The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress
Open accessAbstract
Background The nucleus accumbens is a critical mediator of depression-related outcomes to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 versus dopamine receptor D2, in reward and reinforcement leading to opposing roles for these MSNs in these behaviors. However, the distinct roles of nucleus accumbens MSN subtypes, in depression, remain poorly understood.Methods Using whole-cell patch clamp electrophysiology, we examined excitatory input to MSN subtypes and intrinsic excitability measures in D1-green fluorescent protein and D2-green fluorescent protein bacterial artificial chromosome transgenic mice that underwent chronic social defeat stress (CSDS). Optogenetic and pharmacogenetic approaches were used to bidirectionally alter firing of D1-MSNs or D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial chromosome transgenic mice.Results We demonstrate that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in D2-MSNs in mice displaying depression-like behaviors after CSDS. Enhancing activity in D1-MSNs results in resilient behavioral outcomes, while inhibition of these MSNs induces depression-like outcomes after CSDS. Bidirectional modulation of D2-MSNs does not alter behavioral responses to CSDS; however, repeated activation of D2-MSNs in stress naïve mice induces social avoidance following subthreshold social defeat stress.Conclusions Our studies uncover novel functions of MSN subtypes in depression-like outcomes. Notably, bidirectional alteration of D1-MSN activity promotes opposite behavioral outcomes to chronic social stress. Therefore, targeting D1-MSN activity may provide novel treatment strategies for depression or other affective disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nevertheless, activity in D1 MSNs is more likely to be associated with motivation, reward, and positive responses [193,[223][224][225] and resilience to stress [226].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to social defeat stress is accompanied by an increase in input resistance and firing in response to depolarizing currents pulses in D1 MSNs, but not D2 MSNs [226,234].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“We recently found D1-MSNs display reduced mEPSC frequency and D2-MSNs display enhanced frequency of mEPSCs in CSDS susceptible mice (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Like DBS, repeated high frequency stimulation of all NAc neurons alleviated depression-like outcomes to CSDS.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“It is likely D1-MSNs mediate this effect as cell-type specific stimulation of D1-MSNs mimicked non-specific NAc neuronal stimulation (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Furthermore, repeated, but not acute stimulation is necessary for this behavioral effect.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“This interpretation would be consistent with observed excitatory changes on NAc MSN subtypes as well as stimulation-mediated antidepressant outcomes (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Thus, we believe the stress-related changes to spine density occur on D2-MSNs, as D2-MSNs do not undergo dendritic atrophy but have enhanced excitatory input [82].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 5×
“This is a well-established protocol that yields stress susceptible (mice displaying depression-like behaviors) or resilient cohorts (1,2,41).”
InfluentialEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 380
Sato, D., Hamada, Y., Narita, M., Mori, T., Tezuka, H., Suda, Y., Tanaka, K., Yoshida, S., Tamura, H., Yamanaka, A., et al. (2022) · Molecular Brain · doi:10.1186/s13041-022-00902-1 · Cited by 15
Shan, Q., Fang, Q., & Tian, Y. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00304 · Cited by 15
Astrocytic CREB in Nucleus Accumbens Promotes Susceptibility to Chronic Stress
