Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

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<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

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The cancer genome atlas pan-cancer analysis project

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

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Biological insights from 108 schizophrenia-associated genetic loci

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Comprehensive molecular characterization of gastric adenocarcinoma

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Integrated genomic characterization of endometrial carcinoma

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Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer

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Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

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Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors

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Can the pharmaceutical industry reduce attrition rates?

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Comprehensive molecular characterization of clear cell renal cell carcinoma

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Direct conversion of fibroblasts to functional neurons by defined factors

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Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

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Alzheimer disease in the United States (2010–2050) estimated using the 2010 census

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Systematic identification of genomic markers of drug sensitivity in cancer cells

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Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies

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Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer

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Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab

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Disease-Specific Induced Pluripotent Stem Cells.

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Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

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Genome-wide association study identifies five new schizophrenia loci

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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

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Alzheimer’s disease drug-development pipeline: Few candidates, frequent failures

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Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution

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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

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Rapid single-step induction of functional neurons from human pluripotent stem cells

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Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

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Genetics of gene expression surveyed in maize, mouse and man

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Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

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Induced pluripotent stem cells from a spinal muscular atrophy patient

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A polygenic burden of rare disruptive mutations in schizophrenia

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Prevalence of autism spectrum disorder among children aged 8 Years - Autism and developmental disabilities monitoring network, 11 Sites, United States, 2014

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Modelling schizophrenia using human induced pluripotent stem cells

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BRAF mutation predicts sensitivity to MEK inhibition

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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Genetics of gene expression and its effect on disease

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A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data

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Induction of human neuronal cells by defined transcription factors

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Discovering regulatory and signalling circuits in molecular interaction networks

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Common variants on chromosome 6p22.1 are associated with schizophrenia

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Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

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An integrative genomics approach to infer causal associations between gene expression and disease

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EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of <i>BRAF</i> -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib

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A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene

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Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

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Mapping the Genetic Architecture of Gene Expression in Human Liver

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The ALK Inhibitor Ceritinib Overcomes Crizotinib Resistance in Non–Small Cell Lung Cancer

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Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

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Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins

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A long-term, phase 2, multicenter, randomized, open-label, comparative safety study of pomaglumetad methionil (LY2140023 monohydrate) versus atypical antipsychotic standard of care in patients with schizophrenia

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RAF Suppression Synergizes with MEK Inhibition in KRAS Mutant Cancer Cells

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Common variant at 16p11.2 conferring risk of psychosis

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Synthetic lethal approaches to breast cancer therapy

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Occurrence of resistance to retinoic acid in the acute promyelocytic leukemia cell line NB4 is associated with altered expression of the pml/RAR alpha protein

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Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM -Defective Tumors

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EOS lentiviral vector selection system for human induced pluripotent stem cells

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Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes

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From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets

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Genomic analysis of metabolic pathway gene expression in mice

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Pomaglumetad Methionil (LY2140023 Monohydrate) and Aripiprazole in Patients with Schizophrenia: A Phase 3, Multicenter, Double-Blind Comparison

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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers

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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context

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Inferring causal genomic alterations in breast cancer using gene expression data

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Exploiting epigenetic vulnerabilities for cancer therapeutics

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Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation

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Characterizing Dynamic Changes in the Human Blood Transcriptional Network

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The Evolution of Melanoma Resistance Reveals Therapeutic Opportunities

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Identification and validation of genes affecting aortic lesions in mice

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Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits

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Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations

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Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma

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A Drosophila approach to thyroid cancer therapeutics

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Role of Inflammation and Tumor Microenvironment in the Development of Gastrointestinal Cancers: What Induced Pluripotent Stem Cells Can Do?

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Bench to bedside with fruit flies: an interview with Ross Cagan

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Exploiting machine learning for end-to-end drug discovery and development

Ekins, S., Puhl, A. C., Zorn, K. M., Lane, T. R., Russo, D. P., Klein, J. J., Hickey, A. J., & Clark, A. M. (2019) · Nature Materials · doi:10.1038/s41563-019-0338-z · Cited by 578 · see citing works

Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms

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Human pluripotent stem cells as tools for high-throughput and high-content screening in drug discovery

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Induced Pluripotent Stem Cells in Cardiovascular Drug Discovery

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Biological Systems to Computational Systems Biology

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Systems Biology: Definitions and Perspectives

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Computational systems biology: integration of sequence, structure, network, and dynamics

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