Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress
Open accessAbstract
Background The nucleus accumbens is a critical mediator of depression-related outcomes to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 versus dopamine receptor D2, in reward and reinforcement leading to opposing roles for these MSNs in these behaviors. However, the distinct roles of nucleus accumbens MSN subtypes, in depression, remain poorly understood.Methods Using whole-cell patch clamp electrophysiology, we examined excitatory input to MSN subtypes and intrinsic excitability measures in D1-green fluorescent protein and D2-green fluorescent protein bacterial artificial chromosome transgenic mice that underwent chronic social defeat stress (CSDS). Optogenetic and pharmacogenetic approaches were used to bidirectionally alter firing of D1-MSNs or D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial chromosome transgenic mice.Results We demonstrate that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in D2-MSNs in mice displaying depression-like behaviors after CSDS. Enhancing activity in D1-MSNs results in resilient behavioral outcomes, while inhibition of these MSNs induces depression-like outcomes after CSDS. Bidirectional modulation of D2-MSNs does not alter behavioral responses to CSDS; however, repeated activation of D2-MSNs in stress naïve mice induces social avoidance following subthreshold social defeat stress.Conclusions Our studies uncover novel functions of MSN subtypes in depression-like outcomes. Notably, bidirectional alteration of D1-MSN activity promotes opposite behavioral outcomes to chronic social stress. Therefore, targeting D1-MSN activity may provide novel treatment strategies for depression or other affective disorders.
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D1 medium spiny neuron activity is more associated with motivation, reward, positive responses, and stress resilience.
“Nevertheless, activity in D1 MSNs is more likely to be associated with motivation, reward, and positive responses [193,[223][224][225] and resilience to stress [226].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
Susceptibility to chronic social defeat stress is accompanied by atrophy of D1 medium spiny neuron dendrites, but not D2 dendrites.
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
Susceptibility to chronic social defeat stress is accompanied by loss of dendritic spines in D1 medium spiny neurons.
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
Susceptibility to social defeat stress increases input resistance and firing in response to depolarizing current pulses in D1 medium spiny neurons, but not D2 neurons.
“Susceptibility to social defeat stress is accompanied by an increase in input resistance and firing in response to depolarizing currents pulses in D1 MSNs, but not D2 MSNs [226,234].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In chronic social defeat stress susceptible mice, D1 medium spiny neurons show reduced miniature excitatory postsynaptic current frequency and D2 medium spiny neurons show enhanced frequency.
“We recently found D1-MSNs display reduced mEPSC frequency and D2-MSNs display enhanced frequency of mEPSCs in CSDS susceptible mice (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
Repeated high frequency stimulation of all nucleus accumbens neurons alleviates depression-like outcomes to chronic social defeat stress.
“Like DBS, repeated high frequency stimulation of all NAc neurons alleviated depression-like outcomes to CSDS.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
D1 medium spiny neurons likely mediate the antidepressant effect of non-specific nucleus accumbens stimulation because D1 medium spiny neuron-specific stimulation mimicked it.
“It is likely D1-MSNs mediate this effect as cell-type specific stimulation of D1-MSNs mimicked non-specific NAc neuronal stimulation (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
An imbalance in firing of medium spiny neuron subtypes could mediate depressive symptoms.
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
D2 medium spiny neuron stimulation promotes depressive-like outcomes.
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
Repeated, but not acute, stimulation is necessary for the behavioral effect of nucleus accumbens stimulation.
“Furthermore, repeated, but not acute stimulation is necessary for this behavioral effect.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
This interpretation is consistent with observed excitatory changes on nucleus accumbens medium spiny neuron subtypes and with stimulation-mediated antidepressant outcomes.
“This interpretation would be consistent with observed excitatory changes on NAc MSN subtypes as well as stimulation-mediated antidepressant outcomes (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
Stress-related changes to spine density occur on D2-MSNs.
