Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Open accessAbstract
Oxytocin promotes social interactions and recognition of conspecifics that rely on olfaction in most species. The circuit mechanisms through which oxytocin modifies olfactory processing are incompletely understood. Here, we observed that optogenetically induced oxytocin release enhanced olfactory exploration and same-sex recognition of adult rats. Consistent with oxytocin's function in the anterior olfactory cortex, particularly in social cue processing, region-selective receptor deletion impaired social recognition but left odor discrimination and recognition intact outside a social context. Oxytocin transiently increased the drive of the anterior olfactory cortex projecting to olfactory bulb interneurons. Cortical top-down recruitment of interneurons dynamically enhanced the inhibitory input to olfactory bulb projection neurons and increased the signal-to-noise of their output. In summary, oxytocin generates states for optimized information extraction in an early cortical top-down network that is required for social interactions with potential implications for sensory processing deficits in autism spectrum disorders.
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Oxytocin in the anterior olfactory nucleus facilitates an increased inhibitory tone in the main olfactory bulb, resulting in a greater signal-to-noise ratio for odors associated with social interactions.
“OT in the AON facilitates an increased inhibitory tone in the main olfactory bulb (MOB), resulting in a greater signal-to-noise ratio for odors associated with social interactions and subsequently leading to a higher quality signal being transmitted to downstream regions [9,88].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [88]
Social recognition is enhanced by optogenetically-induced OT release in the brain in female rats.
“For example, social recognition is enhanced by optogenetically-induced OT release in the brain in female rats [63]”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [63]
The presence of a conspecific activates the oxytocin system, increases oxytocin release, activates dopamine neurons of the VTA, and promotes the initiation and maintenance of social interaction.
“Indeed, the presence of a conspecific activates the oxytocin system, which increases oxytocin release, activates DA neurons of the VTA, and promotes the initiation and maintenance of social interaction (Resendez et al., 2020; Oettl et al., 2016).”
From Oxytocin neurons mediate the effect of social isolation via the VTA circuits (2022) · cites this paper as Oettl et al., 2016
In rodents, oxytocin enhances social discrimination by increasing the signal-to-noise ratio of olfactory bulb output.
“shown to occur in olfactory bulb in rodents, where oxytocin enhances social discrimination by increasing the signal-to-noise ratio of olfactory bulb output [16].”
From Translational opportunities for circuit-based social neuroscience: advancing 21st century psychiatry (2021) · cites this paper as [16]
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Self-citation
- Authors
- Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., Meyer-Lindenberg, A., Grinevich, V., Shusterman, R., & Kelsch, W.
- Affiliations
- Heidelberg University (DE)
- New York University (US)
- National Institutes of Health (US)
- German Cancer Research Center (DE)
- University of Haifa (IL)
- Corresponding author
- Kelsch, Wolfgang
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 90
- Issue
- 3
- Pages
- 609-621
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4860033
- OpenAlex
- W2336641763
- Cited by
- 359
- References
- 99
- Citations by year
- 2026: 28 · 2025: 23 · 2024: 40 · 2023: 26 · 2022: 34 · 2021: 43 · 2020: 48 · 2019: 31 · 2018: 42 · 2017: 30 · 2016: 14
- FWCI
- 61.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (ZIAMH002498, Z01MH002498)
- National Institute of Neurological Disorders and Stroke (T32NS086750)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- oxytocin, social recognition, olfactory processing, olfactory bulb interneurons, top-down control, odor discrimination, autism spectrum disorder, social behavior
- MeSH terms
- Animals, Behavior, Animal, Interneurons, Mice, Transgenic, Nerve Net, Olfactory Bulb, Oxytocin, Smell, Social Behavior, Rats, Wistar
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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