The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress
Open accessAbstract
Background The nucleus accumbens is a critical mediator of depression-related outcomes to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in the two medium spiny neuron (MSN) subtypes, those enriched in dopamine receptor D1 versus dopamine receptor D2, in reward and reinforcement leading to opposing roles for these MSNs in these behaviors. However, the distinct roles of nucleus accumbens MSN subtypes, in depression, remain poorly understood.Methods Using whole-cell patch clamp electrophysiology, we examined excitatory input to MSN subtypes and intrinsic excitability measures in D1-green fluorescent protein and D2-green fluorescent protein bacterial artificial chromosome transgenic mice that underwent chronic social defeat stress (CSDS). Optogenetic and pharmacogenetic approaches were used to bidirectionally alter firing of D1-MSNs or D2-MSNs after CSDS or before a subthreshold social defeat stress in D1-Cre or D2-Cre bacterial artificial chromosome transgenic mice.Results We demonstrate that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in D2-MSNs in mice displaying depression-like behaviors after CSDS. Enhancing activity in D1-MSNs results in resilient behavioral outcomes, while inhibition of these MSNs induces depression-like outcomes after CSDS. Bidirectional modulation of D2-MSNs does not alter behavioral responses to CSDS; however, repeated activation of D2-MSNs in stress naïve mice induces social avoidance following subthreshold social defeat stress.Conclusions Our studies uncover novel functions of MSN subtypes in depression-like outcomes. Notably, bidirectional alteration of D1-MSN activity promotes opposite behavioral outcomes to chronic social stress. Therefore, targeting D1-MSN activity may provide novel treatment strategies for depression or other affective disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Nevertheless, activity in D1 MSNs is more likely to be associated with motivation, reward, and positive responses [193,[223][224][225] and resilience to stress [226].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to chronic social defeat stress is accompanied by atrophy of MSN dendrites, specifically in D1 MSNs and not D2 MSNs, and a corresponding loss of dendritic spines [226,234,235].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“Susceptibility to social defeat stress is accompanied by an increase in input resistance and firing in response to depolarizing currents pulses in D1 MSNs, but not D2 MSNs [226,234].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [226]
In the citing paper
“We recently found D1-MSNs display reduced mEPSC frequency and D2-MSNs display enhanced frequency of mEPSCs in CSDS susceptible mice (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Like DBS, repeated high frequency stimulation of all NAc neurons alleviated depression-like outcomes to CSDS.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“It is likely D1-MSNs mediate this effect as cell-type specific stimulation of D1-MSNs mimicked non-specific NAc neuronal stimulation (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“D2-MSN stimulation promotes depressive-like outcomes (41), suggesting an imbalance in firing of MSN subtypes could mediate these symptoms.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Furthermore, repeated, but not acute stimulation is necessary for this behavioral effect.”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“This interpretation would be consistent with observed excitatory changes on NAc MSN subtypes as well as stimulation-mediated antidepressant outcomes (41).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [41]
In the citing paper
“Thus, we believe the stress-related changes to spine density occur on D2-MSNs, as D2-MSNs do not undergo dendritic atrophy but have enhanced excitatory input [82].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The functional anatomy of basal ganglia disorders
Albin, R. L., Young, A. B., & Penney, J. B. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90074-x · Cited by 5,353
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 5×
“This is a well-established protocol that yields stress susceptible (mice displaying depression-like behaviors) or resilient cohorts (1,2,41).”
InfluentialEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885
Self-citationThe brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–380 of 380
Involvement of nucleus accumbens D2-MSN projections to the ventral pallidum in anxious-like behaviorPreprint
Correia, R. G., Domingues, A. V., Coimbra, B., Vieitas‐Gaspar, N., Sousa, N., Pinto, L., Rodrigues, A. J., & Soares‐Cunha, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.23.493058 · Cited by 2
Distinct Dendritic Morphological Changes in the Nucleus Accumbens of Microbiota-deficient Male MicePreprint
García‐Cabrerizo, R., Viola, M. F., Luczynski, P., Clarke, G. A., & Cryan, J. F. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.582301 · Cited by 3
Goñi‐Balentziaga, O., Díez-Solinska, A., Beitia, G., Muñoz‐Culla, M., Azkona, G., & Vegas, Ó. (2024) · NeuroSci · doi:10.3390/neurosci5020014 · Cited by 1
Social defeat stress induces an anxiety-like outcome in male prairie voles (Microtus ochrogaster)
Rodriguez, M., Themann, A., Calvo, D. E., Garcia, J. A., Lira, O., Garcia-Carachure, I., & Iñiguez, S. D. (2024) · Oxford Open Neuroscience · doi:10.1093/oons/kvae012 · Cited by 1
Self-citationNucleus accumbens neuron subtype translatome signatures in socially stressed females
Kumar, G., Franco, D., Basu, M., Olusakin, J., Campbell, R. R., Ament, S. A., Fox, M. E., & Lobo, M. K. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02414-1 · Cited by 1
Self-citationLi, C., Wang, Z., Ye, X., Lv, J., Chen, F., Zhang, Y., Liu, J., Li, X., Duan, J., Wang, Y., et al. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1692751 · Cited by 2
Miya, K., Suzuki, E., Keino‐Masu, K., Okada, T., Kobayashi, K., Momiyama, T., & Masu, M. (2025) · eNeuro · doi:10.1523/eneuro.0088-25.2025 · Cited by 2
Genome-wide methylation patterns associated with chronic stress
O’Toole, N., Zhang, T., Fitzgerald, E., Wen, X., Diorio, J. C., Silveira, P. P., Labonté, B., Nestler, E. J., & Meaney, M. J. (2026) · Epigenomics · doi:10.1080/17501911.2026.2613012 · Cited by 1
Chen, W., Kaigawa, T., Yokose, J., Yano, Y., Shigetsura, Y., Shin-ichi, M., & Nitta, A. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153309 · Cited by 1
Altered Postnatal Chromatin Development in the Nucleus Accumbens Primes Enduring Stress Sensitivity
Rashford, R. L., Fang, L. Z., DeBerardine, M., Kim, H. J. J., Hirschfield, L. W., Cervi, E., Barrett, M. R., Thompson, J. M., Creed, M. C., & Peña, C. J. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.2217-25.2026 · Cited by 4
Clauss, N. J., Allen, K. B., Billings, K. D., Tolliver, M., Garza, R., Byrd‐Craven, J., & Polly Campbell, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169245 · Cited by 1
Sequeira, S. L., Carmel, T. C., Tervo‐Clemmens, B., & Edmiston, E. K. (2023) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2023.2272972 · Cited by 1
Hypocretin modulation of behavioral coping strategies for social stress
Luo, P. X., & Trainor, B. C. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.031 · Cited by 1
Grossman, Y. S., Fillinger, C., Manganaro, A., Voren, G., Waldman, R. N., Zou, T., Janssen, W. G. M., Kenny, P. J., & Dumitriu, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.11.147231 · Cited by 1
Insular cortex to ventral striatum synapses encode valence of social interactionPreprint
Bellone, C., Espinosa, P., Girard, B. J. T., Lucchini, M., Campanelli, F., & Tiriticco, V. (2022) · Research Square · doi:10.21203/rs.3.rs-2251998/v1 · Cited by 1
Cell-Specific Disruptions in the Basolateral Amygdala-Accumbens Pathway of Fragile X mousePreprint
Giua, G., Lassalle, O., Chavis, P., & Manzoni, O. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.01.551430 · Cited by 1
