panza, F. (2021) · Epigenomics · doi:10.2217/epi-2021-0390 · Cited by 3
Latchney, S. E., Cadney, M. D., Hopkins, A., & Garland, T. (2023) · Genes Brain & Behavior · doi:10.1111/gbb.12858 · Cited by 2
“118 It is possible that the decreased methylation of Bdnf and corresponding upregulation of Bdnf transcript in HR mice could be a result of increased neuronal activation.”
BackgroundQuiroz, J. A., Chen, G., Drevets, W. C., Henter, I. D., & Manji, H. K. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511980053.004 · Cited by 3
Zender, R., & Olshansky, E. F. (2012) · Biological Research for Nursing · doi:10.1177/1099800412450505 · Cited by 2
In Utero Bisphenol A Exposure and Epigenetic Programming of Neurobehavioral Outcomes
Kundaković, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-25325-1_3 · Cited by 3
Munshi, A., Srirama, K., & Ahuja, Y. R. (2013) · CRC Press eBooks · doi:10.1201/b14289-4 · Cited by 3
Landoni, M., Muta, A. D., Tella, S. D., Ciuffo, G., Blasio, P. D., & Ionio, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074052 · Cited by 2
“A similar process may also affect the gene encoding brain-derived neurotrophic factor [47].”
BackgroundRisiko, Vulnerabilität, Resilienz und Prävention
Fegert, J. M., & Resch, F. (2011) · Springer eBooks · doi:10.1007/978-3-642-19846-5_5 · Cited by 3
Epigenetics in Posttraumatic Stress Disorder
Hunter, R. G. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00016-4 · Cited by 3
Kumar, A., Kumar, P., Pareek, V., Faiq, M. A., Raza, K., Prasoon, P., Mochan, S., & Sharma, V. (2017) · Preprints.org · doi:10.20944/preprints201710.0047.v1 · Cited by 3
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BackgroundTurner, J. D., Kirschner, S. A., Molitor, A. M., Evdokimov, K., & Muller, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-08-097086-8.14142-x · Cited by 3
Roddy, S. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-10944-7.00034-2 · Cited by 4
From “Gig” to Genes: The enduring legacy of Seymour Levine in developmental stress neurobiology
Schmidt, M. V. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100772 · Cited by 2
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Rachmany, L., Abreu, F. F., Walker, V., O'Neill, O. S., Sargin, D., & Teixeira, C. M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106663 · Cited by 5
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Wenderski, W., & Maze, I. S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00021-8 · Cited by 2
Peregud, D., Freiman, S. V., Тишкина, А. О., Sokhranyaeva, L. S., Лазарева, Н. А., Onufriev, M. V., Stepanichev, M. Y., & Gulyaeva, N. V. (2017) · Russian Journal of Genetics Applied Research · doi:10.1134/s2079059717010117 · Cited by 2
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BackgroundResultInfluentialFrom animal to human epigenetics
Berretta, E., Cutuli, D., Laricchiuta, D., & Petrosini, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819262-7.00002-7 · Cited by 2
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Gargiulo, Á. J. M., Scévola, L., Sarudiansky, M., Kochen, S. S., & D’Alessio, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-61721-9_38 · Cited by 2
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van Heeringen, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316563205.003 · Cited by 3
Suriyaprom, K., Pheungruang, B., Pooudong, S., Putpadungwipon, P., & Sirikulchayanonta, C. (2023) · Journal of Nutrition and Metabolism · doi:10.1155/2023/9668626 · Cited by 2
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BackgroundAdolescent nonpharmacological interventions for early-life stress and their mechanisms
Li, Y., Shi, D., & Wang, Z. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114580 · Cited by 2
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Bock, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-59286-7_8 · Cited by 2
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Zhao, Y., & Bhatnagar, S. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-66686-5_4 · Cited by 2
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Campbell, T. S., Donoghue, K. M., & Roth, T. L. (2025) · Developmental Psychobiology · doi:10.1002/dev.70017 · Cited by 2
Self-citationDissociative Disorders: Neuroimaging as a New Narrative
Modesti, M. N., & CASALE, A. D. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_47 · Cited by 2
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Moshe Szyf, A. (2013) · Epigenetics and human health · doi:10.1007/978-3-642-36827-1_2 · Cited by 1
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BackgroundEpigenetics, Gender, and Sex in the Diagnosis of Depression
Mehl‐Madrona, L., McFarlane, P. S., & Mainguy, B. (2019) · Current Psychiatry Research and Reviews · doi:10.2174/2666082215666191029141418 · Cited by 3
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Champagne, F. A., & Curley, J. P. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10028-9 · Cited by 3
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Labonté, B., & Turecki, G. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8078-5_8 · Cited by 2
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BackgroundInfluentialNeonatal maltreatment and brain development
Yurdakök, K. (2014) · Journal of pediatric and neonatal individualized medicine · doi:10.7363/030228 · Cited by 2
“Epigenetic silencing of BDNF gene may account for the profound effect of childhood maltreatment and lead to heightened risk of psychopathology among abused children [48].”