Holt, L. M., Gyles, T. M., Parise, E. M., Minier-Toribio, A. M., Rivera, M., Markovic, T., Yeh, S.-Y., & Nestler, E. J. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.09.021 · Cited by 15
Tobar, I. D. B., Fernández, P., Sáez, J. C., & Dagnino‐Subiabre, A. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24902 · Cited by 16
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
Ruan, H., Tong, G., Jin, M., Koch, K., & Wang, Z. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.06.009 · Cited by 14
Dvorak, N. M., Wadsworth, P. A., Wang, P., Chen, H., Zhou, J., & Laezza, F. (2020) · Molecules · doi:10.3390/molecules25153365 · Cited by 14
Miceli, M. D., Martinat, M., Rossitto, M., Aubert, A., Alashmali, S. M., Bosch‐Bouju, C., Fioramonti, X., Joffre, C., Bazinet, R. P., & Layé, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126650 · Cited by 14
Off-Target Influences of Arch-Mediated Axon Terminal Inhibition on Network Activity and Behavior
Lafferty, C. K., & Britt, J. P. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00010 · Cited by 13
Oxytocin Signaling as a Target to Block Social Defeat-Induced Increases in Drug Abuse Reward
Perez, C. F., Reguilón, M. D., Miñarro, J., & Rodríguez‐Arias, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052372 · Cited by 15
Lin, R., Learman, L. N., Na, C. H., Renuse, S., Chen, K. T., Chen, P. Y., Lee, G.-H., Xiao, B., Resnick, S. M., Troncoso, J. C., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.10.012 · Cited by 16
Francis, T. C., & Porcu, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1188184 · Cited by 15
Self-citationGuan, J., Sun, Y., Fan, Y., Liang, J., Liu, C., Yu, H., & Liu, J. (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1406670 · Cited by 18
Optogenetics: What it has uncovered in potential pathways of depression
Cheng, Z., Cui, R., Ge, T., Yang, W., & Li, B. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104596 · Cited by 14
α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice
Benham, R. S., Choi, C., Hodgson, N., Hewage, N. B., Kästli, R., Donahue, R. J., Muschamp, J. W., Engin, E., Carlezon, W. A., Hensch, T. K., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01144-w · Cited by 14
Siemsen, B. M., Franco, D., & Lobo, M. K. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.12.014 · Cited by 12
Self-citationRiga, D., Schmitz, L. J. M., van Mourik, Y., Hoogendijk, W. J. G., Vries, T. J. D., Smit, A. B., & Spijker, S. (2018) · Addiction Biology · doi:10.1111/adb.12701 · Cited by 12
Using social rank as the lens to focus on the neural circuitry driving stress coping styles
LeClair, K. B., & Russo, S. J. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.03.007 · Cited by 12
Sleep-Wake Dynamics Pre- and Post-Exposure to Chronic Social Stress
Radwan, B., Jansen, G., & Chaudhury, D. (2021) · iScience · doi:10.1016/j.isci.2021.103204 · Cited by 12
Yu, X., Chen, S., & Shan, Q. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab031 · Cited by 12
Dvorak, N. M., Wadsworth, P. A., Aquino-Miranda, G., Wang, P., Engelke, D. S., Zhou, J., Nguyen, N. H., Singh, A. K., Aceto, G., Haghighijoo, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55554-7 · Cited by 13
Laterodorsal tegmentum–ventral tegmental area projections encode positive reinforcement signals
Coimbra, B., Domingues, A. V., Soares‐Cunha, C., Correia, R. G., Pinto, L., Sousa, N., & Rodrigues, A. J. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24931 · Cited by 13
Differential mitochondrial morphology in ventral striatal projection neuron subtypes
Chandra, R., Calarco, C. A., & Lobo, M. K. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24511 · Cited by 14
Self-citationNavarrete, J. S., Schneider, K. N., Smith, B. M., Goodwin, N. L., Zhang, Y. Y., Salazar, A. S., Gonzalez, Y. E., Anumolu, P., Gross, E., Tsai, V. S., et al. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.01.007 · Cited by 12