Chronic social defeat stress induces a depression-relevant outcome in male prairie volesPreprint
Rodriguez, M., Themann, A., Garcia-Carachure, I., Lira, O., Robison, A. J., Cushing, B. S., & Iñiguez, S. D. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.16.562541 · Cited by 1
Self-citationNguyen, J., Byragoni, N., Arinzeh, N., Bortolami, A., Sidoli, S., Russo, S. J., Nestler, E. J., & Torres‐Berrío, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690167 · Cited by 1
A NAc for Spinal Adjustments After Cocaine or Stress
Mendoza, M. L., Anderson, E. M., Kourrich, S., & Eisch, A. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.013
Investigating Basal Ganglia Function With Cell-Type-Specific Manipulations
Kravitz, A. V., Devarakonda, K., & Kreitzer, A. C. (2016) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-802206-1.00033-7
Self-citationUnderstanding Mood Disorders Using Electrophysiology and Circuit Breaking
Liu, H., & Chaudhury, D. (2017) · Springer eBooks · doi:10.1007/978-3-319-57363-2_14
Garr, E. (2019) · CUNY Academic Works (City University of New York)
Friedman, A. K. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.09.007
All-optical approaches to studying psychiatric disease
Lafferty, C. K., Christinck, T., & Britt, J. P. (2021) · Methods · doi:10.1016/j.ymeth.2021.07.007
Song, N., Yan, G., Shanshan, L., Yang, S., Yuan, C., & Wenyu, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.01.470503
Evolutionary Function and Therapeutic Implications of Reactions to Success and Failure
Sloman, L., Sturman, E. D., & Quesnel, S. (2022) · American Journal of Family Therapy · doi:10.1080/01926187.2021.2019141
Neural Circuits Underlying the Pathophysiology of Major Depression
Amidfar, M., & Kim, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2083-0_3
Farooq, U. (2022) · Journal of Humanities Social and Management Sciences (JHSMS) · doi:10.47264/idea.jhsms/3.1.7
Faculty Opinions recommendation of Nucleus accumbens modulation in reward and aversion.
Wolf, M. E. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734917622.793558354
Giua, G., Lassalle, O., Makrini, L., Valjent, E., Chavis, P., & Manzoni, O. J. (2022) · Research Square · doi:10.1101/2022.07.06.498928
Navarrete, J. S., Schneider, K. N., Smith, B. M., Goodwin, N. L., Zhang, Y. Y., Gross, E., Tsai, V. S., Heshmati, M., & Golden, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.08.515718
Liu, W.-Z., Wang, C., Wang, Y., Cai, M.-T., Zhong, W.-X., Liu, T., Wang, Z.-H., Pan, H., Zhang, W., & Pan, B. (2023) · Figshare · doi:10.6084/m9.figshare.22978259
Pathological cell assembly dynamics in a striatal MSN network model
Correa, A., Ponzi, A. P. D., Calderón, V., & Migliore, R. (2024) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2024.1410335
Astrocytic CREB: The Hidden Driver of Stress Susceptibility
Guayasamin, M., & Murphy‐Royal, C. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.02.892
Altérations du sommeil dans les troubles anxio-dépressifs : apports des modèles précliniques
Pujol, M., & Fabre, V. (2025) · Médecine du Sommeil · doi:10.1016/j.msom.2025.05.004
An Emerging Role for Gut-Brain Signaling Involving Ghrelin in Chronic Stress
Salcido, A. A., Reyes, N. F., Macias, A. Y., Batson, S. A., Beck, D. W., Friedman, A., & Goosens, K. A. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_7
Zuo, X., Kuang, X., Li, R., Zhao, Y., Tuo, J., Qiu, J., Zhao, Q., Bai, H., Zhao, X. J., & Feng, X. (2025) · Environmental Research · doi:10.1016/j.envres.2025.122733
Hauser, S. R., Deehan, G., Knight, C. P., Waeiss, R. A., Engleman, E., Johnson, P. L., McBride, W. J., Bell, R. L., Truitt, W., & Rodd, Z. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1634350