“Thus, we believe the stress-related changes to spine density occur on D2-MSNs, as D2-MSNs do not undergo dendritic atrophy but have enhanced excitatory input [82].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [82]
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Cites
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353 · see citing works
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 5× · see citing works
“This is a well-established protocol that yields stress susceptible (mice displaying depression-like behaviors) or resilient cohorts (1,2,41).”
InfluentialEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471 · see citing works
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons
Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature · doi:10.1038/nature11713 · Cited by 1,156 · see citing works
Self-citationA translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Distinct roles for direct and indirect pathway striatal neurons in reinforcement
Kravitz, A. V., Tye, L. D., & Kreitzer, A. C. (2012) · Nature Neuroscience · doi:10.1038/nn.3100 · Cited by 972 · see citing works
Self-citationCell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works
Self-citationExcitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
Stuber, G. D., Sparta, D. R., Stamatakis, A. M., van Leeuwen, W. A., Hardjoprajitno, J. E., Cho, S., Tye, K. M., Kempadoo, K. A., Zhang, F., Deisseroth, K., et al. (2011) · Nature · doi:10.1038/nature10194 · Cited by 878 · see citing works
Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716 · see citing works
From reinforcement learning models to psychiatric and neurological disorders
Maia, T. V., & Frank, M. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2723 · Cited by 715 · see citing works
Gerfen, C. R., Paletzki, R., & Heintz, N. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.016 · Cited by 647 · see citing works
Antidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex
Covington, H. E., Lobo, M. K., Maze, I., Vialou, V., Hyman, J. M., Zaman, S., LaPlant, Q., Mouzon, E., Ghose, S., Tamminga, C. A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-10.2010 · Cited by 621 · see citing works
Self-citationDnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works
Self-citationHikida, T., Kimura, K., Wada, N., Funabiki, K., & Nakanishi, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.011 · Cited by 592 · see citing works
Biological substrates of reward and aversion: A nucleus accumbens activity hypothesis
Carlezon, W. A., & Thomas, M. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.075 · Cited by 561 · see citing works
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542 · see citing works
Repeated cortico-striatal stimulation generates persistent OCD-like behavior
Ahmari, S. E., Spellman, T., Douglass, N. L., Kheirbek, M. A., Simpson, H. B., Deisseroth, K., Gordon, J. A., & Hen, R. (2013) · Science · doi:10.1126/science.1234733 · Cited by 502 · cited 1× · see citing works
“Recent studies demonstrate that repeated optogenetic stimulation paradigms alter emotional behaviors and molecules implicated in such behaviors (14,36,49,50).”
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Self-citationFerguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience · doi:10.1038/nn.2703 · Cited by 418 · see citing works
FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
Lobo, M. K., Karsten, S. L., Gray, M., Geschwind, D. H., & Yang, X. W. (2006) · Nature Neuroscience · doi:10.1038/nn1654 · Cited by 411 · see citing works
Self-citationControl of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons
Freeze, B. S., Kravitz, A. V., Hammack, N., Berke, J. D., & Kreitzer, A. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1278-13.2013 · Cited by 405 · see citing works
Self-citationTransient stimulation of distinct subpopulations of striatal neurons mimics changes in action value
Tai, L.-H., Lee, A. M., Benavidez, N., Bonci, A., & Wilbrecht, L. (2012) · Nature Neuroscience · doi:10.1038/nn.3188 · Cited by 399 · see citing works
Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits
Sparta, D. R., Stamatakis, A. M., Phillips, J. L., Hovelsø, N., van Zessen, R., & Stuber, G. D. (2012) · Nature Protocols · doi:10.1038/nprot.2011.413 · Cited by 394 · see citing works
Lobo, M. K., & Nestler, E. J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00041 · Cited by 371 · see citing works
Self-citationBewernick, B. H., Kayser, S., Sturm, V., & Schlaepfer, T. E. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.44 · Cited by 371 · see citing works
Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens
Lim, B. K., Huang, K. W., Grueter, B. A., Rothwell, P. E., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11160 · Cited by 368 · see citing works
The nucleus accumbens as part of a basal ganglia action selection circuit
Nicola, S. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0510-4 · Cited by 360 · see citing works
Remote Control of Neuronal Signaling
Rogan, S. C., & Roth, B. L. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003020 · Cited by 339 · see citing works
Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use
Bock, R., Shin, J. H., Kaplan, A. R., Dobi, A., Markey, E., Kramer, P. F., Gremel, C. M., Christensen, C. H., Adrover, M. F., & Alvarez, V. A. (2013) · Nature Neuroscience · doi:10.1038/nn.3369 · Cited by 307 · see citing works
Vialou, V., Bagot, R. C., Cahill, M. E., Ferguson, D., Robison, A. J., Dietz, D. M., Fallon, B., Mazei-Robison, M., Ku, S. M., Harrigan, E., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1787-13.2014 · Cited by 283 · cited 1× · see citing works
“The medial prefrontal cortex (mPFC) is a likely candidate because previous studies demonstrate optogenetic manipulation of mPFC or mPFC-NAc terminals promotes resilient responses after CSDS (10,11,53,54).”