Kurauchi, Y., Ohta, Y., Matsuda, K., Sanematsu, W., Devkota, H. P., Seki, T., & Katsuki, H. (2023) · Nutrients · doi:10.3390/nu15030581 · Cited by 12
Giua, G., Lassalle, O., Makrini, L., Valjent, E., Chavis, P., & Manzoni, O. J. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1146647 · Cited by 9
Yang, R., Zhao, X., Liu, J., Yao, X., Hou, F., Xu, Y., & Feng, Q. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00217-1 · Cited by 10
Oizumi, H., Imai, R., Suzuki, T., Omiya, Y., Tanaka, K. F., Mimura, M., & Mizoguchi, K. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001667 · Cited by 10
Coleman, B. C., Manz, K. M., & Grueter, B. A. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01146-8 · Cited by 10
Guilherme, M. D. S., Tsoutsouli, T., Chongtham, M. C., Winter, J., Gerber, S., Müller, M. B., & Endres, K. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105700 · Cited by 10
Gan, Y., Dong, Y., Dai, S., Shi, H., Li, X., Wang, F., Fu, Y., & Dong, Y. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109714 · Cited by 9
An accumbal microcircuit for the transition from acute to chronic pain
Yu, Y., Xia, S.-H., Xu, Z., Zhao, W.-N., Song, L., Pan, X., Zhong, C., Wang, D., Gao, Y., Yang, J., et al. (2025) · Current Biology · doi:10.1016/j.cub.2025.02.055 · Cited by 9
Tang, S., Cui, L., Pan, J., & Xu, N.-L. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114726 · Cited by 9
Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain
Georgiou, P., Postle, A. F., Mou, T.-C. M., Potter, L. E., An, X., Zanos, P., Patton, M. S., Pultorak, K. J., Clark, S. M., Ngyuyen, V., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03027-8 · Cited by 8
D1 and D2 Type Medium Spiny Neuron Contributions to Depression
Peña, C. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.02.010 · Cited by 8
Maria-Rios, C. E., Murphy, G. G., & Morrow, J. D. (2023) · eNeuro · doi:10.1523/eneuro.0432-22.2023 · Cited by 8
Díez-Solinska, A., Goñi‐Balentziaga, O., Beitia, G., Muñoz‐Culla, M., Vegas, Ó., & Azkona, G. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115023 · Cited by 7
Deng, Q., Zhang, S.-Q., Yang, P., Dong, W., Wang, F., Long, L., & Chen, J. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01074-x · Cited by 7
Mitochondrial control of ciliary gene expression and structure in striatal neurons
Ülgen, D. H., Chioino, A., Zanoletti, O., Quintana, A., Sanz, E., & Sandi, C. (2025) · The Journal of Physiology · doi:10.1113/jp287948 · Cited by 8
Light Modulation of Brain and Development of Relevant Equipment
Li, X., Liu, C., & Wang, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191240 · Cited by 8
Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping
Zangrandi, L., Schmuckermair, C., Ghareh, H., Castaldi, F., Heilbronn, R., Zernig, G., Ferraguti, F., & Ramos-Prats, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157826 · Cited by 8
Deng, Q., Zhang, S.-Q., Yang, P., Dong, W., Wang, J., Chen, J., Wang, F., & Long, L. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14046 · Cited by 7
Attachaipanich, S., Ozawa, T., Macpherson, T., & Hikida, T. (2023) · eNeuro · doi:10.1523/eneuro.0082-23.2023 · Cited by 8
Involvement of brain cell phenotypes in stress-vulnerability and resilience
Favoretto, C. A., Pagliusi, M., & Morais‐Silva, G. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1175514 · Cited by 10
Borland, J. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105809 · Cited by 8
The Impact of Psychosocial Factors on the Human—Pet Bond: Insights from Cat and Dog Owners
Azkona, G. (2025) · Animals · doi:10.3390/ani15131895 · Cited by 7
Bevilacqua, L. M., Neto, F. D. S., Rosado, A. F., Pinho, C. M., Platt, N., & Kaster, M. P. (2026) · Purinergic Signalling · doi:10.1007/s11302-025-10118-2 · Cited by 7
GABAergic neurons in the nucleus accumbens core mediate the antidepressant effects of sevoflurane
