Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects
Abstract
CONTEXT: The mechanisms underlying weight loss after Roux-en-Y gastric bypass (RYGBP) are not well understood. OBJECTIVE: The objective of the study was to assess the changes in active glucagon-like peptide 1 (GLP-1) and total peptide YY (PYY) after RYGBP and examine their relationship with changes in hunger and satiety. DESIGN: This was a prospective study on the changes in active GLP-1, PYY, hunger, and satiety in response to a standardized test meal in nine normal-glucose-tolerant obese subjects [body mass index (BMI) 47.4 +/- 6.1 kg/m(2)] before and 6 wk after RYGBP. RESULTS: Before surgery, meal ingestion failed to stimulate GLP-1 and PYY secretion. Six weeks after surgery, despite subjects still being markedly obese (BMI 43.6 +/- 7.8 kg/m(2)), the area under the curve(0-120') of GLP-1 and of PYY in response to the standardized test meal were significantly elevated (P < 0.05 and P < 0.01, respectively). These hormonal responses were significantly larger (P < 0.01) than those observed in a group matched for the BMI attained 6 wk after surgery. The 2.9 +/- 1.2- and 1.6 +/- 1.9-fold increase, respectively, in the area under the curve(0-120') of GLP-1 and PYY were accompanied by a significant decrease in fasting (P < 0.05) and postprandial hunger (P = 0.05) and a significant increase in satiety (P < 0.05) after meal intake. Nevertheless, a significant correlation between changes in the hormonal and eating behavior parameters was not found. CONCLUSION: Our data show that RYGBP is associated with an improvement in the active GLP-1 and total PYY response to a liquid-meal intake. Moreover, we provide circumstantial evidence for a potential role of these gastrointestinal hormones on the decreased appetite after RYGBP.
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Gastric bypass subjects have elevated plasma concentrations of GLP-1.
“GB subjects have elevated plasma concentrations of GLP-1 (6,8–13).”
From Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans (2011) · cites this paper as [11]
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- Authors
- Morínigo, R., Moizé, V., Musri, M., Lacy, A. M., Navarro, S., Marín, J. L., Delgado, S., Casamitjana, R., & Vidal, J.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- ORCID
- Musri, Melina
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-05
- Volume
- 91
- Issue
- 5
- Pages
- 1735-1740
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2132275840
- Cited by
- 397
- References
- 36
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 14 · 2023: 7 · 2022: 7 · 2021: 22 · 2020: 11 · 2019: 20 · 2018: 9 · 2017: 22 · 2016: 16 · 2015: 25 · 2014: 17 · 2013: 35 · 2012: 28
- FWCI
- 28.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- glucagon-like peptide-1, peptide YY, Roux-en-Y gastric bypass, morbid obesity, hunger, satiety, appetite regulation, gastrointestinal hormones, weight loss mechanisms, postprandial hormone secretion, bariatric surgery
- MeSH terms
- Adult, Eating, Female, Gastric Emptying, Gastrointestinal Transit, Humans, Hunger, Male, Obesity, Morbid, Prospective Studies, Satiety Response, Gastric Bypass, Peptide YY, Glucagon-Like Peptide 1
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