VGF in the Nucleus Accumbens Regulates Synaptic and Opioid-Evoked PlasticityPreprint
Adke, A. P., Cunitz, L. B., Dick, R. M., Ali, T. H., Rocha, C. J. S., Zhang, Y., Vulchanova, L., & Rothwell, P. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693464
Wang, J., Lai, S., Zhou, T., Xia, Z., Li, W., Sha, W., LIU, J., & Chen, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26558198
Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880435
Self-citationCole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880432
Self-citationWang, J., Lai, S., Zhou, T., Xia, Z., Li, W., Sha, W., Liu, J., & Chen, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26558201
Chen, X., Cui, Q.-Q., Hu, X.-H., Ye, J., Liu, Z.-C., Mei, Y.-X., Wang, F., Hu, Z.-L., & Chen, J.-G. (2023) · Figshare · doi:10.6084/m9.figshare.23612412
Wang, J., Lai, S., Zhou, T., Xia, Z., Li, W., Sha, W., Liu, J., & Chen, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26558192
Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880426
Self-citationLiu, W.-Z., Wang, C.-Y., Wang, Y., Cai, M.-T., Zhong, W.-X., Liu, T., Wang, Z.-H., Pan, H.-Q., Zhang, W.-H., & 潘秉兴 (2023) · Figshare · doi:10.6084/m9.figshare.22978256
Cole, S. L., Chandra, R., Harris, M., Patel, I., Wang, T., Kim, H., Jensen, L., Russo, S. J., Turecki, G., Gancarz, A. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14880429
Self-citationWang, J., Lai, S., Zhou, T., Xia, Z., Li, W., Sha, W., Liu, J., & Chen, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26558195
Fonteneau, M., Terrier, C., Bolot, F., Pantouli, F., Brugoux, A., Malhaire, F., Wagnon, I. M., Borràs‐Tudurí, R., Rossolillo, P., McCort‐Tranchepain, I., et al. (2026) · Pharmacological Research · doi:10.64898/2026.01.12.699042
I’ve got a friend somewhere: control of social behavior across striatal subregions
Li, M. X., Baek, J., Guo, M. Y., Pomrenze, M. B., & Chen, A. P. F. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1763517
Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes
Tian, D., Xia, Z., Wang, S.-Y., Cao, T., Pan, Y., Zhao, Y., Zheng, L., Wei, B.-J., Yang, S.-W., Chen, W., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03516-4
Cue-Dependent Fear Learning Drives Nucleus Accumbens Spine PlasticityPreprint
Ratna, D. D., Gray, C., Lee, E., Kiaris, H., Hamilton, M., & Francis, T. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.25.707962
Self-citationLv, X., Cao, Y., Wang, Y., Wu, Y., Zhang, Y., Ye, K., Qiu, X., Sun, Q., Bian, L., Paerhati, H., et al. (2026) · Advanced Science · doi:10.1002/advs.202521943
Li, B., Han, X., Song, J., Cheng, Z., & Geng, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-9045113/v1
Regulation of the protein synthesis machinery in the striatum
Biever, A. (2016) · theses.fr (ABES) · doi:10.70675/d51e3b2cz4ba2z4930z8686z2d89c7f3949d
The role of chromatin remodelers in dopaminoceptive neurons
Zayed, A. (2019) · theses.fr (ABES) · doi:10.70675/f1d09c9dz29c5z44e4zae26z358715db672e
Rang social, système dopaminergique et réponse au stress
Battivelli, D. (2019) · theses.fr (ABES) · doi:10.70675/b11d29f4z1bf3z4003z81f9z8c69988b277b
Castell, L. (2020) · theses.fr (ABES) · doi:10.70675/1b15015az415cz4441zb0bdz7ce3de06f632
Socio-communicative and nucleus accumbens core dysfunctions in fragile X syndrome
Giua, G. (2023) · theses.fr (ABES) · doi:10.70675/e45d048ez2538z4905zba74z1de16201406a
Noise-evoked dopamine dynamics in the nucleus accumbens and tail of the striatum
Furuyama, T., Ono, M., Kato, N., & Yamamoto, R. (2026) · iScience · doi:10.1016/j.isci.2026.115789
