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Dopamine D2 Receptor Levels in Striatum, Thalamus, Substantia Nigra, Limbic Regions, and Cortex in Schizophrenic Subjects

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Kessler, Robert M., Woodward, Neil D., Riccardi, Patrizia, Li, Rui, Ansari, M. Sib, Anderson, Sharlett, Dawant, Benoit, Zald, David +1 more·2009·Biological Psychiatry
DOI 10.1016/j.biopsych.2008.12.029PMC PMC2951678
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Abstract

Background Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments. Methods [(18)F]fallypride positron emission tomography studies were performed in off-medication or never-medicated schizophrenic subjects (n = 11, 6 men, 5 women; mean age of 30.5 +/- 8.0 [SD] years; 4 drug-naive) and age-matched healthy subjects (n = 11, 5 men, 6 women, mean age of 31.6 +/- 9.2 [SD]) to examine dopamine D(2) receptor (DA D(2)r) levels in the caudate, putamen, ventral striatum, medial thalamus, posterior thalamus, substantia nigra, amygdala, temporal cortex, anterior cingulate, and hippocampus. Results In schizophrenic subjects, increased DA D(2)r levels were seen in the substantia nigra bilaterally; decreased levels were seen in the left medial thalamus. Correlations of symptoms with ROI data demonstrated a significant correlation of disorganized thinking/nonparanoid delusions with the right temporal cortex ROI (r = .94, p = .0001), which remained significant after correction for multiple comparisons (p < .03). Correlations of symptoms with parametric images of DA D(2)r levels revealed no significant clusters of correlations with negative symptoms but significant clusters of positive correlations of total positive symptoms, delusions and bizarre behavior with the lateral and anterior temporal cortex, and hallucinations with the left ventral striatum. Conclusions The results of this study demonstrate abnormal DA D(2)r-mediated neurotransmission in the substantia nigra consistent with nigral dysfunction in schizophrenia and suggest that both temporal cortical and ventral striatal DA D(2)r mediate positive symptoms.

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  • D2R levels in cortical and striatal areas correlate with positive but not negative symptom scores.

    “D2R levels in cortical and striatal areas correlate with positive but not negative symptom scores (Kessler et al., 2009)”

    From The Computational Anatomy of Psychosis (2013) · cites this paper as Kessler et al., 2009

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Authors
Kessler, R. M., Woodward, N. D., Riccardi, P., Li, R., Ansari, M. S., Anderson, S., Dawant, B., Zald, D., & Meltzer, H. Y.
Affiliations
Vanderbilt University (US)
Corresponding author
Kessler, Robert M.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2009-06
Volume
65
Issue
12
Pages
1024-1031
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2008.12.029
PMC
PMC2951678
OpenAlex
W2113589752
Cited by
136
References
7
Citations by year
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FWCI
10.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (R21MH68757, RO1MH60890)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
dopamine D2 receptor, schizophrenia, substantia nigra, thalamus, striatum, temporal cortex, ventral striatum, positive symptoms, delusions, hallucinations, drug-naive patients
MeSH terms
Adult, Benzamides, Brain Chemistry, Cerebral Cortex, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Male, Middle Aged, Pyrrolidines, Schizophrenia, Substantia Nigra, Thalamus, Neostriatum, Receptors, Dopamine D2, Radiopharmaceuticals, Positron-Emission Tomography, Young Adult

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