Regulation of novelty seeking by midbrain dopamine D2/D3 signaling and ghrelin is altered in obesity: Novelty Seeking in Obesity
Open accessAbstract
OBJECTIVE: To investigate the relationship of novelty seeking traits (NS) with midbrain dopamine (DA) receptors and acyl ghrelin levels (AG) in normal weight (NW) and obese females.NS predict addictive behaviors and are hypothesized to contribute to eating behaviors. In healthy, NS are negatively associated with DA receptors in the substantia nigra (SN). The influence of obesity on the regulation of NS by DA signaling and AG was hypothesized. METHODS: PET scanning to measure DA type 2/type 3 receptor (D2/D3R) binding potential (BPND ) in the SN was used. Participants completed Tridimensional Personality Questionnaire-Novelty-Seeking Scale (TPQ-NS) and AG were measured. RESULTS: In eight NW and 19 obese (BMI 22 vs 38 kg/m(2) ), TPQ-NS (16 vs 15) and SN D2/D3R BPND (2.48 vs 2.66) were similar, while AG higher (256 vs 60, P < 0.01), respectively. D2/D3R BPND and TPQ-NS had a negative relationship in NW (r = -0.7) but not in obese (P > 0.10). AG and TPQ-NS were positively correlated in NW (r = 0.9) but not in obese (P > 0.10). D2R BPND and AG were negatively correlated in NW (r = -0.8) but positively in obese (r = 0.6). CONCLUSION: Obese do not maintain posited regulatory relationships for NS to either midbrain D2/D3R availability or AG present in NW. Also opposite relationships exist for NW and obese between SN D2/D3R availability and AG. The altered regulation of NS in obesity needs to be further explored.
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Impulsivity hinders inhibitory control and is associated with increased intake of food and drugs, often heightened in response to novel stimuli.
“Impulsivity hinders inhibitory control and is associated with increased intake of food [80] and drugs [81], often heightened in response to novel stimuli [82].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [82]
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- Authors
- Savage, S. W., Zald, D. H., Cowan, R. L., Volkow, N. D., Marks-Shulman, P. A., Kessler, R. M., Abumrad, N. N., & Dunn, J. P.
- Affiliations
- Vanderbilt University (US)
- National Institute on Drug Abuse (US)
- Department of Surgery; Vanderbilt University School of Medicine; Nashville Tennessee USA
- Corresponding author
- Dunn, Julia P.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2014-02-11
- Volume
- 22
- Issue
- 6
- Pages
- 1452-1457
- ISSN
- 1930-7381 (ISSN-L)
- PMC
- PMC4037348
- OpenAlex
- W1681536332
- Cited by
- 27
- References
- 39
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 2
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2 CX000943)
- Vanderbilt University
- National Institutes of Health (UL1TR000445, 5p60dk020593-31, DK 20593)
- U.S. Public Health Service (K12-ESO15855)
- Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (DK058404, P60-DK020593, R01DK091748, DK 20593, DK 70860, R01DK070860, P30DK058404, P30DK056341, P30DK020593)
- National Institute of Environmental Health Sciences (K12ES015855)
- National Center for Research Resources (UL1RR024975)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- novelty seeking, midbrain dopamine, D2/D3 receptors, acylated ghrelin, substantia nigra, dietary habits, addictive behavior, personality traits, women
- MeSH terms
- Adult, Body Weight, Dopamine, Exploratory Behavior, Female, Humans, Magnetic Resonance Imaging, Mesencephalon, Middle Aged, Obesity, Surveys and Questionnaires, Signal Transduction, Body Mass Index, Positron-Emission Tomography, Ghrelin, Neuroimaging
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