Cited by 239Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

Open access

Sanacora, Gerard, Banasr, Mounira·2013·Biological Psychiatry

DOI 10.1016/j.biopsych.2013.03.032PMC PMC3688253

Open this paper in CoChat — free account

Abstract

Several structural and cellular changes, including marked glial anomalies, have been observed in association with major depressive disorder. Here we review these cellular alterations and highlight the importance of glial cell pathology, especially astroglial dysfunction, in the pathophysiology of neuropsychiatric disorders with a particular interest in major depressive disorder. The functional role of astrocytes in glutamate uptake and glutamate/glutamine cycling is discussed, as is the deleterious effects of chronic stress on glial cell function. Lastly, we discuss the effect of antidepressants on glial cell function and the possibility of targeting glial cells in the quest to develop novel therapeutics.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2013.03.032

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Bipolar Disorder
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881
Self-citation
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 1×
“Excessive activation of extrasynaptic to synaptic NMDA receptors has been linked to various forms of excitotoxicity, and has been implemented in the pathophysiology of multiple neurodegenerative disorders (57).”
Background
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477
Repertoire of microglial and macrophage responses after spinal cord injury
David, S., & Kroner, A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3053 · Cited by 1,297
Regulation of synaptic connectivity by glia.
Eroglu, C., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09612 · Cited by 813 · cited 1×
“Disrupted function of any of these cell types is likely to alter normal brain function and possibly contribute to the development of neuropsychiatric disorders (4).”
Background
Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists
Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J., & Oliet, S. H. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.029 · Cited by 798
Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
Steiner, J., Bielau, H., Brisch, R., Danos, P., Ullrich, O., Mawrin, C., Bernstein, H.-G., & Bogerts, B. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.10.013 · Cited by 791
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
Cotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766
Astrocytes and disease: a neurodevelopmental perspective
Molofsky, A. V., Krenick, R., Ullian, E., Tsai, H.-H., Deneen, B., Richardson, W. D., Barres, B. A., & Rowitch, D. H. (2012) · Genes & Development · doi:10.1101/gad.188326.112 · Cited by 682
Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: a study from the Stanley Neuropathology Consortium
Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00181-6 · Cited by 659
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653
Myelination and the trophic support of long axons
Nave, K.-A. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2797 · Cited by 648
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638
Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder
Cotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 622
Self-citation
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572
Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair
Tsai, H., Li, H., Fuentealba, L. C., Molofsky, A. V., Taveira‐Marques, R., Zhuang, H., Tenney, A., Murnen, A. T., Fancy, S. P. J., Merkle, F. T., et al. (2012) · Science · doi:10.1126/science.1222381 · Cited by 555
Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder
Johnston-Wilson, N. L., Sims, C. D., Hofmann, J.-P., Anderson, L., Shore, A. D., Torrey, E. F., Yolken, R. H., & the Stanley Neuropathology Consortium (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000696 · Cited by 531
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 518
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458
Self-citation
Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment
Czéh, B., Simon, M., Schmelting, B., Hiemke, C., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300982 · Cited by 434
Art. XIV.???Die Cellular Pathologie, in ihrer Begr??ndung auf physiologische und pathologische Gewebelehre
Virchow, V. R. (1861) · The American Journal of the Medical Sciences · doi:10.1097/00000441-186104000-00025 · Cited by 402
Ceftriaxone Restores Glutamate Homeostasis and Prevents Relapse to Cocaine Seeking
Knackstedt, L. A., Meléndez, R. I., & Kalivas, P. W. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.018 · Cited by 396
Transporters for L ‐glutamate: An update on their molecular pharmacology and pathological involvement
Beart, P. M., & O’Shea, R. D. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706949 · Cited by 381
Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression
Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372
Glial reduction in amygdala in major depressive disorder is due to oligodendrocytes
Hamidi, M., Drevets, W. C., & Price, J. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.006 · Cited by 369
The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes
Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347
Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
Koike, H., Iijima, M., & Chaki, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.035 · Cited by 346
Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder
Miguel-Hidalgo, J. J., Baucom, C. C., Dilley, G. E., Overholser, J. C., Meltzer, H. Y., Stockmeier, C. A., & Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00999-9 · Cited by 339
Course of improvement in depressive symptoms to a single intravenous infusion of ketamine vs add-on riluzole: results from a 4-week, double-blind, placebo-controlled study
Ibrahim, L., DiazGranados, N., Franco-Chaves, J., Brutsche, N., Henter, I. D., Kronstein, P., Moaddel, R., Wainer, I., Luckenbaugh, D. A., Manji, H. K., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.338 · Cited by 309
Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial
Mathew, S. J., Murrough, J. W., Rot, M. A. H., Collins, K. A., Reich, D. L., & Charney, D. S. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000169 · Cited by 297
Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse
Miller, B. R., Dorner, J. L., Shou, M., Sari, Y., Barton, S. J., Sengelaub, D. R., Kennedy, R. T., & Rebec, G. V. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.004 · Cited by 280
Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression
Si, X., Miguel-Hidalgo, J. J., O'Dwyer, G., Stockmeier, C. A., & Rajkowska, G. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300525 · Cited by 268
Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats
Sun, J.-D., Liu, Y., Yuan, Y.-H., Li, J., & Chen, N.-H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.319 · Cited by 258
Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus
Müller, M. B., Lucassen, P. J., Yassouridis, A., Hoogendijk, W. J. G., Holsboer, F., & Swaab, D. F. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01784.x · Cited by 249
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1
Fumagalli, E. R., Funicello, M., Rauen, T., Gobbi, M., & Mennini, T. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.10.023 · Cited by 248
Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218
Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes
Allaman, I., Fiumelli, H., Magistretti, P. J., & Martin, J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2190-y · Cited by 216
Microglia as modulators of cognition and neuropsychiatric disorders
Blank, T., & Prinz, M. (2012) · Glia · doi:10.1002/glia.22372 · Cited by 195
A putative functional role for oligodendrocytes in mood regulation
Edgar, N. M., & Sibille, E. L. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.34 · Cited by 191
Immunohistochemical Localization of Phosphorylated Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus from Patients with Schizophrenia, Bipolar Disorder, and Depression
Webster, M. J., Knable, M. B., Johnston-Wilson, N., Nagata, K., Inagaki, M., & Yolken, R. H. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2001.0646 · Cited by 179
Riluzole in the Treatment of Mood and Anxiety Disorders
Pittenger, C., Coric, V., Banasr, M., Bloch, M., Krystal, J. H., & Sanacora, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822090-00004 · Cited by 177
Self-citation
Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression
Zink, M., Vollmayr, B., Gebicke-Haerter, P. J., & Henn, F. A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.09.005 · Cited by 177
mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
Dwyer, J. M., Lepack, A. E., & Duman, R. S. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001702 · Cited by 169
Region specific decrease in glial fibrillary acidic protein immunoreactivity in the brain of a rat model of depression
Gosselin, R., Gibney, S. M., O’Malley, D., Dinan, T. G., & Cryan, J. F. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.10.018 · Cited by 169
Rapid Enhancement of Glutamatergic Neurotransmission in Bipolar Depression Following Treatment with Riluzole
Brennan, B. P., Hudson, J. I., Jensen, J. E., McCarthy, J., Roberts, J. L., Prescot, A. P., Cohen, B. M., Pope, H. G., Renshaw, P. F., & Öngür, D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.191 · Cited by 168
Amygdala astrocyte reduction in subjects with major depressive disorder but not bipolar disorder
Altshuler, L. L., Abulseoud, O. A., Foland‐Ross, L. C., Bartzokis, G., Chang, S., Mintz, J., Hellemann, G., & Vinters, H. V. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00838.x · Cited by 167
[From the library of the Netherlands Journal of Medicine. Rudolf Virchow: Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre; 1858].
Jc, M. (2003) · PubMed · Cited by 167
Clinical Studies Implementing Glutamate Neurotransmission in Mood Disorders
Sanacora, G., Rothman, D. L., Mason, G. F., & Krystal, J. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.018 · Cited by 158
Self-citation
Blockade of Astrocytic Glutamate Uptake in Rats Induces Signs of Anhedonia and Impaired Spatial Memory
Bechtholt, A. J., Walther, H. V., Adams, M. A., Carlezon, W. A., Öngür, D., & Cohen, B. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.74 · Cited by 157
Dysfunction of Astrocyte Connexins 30 and 43 in Dorsal Lateral Prefrontal Cortex of Suicide Completers