Smith, R. J., Lobo, M. K., Spencer, S., & Kalivas, P. W. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.026 · Cited by 272 · see citing works
Self-citationIκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., & Nestler, E. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0932-09.2009 · Cited by 262 · see citing works
Lobo, M. K., Zaman, S., Damez-Werno, D. M., Koo, J. W., Bagot, R. C., DiNieri, J. A., Nugent, A., Finkel, E., Chaudhury, D., Chandra, R., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1875-13.2013 · Cited by 245 · see citing works
Self-citationThe neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Springer eBooks · doi:10.1007/978-3-7091-9211-5_4 · Cited by 232 · see citing works
Striatal mechanisms underlying movement, reinforcement, and punishment
Kravitz, A. V., & Kreitzer, A. C. (2012) · Physiology · doi:10.1152/physiol.00004.2012 · Cited by 224 · see citing works
Self-citationChronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons
Barik, J., Marti, F., Morel, C., Fernandez, S. P., Lanteri, C., Godeheu, G., Tassin, J.-P., Mombereau, C., Faure, P., & Tronche, F. (2013) · Science · doi:10.1126/science.1226767 · Cited by 214 · see citing works
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
Walsh, J. J., Friedman, A. K., Sun, H., Heller, E. A., Ku, S. M., Juarez, B., Burnham, V. L., Mazei-Robison, M. S., Ferguson, D., Golden, S. A., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3591 · Cited by 210 · see citing works
Wilkinson, M. B., Dias, C., Magida, J., Mazei-Robison, M., Lobo, M., Kennedy, P., Dietz, D., Covington, H., Russo, S., Neve, R., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-11.2011 · Cited by 170 · see citing works
Self-citationChallis, C., Beck, S. G., & Berton, O. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00043 · Cited by 137 · see citing works
McCracken, C. B., & Grace, A. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0131-09.2009 · Cited by 127 · see citing works
Cortical Control of Affective Networks
Kumar, S., Black, S. J., Hultman, R., Szabo, S. T., DeMaio, K. D., Du, J., Katz, B. M., Feng, G., Covington, H. E., & Dzirasa, K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0092-12.2013 · Cited by 110 · see citing works
Optogenetic insights into striatal function and behavior
Lenz, J. D., & Lobo, M. K. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.018 · Cited by 93 · see citing works
Self-citationChandra, R., Lenz, J. D., Gancarz, A. M., Chaudhury, D., Schroeder, G. L., Han, M., Cheer, J. F., Dietz, D., & Lobo, M. K. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00013 · Cited by 81 · see citing works
Self-citationSubcellular connectivity underlies pathway-specific signaling in the nucleus accumbens
MacAskill, A. F., Little, J. P., Cassel, J. M., & Carter, A. G. (2012) · Nature Neuroscience · doi:10.1038/nn.3254 · Cited by 80 · see citing works
