The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach
Open accessAbstract
Background Schizophrenia is hypothesized to involve disordered connectivity between brain regions. Currently, there are no direct measures of brain connectivity; functional and structural connectivity used separately provide only limited insight. Simultaneous measure of anatomical and functional connectivity and its interactions allow for better understanding of schizophrenia-related alternations in brain connectivity. Methods 27 schizophrenia patients and 27 healthy controls undergone MRI imaging using resting state fMRI and Diffusion Tensor Imaging. Separate functional and anatomical connectivity maps were calculated and combined for each subject. Global, regional and voxel measures and K-means network analysis were employed to identify group differences and correlation with clinical symptoms. Results A global connectivity analysis indicated that patients had lower anatomical connectivity and lower coherence between the two imaging modalities. In schizophrenia these group differences correlated with clinical symptom severity. While anatomical connectivity nearly uniformly decreased, functional connectivity in schizophrenia was lower for some connections (e.g. middle temporal gyrus) and higher for others (e.g. cingulate and thalamus). Within the Default Mode Network (DMN) two separate subsystems can be identified. Schizophrenia patients showed decoupling between structural and functional connectivity that can be localized to networks originating in Posterior Cingulate Cortex as well as in the Task Positive Network and one of DMN components. Conclusions Combining two measures of brain connectivity provides more comprehensive descriptions of altered brain connectivity underlying schizophrenia. Patients show deficits in white matter anatomy but functional connectivity alterations are more complex. Fusion of both methods allows identification of subsystems showing both increased and decreased functional connectivity.
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Cites
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Large-scale brain networks and psychopathology: a unifying triple network model
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Default Mode Network Activity and Connectivity in Psychopathology
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Schizophrenia, neuroimaging and connectomics
Fornito, A., Zalesky, A., Pantelis, C., & Bullmore, E. T. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.090 · Cited by 716
Dysconnectivity in schizophrenia: where are we now?
Pettersson-Yeo, W., Allen, P., Benetti, S., McGuire, P., & Mechelli, A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.004 · Cited by 712
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Metadata
- Authors
- Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 68
- Issue
- 1
- Pages
- 61-69
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2064598115
- Cited by
- 466
- References
- 7
- FWCI
- 21.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G. (2010). Brain Connectivity Is Not Only Lower but Different in Schizophrenia: A Combined Anatomical and Functional Approach. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2010.03.035
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