Ernst, C., Nagy, C., Kim, S., Yang, J., Deng, X., Hellstrom, I. C., Choi, K. H., Gershenfeld, H. K., Meaney, M. J., & Turecki, G. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.038 · Cited by 152
Antidepressant-Like Effects of Ceftriaxone in Male C57BL/6J Mice
Mineur, Y. S., Picciotto, M. R., & Sanacora, G. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.04.037 · Cited by 150
Self-citation
Receptor Actions of Synaptically Released Glutamate: The Role of Transporters on the Scale from Nanometers to Microns
Zheng, K., Scimemi, A., & Rusakov, D. A. (2008) · Biophysical Journal · doi:10.1529/biophysj.108.129874 · Cited by 146
Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia
Fatemi, S. H., Laurence, J. A., Araghi‐Niknam, M., Stary, J. M., Schulz, S. C., Lee, S. S., & Gottesman, I. I. (2003) · Schizophrenia Research · doi:10.1016/j.schres.2003.08.014 · Cited by 141
Astrocytes: Multitalented Stars of the Central Nervous System
Ransom, B. R., & Ransom, C. B. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-452-0_1 · Cited by 139
Ceftriaxone, a Beta-Lactam Antibiotic, Reduces Ethanol Consumption in Alcohol-Preferring Rats
Sari, Y., Sakai, M., Weedman, J. M., Rebec, G. V., & Bell, R. L. (2011) · Alcohol and Alcoholism · doi:10.1093/alcalc/agr023 · Cited by 137
Blockade of Astrocytic Glutamate Uptake in the Prefrontal Cortex Induces Anhedonia
John, C. S., Smith, K. L., Van'T Veer, A., Gompf, H. S., Carlezon, W. A., Cohen, B. M., Öngür, D., & Bechtholt-Gompf, A. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.105 · Cited by 136
Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression
Ye, Y., Wang, G., Wang, H., & Wang, X. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.055 · Cited by 133
Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
Feyissa, A. M., Woolverton, W. L., Miguel-Hidalgo, J. J., Wang, Z., Kyle, P. B., Hasler, G., Stockmeier, C. A., Iyo, A. H., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.018 · Cited by 126
Long-term effects of early life deprivation on brain glia in Fischer rats
Leventopoulos, M., Rüedi‐Bettschen, D., Knuesel, I., Feldon, J., Pryce, C. R., & Opacka‐Juffry, J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.039 · Cited by 125
A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder
Gittins, R., & Harrison, P. J. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.03.042 · Cited by 118
Requirement of AQP4 for antidepressive efficiency of fluoxetine: implication in adult hippocampal neurogenesis
Kong, H., Sha, L.-L., Fan, Y., Xiao, M., Ding, J.-H., Wu, J., & Hu, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.185 · Cited by 115
The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke
Thöne‐Reineke, C., Neumann, C., Namsolleck, P., Schmerbach, K., Krikov, M., Schefe, J. H., Lucht, K., Hörtnagl, H., Godes, M., Müller, S., et al. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e328313e403 · Cited by 115
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
Koike, H., Iijima, M., & Chaki, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.034 · Cited by 114
Aquaporin-4 Deficiency Impairs Synaptic Plasticity and Associative Fear Memory in the Lateral Amygdala: Involvement of Downregulation of Glutamate Transporter-1 Expression
Li, Y., Wang, F., Wang, W., Luo, Y., Wu, P.-F., Xiao, J., Hu, Z., Jin, Y., Hu, G., & Chen, J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.34 · Cited by 114
Astrocyte decrease in the subgenual cingulate and callosal genu in schizophrenia
Williams, M. R., Hampton, T., Pearce, R. K. B., Hirsch, S. R., Ansorge, O., Thom, M., & Maier, M. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0328-5 · Cited by 111
Chronic psychosocial stress and citalopram modulate the expression of the glial proteins GFAP and NDRG2 in the hippocampus
Araya-Callís, C., Hiemke, C., Abumaria, N., & Flugge, G. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2741-x · Cited by 109
Up‐regulation of GLT‐1 severely impairs LTD at mossy fibre–CA3 synapses
Omrani, A., Melone, M., Bellesi, M., Safiulina, V. F., Aida, T., Tanaka, K., Cherubini, E., & Conti, F. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.177881 · Cited by 99
Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers
Ernst, C., Chen, E. S., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.35 · Cited by 98
Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine
Sillaber, I., Panhuysen, M., Henniger, M. S. H., Ohl, F., Kühne, C., Pütz, B., Pohl, T., Deussing, J. M., Páez-Pereda, M., & Holsboer, F. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1232-6 · Cited by 95
Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
Gourley, S. L., Espitia, J. W., Sanacora, G., & Taylor, J. R. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2403-4 · Cited by 89
Self-citation
Riluzole Normalizes Early-Life Stress-Induced Visceral Hypersensitivity in Rats: Role of Spinal Glutamate Reuptake Mechanisms
Gosselin, R., O’Connor, R. M., Tramullas, M., Julio‐Pieper, M., Dinan, T. G., & Cryan, J. F. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.003 · Cited by 87
Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy
Ubhi, K. K., Inglis, C. A., Mante, M., Patrick, C., Adame, A., Spencer, B. J., Rockenstein, E. M., May, V. E. L., Winkler, J., & Masliah, E. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.008 · Cited by 87