Direct-Pathway Striatal Neurons Regulate the Retention of Decision-Making Strategies
Ferguson, S. M., Phillips, P. E. M., Roth, B. L., Wess, J., & Neumaier, J. F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4783-12.2013 · Cited by 78 · see citing works
The nucleus accumbens: a target for deep brain stimulation in resistant major depressive disorder
Nauczyciel, C., Robic, S., Dondaine, T., Vérin, M., Robert, G., Drapier, D., Naudet, F., & Millet, B. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-17 · Cited by 71 · see citing works
Timing matters: using optogenetics to chronically manipulate neural circuitry and rhythms
Sidor, M. M., & McClung, C. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00041 · Cited by 33 · see citing works
Schlaepfer, T. E., & Bewernick, B. H. (2014) · Brain Topography · doi:10.1007/s10548-013-0315-9 · Cited by 17 · see citing works
Optogenetic Regulation of Dopamine Receptor-Expressing Neurons
Francis, T. C., & Lobo, M. K. (2014) · Neuromethods · doi:10.1007/978-1-4939-2196-6_18 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Stress and the social brain: behavioural effects and neurobiological mechanisms
Sandi, C., & Haller, J. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3918 · Cited by 614 · see citing works
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression
Bagot, R. C., Parise, E. M., Peña, C. J., Zhang, H.-X., Maze, I., Chaudhury, D., Persaud, B., Cachope, R., Bolaños-Guzmán, C. A., Cheer, J. F., et al. (2015) · Nature Communications · doi:10.1038/ncomms8062 · Cited by 491 · see citing works
Animal models of major depression: drawbacks and challenges
Planchez, B., Surget, A., & Belzung, C. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02084-y · Cited by 480 · see citing works
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 442 · see citing works
Stress and the dopaminergic reward system
Baik, J. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00532-4 · Cited by 446 · see citing works
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states
Parker, J. G., Marshall, J. D., Ahanonu, B., Wu, Y., Kim, T. H., Grewe, B. F., Zhang, Y., Li, J. Z., Ding, J., Ehlers, M., et al. (2018) · Nature · doi:10.1038/s41586-018-0090-6 · Cited by 342 · see citing works
Chronic stress and glucocorticoids: From neuronal plasticity to neurodegeneration
Vyas, S., Rodrigues, A. J., Silva, J. M., Tronche, F., Almeida, O. F. X., Sousa, N., & Sotiropoulos, I. (2016) · Neural Plasticity · doi:10.1155/2016/6391686 · Cited by 297 · see citing works
Neurobiology of Resilience: Interface Between Mind and Body
Cathomas, F., Murrough, J. W., Nestler, E. J., Han, M.-H., & Russo, S. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.011 · Cited by 296 · see citing works
“Francis and colleagues (66) expanded upon these initial findings to show increased glutamate transmission specifically on D2 MSNs of susceptible mice relative to Cathomas et al.”
BackgroundAlexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 329 · see citing works
Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
An excitatory synapse hypothesis of depression
Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265 · see citing works
5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., & Malenka, R. C. (2018) · Nature · doi:10.1038/s41586-018-0416-4 · Cited by 256 · see citing works
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Soares-Cunha, C., de Vasconcelos, N. A. P., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., Gaspar, R., Sotiropoulos, I., Sousa, N., & Rodrigues, A. J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0484-3 · Cited by 256 · see citing works
A Novel Method for Chronic Social Defeat Stress in Female Mice
Harris, A. Z., Atsak, P., Bretton-Granatoor, Z., Holt, E. S., Alam, R., Morton, M. P., Abbas, A. I., Leonardo, E. D., Bolkan, S. S., Hen, R., et al. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.259 · Cited by 254 · see citing works
Rodent models of post-traumatic stress disorder: behavioral assessment
Verbitsky, A., Dopfel, D., & Zhang, N. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0806-x · Cited by 250 · see citing works
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230 · see citing works
Self-citationAnhedonia and the Brain Reward Circuitry in Depression
Heshmati, M., & Russo, S. J. (2015) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-015-0044-3 · Cited by 236 · see citing works
Luo, Y., Li, Y., Wang, L., Yang, S.-R., Yuan, X.-S., Wang, J., Chérasse, Y., Lazarus, M., Chen, J., Qu, W., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03889-3 · Cited by 236 · see citing works
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Self-citationWook Koo, J., Labonté, B., Engmann, O., Calipari, E. S., Juarez, B., Lorsch, Z., Walsh, J. J., Friedman, A. K., Yorgason, J. T., Han, M.-H., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.009 · Cited by 231 · see citing works
Shen, C.-J., Zheng, D., Li, K., Yang, J., Pan, H., Yu, X.-D., Fu, J., Zhu, Y., Sun, Q.-X., Tang, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0299-9 · Cited by 223 · see citing works
Reappraising striatal D1- and D2-neurons in reward and aversion
Soares‐Cunha, C., Coimbra, B., Sousa, N., & Rodrigues, A. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.021 · Cited by 190 · see citing works
Neural circuits of social behaviors: Innate yet flexible
Wei, D., Talwar, V., & Lin, D. (2021) · Neuron · doi:10.1016/j.neuron.2021.02.012 · Cited by 185 · see citing works
Circulating myeloid-derived MMP8 in stress susceptibility and depression
Cathomas, F., Lin, H.-Y., Chan, K. L., Li, L., Parise, L. F., Alvarez, J., Durand-de Cuttoli, R., Aubry, A. V., Muhareb, S., Desland, F., et al. (2024) · Nature · doi:10.1038/s41586-023-07015-2 · Cited by 189 · see citing works
Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum
Creed, M. C., Ntamati, N. R., Chandra, R., Lobo, M. K., & Lüscher, C. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.001 · Cited by 176 · see citing works
Self-citationNucleus Accumbens Modulation in Reward and Aversion
Klawonn, A. M., & Malenka, R. C. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037457 · Cited by 163 · see citing works
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
Liu, H., Zhang, C., Ji, Y., & Yang, L. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00326 · Cited by 149 · see citing works
Neuronal correlates of depression
Chaudhury, D., Liu, H., & Han, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2044-6 · Cited by 142 · see citing works
Gebara, E., Zanoletti, O., Ghosal, S., Grosse, J., Schneider, B. L., Knott, G. W., Astori, S., & Sandi, C. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.003 · Cited by 144 · see citing works
Kirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 136 · see citing works
Architectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 133 · see citing works
Loss of Plasticity in the D2-Accumbens Pallidal Pathway Promotes Cocaine Seeking
Heinsbroek, J. A., Neuhofer, D., Griffin, W. C., Siegel, G. S., Bobadilla, A., Kupchik, Y. M., & Kalivas, P. W. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2659-16.2016 · Cited by 129 · see citing works
Neurobiological basis of stress resilience
Nestler, E. J., & Russo, S. J. (2024) · Neuron · doi:10.1016/j.neuron.2024.05.001 · Cited by 137 · see citing works
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders
Macpherson, T., & Hikida, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12830 · Cited by 131 · see citing works
van der Kooij, M. A., Hollis, F., Lozano, L., Zalachoras, I., Abad, S., Zanoletti, O., Grosse, J., Guillot de Suduiraut, I., Canto, C., & Sandi, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.135 · Cited by 127 · see citing works
Impact of Early Life Stress on Reward Circuit Function and Regulation
Hanson, J. L., Williams, A. V., Bangasser, D. A., & Peña, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.744690 · Cited by 123 · see citing works
A competitive model for striatal action selection
Bariselli, S., Fobbs, W. C., Creed, M. C., & Kravitz, A. V. (2018) · Brain Research · doi:10.1016/j.brainres.2018.10.009 · Cited by 113 · see citing works
Self-citationAn endocannabinoid-regulated basolateral amygdala–nucleus accumbens circuit modulates sociability
Folkes, O. M., Báldi, R., Kondev, V., Marcus, D. J., Hartley, N. D., Turner, B. D., Ayers, J. K., Baechle, J. J., Misra, M. P., Altemus, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci131752 · Cited by 119 · see citing works
Neurobiology and systems biology of stress resilience
Kalisch, R., Russo, S. J., & Müller, M. B. (2024) · Physiological Reviews · doi:10.1152/physrev.00042.2023 · Cited by 137 · see citing works
Stress effects on the neural substrates of motivated behavior
Hollon, N. G., Burgeno, L. M., & Phillips, P. E. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4114 · Cited by 118 · see citing works
Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking
Pardo-García, T. R., García‐Keller, C., Penaloza, T., Richie, C. T., Pickel, J. M., Hope, B. T., Harvey, B. K., Kalivas, P. W., & Heinsbroek, J. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2822-18.2018 · Cited by 112 · see citing works
GABAA receptors as targets for treating affective and cognitive symptoms of depression
Lüscher, B., Maguire, J. L., Rudolph, U., & Sibille, E. L. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.06.009 · Cited by 118 · see citing works
In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens
Muir, J., Lorsch, Z. S., Ramakrishnan, C., Deisseroth, K., Nestler, E. J., Calipari, E. S., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.122 · Cited by 116 · see citing works
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112 · see citing works
Golden, S. A., Jin, M., Heins, C., Vènniro, M., Michaelides, M., & Shaham, Y. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2409-18.2019 · Cited by 111 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Role of the Brain's Reward Circuitry in Depression
Nestler, E. J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.07.003 · Cited by 108 · see citing works
Kronman, H., Torres-Berrío, A., Sidoli, S., Issler, O., Godino, A., Ramakrishnan, A., Mews, P., Lardner, C. K., Parise, E. M., Walker, D. M., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00814-8 · Cited by 108 · see citing works
Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100 · see citing works
Self-citationBosch-Bouju, C., Larrieu, T., Linders, L., Manzoni, O. J., & Layé, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.082 · Cited by 100 · see citing works
Yohn, S. E., Santerre, J. L., Nunes, E. J., Kozak, R., Podurgiel, S. J., Correa, M., & Salamone, J. D. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.05.003 · Cited by 99 · see citing works
Striatal direct and indirect pathways control decision-making behavior
Macpherson, T., Morita, M., & Hikida, T. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01301 · Cited by 94 · see citing works
Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning
Hikida, T., Morita, M., & Macpherson, T. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.01.004 · Cited by 92 · see citing works
Muir, J., Lopez, J., & Bagot, R. C. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0291-6 · Cited by 92 · see citing works
Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 98 · see citing works
Ketzef, M., Spigolon, G., Johansson, Y., Bonito-Oliva, A., Fisone, G., & Silberberg, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.004 · Cited by 87 · see citing works
Molecular basis of dendritic atrophy and activity in stress susceptibility
Francis, T. C., Chandra, R., Gaynor, A., Konkalmatt, P., Metzbower, S. R., Evans, B., Engeln, M., Blanpied, T. A., & Lobo, M. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.178 · Cited by 89 · see citing works
