Decreased Dopamine Type 2 Receptor Availability After Bariatric Surgery: Preliminary Findings
Open accessAbstract
Background Diminished dopaminergic neurotransmission contributes to decreased reward and negative eating behaviors in obesity. Bariatric surgery is the most effective therapy for obesity and rapidly reduces hunger and improves satiety through unknown mechanisms. We hypothesized that dopaminergic neurotransmission would be enhanced after Roux-en-Y-Gastric Bypass (RYGB) and Vertical Sleeve Gastrectomy (VSG) surgery and that these changes would influence eating behaviors and contribute to the positive outcomes from bariatric surgery.Methods Five females with obesity were studied preoperatively and at approximately 7 weeks after RYGB or VSG surgery. Subjects underwent positron emission tomography (PET) imaging with a dopamine type 2 (DA D2) receptor radioligand whose binding is sensitive to competition with endogenous dopamine. Regions of interest (ROI) relevant to eating behaviors were delineated. Fasting enteroendocrine hormones were quantified at each time point.Results Body weight decreased as expected after surgery. DA D2 receptor availability decreased after surgery. Regional decreases (mean+/-SEM) were caudate 10+/-3%, putamen 9+/-4%, ventral striatum 8+/-4%, hypothalamus 9+/-3%, substantia nigra 10+/-2%, medial thalamus 8+/-2%, and amygdala 9+/-3%. These were accompanied by significant decreases in plasma insulin (62%) and leptin (41%).Conclusion The decreases in DA D2 receptor availability after RYGB and VSG most likely reflect increases in extracellular dopamine levels. Enhanced dopaminergic neurotransmission may contribute to improved eating behavior (e.g. reduced hunger and improved satiety) following these bariatric procedures.
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Dopamine signaling changes in those who have undergone bariatric surgery, thereby reducing the inherent rewarding properties of many foods.
“Moreover, dopamine signaling changes in those who have undergone bariatric surgery, thereby reducing the inherent rewarding properties of many foods (54, 55).”
From Behavioral Interventions to Attenuate Driven Overeating and Weight Regain After Bariatric Surgery (2022) · cites this paper as [54]
The Discussion (page unavailable) interprets the postoperative dopamine change as increased dopamine levels and says this would positively influence reward. It also suggests food pleasure may increase. Although the paper proposes that food cravings may decrease, it does not equate that with reduced rewarding properties of foods; on that point, it suggests the opposite. (LLM, conf=0.88)
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- Authors
- Dunn, J. P., Cowan, R. L., Volkow, N. D., Feurer, I. D., Li, R., Williams, D. B., Kessler, R. M., & Abumrad, N. N.
- Affiliations
- Vanderbilt University (US)
- National Institute on Drug Abuse (US)
- Corresponding author
- Dunn, Julia P.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 1350
- Pages
- 123-130
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2926260
- OpenAlex
- W2038290634
- Cited by
- 151
- References
- 52
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 16 · 2016: 16 · 2015: 17 · 2014: 16 · 2013: 14 · 2012: 11
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Vanderbilt Environmental Health Science Scholars Program (NIEHS K12 ESO15855)
- NIDDK (RO1-DK070860)
- NCRR/NIH (1 UL1 RR024975)
- Vanderbilt Diabetes Research and Training Center (DK20593)
- Vanderbilt Digestive Diseases Research Center (DK058404)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- bariatric surgery, Roux-en-Y gastric bypass, sleeve gastrectomy, obesity, dopamine signaling, dietary habits, satiety, hunger, enteroendocrine hormones, leptin, insulin, caudate nucleus, putamen, ventral striatum, hypothalamus, substantia nigra, amygdala, medial thalamus
- MeSH terms
- Adult, Analysis of Variance, Brain, Female, Humans, Insulin, Middle Aged, Obesity, Radioimmunoassay, Radionuclide Imaging, Receptors, Dopamine D2, Leptin, Bariatric Surgery
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