Riluzole Augmentation in Treatment-Refractory Obsessive-Compulsive Disorder
Pittenger, C., Kelmendi, B., Wasylink, S., Bloch, M. H., & Coric, V. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181727548 · Cited by 83
Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression
Liu, Q., Li, B., Zhu, H., Wang, Y., Yu, J. M., & Wu, G.-C. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2009.06.010 · Cited by 81
Chronic restraint stress decreases glial fibrillary acidic protein and glutamate transporter in the periaqueductal gray matter
Imbe, H., Kimura, A., Donishi, T., & Kaneoke, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.007 · Cited by 73
Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.
Fatemi, S., Folsom, T., Reutiman, T. J., Pandian, T., Braun, N. N., & Haug, K. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.05.016 · Cited by 72
Glia mechanisms in mood regulation: a novel model of mood disorders
Lee, Y., Gaskins, D. L., Anand, A., & Shekhar, A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0652-4 · Cited by 66
Neuroprotective Drug Riluzole Amplifies the Heat Shock Factor 1 (HSF1)- and Glutamate Transporter 1 (GLT1)-dependent Cytoprotective Mechanisms for Neuronal Survival
Liu, A. Y. ‐., Mathur, R., Mei, N., Langhammer, C. G., Babiarz, B., & Firestein, B. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158220 · Cited by 66
Morphological Brain Changes in Depression: Can Antidepressants Reverse Them?
Miguel-Hidalgo, J. J., & Rajkowska, G. (2002) · CNS Drugs · doi:10.2165/00023210-200216060-00001 · Cited by 64
Chronic clomipramine treatment restores hippocampal expression of glial cell line-derived neurotrophic factor in a rat model of depression
Liu, Q., Zhu, H., Li, B., Wang, Y.-Q., Yu, J. M., & Wu, G.-C. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.018 · Cited by 59
Na(+)-dependent, fluoxetine-sensitive serotonin uptake by astrocytes tissue-printed from rat cerebral cortex
Dave, V., & Kimelberg, H. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04972.1994 · Cited by 52
Chronic Riluzole Treatment Increases Glucose Metabolism in Rat Prefrontal Cortex and Hippocampus
Chowdhury, G. M. I., Banasr, M., de Graaf, R. A., Rothman, D. L., Behar, K. L., & Sanacora, G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.78 · Cited by 48
Self-citation
[One hundred books which build up neurology--Rudolf Ludwig Carl Virchow "Die Cellularpathologie in ihrer Begrundung auf physiologische und pathologische Gewebelehre"].
Sakuta, M. (2011) · PubMed · Cited by 45
Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes
YOSHIZUMI, M., Eisenach, J. C., & Hayashida, K. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.12.015 · Cited by 39
Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiazepines
Sugiyama, A., Saitoh, A., Iwai, T., Takahashi, K., Yamada, M., Sasaki-Hamada, S., Oka, J.-I., Inagaki, M., & Yamada, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.012 · Cited by 38 · cited 1×
“In different rodent models, riluzole was also shown to have rapid anxiolytic effects (78), and to reverse the hyperemotionality and decrease the extracellular glutamate levels seen in bulbectomized animals (79).”
Background
Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression
Takahashi, K., Murasawa, H., Yamaguchi, K., Yamada, M., Nakatani, A., Yoshida, M., Iwai, T., Inagaki, M., Yamada, M., & Saitoh, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.07.002 · Cited by 37
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
Koike, H., Iijima, M., & Chaki, S. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.07.860 · Cited by 36
Female Early Adult Depression Results in Detrimental Impacts on the Behavioral Performance and Brain Development in Offspring
Gong, Y. L., Sun, X., Wu, F., Su, C., Ding, J., & Hu, G. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2012.00324.x · Cited by 35
Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model
Verhave, P. S., Jongsma, M. J., van den Berg, R. M., Vanwersch, R. A. P., Smit, A. B., & Philippens, I. H. C. H. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.016 · Cited by 33
Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats
Miguel-Hidalgo, J. J., Shoyama, Y., & Wanzo, V. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108091074 · Cited by 31
Role of astrocytes and altered regulation of spinal glutamatergic neurotransmission in stress-induced visceral hyperalgesia in rats
Bradesi, S., Golovatscka, V., Ennes, H. S., McRoberts, J. A., Karagiannidis, I., Bakirtzi, K., Pothoulakis, C., & Mayer, E. A. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00182.2011 · Cited by 27
Fluoxetine treatment induces EAAT2 expression in rat brain
Zink, M., Rapp, S., Donev, R., Gebicke‐Haerter, P. J., & Thome, J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0536-y · Cited by 24
Glutamate and disorders of cognition and motivation
Moghaddam, B., & Wolf, M. E. (2003) · Cited by 21
Fluoxetine promotes gliogenesis during neural differentiation in mouse embryonic stem cells
Kusakawa, S., Nakamura, K., Miyamoto, Y., Sanbe, A., Torii, T., Yamauchi, J., & Tanoue, A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22509 · Cited by 19

