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Repertoire of microglial and macrophage responses after spinal cord injury

David, Samuel, Kroner, Antje·2011·Nature Reviews Neuroscience
DOI 10.1038/nrn3053
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Abstract

Macrophages from the peripheral circulation and those derived from resident microglia are among the main effector cells of the inflammatory response that follows spinal cord trauma. There has been considerable debate in the field as to whether the inflammatory response is good or bad for tissue protection and repair. Recent studies on macrophage polarization in non-neural tissues have shed much light on their changing functional states. In the context of this literature, we discuss the activation of macrophages and microglia following spinal cord injury, and their effects on repair. Harnessing their anti-inflammatory properties could pave the way for new therapeutic strategies for spinal cord trauma.

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Metadata

Authors
David, S., & Kroner, A.
Venue
Nature Reviews Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2011-06-15
Volume
12
Issue
7
Pages
388-399
ISSN
  • 1471-003X
  • 1471-0048
DOI
10.1038/nrn3053
Cited by
1,297
References
28
Language
en
Licence
www.springer.com/tdm (tdm)

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