Wu, M., Li, A., Guo, Y., Cao, F., You, S., Cao, J., Mi, W., & Li, T. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175627 · Cited by 8
Семина, И. И., Валерьевна, В. Е., Олегович, Н. Д., Байчурина, А. З., Nikitina, A. V., Shilovskaya, E. V., & Kravtsova, O. A. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01458-w · Cited by 7
Kanigowski, D., & Urban‐Ciećko, J. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae109 · Cited by 6
Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking
Heinsbroek, J. A., Neuhofer, D. N., Griffin, W. C., Siegel, G. S., Bobadilla, A., Kupchik, Y. M., & Kalivas, P. W. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2659-16.2017 · Cited by 7
Fitzgerald, E., Arcego, D. M., Shen, M., O’Toole, N., Wen, X., Nagy, C., Mostafavi, S., Craig, K., Silveira, P. P., Rayan, N. A., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104749 · Cited by 10
Shi, Z., Wen, K., Sammudin, N. H., LoRocco, N. C., & Zhuang, X. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03013-0 · Cited by 7
How dopamine guides our social world
Padilla-Coreano, N., & Martínez-Rivera, F. J. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100085 · Cited by 6
Wang, A., Chao, O. Y.-H., Nikolaus, S., Lamounier‐Zepter, V., Hollenberg, C. P., Lübec, G., Trossbach, S. V., Korth, C., & Huston, J. P. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.013 · Cited by 6
Transcription factor Pitx3 mutant mice as a model for Parkinson’s disease
Zhou, F.-M., Li, L., Yue, J., & Dani, J. A. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1429-8 · Cited by 6
Merrer, J. L., Detraux, B., Gandía, J., Groote, A. D., Fonteneau, M., d’Exaerde, A. D. K., & Becker, J. A. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.28.518147 · Cited by 6
Pagliusi, M., Amorim-Marques, A. P., Lobo, M. K., Guimarães, F. S., Lisboa, S. F. D. S., & Gomes, F. V. (2024) · Pain · doi:10.1097/j.pain.0000000000003257 · Cited by 5
Self-citationOptogenetics: illuminating the neural bases of rodent behavior
Lobo, M. K., Francis, C., & Chaudhury, D. (2014) · Open Access Animal Physiology · doi:10.2147/oaap.s42339 · Cited by 6
Self-citationThe Ventral Pallidum: Proposed Integrator of Positive and Negative Factors in Cocaine Abuse
James, M. H., & Aston‐Jones, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.042 · Cited by 5
Alexander, R., & Gatt, J. M. (2019) · Oxford University Press eBooks · doi:10.1093/oso/9780198793014.003.0020 · Cited by 5
Cognition and mood-related behaviors in L3mbtl1 null mutant mice
Shen, E. Y., Jiang, Y., Mao, W., Futai, K., Hock, H., & Akbarian, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121252 · Cited by 4
Depression: epigenetics and epitranscriptomic modifications
Banerjee, S., Shrilaxmi, M. S., Banerjee, S., Prajwal, B. G., Smith, C., D’Mello, S. R., & Dastidar, S. G. (2025) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2025.2602171 · Cited by 4
Social stress and affiliative touch: A tale of two affective states
Papantoniou, L. P., Vityk, O., & Tzanoulinou, S. (2026) · iScience · doi:10.1016/j.isci.2026.114833 · Cited by 4
Neural basis of social hierarchy across species
Yan, R., & Lin, D. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01047-z · Cited by 4
Laymon, J. L., Whitten, C. J., Radford, A. F., Brewer, A. R., Deo, Y. S., Hooker, M. K., Geddati, A. A., & Cooper, M. A. (2025) · Neurobiology of Stress · doi:10.1016/j.ynstr.2025.100720 · Cited by 4
Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment
Pan, H., Xia, T., Zhang, Y., Zhang, H., Xu, M., Guo, J., Liu, Y., Bai, X.-Y., Liu, Q., Liu, W.-Z., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-025-3024-y · Cited by 5
The neural mechanism underlying resilience
Liu, H., Zhang, C., & Yang, L. (2019) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2019.00312 · Cited by 5
Luo, P. X., Godoy, A. S., Zakharenkov, H. C., Vang, N., Wright, E. C., Balantac, T. A., Archdeacon, S. C., Black, A. M., Lake, A. A., Ramirez, A. V., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01937-9 · Cited by 4
Solomon, M. G., Nennig, S. E., Cotton, M. R., Whiting, K. E., Fulenwider, H. D., & Schank, J. R. (2024) · Addiction Neuroscience · doi:10.1016/j.addicn.2024.100174 · Cited by 4
Tong, G., Chen, Y., & Liang, Y. (2024) · Guidelines and Standards of Chinese Medicine · doi:10.1097/gscm.0000000000000031 · Cited by 5
Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity
Alberquilla, S., Nanclares, C., Expósito, S., Gall, G., Kofuji, P., Araque, A., Martín, E. D., & Moratalla, R. (2025) · Glia · doi:10.1002/glia.24672 · Cited by 5
Stressing the other paraventricular nucleus
Fraser, K. M., & Janak, P. H. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0178-1 · Cited by 4
Schneider, M. L., Moore, C. F., Ahlers, E. O., Barnhart, T. E., Christian, B. T., DeJesus, O. T., Engle, J. W., Holden, J. E., Larson, J. A., Moirano, J. M., et al. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00029 · Cited by 5
Cholinergic Interneurons Provide a Link to Balance Excitation across Striatal Output Neurons
Gong, S., & Ford, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.023 · Cited by 4
Valence-dependent synaptic plasticity drives approach and avoidance behavior in social contextPreprint
Espinosa, P., Girard, B. J. T., Lucchini, M., Campanelli, F., Tiriticco, V., Mohrhauer, L., & Bellone, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515650 · Cited by 5
Teng, T., Wu, Q., Yin, B., Zhang, J., Li, X., Zhang, L., Zhou, X., & Xie, P. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01412-5 · Cited by 3
A circuit-based framework for depression: Reshaping the pathological attractor
Yuan, Z., Quan, J., Cui, Y., & Luo, M. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.009 · Cited by 5
Dogra, S., Aguayo, C., Xiang, Z., Putnam, J., Smith, J., Johnston, C., Foster, D. J., Lindsley, C. W., Niswender, C. M., & Conn, P. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.11.023 · Cited by 4
Petri, A., Sullivan, A., Allen, K., & Sachs, B. D. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1315366 · Cited by 3
de Schultz, T. F., Braun, K. A., & Bock, J. (2023) · Developmental Neuroscience · doi:10.1159/000530050 · Cited by 3
Rodriguez, M., Themann, A., Garcia-Carachure, I., Lira, O., Robison, A. J., Cushing, B. S., & Iñiguez, S. D. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.02.001 · Cited by 3
Self-citationTang, J., Yang, C., Shi, M., & Chen, W. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113759 · Cited by 3
Optogenetics: Illuminating the Neural Circuits of Depression
Muir, J., & Bagot, R. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00014-7 · Cited by 3
Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathwaysPreprint
Quessy, F., Bittar, T. P., Blanchette, L.-J., Lévesque, M., & Labonté, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.04.425341 · Cited by 3
Attachaipanich, S., Ozawa, T., Macpherson, T., & Hikida, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.25.534237 · Cited by 3
Altered postnatal chromatin development in the nucleus accumbens primes lifelong stress sensitivityPreprint
Rashford, R. L., Fang, L. Z., DeBerardine, M., Kim, H. J. J., Hirschfield, L. W., Cervi, E., Barrett, M. R., Thompson, J. M., Creed, M. C., & Peña, C. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.12.589272 · Cited by 3
Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility
Russo, S., Cathomas, F., Lin, H.-Y., Chan, K., Li, L., Durand-de Cuttoli, R., Parise, L., Aubry, A., Muhareb, S., Desland, F., et al. (2023) · doi:10.21203/rs.3.rs-1647827/v1 · Cited by 189
“These findings, which emphasize the role of peripheral myeloid cells in stress-linked disorders such as MDD, are in line with several pre-clinical studies 13,34,12,35 and studies in humans 36,37,38 .”