Flagged first, then by citations

Sorted by citations

Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584
Self-citation
The Impact of Stress and Major Depressive Disorder on Hippocampal and Medial Prefrontal Cortex Morphology
Belleau, E. L., Treadway, M. T., & Pizzagalli, D. A. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.031 · Cited by 550
Targeting glutamate signalling in depression: progress and prospects
Murrough, J. W., Abdallah, C. G., & Mathew, S. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.16 · Cited by 482
Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
Pan, Y., Chen, X.-Y., Zhang, Q.-Y., & Kong, L.-D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.04.007 · Cited by 405

See all 239

Authors: Sanacora, G., & Banasr, M.
Affiliations: Yale University (US)
Corresponding author: Sanacora, Gerard
ORCID: Sanacora, Gerard
Banasr, Mounira
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2013-06
Volume: 73
Issue: 12
Pages: 1172-1179
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2013.03.032
PMC: PMC3688253
OpenAlex: W2077129553
Cited by: 239
References: 102
Citations by year: 2026: 13 · 2025: 10 · 2024: 14 · 2023: 17 · 2022: 17 · 2021: 22 · 2020: 15 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 17 · 2015: 27 · 2014: 24 · 2013: 4
FWCI: 3.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH085055, R01MH081211, R01 MH08055)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: glial cells, astrocytes, major depressive disorder, mood disorders, glutamate uptake, chronic stress, antidepressants, neuroinflammation
MeSH terms: Animals, Antidepressive Agents, Cell Communication, Humans, Neuroglia, Neurons, Mood Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks