The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
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Greater precision in quantification of elements delivered, received, and applied could inform improvements to existing treatments.
“greater precision in quantification of elements delivered, received, and applied could inform improvements to existing treatments (Holmes et al., 2018).”
From Measuring the active elements of cognitive-behavioral therapies (2023) · cites this paper as Holmes et al., 2018
The ‘Assessment of mechanisms’ section says that greater precision may come from assessing the mechanisms of individual therapeutic elements, supporting the idea that closer study of elements could improve treatments. The passages do not specifically discuss quantifying which elements are delivered, received, and applied, so that three-part claim is not established by our copy. (LLM, conf=0.81)
Experimental — accuracy not yet measuredThe threshold of engagement with the digital component that successfully facilitates the "non-digital target behaviour" can demonstrably vary between individuals, supporting a shift toward patient-treatment matching and person-centered care.
“Notably, the threshold of engagement with the digital component that successfully facilitates the “non-digital target behaviour” can demonstrably vary between individuals [71], supporting a shift toward patient-treatment matching and person-centered care [72]”
From Experiences of Using Digital Mindfulness-Based Interventions: Rapid Scoping Review and Thematic Synthesis (2023) · cites this paper as [72]
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredMost studies fail to account for the temporal relationship between the mediator and outcome.
“Even when establishing statistical mediation, most studies fail to account for the temporal relationship between the mediator and outcome (Holmes et al., 2018).”
From Mediators of acceptance and mindfulness-based therapies for anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as Holmes et al., 2018
The Assessment of mechanisms section says that establishing mediation requires mediator changes to precede and predict outcome changes, and recommends repeated measurement. It does not say that most studies fail to account for this temporal relationship; that prevalence claim is unsupported. (LLM, conf=0.78)
Experimental — accuracy not yet measuredUnderstanding treatment mechanisms is critical to target treatments more efficiently.
“Understanding treatment mechanisms is critical to target treatments more efficiently: indeed, this goal has been identified as a priority for psychological treatment research in general (Holmes et al., 2018; Kazdin, 2007).”
From Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application (2019) · cites this paper as Holmes et al., 2018
Assessment of negative or iatrogenic effects in psychological therapy is often neglected.
“Assessment of negative or iatrogenic effects in psychological therapy is often neglected (Barlow, 2010; Holmes et al., 2018).”
From Intrusive memories of trauma: A target for research bridging cognitive science and its clinical application (2019) · cites this paper as Holmes et al., 2018
Internet-delivered psychological treatment may increase access to evidence-based care by reducing barriers such as limited therapist time, long waiting times, geographical inequalities, and inflexibility in when and where to access treatment.
“Internet-delivered psychological treatment may increase access to evidence-based care by reducing some of the barriers that exist in health care, such as limited therapist time, long waiting times for treatment, geographical inequalities in access to care, and inflexibility in when and where to access treatment (Holmes et al., 2018).”
From Effectiveness of and processes related to internet-delivered acceptance and commitment therapy for adolescents with anxiety disorders: a randomized controlled trial (2023) · cites this paper as Holmes et al., 2018
Eight study quality criteria were extracted based on recommendations of Holmes et al., 2018 and Kazdin, 2007.
“As no validated risk of bias instrument exists for meta-analyses focusing on mediation, we extracted eight study quality criteria based on the recommendations of Holmes et al., 2018 and Kazdin, 2007: 1) Did the study register pre-defined hypotheses regarding mediators of the study?, 2) Did the study present a model of explanatory specificity?, 3) Did the study establish an effect of the therapy on”
From Mediators of acceptance and mindfulness-based therapies for anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as Holmes et al., 2018
Knowledge about treatment mediators is an essential step in the optimization of treatments.
“While the evidence is promising regarding the efficacy of acceptance and mindfulness-based therapies in treating anxiety and depressive disorders, knowledge about treatment mediators is an essential step in the optimization of treatments (Holmes et al., 2018; Kazdin & Blase, 2011).”
From Mediators of acceptance and mindfulness-based therapies for anxiety and depression: A systematic review and meta-analysis (2022) · cites this paper as Holmes et al., 2018
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The future of psychological treatments: The Marburg Declaration
Rief, W., Asmundson, G. J. G., Bryant, R. A., Clark, D. M., Ehlers, A., Holmes, E. A., McNally, R. J., Neufeld, C. B., Wilhelm, S., Jaroszewski, A. C., et al. (2024) · Clinical Psychology Review · doi:10.1016/j.cpr.2024.102417 · Cited by 54 · see citing works
Self-citationKanstrup, M., Kontio, E., Geranmayeh, A., Lauri, K. O., Moulds, M. L., & Holmes, E. A. (2020) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2489 · Cited by 52 · see citing works
Self-citationJi, J. L., Geiles, D., & Saulsman, L. M. (2021) · Behaviour Research and Therapy · doi:10.1016/j.brat.2021.103947 · Cited by 53 · see citing works
Singh, L., Espinosa, L., Ji, J. L., Moulds, M. L., & Holmes, E. A. (2020) · Cognitive Neuropsychiatry · doi:10.1080/13546805.2020.1804845 · Cited by 49 · see citing works
Self-citationWoud, M. L., Blackwell, S. E., Shkreli, L., Würtz, F., Cwik, J. C., Margraf, J., Holmes, E. A., Steudte‐Schmiedgen, S., Herpertz, S., & Kessler, H. (2021) · Psychotherapy and Psychosomatics · doi:10.1159/000514166 · Cited by 51 · see citing works
Self-citationBighelli, I., Huhn, M., Schneider‐Thoma, J., Krause, M., Reitmeir, C., Wallis, S., Schwermann, F., Pitschel‐Walz, G., Barbui, C., Furukawa, T. A., et al. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1964-8 · Cited by 51 · see citing works
Factorial Designs Help to Understand How Psychological Therapy Works
Watkins, E. R., & Newbold, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00429 · Cited by 52 · see citing works
- Authors
- Holmes, E. A., Ghaderi, A., Harmer, C. J., Ramchandani, P. G., Cuijpers, P., Morrison, A. P., Roiser, J. P., Bockting, C. L. H., O'Connor, R. C., Shafran, R., Moulds, M. L., & Craske, M. G.
- Affiliations
- Karolinska Institutet (SE)
- Oxford Health NHS Foundation Trust (GB)
- Centre for Mental Health (GB)
- Amsterdam Public Health (NL)
- University of Manchester (GB)
- University College London (GB)
- Amsterdam UMC Location University of Amsterdam (NL)
- UNSW Sydney (AU)
- University of California, Los Angeles (US)
- Corresponding author
- Holmes, Emily A
- ORCID
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 5
- Issue
- 3
- Pages
- 237-286
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W2789137369
- Cited by
- 624
- References
- 339
- Citations by year
- 2026: 45 · 2025: 59 · 2024: 77 · 2023: 71 · 2022: 78 · 2021: 132 · 2020: 68 · 2019: 58 · 2018: 36
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The Lancet Psychiatry (acceptedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- National Aeronautics and Space Administration (NNX15AP57G)
- Wellcome Trust (101798/Z/13/Z)
- National Institute of Mental Health (R01 MH1014531, R34MH101359, R01MH100117, R01MH102274)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- psychological intervention, treatment implementation, treatment response heterogeneity, interdisciplinary collaboration
- MeSH terms
- Mental Disorders, Humans, Mental Health Services, Psychiatry, Research, Randomized Controlled Trials as Topic, Treatment Outcome, Evidence-Based Medicine
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