The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders
Open accessAbstract
Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.
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“Several human postmortem studies have also shown reductions in the expression of several components critical to astrocyte function, largely in the mPFC, but also some evidence in the hippocampus, suggesting impaired glutamate-glutamine cycling (133).”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [133]
In the citing paper
“There is also emerging evidence of impaired glutamate-glutamine cycling in the mPFC and hippocampus amongst those with MDD.”
From The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology (2019) · cites this paper as [133]
In the citing paper
“Subjects with depression have been shown to display a variety of glutamatergic abnormalities, including reduced glial density, decreased expression of the glutamate reuptake transporters EAAT1 and EAAT2 and decreased enzymatic conversion from glutamate to glutamine [33].”
From Pharmacotherapies Targeting GABA-Glutamate Neurotransmission for Treatment-Resistant Depression (2023) · cites this paper as [33]
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Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Self-citationSynaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 1×
“Excessive activation of extrasynaptic to synaptic NMDA receptors has been linked to various forms of excitotoxicity, and has been implemented in the pathophysiology of multiple neurodegenerative disorders (57).”
BackgroundGlial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
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Snijders, G. J. L., & Gigase, F. A. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19102-2.00010-7 · Cited by 1
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[Research advances in susceptible genes for developmental dyslexia in children].
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Kiselycznyk, C., & Sanacora, G. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1056-4_17
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Lawford‐Smith, H. (2015)
Misquitta, K. A. (2016) · TSpace (University of Toronto)
Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain
Brooks, A. K. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Bhardwaj, P. P. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3js9hn59
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Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00005-5
Iwai, T., Mishima, R., Hirayama, S., Nakajima, H., Oyama, M., Watanabe, S., Fujii, H., & Tanabe, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020608
Fong, T. H., Li, T., Ma, X., Cai, X., & Zhou, Q. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.20.619255
Lullau, A. P. M., & Haga, E. M. W. (2025) · Neuromethods · doi:10.1007/978-1-0716-4603-8_3
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Olianas, M. C., Dedoni, S., & Onali, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083660
Pradhan, A., Pati, S., Saba, K., Chaudhari, P. R., Tiwari, P., Kapri, D., Balakrishnan, A., Patel, A. B., & Vaidya, V. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.16.725656
Fronto-striatal neurometabolite signatures of impulsivity in early abstinence from methamphetamine
Dumitrescu, A. M., Vest, M. F., Loftis, J. M., & Murnane, K. S. (2026) · NeuroImage Clinical · doi:10.1016/j.nicl.2026.104015
Yang, S., Wang, L. J., Sun, Y., Ma, X. Y., Rong, Y., Fong, T. H., Li, T., Deng, D., Li, X.-X., Zhang, Z., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.31.727553
Pradhan, A., Pati, S., Saba, K., Chaudhari, P. R., Tiwari, P., Kapri, D., Balakrishnan, A., Patel, A. B., & Vaidya, V. A. (2026) · European Journal of Neuroscience · doi:10.1111/ejn.70702
Sulej, Z., & Zielińska, M. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1950244
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Metadata
- Authors
- Sanacora, G., & Banasr, M.
- Affiliations
- Yale University (US)
- Corresponding author
- Sanacora, Gerard
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 73
- Issue
- 12
- Pages
- 1172-1179
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC3688253
- OpenAlex
- W2077129553
- Cited by
- 239
- References
- 102
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 17 · 2021: 22 · 2020: 15 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 17 · 2015: 27 · 2014: 24 · 2013: 4
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH085055, R01MH081211, R01 MH08055)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- glial cells, astrocytes, major depressive disorder, mood disorders, glutamate uptake, chronic stress, antidepressants, neuroinflammation
- MeSH terms
- Animals, Antidepressive Agents, Cell Communication, Humans, Neuroglia, Neurons, Mood Disorders
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