The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder
Abstract
Background Autism spectrum disorder (ASD) is associated with altered face processing and decreased activity in brain regions involved in face processing. The neuropeptide oxytocin has been shown to promote face processing and modulate brain activity in healthy adults. The present study examined the effects of oxytocin on the neural basis of face processing in adults with Asperger syndrome (AS).Methods A group of 14 individuals with AS and a group of 14 neurotypical control participants performed a face-matching and a house-matching task during functional magnetic resonance imaging. The effects of a single dose of 24 IU intranasally administered oxytocin were tested in a randomized, placebo-controlled, within-subject, cross-over design.Results Under placebo, the AS group showed decreased activity in the right amygdala, fusiform gyrus, and inferior occipital gyrus compared with the control group during face processing. After oxytocin treatment, right amygdala activity to facial stimuli increased in the AS group.Conclusions These findings indicate that oxytocin increases the saliency of social stimuli and in ASD and suggest that oxytocin might promote face processing and eye contact in individuals with ASD as prerequisites for neurotypical social interaction.
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In the citing paper
“This route of administration has been validated for both OT (6, 71) and NAL (72–74) in previous human studies”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [71]
In the citing paper
“Similarly, oxytocin administration has been shown to increase amygdala activation during face processing specifically in adults with ASD, accompanied by improvements in emotion recognition51,52.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
In the citing paper
“Moreover, previous studies showing oxytocin effects on emotion recognition, empathy, or face processing in adults with ASD had an average sample size of 21.5 participants48,50,51,86–88.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
In the citing paper
“While most randomized clinical trials have found some oxytocin effects on ASD symptoms33,50–52 and brain function50–52,80,81, not all trials have reported effects82.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
In the citing paper
“While this finding fits with previous reports that oxytocin administration leads to an increase in amygdala activation during the processing of faces in men with ASD51,52, these findings are not consistent with studies that examine neural responses to aversive stimuli in men without an ASD diagnosis.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
Citations
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“Studies with adults have demonstrated diminished eye gaze (8–10) and impaired facial emotion recognition (11,12) in persons with ASD.”
BackgroundBaron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Self-citationPragmatics of measuring recognition memory: Applications to dementia and amnesia.
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Autism Spectrum Disorder: Classification, diagnosis and therapy
Sharma, S., Gonda, X., & Tarazi, F. I. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.007 · Cited by 745
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393
Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336
Metadata
- Authors
- Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- University of Rostock (DE)
- Heidelberg University (DE)
- Corresponding author
- Domes, Gregor
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 74
- Issue
- 3
- Pages
- 164-171
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2044266604
- Semantic Scholar
- 02b25bec70f500269e547014635b42f556d8e173
- Cited by
- 255
- References
- 72
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 21 · 2015: 32 · 2014: 35 · 2013: 13
- FWCI
- 50.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- oxytocin, autism spectrum disorder, Asperger syndrome, face processing, amygdala, fusiform gyrus, inferior occipital gyrus, social cognition, social salience, eye contact, neuroimaging
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Amygdala, Brain Mapping, Child, Child Development Disorders, Pervasive, Discrimination, Psychological, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Time Factors, Cross-Over Studies, Young Adult
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