Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats
Abstract
Background Roux-en-Y gastric bypass (RYGB) surgery is an effective weight loss strategy employed to treat obesity and associated complications. Importantly, the RYGB procedure has been reported to attenuate reward-related consummatory behaviors. The present work examined the hypothesis that RYGB surgery attenuates ethanol intake and reward in the context of frequent ethanol consumption.Methods To do this, self-report of ethanol intake was examined in human bariatric patients (n = 6165) before and following the RYGB procedure. In addition, we utilized a rodent model of RYGB and examined ethanol consumption and ethanol reward in male ethanol-preferring (P) rats, which are selectively bred to consume large volumes of ethanol.Results Patients that reported frequent consumption of ethanol before RYGB reported decreased consumption following RYGB surgery. Moreover, the RYGB procedure decreased ethanol intake and the reinforcing properties of ethanol in P rats. Notably, the attenuating effect of RYGB surgery on ethanol consumption was associated with ethanol-induced increases in the gut hormone glucagon-like peptide-1 (GLP-1). Pharmacologic administration of GLP-1 agonists attenuated ethanol consumption in sham P rats. In addition, pharmacologic replacement of the gut hormone ghrelin restored drinking behavior in P rats following RYGB.Conclusions Collectively, these findings unveil the potential of RYGB surgery to attenuate ethanol consumption in some humans and rats. Furthermore, our data indicate that this regulation is achieved, in part, through reduction of reward and is modified by the gut hormones GLP-1 and ghrelin.
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Ghrelin is primarily recognized for its function in regulating appetite through the hypothalamic arcuate nucleus.
“Ghrelin is primarily recognized for its function in regulating appetite through the hypothalamic arcuate nucleus”
From A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder (2024) · cites this paper as [89]
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- Authors
- Davis, J. F., Schurdak, J. D., Magrisso, I. J., Mul, J. D., Grayson, B. E., Pfluger, P. T., Tschöp, M. H., Seeley, R. J., & Benoit, S. C.
- Affiliations
- University of Cincinnati (US)
- Corresponding author
- Davis, Jon F.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 72
- Issue
- 5
- Pages
- 354-360
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2051342842
- Cited by
- 81
- References
- 38
- Citations by year
- 2025: 7 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 7 · 2015: 4 · 2014: 10 · 2013: 11 · 2012: 3
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R24AA015512, R24 3R24AA015512-06)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- Roux-en-Y gastric bypass, ethanol consumption, ethanol reward, bariatric surgery, glucagon-like peptide-1, ghrelin, gastrointestinal hormones, GLP-1 receptor agonists, alcoholism, binge drinking
- MeSH terms
- Alcohol Drinking, Ethanol, Analysis of Variance, Animals, Humans, Male, Obesity, Prospective Studies, Rats, Inbred Strains, Gastric Bypass, Weight Loss, Models, Animal, Rats, Glucagon-Like Peptide 1, Ghrelin
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