Cited by 151Bariatric Surgery and OutcomesRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Decreased Dopamine Type 2 Receptor Availability After Bariatric Surgery: Preliminary Findings

Open access
Dunn, Julia P., Cowan, Ronald L., Volkow, Nora D., Feurer, Irene D., Li, Rui, Williams, D. Brandon, Kessler, Robert M., Abumrad, Naji N.·2010·Brain Research

Abstract

Background Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would be enhanced after Roux-en-Y-Gastric Bypass (RYGB) and Vertical Sleeve Gastrectomy (VSG) surgery and that these changes would influence eating behaviors and contribute to the positive outcomes from bariatric surgery.Methods Five females with obesity were studied preoperatively and at approximately 7 weeks after RYGB or VSG surgery. Subjects underwent positron emission tomography (PET) imaging with a dopamine type 2 (DA D2) receptor radioligand whose binding is sensitive to competition with endogenous dopamine. Regions of interest (ROI) relevant to eating behaviors were delineated. Fasting enteroendocrine hormones were quantified at each time point.Results Body weight decreased as expected after surgery. DA D2 receptor availability decreased after surgery. Regional decreases (mean+/-SEM) were caudate 10+/-3%, putamen 9+/-4%, ventral striatum 8+/-4%, hypothalamus 9+/-3%, substantia nigra 10+/-2%, medial thalamus 8+/-2%, and amygdala 9+/-3%. These were accompanied by significant decreases in plasma insulin (62%) and leptin (41%).Conclusion The decreases in DA D2 receptor availability after RYGB and VSG most likely reflect increases in extracellular dopamine levels. Enhanced dopaminergic neurotransmission may contribute to improved eating behavior (e.g. reduced hunger and improved satiety) following these bariatric procedures.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2010.03.064

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dopamine signaling changes in those who have undergone bariatric surgery, thereby reducing the inherent rewarding properties of many foods.

    “Moreover, dopamine signaling changes in those who have undergone bariatric surgery, thereby reducing the inherent rewarding properties of many foods (54, 55).”

    From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [54]

    The Discussion (page unavailable) interprets the postoperative dopamine change as increased dopamine levels and says this would positively influence reward. It also suggests food pleasure may increase. Although the paper proposes that food cravings may decrease, it does not equate that with reduced rewarding properties of foods; on that point, it suggests the opposite. (LLM, conf=0.88)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 52 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Karamanakos SNMD Vagenas KMD Kalfarentzos FMDF Alexandrides TKMD Weight Loss, Appetite Suppression, and Changes in Fasting and Postprandial Ghrelin and Peptide-YY Levels After Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A Prospective, Double Blind Study Annals of Surgery 2008b 247 401 407 18376181
  2. Riccardi P Baldwin R Salomon R Anderson S Ansari MS Li R Dawant B Bauernfeind A Schmidt D Kessler R Estimation of baseline dopamine D2 receptor occupancy in striatum and extrastriatal regions in humans with positron emission tomography with [18F] fallypride Biol Psychiatry 2008a 63 241 244 17586476
  3. Riccardi P Baldwin R Salomon R Anderson S Ansari MS Li R Dawant B Bauernfeind A Schmidt D Kessler R Estimation of Baseline Dopamine D2 Receptor Occupancy in Striatum and Extrastriatal Regions in Humans with Positron Emission Tomography with [18F] Fallypride Biological Psychiatry 2008b 63 241 244 17586476
  4. Wang GJ Volkow ND Logan J Pappas NR Wong CT Zhu W Netusil N Fowler JS Brain dopamine and obesity Lancet 2001b 357 354 357 11210998

Cited by

Sorted by citations

Authors
Dunn, J. P., Cowan, R. L., Volkow, N. D., Feurer, I. D., Li, R., Williams, D. B., Kessler, R. M., & Abumrad, N. N.
Affiliations
  • Vanderbilt University (US)
  • National Institute on Drug Abuse (US)
Corresponding author
Dunn, Julia P.
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-09
Volume
1350
Pages
123-130
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2038290634
Cited by
151
References
52
Citations by year
2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 14 · 2012: 11
FWCI
11.15
Type
journal article
Language
en
Open access
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Vanderbilt Environmental Health Science Scholars Program (NIEHS K12 ESO15855)
  • NIDDK (RO1-DK070860)
  • NCRR/NIH (1 UL1 RR024975)
  • Vanderbilt Diabetes Research and Training Center (DK20593)
  • Vanderbilt Digestive Diseases Research Center (DK058404)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
bariatric surgery, Roux-en-Y gastric bypass, sleeve gastrectomy, obesity, dopamine signaling, dietary habits, satiety, hunger, enteroendocrine hormones, leptin, insulin, caudate nucleus, putamen, ventral striatum, hypothalamus, substantia nigra, amygdala, medial thalamus
MeSH terms
Adult, Analysis of Variance, Brain, Female, Humans, Insulin, Middle Aged, Obesity, Radioimmunoassay, Radionuclide Imaging, Receptors, Dopamine D2, Leptin, Bariatric Surgery

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review