Self-citationMild Prenatal Stress Causes Emotional and Brain Structural Modifications in Rats of Both Sexes
Soares‐Cunha, C., Coimbra, B., Borges, S., Domingues, A. V., Silva, D., Sousa, N., & Rodrigues, A. J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00129 · Cited by 86 · see citing works
Circuit-based frameworks of depressive behaviors: The role of reward circuitry and beyond
Knowland, D., & Lim, B. K. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.12.010 · Cited by 85 · see citing works
Zachry, J. E., Kutlu, M. G., Yoon, H. J., Leonard, M. Z., Chevée, M., Patel, D. D., Gaidici, A., Kondev, V., Thibeault, K. C., Bethi, R., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.11.023 · Cited by 81 · see citing works
Liu, S., Tang, Y., Shu, H., Tatum, D., Bai, Q., Crawford, J. A., Xing, Y., Lobo, M. K., Bellinger, L. L., Kramer, P. R., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001414 · Cited by 77 · see citing works
Self-citationWarren, B. L., Mazei‐Robison, M. S., Robison, A. J., & Iñiguez, S. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.004 · Cited by 75 · see citing works
Self-citationCell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
Heshmati, M., Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719014115 · Cited by 75 · see citing works
Self-citationMoreno-Rius, J. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100774 · Cited by 75 · see citing works
Heshmati, M., Christoffel, D. J., LeClair, K. B., Cathomas, F., Golden, S. A., Aleyasin, H., Turecki, G., Friedman, A. K., Han, M., Ménard, C., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2568-19.2020 · Cited by 73 · see citing works
Biselli, T., Lange, S. S., Sablottny, L., Steffen, J., & Walther, A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14603 · Cited by 72 · see citing works
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 77 · see citing works
Hussein, A., Guevara, C. A., Valle, P. D., Gupta, S., Benson, D. L., & Huntley, G. W. (2021) · The Neuroscientist · doi:10.1177/10738584211011979 · Cited by 73 · see citing works
Khibnik, L. A., Beaumont, M., Doyle, M., Heshmati, M., Slesinger, P. A., Nestler, E. J., & Russo, S. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.022 · Cited by 67 · see citing works
Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors
de Kloet, S. F., Mansvelder, H. D., & De Vries, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.014 · Cited by 69 · see citing works
Brancato, A., Bregman, D., Ahn, H. F., Pfau, M. L., Ménard, C., Cannizzaro, C., Russo, S. J., & Hodes, G. E. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.03.014 · Cited by 67 · see citing works
Kashima, D. T., & Grueter, B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705974114 · Cited by 66 · see citing works
High-Frequency Activation of Nucleus Accumbens D1-MSNs Drives Excitatory Potentiation on D2-MSNs
Francis, T. C., Yano, H., Demarest, T. G., Shen, H., & Bonci, A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.031 · Cited by 67 · see citing works
Self-citationNeural correlates of ingroup bias for prosociality in rats
Bartal, I. B.-A., Breton, J., Sheng, H., Long, K. L. P., Chen, S., Halliday, A., Kenney, J. W., Wheeler, A. L., Frankland, P. W., Shilyansky, C., et al. (2021) · eLife · doi:10.7554/elife.65582 · Cited by 68 · see citing works
Stress relief as a natural resilience mechanism against depression-like behaviors
Dong, Y., Li, Y., Xiang, X., Xiao, Z.-C., Hu, J., Li, Y., Li, H., & Hu, H. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.004 · Cited by 69 · see citing works
Depression and substance use disorders: Clinical comorbidity and shared neurobiology
Calarco, C. A., & Lobo, M. K. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.09.004 · Cited by 69 · see citing works
Self-citationYun, S., Yang, B., Anair, J. D., Martin, M. M., Fleps, S. W., Pamukcu, A., Yeh, N.-H., Contractor, A., Kennedy, A., & Parker, J. G. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01390-9 · Cited by 66 · see citing works
Matikainen‐Ankney, B. A., Kezunovic, N., Ménard, C., Flanigan, M. E., Zhong, Y., Russo, S. J., Benson, D. L., & Huntley, G. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1457-18.2018 · Cited by 65 · see citing works
Transient and sustained effects of dopamine and serotonin signaling in motivation‐related behavior
Yagishita, S. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12942 · Cited by 64 · see citing works
Stress‐Induced Depression: Is Social Rank a Predictive Risk Factor?
