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Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress
Open accessAbstract
Background The nucleus accumbens is a critical mediator of depression-related outcomes to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 versus dopamine receptor D2, in reward and reinforcement leading to opposing roles for these MSNs in these behaviors. However, the distinct roles of nucleus accumbens MSN subtypes, in depression, remain poorly understood.Methods Using whole-cell patch clamp electrophysiology, we examined excitatory input to MSN subtypes and intrinsic excitability measures in D1-green fluorescent protein and D2-green fluorescent protein bacterial artificial chromosome transgenic mice that underwent chronic social defeat stress (CSDS). Optogenetic and pharmacogenetic approaches were used to bidirectionally alter firing of D1-MSNs or D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial chromosome transgenic mice.Results We demonstrate that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in D2-MSNs in mice displaying depression-like behaviors after CSDS. Enhancing activity in D1-MSNs results in resilient behavioral outcomes, while inhibition of these MSNs induces depression-like outcomes after CSDS. Bidirectional modulation of D2-MSNs does not alter behavioral responses to CSDS; however, repeated activation of D2-MSNs in stress naïve mice induces social avoidance following subthreshold social defeat stress.Conclusions Our studies uncover novel functions of MSN subtypes in depression-like outcomes. Notably, bidirectional alteration of D1-MSN activity promotes opposite behavioral outcomes to chronic social stress. Therefore, targeting D1-MSN activity may provide novel treatment strategies for depression or other affective disorders.
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“Nevertheless, activity in D1 MSNs is more likely to be associated with motivation, reward, and positive responses [193,[223][224][225] and resilience to stress [226].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to social defeat stress is accompanied by an increase in input resistance and firing in response to depolarizing currents pulses in D1 MSNs, but not D2 MSNs [226,234].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“We recently found D1-MSNs display reduced mEPSC frequency and D2-MSNs display enhanced frequency of mEPSCs in CSDS susceptible mice (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Like DBS, repeated high frequency stimulation of all NAc neurons alleviated depression-like outcomes to CSDS.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“It is likely D1-MSNs mediate this effect as cell-type specific stimulation of D1-MSNs mimicked non-specific NAc neuronal stimulation (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Furthermore, repeated, but not acute stimulation is necessary for this behavioral effect.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“This interpretation would be consistent with observed excitatory changes on NAc MSN subtypes as well as stimulation-mediated antidepressant outcomes (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Thus, we believe the stress-related changes to spine density occur on D2-MSNs, as D2-MSNs do not undergo dendritic atrophy but have enhanced excitatory input [82].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [82]
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Citations
Cites
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 5×
“This is a well-established protocol that yields stress susceptible (mice displaying depression-like behaviors) or resilient cohorts (1,2,41).”
InfluentialEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Cited by
Sorted by citations
Stress and the social brain: behavioural effects and neurobiological mechanisms
Sandi, C., & Haller, J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3918 · Cited by 655
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491
Animal models of major depression: drawbacks and challenges
Planchez, B., Surget, A., & Belzung, C. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02084-y · Cited by 480
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 460
Stress and the dopaminergic reward system
Baik, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00532-4 · Cited by 477
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states
Parker, J. G., Marshall, J. D., Ahanonu, B., Wu, Y., Kim, T. H., Grewe, B. F., Zhang, Y., Li, J. Z., Ding, J., Ehlers, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0090-6 · Cited by 360
Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296
“Francis and colleagues (66) expanded upon these initial findings to show increased glutamate transmission specifically on D2 MSNs of susceptible mice relative to Cathomas et al.”
BackgroundAlexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 364
Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265
5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., & Malenka, R. C. (2018) · Nature · doi:10.1038/s41586-018-0416-4 · Cited by 256
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, C., de Vasconcelos, N. A. P., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., Gaspar, R., Sotiropoulos, I., Sousa, N., & Rodrigues, A. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0484-3 · Cited by 256
A Novel Method for Chronic Social Defeat Stress in Female Mice
Harris, A. Z., Atsak, P., Bretton-Granatoor, Z., Holt, E. S., Alam, R., Morton, M. P., Abbas, A. I., Leonardo, E. D., Bolkan, S. S., Hen, R., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.259 · Cited by 261
Rodent models of post-traumatic stress disorder: behavioral assessment
Verbitsky, A., Dopfel, D., & Zhang, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0806-x · Cited by 260
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230
Self-citationAnhedonia and the Brain Reward Circuitry in Depression
Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 249
Luo, Y., Li, Y., Wang, L., Yang, S.-R., Yuan, X.-S., Wang, J., Chérasse, Y., Lazarus, M., Chen, J., Qu, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03889-3 · Cited by 236
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 242
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232
Self-citationWook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231
Shen, C.-J., Zheng, D., Li, K., Yang, J., Pan, H., Yu, X.-D., Fu, J., Zhu, Y., Sun, Q.-X., Tang, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0299-9 · Cited by 231
Reappraising striatal D1- and D2-neurons in reward and aversion
Soares‐Cunha, C., Coimbra, B., Sousa, N., & Rodrigues, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.021 · Cited by 203
Neural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 195
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Cathomas, F., Lin, H.-Y., Chan, K. L., Li, L., Parise, L. F., Alvarez, J., Durand-de Cuttoli, R., Aubry, A. V., Muhareb, S., Desland, F., et al. (2024) · Nature · doi:10.1038/s41586-023-07015-2 · Cited by 189
Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum
Creed, M. C., Ntamati, N. R., Chandra, R., Lobo, M. K., & Lüscher, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.001 · Cited by 161
Self-citationNucleus Accumbens Modulation in Reward and Aversion
Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158
Liu, H., Zhang, C., Ji, Y., & Yang, L. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00326 · Cited by 171
Neuronal correlates of depression
Chaudhury, D., Liu, H., & Han, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 150
Gebara, E., Zanoletti, O., Ghosal, S., Grosse, J., Schneider, B. L., Knott, G. W., Astori, S., & Sandi, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.003 · Cited by 152
Kirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 139
Architectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 146
Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking
Heinsbroek, J. A., Neuhofer, D., Griffin, W. C., Siegel, G. S., Bobadilla, A., Kupchik, Y. M., & Kalivas, P. W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2659-16.2016 · Cited by 129
Neurobiological basis of stress resilience
Nestler, E. J., & Russo, S. J. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.001 · Cited by 141
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders
Macpherson, T., & Hikida, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12830 · Cited by 135
van der Kooij, M. A., Hollis, F., Lozano, L., Zalachoras, I., Abad, S., Zanoletti, O., Grosse, J., Guillot de Suduiraut, I., Canto, C., & Sandi, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.135 · Cited by 127
Impact of Early Life Stress on Reward Circuit Function and Regulation
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.744690 · Cited by 131
A competitive model for striatal action selection
Bariselli, S., Fobbs, W. C., Creed, M. C., & Kravitz, A. V. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.009 · Cited by 123
Self-citationAn endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability
Folkes, O. M., Báldi, R., Kondev, V., Marcus, D. J., Hartley, N. D., Turner, B. D., Ayers, J. K., Baechle, J. J., Misra, M. P., Altemus, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131752 · Cited by 119
Neurobiology and systems biology of stress resilience
Kalisch, R., Russo, S. J., & Müller, M. B. (2024) · Physiological Reviews · doi:10.1152/physrev.00042.2023 · Cited by 145
Stress effects on the neural substrates of motivated behavior
Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 129
Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking
Pardo-García, T. R., García‐Keller, C., Penaloza, T., Richie, C. T., Pickel, J. M., Hope, B. T., Harvey, B. K., Kalivas, P. W., & Heinsbroek, J. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2822-18.2018 · Cited by 120
GABAA receptors as targets for treating affective and cognitive symptoms of depression
Lüscher, B., Maguire, J. L., Rudolph, U., & Sibille, E. L. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.06.009 · Cited by 122
In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens
Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112
Golden, S. A., Jin, M., Heins, C., Vènniro, M., Michaelides, M., & Shaham, Y. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2409-18.2019 · Cited by 116
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106
Role of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108
Kronman, H., Torres-Berrío, A., Sidoli, S., Issler, O., Godino, A., Ramakrishnan, A., Mews, P., Lardner, C. K., Parise, E. M., Walker, D. M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00814-8 · Cited by 108
Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100
Self-citationBosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.082 · Cited by 100
Yohn, S. E., Santerre, J. L., Nunes, E. J., Kozak, R., Podurgiel, S. J., Correa, M., & Salamone, J. D. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.05.003 · Cited by 99
Striatal direct and indirect pathways control decision-making behavior
Macpherson, T., Morita, M., & Hikida, T. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01301 · Cited by 105
Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning
Hikida, T., Morita, M., & Macpherson, T. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.01.004 · Cited by 98
Muir, J., Lopez, J., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0291-6 · Cited by 97
Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 101
Ketzef, M., Spigolon, G., Johansson, Y., Bonito-Oliva, A., Fisone, G., & Silberberg, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.004 · Cited by 87
Molecular basis of dendritic atrophy and activity in stress susceptibility
Francis, T. C., Chandra, R., Gaynor, A., Konkalmatt, P., Metzbower, S. R., Evans, B., Engeln, M., Blanpied, T. A., & Lobo, M. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.178 · Cited by 89
Self-citationMild Prenatal Stress Causes Emotional and Brain Structural Modifications in Rats of Both Sexes
Soares‐Cunha, C., Coimbra, B., Borges, S., Domingues, A. V., Silva, D., Sousa, N., & Rodrigues, A. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00129 · Cited by 91
Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond
Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 88
Zachry, J. E., Kutlu, M. G., Yoon, H. J., Leonard, M. Z., Chevée, M., Patel, D. D., Gaidici, A., Kondev, V., Thibeault, K. C., Bethi, R., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.023 · Cited by 75
Liu, S., Tang, Y., Shu, H., Tatum, D., Bai, Q., Crawford, J. A., Xing, Y., Lobo, M. K., Bellinger, L. L., Kramer, P. R., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001414 · Cited by 81
Self-citationWarren, B. L., Mazei‐Robison, M. S., Robison, A. J., & Iñiguez, S. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.004 · Cited by 78
Self-citationCell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
Heshmati, M., Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719014115 · Cited by 75
Self-citationMoreno-Rius, J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100774 · Cited by 77
Heshmati, M., Christoffel, D. J., LeClair, K. B., Cathomas, F., Golden, S. A., Aleyasin, H., Turecki, G., Friedman, A. K., Han, M., Ménard, C., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2568-19.2020 · Cited by 78
Biselli, T., Lange, S. S., Sablottny, L., Steffen, J., & Walther, A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14603 · Cited by 76
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 85
Hussein, A., Guevara, C. A., Valle, P. D., Gupta, S., Benson, D. L., & Huntley, G. W. (2021) · The Neuroscientist · doi:10.1177/10738584211011979 · Cited by 78
Khibnik, L. A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P. A., Nestler, E. J., & Russo, S. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.022 · Cited by 67
Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors
de Kloet, S. F., Mansvelder, H. D., & De Vries, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.014 · Cited by 69
Brancato, A., Bregman, D., Ahn, H. F., Pfau, M. L., Ménard, C., Cannizzaro, C., Russo, S. J., & Hodes, G. E. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.014 · Cited by 71
Kashima, D. T., & Grueter, B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705974114 · Cited by 67
High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs
Francis, T. C., Yano, H., Demarest, T. G., Shen, H., & Bonci, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.031 · Cited by 67
Self-citationNeural correlates of ingroup bias for prosociality in rats
Bartal, I. B.-A., Breton, J., Sheng, H., Long, K. L. P., Chen, S., Halliday, A., Kenney, J. W., Wheeler, A. L., Frankland, P. W., Shilyansky, C., et al. (2021) · eLife · doi:10.7554/elife.65582 · Cited by 66
Stress relief as a natural resilience mechanism against depression-like behaviors
Dong, Y., Li, Y., Xiang, X., Xiao, Z.-C., Hu, J., Li, Y., Li, H., & Hu, H. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.004 · Cited by 71
Depression and substance use disorders: Clinical comorbidity and shared neurobiology
Calarco, C. A., & Lobo, M. K. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.004 · Cited by 74
Self-citationYun, S., Yang, B., Anair, J. D., Martin, M. M., Fleps, S. W., Pamukcu, A., Yeh, N.-H., Contractor, A., Kennedy, A., & Parker, J. G. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01390-9 · Cited by 72
Matikainen-Ankney, B. A., Kezunovic, N., Menard, C., Flanigan, M. E., Zhong, Y., Russo, S. J., Benson, D. L., & Huntley, G. W. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1457-18.2018 · Cited by 69
Transient and sustained effects of dopamine and serotonin signaling in motivation‐related behavior
Yagishita, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12942 · Cited by 68
Stress‐Induced Depression: Is Social Rank a Predictive Risk Factor?
Larrieu, T., & Sandi, C. (2018) · BioEssays · doi:10.1002/bies.201800012 · Cited by 62
Tsai, S., Hsu, P., Chen, Y., Hossain, M. S., Chen, P., Tzeng, S., Chen, P. S., & Kuo, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01787-1 · Cited by 63
Francis, T. C., Gaynor, A., Chandra, R., Fox, M. E., & Lobo, M. K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.007 · Cited by 61
Self-citationPignatelli, M., Tejeda, H. A., Barker, D. J., Bontempi, L., Wu, J., Lopez, A., Ribeiro, S. P., Lucantonio, F., Parise, E. M., Torres‐Berrío, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0686-8 · Cited by 60
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Turner, B. D., Kashima, D. T., Manz, K. M., Grueter, C. A., & Grueter, B. A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00420 · Cited by 61
Ventral pallidal regulation of motivated behaviors and reinforcement
Soares‐Cunha, C., & Heinsbroek, J. A. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1086053 · Cited by 61
Cytokine variations and mood disorders: influence of social stressors and social support
Audet, M., McQuaid, R. J., Merali, Z., & Anisman, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00416 · Cited by 60
Ike, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 64
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 60
Bath, K. G., Russo, S. J., Pleil, K. E., Wohleb, E. S., Duman, R. S., & Radley, J. J. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.05.001 · Cited by 58
Scala, F., Nenov, M. N., Crofton, E. J., Singh, A. K., Folorunso, O. O., Zhang, Y., Chesson, B. C., Wildburger, N. C., James, T. F., Alshammari, M. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.062 · Cited by 58
Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Zhao, F., Cheng, Z., Piao, J., Cui, R., & Li, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.947785 · Cited by 63
Circuit-Based Biomarkers for Mood and Anxiety Disorders
Xia, F., & Kheirbek, M. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.004 · Cited by 56
Padula, A. E., Griffin, W. C., Lopez, M. F., Nimitvilai, S., Cannady, R., McGuier, N. S., Chesler, E. J., Miles, M. F., Williams, R. W., Randall, P. K., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.42 · Cited by 53
Epigenetic mechanisms impacted by chronic stress across the rodent lifespan
Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54
Bayassi-Jakowicka, M., Lietzau, G., Czuba, E., Patrone, C., & Kowiański, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052618 · Cited by 54
Striatopallidal neurons control avoidance behavior in exploratory tasks
LeBlanc, K. H., London, T. D., Szczot, I., Bocarsly, M. E., Friend, D. M., Nguyen, K. P., Mengesha, M. M., Rubinstein, M., Alvarez, V. A., & Kravitz, A. V. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0051-3 · Cited by 46
Self-citationMa, K., Zhang, H., Wang, S., Wang, H., Wang, Y., Liu, J., Song, X., Dong, Z., Han, X., Zhang, Y., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14596 · Cited by 51
Song, N., Liu, Z., Gao, Y., Lu, S., Yang, S., & Yuan, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02476-x · Cited by 52
Metadata
- Authors
- Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., & Lobo, M. K.
- Affiliations
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- California State University, San Bernardino (US)
- Corresponding author
- Lobo, Mary Kay
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 77
- Issue
- 3
- Pages
- 212-222
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5534173
- OpenAlex
- W2141609201
- Cited by
- 379
- References
- 60
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 44 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 17 · 2016: 21 · 2015: 19
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH106500)
- National Institute of General Medical Sciences (T34GM083883, SC2GM109811)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- nucleus accumbens, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, chronic social defeat stress, depression-like behavior, excitatory synaptic input, intrinsic excitability, social avoidance, neuronal activity modulation, depression resilience
- MeSH terms
- Action Potentials, Animals, Depressive Disorder, Dominance-Subordination, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Social Behavior, Stress, Psychological, Receptors, Dopamine D1, Receptors, Dopamine D2, Patch-Clamp Techniques, Tissue Culture Techniques, Resilience, Psychological, GABAergic Neurons, Anhedonia, Optogenetics
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