Niu, Y., Li, K., Zhan, K., Pi, M., Xiong, Q., Wang, J., Wang, X. J., Shu, X., Xia, Y., & Huang, M. (2026) · Biomolecules · doi:10.3390/biom16050639
LaChapelle-Sproat, M. V., Anderson, N. S., & LeGates, T. A. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100757 · Cited by 1
Ken, M., Etsuko, S., Keino‐Masu, K., Takuya, O., Kenta, K., Takuya, O., Masayuki, M., 60451697, Kenta, K., Toshihiko, M., et al. (2025) · Institutional Repositories DataBase (IRDB)
McCullough, S., Varela, R. B., Houghton, T., Macpherson, H. K., & Tye, S. J. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70485
Dai, D., Wang, S., Wang, Y., Yu, J., Chen, Y., Shi, H., Lu, S., Wang, Y., Ma, R., & Fang, J. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111068
Folkes, O. M., Donahue, M., Perez, R. E., Minier-Toribio, A. M., Negrón-Moreno, P. N., Picciotto, M. R., & Jiang, Y.-H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.04.730003
Nucleus accumbens DRD2 receptor agonism attenuates escape behavior
Côté, B. E., Grafelman, E. M., Moster, L., Zimolzak, K., Hix, H. E., Cooper, M., Padula, G. N., Wheeler, D. S., Hearing, M. C., Mantsch, J. R., et al. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1881674
Kang, B. J., Kim, B., Kim, M., Choi, Y., Kim, E.-J., Koo, J. W., & Baik, J. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1919290
Early life experiences, the neural epigenome and affective disorder risk
Cunningham, A. M., & Maze, I. S. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-026-01074-w
Riley, B., Hallum, L. E., Vlajkovic, S. M., Montgomery, J. M., & Freestone, P. S. (2026) · Experimental Physiology · doi:10.1113/ep094001
The pathophysiology of depression in Huntington’s disease
Barta, T., Glikmann‐Johnston, Y., McColgan, P., & Razi, A. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106933
Mahmud, A., & Efremov, L. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1948686
Neuroendocrine and circuit remodeling under chronic social stress
So, Y. H., Shin, H. S., Lee, D. H., & Jung, E. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116534
Metadata
- Authors
- Francis, T. C., Chandra, R., Friend, D. M., Finkel, E., Dayrit, G., Miranda, J., Brooks, J. M., Iñiguez, S. D., O’Donnell, P., Kravitz, A., & Lobo, M. K.
- Affiliations
- University of Maryland, Baltimore (US)
- National Institutes of Health (US)
- California State University, San Bernardino (US)
- Corresponding author
- Lobo, Mary Kay
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 77
- Issue
- 3
- Pages
- 212-222
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC5534173
- OpenAlex
- W2141609201
- Cited by
- 379
- References
- 60
- Citations by year
- 2026: 29 · 2025: 28 · 2024: 38 · 2023: 37 · 2022: 36 · 2021: 44 · 2020: 35 · 2019: 41 · 2018: 30 · 2017: 17 · 2016: 21 · 2015: 19
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH106500)
- National Institute of General Medical Sciences (T34GM083883, SC2GM109811)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- nucleus accumbens, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, chronic social defeat stress, depression-like behavior, excitatory synaptic input, intrinsic excitability, social avoidance, neuronal activity modulation, depression resilience
- MeSH terms
- Action Potentials, Animals, Depressive Disorder, Dominance-Subordination, Male, Mice, Inbred C57BL, Mice, Transgenic, Nucleus Accumbens, Social Behavior, Stress, Psychological, Receptors, Dopamine D1, Receptors, Dopamine D2, Patch-Clamp Techniques, Tissue Culture Techniques, Resilience, Psychological, GABAergic Neurons, Anhedonia, Optogenetics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
