Cited by 256Neuroendocrine regulation and behaviorAutism Spectrum Disorder ResearchFace Recognition and Perception

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Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder

Domes, Gregor, Heinrichs, Markus, Kumbier, Ekkehardt, Grossmann, Annette, Hauenstein, Karlheinz, Herpertz, Sabine C.·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.02.007

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Abstract

Background Autism spectrum disorder (ASD) is associated with altered face processing and decreased activity in brain regions involved in face processing. The neuropeptide oxytocin has been shown to promote face processing and modulate brain activity in healthy adults. The present study examined the effects of oxytocin on the neural basis of face processing in adults with Asperger syndrome (AS).Methods A group of 14 individuals with AS and a group of 14 neurotypical control participants performed a face-matching and a house-matching task during functional magnetic resonance imaging. The effects of a single dose of 24 IU intranasally administered oxytocin were tested in a randomized, placebo-controlled, within-subject, cross-over design.Results Under placebo, the AS group showed decreased activity in the right amygdala, fusiform gyrus, and inferior occipital gyrus compared with the control group during face processing. After oxytocin treatment, right amygdala activity to facial stimuli increased in the AS group.Conclusions These findings indicate that oxytocin increases the saliency of social stimuli and in ASD and suggest that oxytocin might promote face processing and eye contact in individuals with ASD as prerequisites for neurotypical social interaction.

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Authors: Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C.
Affiliations: University of Freiburg (DE)
University of Rostock (DE)
Heidelberg University (DE)
Corresponding author: Domes, Gregor
ORCID: Domes, Gregor
Heinrichs, Markus
Kumbier, Ekkehardt
Herpertz, Sabine C.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-08
Volume: 74
Issue: 3
Pages: 164-171
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.02.007
OpenAlex: W2044266604
Semantic Scholar: 02b25bec70f500269e547014635b42f556d8e173
Cited by: 255
References: 72
Citations by year: 2026: 4 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 21 · 2015: 32 · 2014: 35 · 2013: 13
FWCI: 50.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
Keywords: oxytocin, autism spectrum disorder, Asperger syndrome, face processing, amygdala, fusiform gyrus, inferior occipital gyrus, social cognition, social salience, eye contact, neuroimaging
MeSH terms: Administration, Intranasal, Adolescent, Adult, Amygdala, Brain Mapping, Child, Child Development Disorders, Pervasive, Discrimination, Psychological, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Time Factors, Cross-Over Studies, Young Adult

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Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder

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