Cited by 239Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

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From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

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Sanacora, Gerard, Banasr, Mounira·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.03.032PMC PMC3688253

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Abstract

Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.

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Authors: Sanacora, G., & Banasr, M.
Affiliations: Yale University (US)
Corresponding author: Sanacora, Gerard
ORCID: Sanacora, Gerard
Banasr, Mounira
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-06
Volume: 73
Issue: 12
Pages: 1172-1179
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.03.032
PMC: PMC3688253
OpenAlex: W2077129553
Cited by: 239
References: 102
Citations by year: 2026: 13 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 17 · 2021: 22 · 2020: 15 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 17 · 2015: 27 · 2014: 24 · 2013: 4
FWCI: 3.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH085055, R01MH081211, R01 MH08055)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: glial cells, astrocytes, major depressive disorder, mood disorders, glutamate uptake, chronic stress, antidepressants, neuroinflammation
MeSH terms: Animals, Antidepressive Agents, Cell Communication, Humans, Neuroglia, Neurons, Mood Disorders

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From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

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