BackgroundTraces épigénétiques des carences affectives précoces
Ladha, K., Monhonval, P., & Lotstra, F. (2013) · Cahiers critiques de thérapie familiale et de pratiques de réseaux · doi:10.3917/ctf.049.0205 · Cited by 2
Epigenetic Mechanisms in Learning and Memory
Day, J. J., & Sweatt, J. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00005-7 · Cited by 2
Self-citationChallenge of Developing a Validated Animal Model of PTSD – Focus on Juvenile Stress Model
Richter‐Levin, G., Kehat, O., Shtoots, L., & Ruchi, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-08613-2_121-1 · Cited by 2
Epigenetics of Suicidal Behaviour
Turecki, G. (2015) · Advances in biological psychiatry · doi:10.1159/000434738 · Cited by 2
How do signaling molecules organize higher brain functions?
Гомазков, О. А. (2015) · Biology Bulletin Reviews · doi:10.1134/s2079086415040015 · Cited by 2
Environmental Influences on Epigenetic Gene Regulation
Fung, C. M., McKnight, R. A., & Lane, R. H. (2013) · NeoReviews · doi:10.1542/neo.14-3-e121 · Cited by 2
Toward a Diathesis-Stress Model of Schizophrenia in a Neurodevelopmental Perspective
Berry, A., & Cirulli, F. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00013-4 · Cited by 2
Early-Life Adversity and Epigenetic Changes
Labonté, B., Farah, A., & Turecki, G. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9781139424745.012 · Cited by 2
Epigenetic Approaches to Define the Molecular and Genetic Risk Architectures of Schizophrenia
Kundaković, M., Peter, C. J., Roussos, P., & Akbarian, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801829-3.00013-6 · Cited by 2
The Social Environment and Epigenetics in Psychiatry
McGowan, P. O., Sasaki, A., & Roth, T. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00026-7 · Cited by 2
Self-citationEpigenetic Biomarkers for Early-Life Adversity
Turecki, G. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-29901-3_7 · Cited by 2
Epigenetics of Psychiatric Disorders
Kundaković, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00019-3 · Cited by 3
Everyday Epigenetics: From Molecular Intervention to Public Health and Lifestyle Medicine
Herbert, M. R. (2013) · North American Journal of Medicine and Science · Cited by 2
Biological Embedding of Childhood Maltreatment in Adult Depression
Jawahar, M. C., & Baune, B. T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811073-7.00017-9 · Cited by 2
Falcone, T., Staniskyte, M., Forcén, F. E., & Vengoechea, J. (2018) · Springer eBooks · doi:10.1007/978-3-319-74391-2_1 · Cited by 3
The Neurochemistry and Epigenetics of PTSD
Post, R. M. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780190457136.003.0014 · Cited by 2
Lamarck Revisited: The Implications of Epigenetics for Environmental Law
Vandenbergh, M. P., Vandenbergh, D. J., & Vandenbergh, J. G. (2017) · Michigan Journal of Environmental & Administrative Law · doi:10.36640/mjeal.7.1.lamarck · Cited by 2
Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
Short, A. K., Bolton, J. L., & Baram, T. Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00012-4 · Cited by 4
“…outcomes produced by the LBN approach have been reliably reproduced by numerous laboratories and multiple outcome measures (Moriceau et al., 2009; Roth et al., 2009; Dalle Molle et al., 2012; Raineki et al., 2012; Gunn et al., 2013; Malter Cohen et al., 2013; Naninck et al., 2015; Walker et al.,…”
BackgroundGene expression associated with PTSD in World Trade Center responders: An RNA sequencing study
Kuan, P.-F., Waszczuk, M. A., Kotov, R., Clouston, S., Yang, X., Singh, P. K., Glenn, S. T., Cortes Gomez, E., Wang, J., Bromet, E., et al. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0050-1 · Cited by 80
Metadata
- Authors
- Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D.
- Affiliations
- University of Alabama (US)
- University of Alabama at Birmingham (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 65
- Issue
- 9
- Pages
- 760-769
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3056389
- OpenAlex
- W1965636455
- Semantic Scholar
- 73b25ed907cfc11b7dfd5f2e6c7e3f05afbe7148
- Cited by
- 1,273
- References
- 75
- Citations by year
- 2026: 26 · 2025: 27 · 2024: 37 · 2023: 38 · 2022: 39 · 2021: 68 · 2020: 78 · 2019: 77 · 2018: 90 · 2017: 91 · 2016: 107 · 2015: 100 · 2014: 145 · 2013: 105 · 2012: 91
- FWCI
- 86.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG031722)
- National Institute of Mental Health (MH 57014, R01MH057014)
- National Institute of Neurological Disorders and Stroke (NS048811, F32NS048811)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- childhood adversity, child abuse, brain-derived neurotrophic factor, DNA methylation, epigenetics, transgenerational transmission, prefrontal cortex, gene expression, infant rat model, caregiver abuse, neglect
- MeSH terms
- Animals, Animals, Newborn, Cytidine, Female, Hippocampus, Injections, Intraventricular, Male, Maternal Behavior, Stress, Psychological, Gene Expression, Prefrontal Cortex, DNA Methylation, Brain-Derived Neurotrophic Factor, Rats, Long-Evans, Models, Animal, Epigenesis, Genetic, Rats
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