Cited by 272Epigenetics and DNA MethylationNeurotransmitter Receptor Influence on BehaviorPsychoanalysis and Psychopathology Research

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Methylation Matters: Interaction Between Methylation Density and Serotonin Transporter Genotype Predicts Unresolved Loss or Trauma

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van IJzendoorn, Marinus H., Caspers, Kristin, Bakermans-Kranenburg, Marian J., Beach, Steven R.H., Philibert, Robert·2010·Biological Psychiatry

DOI 10.1016/j.biopsych.2010.05.008PMC PMC2921470

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Abstract

Background Do genetic or epigenetic factors play a role in making some individuals more vulnerable than others to loss of attachment figures or other traumatic experiences?Methods DNA was obtained from growth phase entrained Epstein-Barr Virus (EBV) transformed lymphoblast cell lines from 143 adopted participants. Genotype of the serotonin transporter linked polymorphic region (5HTTLPR) was determined, and methylation ratios for each of the C-phosphate-G (CpG) residues were assessed using quantitative mass spectroscopy. Unresolved loss or trauma was established using the Berkeley Adult Attachment Interview.Results Higher levels of methylation of the 5HTT promoter associated CpG island were associated with increased risk of unresolved responses to loss or other trauma in carriers of the usually protective 5HTTLPR//variant. The ss variant of 5HTTLPR predicted more unresolved loss or trauma, but only in case of lower levels of methylation. Higher levels of methylation of the ss variant were associated with less unresolved loss or other trauma.Conclusions Associations between 5HTTLPR polymorphisms and psychological problems are significantly altered by environmentally induced methylation patterns. Methylation may serve as the interface between adverse environment and the developing organism.

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Authors: van IJzendoorn, M. H., Caspers, K., Bakermans-Kranenburg, M. J., Beach, S. R. H., & Philibert, R.
Affiliations: University of Iowa (US)
University of Georgia (US)
ORCID: Beach, Steven R.H.
Philibert, Robert
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2010-09
Volume: 68
Issue: 5
Pages: 405-407
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2010.05.008
PMC: PMC2921470
OpenAlex: W2060345033
Cited by: 264
References: 23
Citations by year: 2026: 4 · 2025: 4 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 10 · 2020: 39 · 2019: 9 · 2018: 23 · 2017: 16 · 2016: 19 · 2015: 22 · 2014: 18 · 2013: 22 · 2012: 26
FWCI: 10.82
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Netherlands Organization for Scientific Research (452-04-306)
U.S. National Institute of Drug Abuse (RO 1 DA05821, R01 DA015789)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: DNA methylation, serotonin transporter, 5-HTTLPR, promoter methylation, CpG islands, epigenetics, unresolved loss, trauma, attachment, genetic susceptibility, gene-environment interaction, adopted children, adult attachment
MeSH terms: Adoption, Cell Line, Transformed, Herpesvirus 4, Human, Female, Humans, Infant, Interview, Psychological, Male, Polymorphism, Genetic, Stress, Psychological, CpG Islands, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic, Serotonin Plasma Membrane Transport Proteins, Genetic Association Studies

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Methylation Matters: Interaction Between Methylation Density and Serotonin Transporter Genotype Predicts Unresolved Loss or Trauma

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