Larrieu, T., & Sandi, C. (2018) · BioEssays · doi:10.1002/bies.201800012 · Cited by 61 · see citing works
Tsai, S., Hsu, P., Chen, Y., Hossain, M. S., Chen, P., Tzeng, S., Chen, P. S., & Kuo, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01787-1 · Cited by 63 · see citing works
Francis, T. C., Gaynor, A., Chandra, R., Fox, M. E., & Lobo, M. K. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.02.007 · Cited by 61 · see citing works
Self-citationPignatelli, M., Tejeda, H. A., Barker, D. J., Bontempi, L., Wu, J., Lopez, A., Ribeiro, S. P., Lucantonio, F., Parise, E. M., Torres‐Berrío, A., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0686-8 · Cited by 57 · see citing works
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience
Turner, B. D., Kashima, D. T., Manz, K. M., Grueter, C. A., & Grueter, B. A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00420 · Cited by 59 · see citing works
Ventral pallidal regulation of motivated behaviors and reinforcement
Soares‐Cunha, C., & Heinsbroek, J. A. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1086053 · Cited by 58 · see citing works
Cytokine variations and mood disorders: influence of social stressors and social support
Audet, M., McQuaid, R. J., Merali, Z., & Anisman, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00416 · Cited by 58 · see citing works
Ike, K. G. O., de Boer, S. F., Buwalda, B., & Kas, M. J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.06.030 · Cited by 61 · see citing works
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 59 · see citing works
Bath, K. G., Russo, S. J., Pleil, K. E., Wohleb, E. S., Duman, R. S., & Radley, J. J. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2017.05.001 · Cited by 55 · see citing works
Scala, F., Nenov, M. N., Crofton, E. J., Singh, A. K., Folorunso, O. O., Zhang, Y., Chesson, B. C., Wildburger, N. C., James, T. F., Alshammari, M. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.062 · Cited by 56 · see citing works
Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
Zhao, F., Cheng, Z., Piao, J., Cui, R., & Li, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.947785 · Cited by 58 · see citing works
Circuit-Based Biomarkers for Mood and Anxiety Disorders
Xia, F., & Kheirbek, M. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.004 · Cited by 54 · see citing works
Padula, A. E., Griffin, W. C., Lopez, M. F., Nimitvilai, S., Cannady, R., McGuier, N. S., Chesler, E. J., Miles, M. F., Williams, R. W., Randall, P. K., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.42 · Cited by 54 · see citing works
Epigenetic mechanisms impacted by chronic stress across the rodent lifespan
Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54 · see citing works
Bayassi-Jakowicka, M., Lietzau, G., Czuba, E., Patrone, C., & Kowiański, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052618 · Cited by 52 · see citing works
Striatopallidal neurons control avoidance behavior in exploratory tasks
LeBlanc, K. H., London, T. D., Szczot, I., Bocarsly, M. E., Friend, D. M., Nguyen, K. P., Mengesha, M. M., Rubinstein, M., Alvarez, V. A., & Kravitz, A. V. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0051-3 · Cited by 45 · see citing works
Self-citationMa, K., Zhang, H., Wang, S., Wang, H., Wang, Y., Liu, J., Song, X., Dong, Z., Han, X., Zhang, Y., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14596 · Cited by 51 · see citing works
Song, N., Liu, Z., Gao, Y., Lu, S., Yang, S., & Yuan, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02476-x · Cited by 50 · see citing works
- Authors
- Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., & Lobo, M. K.
- Affiliations
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- California State University, San Bernardino (US)
- Corresponding author
- Lobo, Mary Kay
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 77
- Issue
- 3
- Pages
- 212-222
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5534173
- OpenAlex
- W2141609201
- Cited by
- 379
- References
- 60
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 44 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 17 · 2016: 21 · 2015: 19 · 2014: 4
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH106500)
- National Institute of General Medical Sciences (T34GM083883, SC2GM109811)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- nucleus accumbens, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, chronic social defeat stress, depression-like behavior, excitatory synaptic input, intrinsic excitability, social avoidance, neuronal activity modulation, depression resilience
- MeSH terms
- Action Potentials, Animals, Depressive Disorder, Dominance-Subordination, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Social Behavior, Stress, Psychological, Receptors, Dopamine D1, Receptors, Dopamine D2, Patch-Clamp Techniques, Tissue Culture Techniques, Resilience, Psychological, GABAergic Neurons, Anhedonia, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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