BackgroundResultCell- and Pathway-Specific Disruptions in the Accumbens of Fragile X Mouse
Giua, G., Pereira-Silva, J., Cáceres-Rodríguez, A., Lassalle, O., Chavis, P., & Manzoni, O. J. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1587-23.2024 · Cited by 2
Campbell, R. R., Green, M., Choi, E. Y., Wulff, A. B., Siclair, A. N., Khatri, S., Virata, G., Barrett, C., Key, S., Patel, S., et al. (2025) · eNeuro · doi:10.1523/eneuro.0157-25.2025 · Cited by 2
Self-citationZheng, Q., Zhao, Y., Cheng, Q., Wang, H., Liu, F., Lai, J., Liu, Y., Zhang, X., Kang, Y., Li, Z., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0382-25.2025 · Cited by 3
Chioino, A., Ülgen, D. H., Zanoletti, O., de Suduiraut, I. G., Maynard, A., Sanz, E., Quintana, A., Astori, S., & Sandi, C. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2601657123 · Cited by 2
Regulation and Modulation of Depression-Related Behaviours: Role of Dopaminergic Neurons
Radwan, B., Liu, H., & Chaudhury, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-46437-4_8 · Cited by 2
Optogenetic Animal Models of Depression: From Mice to Men
Arslan, A., Ünal‐Aydın, P., Dogan, T., & Aydın, O. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_8 · Cited by 2
Early developmental changes in GABAA receptor expression in nucleus accumbens medium spiny neurons
Wang, Z., Folorunso, O. O., Morris, K., Berretta, S., & Engin, E. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1445162 · Cited by 2
From social effort to social behavior: An integrated neural model for social motivation
Kanterman, A., & Shamay‐Tsoory, S. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106170 · Cited by 4
Silva, W. D. S. (2025) · Caderno Pedagógico · doi:10.54033/cadpedv22n10-058 · Cited by 2
Anatomy and Function of the Direct and Indirect Striatal Pathways
Soghomonian, J. (2016) · Innovations in cognitive neuroscience · doi:10.1007/978-3-319-42743-0_3 · Cited by 2
Striatal circuit development and synapse maturation
Peixoto, R. T., & Kozorovitskiy, Y. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00021-1 · Cited by 2
Mechanisms of Stress-Induced Sleep Disturbance Give New Insight Into Stress Vulnerability
Muir, J., & Bagot, R. C. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.030 · Cited by 2
Stress-induced Alterations of Mesocortical and Mesolimbic Dopaminergic PathwaysPreprint
Quessy, F., Bittar, T. P., Blanchette, L.-J., Lévesque, M., & Labonté, B. (2021) · Research Square · doi:10.21203/rs.3.rs-140843/v1 · Cited by 2
Metadata
- Authors
- Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., & Lobo, M. K.
- Affiliations
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- California State University, San Bernardino (US)
- Corresponding author
- Lobo, Mary Kay
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 77
- Issue
- 3
- Pages
- 212-222
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5534173
- OpenAlex
- W2141609201
- Cited by
- 379
- References
- 60
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 44 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 17 · 2016: 21 · 2015: 19
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH106500)
- National Institute of General Medical Sciences (T34GM083883, SC2GM109811)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- nucleus accumbens, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, chronic social defeat stress, depression-like behavior, excitatory synaptic input, intrinsic excitability, social avoidance, neuronal activity modulation, depression resilience
- MeSH terms
- Action Potentials, Animals, Depressive Disorder, Dominance-Subordination, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Social Behavior, Stress, Psychological, Receptors, Dopamine D1, Receptors, Dopamine D2, Patch-Clamp Techniques, Tissue Culture Techniques, Resilience, Psychological, GABAergic Neurons, Anhedonia, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
